12 Questions
What is the primary role of calcium channels in smooth and cardiac muscle contractile function?
Modulation of intracellular calcium concentrations
What is the functional linkage between beta-adrenergic receptors and calcium channels in the heart?
Enhancement of calcium channel activity
What is the primary difference between the sites of action of nifedipine and diltiazem or verapamil?
Nifedipine acts on L-type calcium channels, while diltiazem and verapamil act on T-type calcium channels
What is the most common side effect of calcium channel blockers?
Headache
Which of the following drugs should not be administered with calcium channel blockers due to the risk of excessive depression of cardiac contractility?
Beta blockers
Do the precautions about administering calcium channel blockers with other drugs apply to all types of calcium channel blockers?
Only to verapamil or diltiazem
What is the main effect of calcium channel blockers on vascular smooth muscle?
Vasodilation
What is the primary site of action of dihydropyridines?
Arterioles only
What is the effect of verapamil on the SA node?
Reduces heart rate
What is a common side effect of verapamil in older adults?
Constipation
What is the therapeutic use of verapamil in cardiac dysrhythmias?
Atrial flutter and paroxysmal supraventricular tachycardia
What is the net effect of verapamil on cardiac performance?
Little or no net effect on cardiac performance
Test your knowledge of calcium channel blockers, their effects on smooth and cardiac muscle contractile function, and their relationship with beta-adrenergic receptors. Learn about the sites of action of nifedipine, diltiazem, and verapamil.
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