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Questions and Answers
What is the main cause of death in calves suffering from diarrhea?
What is the main cause of death in calves suffering from diarrhea?
Which of the following is not considered an etiological agent of neonatal calf gastrointestinal disease?
Which of the following is not considered an etiological agent of neonatal calf gastrointestinal disease?
What percentage of calf deaths in the first six weeks of life is related to scour?
What percentage of calf deaths in the first six weeks of life is related to scour?
Which of the following factors is a nutritional cause of diarrhea in calves?
Which of the following factors is a nutritional cause of diarrhea in calves?
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What is a common clinical intervention required for calves suffering from diarrhea?
What is a common clinical intervention required for calves suffering from diarrhea?
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Which of the following cannot lead to secondary gastrointestinal disease in calves?
Which of the following cannot lead to secondary gastrointestinal disease in calves?
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Which protozoan pathogen is associated with calf diarrhea?
Which protozoan pathogen is associated with calf diarrhea?
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What is the financial cost associated with a sick calf due to diarrhea management?
What is the financial cost associated with a sick calf due to diarrhea management?
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Which of the following antibiotics is typically indicated for treatment in calf diarrhoea cases?
Which of the following antibiotics is typically indicated for treatment in calf diarrhoea cases?
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Which therapy is specifically indicated for treating Cryptosporidia in calves?
Which therapy is specifically indicated for treating Cryptosporidia in calves?
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What is the purpose of vaccinating cows and heifers pre-calving?
What is the purpose of vaccinating cows and heifers pre-calving?
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Which of the following is NOT considered in the population-level investigation of calf scour?
Which of the following is NOT considered in the population-level investigation of calf scour?
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What is one effect of administering NSAIDs like Meloxicam to calves?
What is one effect of administering NSAIDs like Meloxicam to calves?
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What is the primary treatment for necrotic stomatitis in calves?
What is the primary treatment for necrotic stomatitis in calves?
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Which condition is characterized by a congenital absence of anus in calves?
Which condition is characterized by a congenital absence of anus in calves?
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What factor contributes to the development of ruminal tympany?
What factor contributes to the development of ruminal tympany?
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What is the prognosis for necrotic laryngitis in calves compared to necrotic stomatitis?
What is the prognosis for necrotic laryngitis in calves compared to necrotic stomatitis?
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What is a treatment option for severe bloat in calves?
What is a treatment option for severe bloat in calves?
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Which pathogen is associated with hypersecretion leading to osmotic diarrhoea?
Which pathogen is associated with hypersecretion leading to osmotic diarrhoea?
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What is the primary mode of infection for Cryptosporidium in calves?
What is the primary mode of infection for Cryptosporidium in calves?
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What characterizes the malabsorptive diarrhoea caused by pathogens like BVD?
What characterizes the malabsorptive diarrhoea caused by pathogens like BVD?
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Which age group is primarily affected by E.coli F5/K99 infections?
Which age group is primarily affected by E.coli F5/K99 infections?
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What is true about the environmental infectivity of Coccidia oocysts?
What is true about the environmental infectivity of Coccidia oocysts?
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Which pathogen is known to cause hypersecretion due to enterotoxin secretion?
Which pathogen is known to cause hypersecretion due to enterotoxin secretion?
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What complication can arise from diarrhoea caused by pathogens in calves?
What complication can arise from diarrhoea caused by pathogens in calves?
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Which of the following statements about Calving pen pathogens is accurate?
Which of the following statements about Calving pen pathogens is accurate?
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What is a major consequence of damaged intestinal enterocytes in calves with diarrhea?
What is a major consequence of damaged intestinal enterocytes in calves with diarrhea?
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What clinical signs are associated with D-lactataemia in calves?
What clinical signs are associated with D-lactataemia in calves?
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How does diarrhea lead to hyperkalaemia in calves?
How does diarrhea lead to hyperkalaemia in calves?
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What is the best approach for treating calves that are unable to suckle due to dehydration?
What is the best approach for treating calves that are unable to suckle due to dehydration?
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What diagnostic method allows rapid testing for the cause of scours in calves?
What diagnostic method allows rapid testing for the cause of scours in calves?
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What is a common misconception regarding potassium levels during diarrhea?
What is a common misconception regarding potassium levels during diarrhea?
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Which intervention is crucial for calves who have suffered significant fluid loss due to diarrhea?
Which intervention is crucial for calves who have suffered significant fluid loss due to diarrhea?
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What effect does hyperkalaemia have on the muscular system of affected calves?
What effect does hyperkalaemia have on the muscular system of affected calves?
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What is the minimum quantity of colostrum that must be administered to a calf within the first 2 hours of birth?
What is the minimum quantity of colostrum that must be administered to a calf within the first 2 hours of birth?
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Which of the following risks is NOT considered a management risk factor for calf rearing?
Which of the following risks is NOT considered a management risk factor for calf rearing?
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What is the primary pathogen associated with calf diphtheria?
What is the primary pathogen associated with calf diphtheria?
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What is the recommended disinfectant for cleaning calf pens to combat faeco-oral transmission?
What is the recommended disinfectant for cleaning calf pens to combat faeco-oral transmission?
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Which factor is crucial for the absorption of immunoglobulin G from colostrum in calves?
Which factor is crucial for the absorption of immunoglobulin G from colostrum in calves?
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What clinical sign may indicate the presence of necrotic stomatitis in calves?
What clinical sign may indicate the presence of necrotic stomatitis in calves?
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What is the purpose of isolating scouring animals in a calf rearing setting?
What is the purpose of isolating scouring animals in a calf rearing setting?
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What is the recommended total protein level in calves to indicate successful passive transfer?
What is the recommended total protein level in calves to indicate successful passive transfer?
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Study Notes
Neonatal Calf Gastrointestinal Disease
- Neonatal calves are susceptible to gastrointestinal (GI) disorders, significantly impacting their survival and productivity.
- Losses from calf scour are substantial, and prompt, appropriate treatment is crucial for survival.
- Cost of the problem is significant: £44 per sick calf (excluding labour), £123 per sick calf, £36.91 per calf born. (Veterinary, Deaths, Capital, Calf value)
- Factors like dehydration, acidosis and gut damage contribute to mortality.
- Diarrhoea affects 48.2% of pre-weaned calves.
Learning Objectives
- Construct a differential diagnosis list based on clinical presentations, associated with neonatal GI diseases, and choose appropriate diagnostics.
- Determine suitable medical and surgical interventions for the management and treatment of neonatal GI diseases in ruminants.
- Assess individual animal and herd prognosis.
- Define control measures for preventing neonatal GI disease.
Aetiological Agents
- Nutritional: Milk replacer quantity and quality, mixing, temperature, irregular feeding, and poor weaning management.
- Stress: Associated with poor weaning management, irregular milk feeding and other variables.
- Infectious:
- Viruses - Rotavirus, Coronavirus (BVD)
- Bacteria - E. coli, Salmonella, Clostridium
- Protozoa - Cryptosporidia, Coccidia
Diarrhoea
- Rotavirus and Coronavirus: Picked up in calving pens, spread among calves. E. coli F5/K99 is a factor in early diarrhoea.
- Salmonella: Neonatal or older, different presentations, from carrier animals
- Clostridium perfringens: Toxin A and B are implicated
- Cryptosporidium: Environmental pressures, oocysts are immediately infective
- Coccidia: Eimeria bovis/zuernii/alabamensis, oocysts need to sporulate in the environment.
Diarrhoea - Duration of Disease
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E. coli (chronic and acute): Under 5 days, Chronic Birth to 3 months
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Rotavirus: 5 to 10 days, 1 to 2 weeks
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Salmonella: 2 to 6 weeks
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Coronavirus: Few days to a few weeks
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Cryptosporidia: 21 days to 2 years
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Coccidia: 5 to 35 days
Hypersecretory vs Malabsorptive
- Malabsorptive: Damage and loss of intestinal cells are higher than cell replacement, leading to reduced surface area for nutrient and water absorption resulting in osmotic diarrhoea
- Hypersecretory: Pathogens like E. coli and Salmonella cause overproduction of fluid, overwhelming the gut's absorptive capacity. Rotavirus is implicated in both categories.
End Result
- Dehydration and metabolic acidosis (electrolyte imbalance or D-lactate build-up)
D-Lactate Acidosis
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Damage to intestinal enterocytes allows undigested carbohydrates to reach the large intestine.
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This acidification favours lactic acid-producing bacteria.
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D-lactate production also occurs from ruminal milk drinking.
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Lower palpebral reflex, broad-based stance and ataxic movements are clinical signs indicating a problem in the brain.
Hyperkalaemia
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Diarrhoea causes potassium imbalance (hyperkalaemia).
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Potassium loss from the body in diarrhoea is complicated by its role in buffering H+ in the blood.
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Impairment of sodium/potassium ATPase disrupts electrolyte levels, resulting in increased intracellular sodium and extracellular potassium.
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Leads to neuromuscular excitability, muscle weakness, inability to stand, and severe dehydration and bradycardia.
Diagnostics
- Enable determination of the correct treatment based on clinical signs.
- It may not always be possible to differentiate specific pathogens based on clinical signs.
- Use rapid on-farm diagnostics like "rainbow tests".
- Consider ELISA, lab PCR, faecal egg counts, haematology, and biochemical tests.
Treatment Considerations
- Oral rehydration therapy, IV fluid therapy based on dehydration severity and status
- Identifying and addressing the hydration status of the calf.
- Fluid therapy response time can vary depending on the underlying cause.
Treatment Decisions Tree
- Monitor animal demeanour, milk intake and haemochezia
- Check if there is fever, determine if there is a loss of appetite
- Clinical assessment of the diseased animal
- Administer appropriate drugs and treatments as per diagnosis.
Other Therapies
- Specific Therapies: Antibacterial, antiprotozoal, and NSAID treatments
- Diagnosis is critical to direct treatment.
Vaccination
- Rotavirus, Coronavirus, E. coli F5 K99 adhesin are target pathogens.
- Vaccinate cows/heifers 12-3 weeks prior to calving.
- Boost colostral antibodies
- Reduce occurrence, intensity and virus shedding
Risk Factors
- Environmental factors: Group size, stocking density, inter-batch disinfection, dry bedding
- Management factors: Mixing ages, feeding practices, nutrition, milk feeding, concentrate provision, forage, cleanliness, and external stressors.
Monitoring Calves and Changes
- Assessing body weights, growth rates, average daily gain.
- Evaluating passive transfer function (protein level, <10 days old).
Prevention
- Colostrum management (quality and quantity).
- Hygiene (cleaning and disinfection of facilities).
- Vaccination (administer to cows/heifers 12-3 weeks before calving).
- Feeding management (practices for prevention of bloat)
Other Conditions
- Calf Diphtheria: Caused by Fusobacterium necrophorum. Necrotic stomatitis (cheeks) and necrotic laryngitis (larynx) are common presentations.
- Ruminal Tympany/Bloat: Accumulation of gas in the rumen, caused by feeding errors. Clinical signs include rapid onset colic and an observable distended rumen; treat with a stomach tube.
- Atresia Coli and Ani: Congenital defects with absence of the anus or impaired colon function. Clinical signs include gradual abdominal distension and, in the case of atresia coli, no passing of faeces. Euthanasia is typically needed for these cases.
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Description
Test your knowledge on the causes, treatments, and prevention measures related to calf diarrhea. This quiz covers various aspects, including etiological agents, nutritional causes, clinical interventions, and financial implications associated with managing sick calves. Ideal for students and professionals in veterinary science or animal husbandry.