Podcast
Questions and Answers
What is the primary mechanism of action for non-dihydropyridines?
What is the primary mechanism of action for non-dihydropyridines?
- Selective activation of L-type calcium channels in the heart.
- Selective blockade of L-type calcium channels in vascular smooth muscle.
- Selective enhancement of calcium influx in cardiac myocytes.
- Non-selective inhibition of L-type calcium channels in both vascular smooth muscle and the heart. (correct)
Which of the following is a potential adverse effect specifically associated with verapamil?
Which of the following is a potential adverse effect specifically associated with verapamil?
- Gum swelling
- Flushing
- Constipation (correct)
- Peripheral edema
How do dihydropyridines primarily affect systemic vascular resistance (SVR)?
How do dihydropyridines primarily affect systemic vascular resistance (SVR)?
- Increase SVR in hypertensive patients and decrease SVR in normotensive patients
- Have no significant effect on SVR
- Decrease SVR (correct)
- Increase SVR
Which of the following conditions is a relative contraindication for the use of non-dihydropyridines?
Which of the following conditions is a relative contraindication for the use of non-dihydropyridines?
Which of the following best describes the antiarrhythmic mechanism of non-dihydropyridines?
Which of the following best describes the antiarrhythmic mechanism of non-dihydropyridines?
A patient is prescribed amlodipine for hypertension but develops noticeable peripheral edema. Which of the following is the MOST appropriate initial step?
A patient is prescribed amlodipine for hypertension but develops noticeable peripheral edema. Which of the following is the MOST appropriate initial step?
In which clinical scenario would a non-dihydropyridine calcium channel blocker be MOST appropriate?
In which clinical scenario would a non-dihydropyridine calcium channel blocker be MOST appropriate?
What is the primary reason non-dihydropyridines are relatively contraindicated in patients taking beta-blockers?
What is the primary reason non-dihydropyridines are relatively contraindicated in patients taking beta-blockers?
Which of the following hemodynamic effects is MOST characteristic of dihydropyridine calcium channel blockers?
Which of the following hemodynamic effects is MOST characteristic of dihydropyridine calcium channel blockers?
How might non-dihydropyridines impact a patient's digoxin level, and why?
How might non-dihydropyridines impact a patient's digoxin level, and why?
A patient with hypertension and Raynaud's phenomenon is considering a calcium channel blocker. Which class would likely be MORE beneficial and why?
A patient with hypertension and Raynaud's phenomenon is considering a calcium channel blocker. Which class would likely be MORE beneficial and why?
What is a key difference in the binding affinity of dihydropyridines compared to non-dihydropyridines?
What is a key difference in the binding affinity of dihydropyridines compared to non-dihydropyridines?
A patient with a known allergy to amlodipine needs a calcium channel blocker for hypertension. Which of the following is LEAST appropriate?
A patient with a known allergy to amlodipine needs a calcium channel blocker for hypertension. Which of the following is LEAST appropriate?
What physiological effect of non-dihydropyridines makes them useful in controlling certain types of arrhythmias?
What physiological effect of non-dihydropyridines makes them useful in controlling certain types of arrhythmias?
In a patient with hypertension and chronic kidney disease, which calcium channel blocker class might be preferred and why?
In a patient with hypertension and chronic kidney disease, which calcium channel blocker class might be preferred and why?
What is the primary advantage of using amlodipine over other dihydropyridines in managing hypertension?
What is the primary advantage of using amlodipine over other dihydropyridines in managing hypertension?
Which of the following scenarios warrants careful monitoring for hypotension when initiating a dihydropyridine calcium channel blocker?
Which of the following scenarios warrants careful monitoring for hypotension when initiating a dihydropyridine calcium channel blocker?
What property of non-dihydropyridines makes them less suitable for patients with left ventricular systolic dysfunction?
What property of non-dihydropyridines makes them less suitable for patients with left ventricular systolic dysfunction?
A patient on verapamil reports new-onset muscle weakness and fatigue. What electrolyte abnormality should be suspected?
A patient on verapamil reports new-onset muscle weakness and fatigue. What electrolyte abnormality should be suspected?
What advice should be given to a patient starting on nifedipine to minimize the risk of reflex tachycardia?
What advice should be given to a patient starting on nifedipine to minimize the risk of reflex tachycardia?
Which of the following calcium channel blockers is LEAST likely to cause significant drug interactions due to CYP3A4 inhibition?
Which of the following calcium channel blockers is LEAST likely to cause significant drug interactions due to CYP3A4 inhibition?
A patient taking a dihydropyridine calcium channel blocker complains of gingival hyperplasia. What is the most appropriate course of action?
A patient taking a dihydropyridine calcium channel blocker complains of gingival hyperplasia. What is the most appropriate course of action?
When are non-dihydropyridines like diltiazem and verapamil contraindicated? (Select all that apply)
When are non-dihydropyridines like diltiazem and verapamil contraindicated? (Select all that apply)
What are the common side effects of Dihydropyridines like Amlodipine and Felodipine? (Select all that apply)
What are the common side effects of Dihydropyridines like Amlodipine and Felodipine? (Select all that apply)
A patient presents with both hypertension and a history of migraine headaches. Which calcium channel blocker might be considered and why?
A patient presents with both hypertension and a history of migraine headaches. Which calcium channel blocker might be considered and why?
A patient on a non-dihydropyridine calcium channel blocker needs to start on erythromycin for a bacterial infection. What is the PRIMARY concern?
A patient on a non-dihydropyridine calcium channel blocker needs to start on erythromycin for a bacterial infection. What is the PRIMARY concern?
Which calcium-channel blocker would primarily lower heart rate and conduction?
Which calcium-channel blocker would primarily lower heart rate and conduction?
What is the best method to deal with Angina pectoris?
What is the best method to deal with Angina pectoris?
What do Dihydropyridines work to inhibit?
What do Dihydropyridines work to inhibit?
How does non-selective calcium channel inhibition by drugs like verapamil and diltiazem impact myocardial oxygen demand?
How does non-selective calcium channel inhibition by drugs like verapamil and diltiazem impact myocardial oxygen demand?
Which of the following is the most likely explanation for why dihydropyridines are more associated with peripheral edema than non-dihydropyridines?
Which of the following is the most likely explanation for why dihydropyridines are more associated with peripheral edema than non-dihydropyridines?
A patient with variant (Prinzmetal's) angina is prescribed a calcium channel blocker. Which class is more appropriate and why?
A patient with variant (Prinzmetal's) angina is prescribed a calcium channel blocker. Which class is more appropriate and why?
What are the indications for Non-Dihydropyridines, like Verapamil and Diltiazem? (Select all that apply)
What are the indications for Non-Dihydropyridines, like Verapamil and Diltiazem? (Select all that apply)
What are the main drugs classes of Ca2+ Channel Blockers?
What are the main drugs classes of Ca2+ Channel Blockers?
Why would Beta Blockers be contraindicated, if a patient is taking non-dihydropyridines?
Why would Beta Blockers be contraindicated, if a patient is taking non-dihydropyridines?
What two drugs come under the Dihydropyridines family of drugs? (Select 2)
What two drugs come under the Dihydropyridines family of drugs? (Select 2)
What do Dihydropyridines lead to?
What do Dihydropyridines lead to?
Which type of drug leads to Hypertension and Angina pectoris?
Which type of drug leads to Hypertension and Angina pectoris?
Which of the following calcium channel blockers is MOST likely to cause constipation as a side effect?
Which of the following calcium channel blockers is MOST likely to cause constipation as a side effect?
A patient with hypertension is prescribed verapamil. Which of the following pre-existing conditions would raise the GREATEST concern regarding the initiation of verapamil therapy?
A patient with hypertension is prescribed verapamil. Which of the following pre-existing conditions would raise the GREATEST concern regarding the initiation of verapamil therapy?
A cardiologist is determining the most appropriate calcium channel blocker for a patient. Considering their differing mechanisms, which factor would be MOST important when choosing between a dihydropyridine and non-dihydropyridine?
A cardiologist is determining the most appropriate calcium channel blocker for a patient. Considering their differing mechanisms, which factor would be MOST important when choosing between a dihydropyridine and non-dihydropyridine?
A patient taking diltiazem reports experiencing persistent constipation. Which of the following strategies is LEAST likely to provide relief without compromising their antihypertensive therapy?
A patient taking diltiazem reports experiencing persistent constipation. Which of the following strategies is LEAST likely to provide relief without compromising their antihypertensive therapy?
A patient with a history of sick sinus syndrome develops symptomatic bradycardia while being treated for hypertension. Which antihypertensive medication is MOST likely contributing to this adverse effect?
A patient with a history of sick sinus syndrome develops symptomatic bradycardia while being treated for hypertension. Which antihypertensive medication is MOST likely contributing to this adverse effect?
A patient with stable angina and hypertension is prescribed a calcium channel blocker. Which of the following combinations of physiological effects makes non-dihydropyridines particularly useful in this scenario?
A patient with stable angina and hypertension is prescribed a calcium channel blocker. Which of the following combinations of physiological effects makes non-dihydropyridines particularly useful in this scenario?
Flashcards
Non-Dihydropyridines
Non-Dihydropyridines
Non-dihydropyridines that include Verapamil and Diltiazem.
Mechanism of NDHPs
Mechanism of NDHPs
Non-selective, inhibit L-type Ca2+ channels in vascular smooth muscle and the heart (AV/SA node).
Side Effects of NDHPs
Side Effects of NDHPs
Bradycardia, arrhythmia, AV block, constipation (verapamil).
Indications for NDHPs
Indications for NDHPs
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Contraindications for NDHPs
Contraindications for NDHPs
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Dihydropyridines
Dihydropyridines
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Dihydropyridines Mechanism
Dihydropyridines Mechanism
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Side Effects of Dihydropyridines
Side Effects of Dihydropyridines
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Dihydropyridines: Indications
Dihydropyridines: Indications
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Contraindications for Dihydropyridines
Contraindications for Dihydropyridines
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Study Notes
- Ca2+ channel blockers include dihydropyridines and non-dihydropyridines
Dihydropyridines
- Drugs include Amlodipine and Felodipine
- Inhibit L-type Ca2+ channels in vascular smooth muscle
- Systemic Vascular Resistance (SVR) decreases
- Adverse Effects include peripheral edema, gum swelling, headache, dizziness, and flushing
- Used to treat hypertension and angina pectoris
- Contraindicated in heart failure (HF) and hypotension
Non-Dihydropyridines
- Drugs include Verapamil and Diltiazem
- Non-selective; inhibit L-Type Ca2+ channels in vascular smooth muscle and heart, specifically the Atrioventricular (AV) and Sinoatrial (SA) nodes
- Contractility decreases
- Heart Rate (HR) decreases and conduction decreases
- Possess antiarrhythmic properties
- Adverse effects include bradycardia, arrhythmia, AV block, and constipation if taking Verapamil
- Used in the treatment of Hypertension, Arrhythmia, and stable angina
- Contraindicated in 2nd or 3rd degree AV block, Heart Failure (HF), Hypotension, and when taking a beta blocker
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