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Questions and Answers
Which herpesvirus is known for causing primary herpetic gingivostomatitis?
Measles is classified as a vesiculo-bullous disease.
False
What is the incubation period for HSV-1?
several days to two weeks
Primary herpetic gingivostomatitis is mainly seen in ______.
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Which of the following conditions is associated with immunologic defects?
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What virus causes genital herpes?
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Epidermolysis bullosa is a hereditary disease.
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What are the common prodromal symptoms of secondary herpes simplex infection?
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Hand-foot-mouth disease is caused by the ______ virus.
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Which of the following is NOT a disease caused by HSV-1?
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Study Notes
Vesiculo-Bullous Diseases Overview
- Consist of viral diseases, immunologic defects, and hereditary conditions affecting the oral mucosa.
Viral Diseases
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Herpes Simplex Virus (HSV)
- HSV-1: Causes primary herpetic gingivostomatitis and secondary herpes; spreads via infected saliva.
- HSV-2: Primarily causes genital herpes but can occasionally affect the oral cavity.
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Varicella Zoster Virus (VZV)
- Causes chickenpox (varicella) and shingles (herpes zoster).
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Coxsackie Virus
- Causes Hand, Foot, and Mouth Disease and Herpangina.
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Measles
- Not classified as a vesiculo-bullous disease.
Conditions Associated with Immunologic Defects
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Pemphigus Vulgaris
- Autoimmune condition affecting mucous membranes, causing painful blisters.
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Cicatricial Pemphigoid
- Chronic autoimmune disorder leading to blisters and scarring in the oral cavity.
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Bullous Pemphigoid
- Similar to Cicatricial Pemphigoid but primarily affects the skin.
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Dermatitis Herpetiformis
- Linked to gluten sensitivity, characterized by itchy blisters.
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Linear IgA Disease
- Rare autoimmune disorder presenting with blistering skin lesions.
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Epidermolysis Bullosa Acquisita
- Characterized by skin and mucosal blistering due to autoantibodies.
Hereditary Diseases
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Epidermolysis Bullosa
- Genetic condition causing fragile skin that blisters easily.
Herpes Simplex Infection Details
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Pathogenesis
- HSV-1 spreads through saliva; causes infections above the waist.
- HSV-2, transmitted sexually, affects the genitalia and skin below the waist.
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Infection Types
- Primary: Usually subclinical in children, can manifest as gingivostomatitis.
- Symptoms include vesicular eruptions, painful gingiva, fever, and cervical lymphadenopathy.
- Secondary: Reactivation can occur due to stress or illness; includes prodromal symptoms like tingling.
- Primary: Usually subclinical in children, can manifest as gingivostomatitis.
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Incubation Period
- Ranges from several days to two weeks for both HSV types.
Clinical Features of Herpetic Simplex Infection
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Primary Herpetic Stomatitis
- Commonly experienced by children; causes vesicular eruptions and painful ulcers in the mouth.
- Diagnosis may involve cytology smear or viral culture if needed.
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Secondary Infection
- Affects 15-45% of the U.S. population; presents with prodromal symptoms followed by vesicle formation.
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Complications
- In adults, may mimic other infections like streptococcal pharyngitis or infectious mononucleosis.
Healing and Prognosis
- Lesions heal without scarring within 7-10 days in both primary and secondary infections.
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Description
This quiz covers Vesiculo-Bullous diseases, focusing on oral pathology including viral diseases such as Herpes Simplex and Varicella Zoster. Additionally, it discusses conditions associated with immunologic defects like Pemphigus vulgaris. Prepare to deepen your understanding of these important topics in Oral Pathology.
