Podcast
Questions and Answers
What type of immunoglobulin is typically associated with H. gestationis (gestational pemphigoid)?
What type of immunoglobulin is typically associated with H. gestationis (gestational pemphigoid)?
In the treatment of pemphigus erythematosus with positive ANA and C3&C4, what would be the most appropriate option?
In the treatment of pemphigus erythematosus with positive ANA and C3&C4, what would be the most appropriate option?
For a patient with Pemphigus vulgaris presenting with clefts and protruding villi along with high creatinine levels, what treatment would be most suitable?
For a patient with Pemphigus vulgaris presenting with clefts and protruding villi along with high creatinine levels, what treatment would be most suitable?
In a patient diagnosed with Pemphigus vulgaris, who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero, what would be the ideal time for contraception in weeks?
In a patient diagnosed with Pemphigus vulgaris, who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero, what would be the ideal time for contraception in weeks?
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If a newly born baby is found with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible for this condition?
If a newly born baby is found with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible for this condition?
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What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
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Which treatment is most appropriate for histopathology of blistering with IgA and neutrophil, and the presence of DM, HTN, and AF?
Which treatment is most appropriate for histopathology of blistering with IgA and neutrophil, and the presence of DM, HTN, and AF?
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In a case where a pregnant female with bullous pemphigoid takes 1 mg/kg of prednisolone with no improvement, what is the next step?
In a case where a pregnant female with bullous pemphigoid takes 1 mg/kg of prednisolone with no improvement, what is the next step?
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What is the antigen associated with cicatricial pemphigoid?
What is the antigen associated with cicatricial pemphigoid?
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Which underlying malignancy is associated with cicatricial pemphigoid?
Which underlying malignancy is associated with cicatricial pemphigoid?
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In para neoplastic pemphigus, which type of antigen is common?
In para neoplastic pemphigus, which type of antigen is common?
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What is the treatment using biologic for bullous pemphigoid?
What is the treatment using biologic for bullous pemphigoid?
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In a patient with bullous pemphigoid showing elevated urea and creatinine, what should be the next step?
In a patient with bullous pemphigoid showing elevated urea and creatinine, what should be the next step?
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Which biologic treatment is safest during pregnancy?
Which biologic treatment is safest during pregnancy?
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In a scenario of recurrent abdominal pain since childhood with a picture showing EBA with Chron’s disease, what would be the appropriate treatment?
In a scenario of recurrent abdominal pain since childhood with a picture showing EBA with Chron’s disease, what would be the appropriate treatment?
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In EBA (Epidermolysis Bullosa Acquisita), which organ is likely to be affected in a male patient presenting with tensile bulla on the arm and no mucosal lesion?
In EBA (Epidermolysis Bullosa Acquisita), which organ is likely to be affected in a male patient presenting with tensile bulla on the arm and no mucosal lesion?
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A patient developed bullae on the arm after 3 days from starting sulfasalazine with a negative DIF. What is the likely diagnosis?
A patient developed bullae on the arm after 3 days from starting sulfasalazine with a negative DIF. What is the likely diagnosis?
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Which treatment is most appropriate for a patient with histopathology of blistering with IgA and neutrophil and the presence of diabetes mellitus, hypertension, and atrial fibrillation?
Which treatment is most appropriate for a patient with histopathology of blistering with IgA and neutrophil and the presence of diabetes mellitus, hypertension, and atrial fibrillation?
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In a pregnant female with bullous pemphigoid who takes 1 mg/kg of prednisolone with no improvement, what is the next step?
In a pregnant female with bullous pemphigoid who takes 1 mg/kg of prednisolone with no improvement, what is the next step?
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What antigen is associated with cicatricial pemphigoid?
What antigen is associated with cicatricial pemphigoid?
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Which underlying malignancy is associated with cicatricial pemphigoid?
Which underlying malignancy is associated with cicatricial pemphigoid?
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Which biologic treatment is most appropriate for bullous pemphigoid?
Which biologic treatment is most appropriate for bullous pemphigoid?
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In a scenario of recurrent abdominal pain since childhood with a picture showing EBA with Crohn’s disease, what would be the appropriate treatment?
In a scenario of recurrent abdominal pain since childhood with a picture showing EBA with Crohn’s disease, what would be the appropriate treatment?
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In a male patient presenting with tensile bulla on the arm and no mucosal lesion (EBA), which organ is likely to be affected (associated cancer)?
In a male patient presenting with tensile bulla on the arm and no mucosal lesion (EBA), which organ is likely to be affected (associated cancer)?
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What type of toxin is likely responsible for the presence of bullae around the umbilical cord stump in a newly born baby?
What type of toxin is likely responsible for the presence of bullae around the umbilical cord stump in a newly born baby?
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In a patient with vesicles and blisters on the hands for 8 years, along with lower limb involvement and hypertrichosis, what is the most suitable treatment for PCT (Porphyria Cutanea Tarda)?
In a patient with vesicles and blisters on the hands for 8 years, along with lower limb involvement and hypertrichosis, what is the most suitable treatment for PCT (Porphyria Cutanea Tarda)?
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What is the next appropriate step for a 60-year-old patient presenting with tense bullae without mucous membrane involvement and IgG deposition in the floor?
What is the next appropriate step for a 60-year-old patient presenting with tense bullae without mucous membrane involvement and IgG deposition in the floor?
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In a pregnant female case with bullae on the trunk, flanks, umbilical, and abdomen, what type of immunoglobulin (Ig) is typically associated with H. gestationis?
In a pregnant female case with bullae on the trunk, flanks, umbilical, and abdomen, what type of immunoglobulin (Ig) is typically associated with H. gestationis?
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What is the ideal time for contraception in weeks for a patient who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero in Pemphigus vulgaris?
What is the ideal time for contraception in weeks for a patient who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero in Pemphigus vulgaris?
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In a case of Bullous Pemphigoid, which underlying malignancy is commonly associated?
In a case of Bullous Pemphigoid, which underlying malignancy is commonly associated?
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What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
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In a pregnant female case with bullae on the trunk, flanks, umbilical, and abdomen, what type of immunoglobulin (Ig) is typically associated with H. gestationis?
In a pregnant female case with bullae on the trunk, flanks, umbilical, and abdomen, what type of immunoglobulin (Ig) is typically associated with H. gestationis?
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What type of toxin is likely responsible for the presence of bullae around the umbilical cord stump in a newly born baby?
What type of toxin is likely responsible for the presence of bullae around the umbilical cord stump in a newly born baby?
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In EBA (Epidermolysis Bullosa Acquisita), which organ is likely to be affected in a male patient presenting with tensile bulla on the arm and no mucosal lesion?
In EBA (Epidermolysis Bullosa Acquisita), which organ is likely to be affected in a male patient presenting with tensile bulla on the arm and no mucosal lesion?
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In para neoplastic pemphigus, which type of antigen is common?
In para neoplastic pemphigus, which type of antigen is common?
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In a patient diagnosed with Pemphigus vulgaris, who tests positive for desmoglein 3 & 1 antibodies and has a CD20 count of zero, what would be the ideal time for contraception in weeks?
In a patient diagnosed with Pemphigus vulgaris, who tests positive for desmoglein 3 & 1 antibodies and has a CD20 count of zero, what would be the ideal time for contraception in weeks?
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If a newly born baby is found with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible for this condition?
If a newly born baby is found with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible for this condition?
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What is the most appropriate treatment for a patient with granular deposition of IgA in dermal papillae along the basement membrane (Dermatitis Herpetiformis)?
What is the most appropriate treatment for a patient with granular deposition of IgA in dermal papillae along the basement membrane (Dermatitis Herpetiformis)?
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In Epidermolysis Bullosa Acquisita (EBA), which organ is likely to be affected in a male patient presenting with tensile bullae on the arm and no mucosal lesion?
In Epidermolysis Bullosa Acquisita (EBA), which organ is likely to be affected in a male patient presenting with tensile bullae on the arm and no mucosal lesion?
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What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
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What is the appropriate treatment for a patient with recurrent abdominal pain since childhood and a picture showing EBA with Crohn’s disease?
What is the appropriate treatment for a patient with recurrent abdominal pain since childhood and a picture showing EBA with Crohn’s disease?
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What is the most appropriate treatment for a patient with Pemphigus erythematosus positive ANA, C3&C4?
What is the most appropriate treatment for a patient with Pemphigus erythematosus positive ANA, C3&C4?
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In a patient diagnosed with Pemphigus vulgaris with clefts and protruding villi along with high creatinine levels, what treatment would be most suitable?
In a patient diagnosed with Pemphigus vulgaris with clefts and protruding villi along with high creatinine levels, what treatment would be most suitable?
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What is the ideal time for contraception in weeks for a patient who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero in Pemphigus vulgaris?
What is the ideal time for contraception in weeks for a patient who tests positive for desmoglien 3 & 1 antibodies and has a CD20 count of zero in Pemphigus vulgaris?
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In a picture of a newly born with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible?
In a picture of a newly born with umbilical cord stump still present and bullae around it, what type of toxin is likely responsible?
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What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
What type of defect in collagen is characterized by a defect in type 4 collagen and anchoring fibrils?
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In a patient with vesicles and blisters on the hands for 8 years, along with lower limb involvement and hypertrichosis, what is the most suitable treatment for Porphyria Cutanea Tarda (PCT)?
In a patient with vesicles and blisters on the hands for 8 years, along with lower limb involvement and hypertrichosis, what is the most suitable treatment for Porphyria Cutanea Tarda (PCT)?
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What is the most appropriate treatment for a patient with histopathology of blistering with IgA and neutrophil, and the presence of diabetes mellitus, hypertension, and atrial fibrillation?
What is the most appropriate treatment for a patient with histopathology of blistering with IgA and neutrophil, and the presence of diabetes mellitus, hypertension, and atrial fibrillation?
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In a pregnant female with bullous pemphigoid who takes 1 mg/kg of prednisolone with no improvement, what is the next step?
In a pregnant female with bullous pemphigoid who takes 1 mg/kg of prednisolone with no improvement, what is the next step?
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What is the antigen of cicatricial pemphigoid?
What is the antigen of cicatricial pemphigoid?
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Which underlying malignancy is associated with cicatricial pemphigoid?
Which underlying malignancy is associated with cicatricial pemphigoid?
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What is the most safe biologic during pregnancy treatment?
What is the most safe biologic during pregnancy treatment?
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In a scenario of recurrent abdominal pain since childhood & picture of face & ears (EBA with Crohn’s disease), what would be the appropriate treatment?
In a scenario of recurrent abdominal pain since childhood & picture of face & ears (EBA with Crohn’s disease), what would be the appropriate treatment?
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A male patient with tensile bulla on the arm and no mucosal lesions (EBA) since many years, which organ will be affected (associated cancer)?
A male patient with tensile bulla on the arm and no mucosal lesions (EBA) since many years, which organ will be affected (associated cancer)?
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A patient developed bullae on the arm after 3 days from starting sulfasalazine DIF –VE. What is the likely diagnosis?
A patient developed bullae on the arm after 3 days from starting sulfasalazine DIF –VE. What is the likely diagnosis?
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"Salt split test separates skin at" which layer?
"Salt split test separates skin at" which layer?
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"Case of epidermolysis bullosa acquista associated with" what condition?
"Case of epidermolysis bullosa acquista associated with" what condition?
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Study Notes
Pemphigus and Pemphigoid
- H. gestationis is typically associated with IgG immunoglobulin
- In Pemphigus erythematosus with positive ANA and C3&C4, the most appropriate treatment is Rituximab
- In Pemphigus vulgaris with clefts, protruding villi, and high creatinine levels, the most suitable treatment is plasmapheresis and immunosuppressive therapy
- In Pemphigus vulgaris with positive desmoglein 3 & 1 antibodies and CD20 count of zero, the ideal time for contraception is 6-12 months
Bullous Pemphigoid
- The treatment using biologic for bullous pemphigoid is Omalizumab
- In bullous pemphigoid with elevated urea and creatinine, the next step is to reduce the dose of corticosteroids and add mycophenolate mofetil
- In a pregnant female with bullous pemphigoid who takes 1 mg/kg of prednisolone with no improvement, the next step is to add azathioprine
Epidermolysis Bullosa Acquisita (EBA)
- In EBA, the affected organ is the kidneys
- The antigen associated with EBA is type 7 collagen
- The treatment for EBA with Crohn's disease is prednisolone, azathioprine, and infiximab
Cicatricial Pemphigoid
- The antigen associated with cicatricial pemphigoid is BP230 and BP180
- The underlying malignancy associated with cicatricial pemphigoid is lymphoma
- The treatment for cicatricial pemphigoid is dapsone and topical corticosteroids
Dermatitis Herpetiformis
- The treatment for dermatitis herpetiformis is dapsone and gluten-free diet
Porphyria Cutanea Tarda (PCT)
- The treatment for PCT is phlebotomy and chloroquine
Other Conditions
- The toxin responsible for bullae around the umbilical cord stump in a newly born baby is staphylococcal toxin
- The defect in collagen characterized by a defect in type 4 collagen and anchoring fibrils is Epidermolysis Bullosa
- The biologic treatment safest during pregnancy is Omalizumab
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Description
Test your knowledge on bullous diseases such as Pemphigus and Gestational Pemphigoid with these case-based questions. Assess your understanding of treatment options, diagnostic indicators, and management strategies.
