Questions and Answers
What is the prototype of Calcitonin?
Calcitonin-salmon (Fortical, Miracalcin)
What is the expected pharmacologic action of Calcitonin?
Which of the following are therapeutic uses of Calcitonin? (Select all that apply)
What are some common adverse effects of Calcitonin?
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Which of the following is a contraindication for Calcitonin?
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What is an important interaction to monitor when administering Calcitonin?
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What evidence indicates the effectiveness of Calcitonin treatment?
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How is Calcitonin most commonly administered?
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Calcitonin should be stored in an ______ position.
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Study Notes
Calcitonin Overview
- Prototype drug: Calcitonin-salmon (marketed as Fortical, Miracalcin).
Expected Pharmacologic Action
- Decreases bone resorption by inhibiting osteoclast activity, beneficial in treating osteoporosis.
- Increases renal calcium excretion by inhibiting tubular resorption, helping to manage calcium levels.
Therapeutic Uses
- Primarily treats postmenopausal osteoporosis (does not prevent it).
- Effective in treating Paget's disease and managing hypercalcemia resulting from hyperparathyroidism and certain cancers.
Adverse Effects
- Common side effect: Nausea; usually self-limiting.
- Nasal dryness and irritation can occur with intranasal administration; advise to alternate nostrils daily and inspect nasal mucosa for possible ulceration.
Contraindications/Precautions
- Classified as pregnancy risk category C.
- Contraindicated for individuals with hypersensitivity to calcitonin or fish protein; skin allergy testing is recommended before administration.
- Caution is advised for lactating women, children, and patients with kidney disease.
Interactions
- Concurrent use with lithium may lead to decreased serum lithium levels; close monitoring of levels is essential.
Evaluation of Effectiveness
- Effectiveness is indicated by increased bone density.
- Serum calcium levels should be maintained within the expected range of 9-10.5 mg/dL.
Administration Guidelines
- Commonly administered via nasal spray; also available through intramuscular (IM) or subcutaneous (SC) injection; rotate injection sites to prevent inflammation.
- Store the medication in an upright position.
- Alternate nostrils daily for nasal administration.
- Regularly check for Chvostek's and Trousseau's signs to detect hypocalcemia.
- Monitor bone density scans periodically.
- Encourage a diet rich in calcium and vitamin D to support treatment goals.
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Description
This quiz covers essential concepts related to Calcitonin, including its prototype, expected pharmacologic actions, and therapeutic uses. It is an excellent resource for students studying pharmacology or preparing for exams related to osteoporosis and related conditions.
