15 Questions
What is the classic definition of COPD?
Chronic airflow obstruction determined by spirometry, usually occurring in the setting of noxious environmental exposures
What is the primary cause of COPD?
Chronic exposure to cigarette smoke in genetically susceptible individuals
What is the pathogenesis of emphysema?
Inflammatory cells releasing proteinases that damage the extracellular matrix
What is the anatomical definition of emphysema?
Destruction of the lung alveoli with air space enlargement
What is the clinical definition of chronic bronchitis?
Chronic cough and phlegm production
What is the third leading cause of death in the United States?
Chronic obstructive pulmonary disease (COPD)
Which major physiologic change is characteristic of chronic obstructive pulmonary disease (COPD)?
Decreased small bronchioles
What contributes to the enlargement of air spaces and the development of emphysema in COPD?
Oxidant-induced damage to structural cells
What is a common feature of chronic bronchitis as part of COPD?
Presence of chronic cough
How does chronic exposure to cigarette smoke contribute to the pathogenesis of COPD?
Causes inflammatory and immune cell recruitment
Which aspect characterizes small airway disease in COPD?
Airway narrowing
What role do proteinases released by inflammatory cells play in the pathogenesis of COPD?
Damage the extracellular matrix
How does disordered repair of elastin contribute to emphysema development?
Contributes to air space enlargement
What occurs within large and small airways due to chronic exposure to cigarette smoke?
Inflammatory and immune cell recruitment
What is a key feature that characterizes the pathogenesis of emphysema in COPD?
Air space enlargement due to structural changes
Explore the characteristics and diagnosis of Chronic Obstructive Pulmonary Disease (COPD) in the context of small airway disease. This quiz is adapted from a lecture by Dr. Jervis T. Salvador at Cagayan State University - Andrews Campus, Batch 2024.
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