Bronchodilator Medications in Respiratory Therapy
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Questions and Answers

Which of the following is a major trigger of bronchoconstriction?

  • Secretions
  • Mucosal edema
  • Bronchospasm (correct)
  • Airway inflammation

Which device is NOT commonly used to administer inhaled aerosols?

  • Oral tablets (correct)
  • Small-volume nebulizer (SVN)
  • Soft-mist inhaler (Respimat)
  • Metered-dose inhaler (MDI)

Which category of bronchodilators is associated with adverse effects such as tachycardia and tremors?

  • Methylxanthine
  • Corticosteroid
  • Anticholinergic
  • Sympathomimetic (correct)

What is the primary mechanism of action of anticholinergic bronchodilators?

<p>Blockade of muscarinic receptors (B)</p> Signup and view all the answers

Which of the following is true about Roflumilast (Daliresp)?

<p>It is used to reduce the risk of acute exacerbations in severe COPD patients (B)</p> Signup and view all the answers

What is the primary function of Magnesium sulfate in severe asthma exacerbations?

<p>Causing smooth muscle relaxation (A)</p> Signup and view all the answers

Which medication is a combined B2 agonist and muscarinic antagonist?

<p>Combivent (A)</p> Signup and view all the answers

What is the primary therapeutic use of Methylxanthines like Theophylline?

<p>Bronchodilation in COPD and asthma (C)</p> Signup and view all the answers

Which medication is used as an adjunctive bronchodilator in severe, life-threatening asthma exacerbations?

<p>Magnesium sulfate (D)</p> Signup and view all the answers

What is the primary effect of combined B2 agonist and muscarinic antagonist medications like Combivent?

<p>Bronchodilation (C)</p> Signup and view all the answers

Which medication is taken orally and used to reduce the risk of acute exacerbations in severe COPD patients?

<p>Roflumilast (Daliresp) (D)</p> Signup and view all the answers

What is the primary adverse effect of Magnesium sulfate used as an adjunctive bronchodilator?

<p>Flushing (A)</p> Signup and view all the answers

What is the primary neurotransmitter for sympathetic (adrenergic) receptors in the lung?

<p>Norepinephrine (B)</p> Signup and view all the answers

Which receptors do adrenergic bronchodilators stimulate to achieve relaxation of bronchial smooth muscle?

<p>Alpha-receptors (C)</p> Signup and view all the answers

Which medication is a long-acting antimuscarinic agent used for extended bronchodilation?

<p>Salmeterol (B)</p> Signup and view all the answers

What is the primary adverse effect of adrenergic bronchodilators?

<p>Insomnia (A)</p> Signup and view all the answers

Which neurotransmitter do anticholinergic bronchodilators act as competitive antagonists for on airway smooth muscle?

<p>Acetylcholine (B)</p> Signup and view all the answers

Which category of bronchodilators is used for maintenance treatment in COPD and during acute asthma attacks?

<p>Anticholinergic (D)</p> Signup and view all the answers

Which medication provides rapid onset (within 10 mins) and is used for acute bronchospasm?

<p>Albuterol (D)</p> Signup and view all the answers

Which medication has a longer duration of action and is usually indicated for patients with cardiac concerns?

<p>Levalbuterol (C)</p> Signup and view all the answers

Which medication is a nonselective sympathomimetic used for conditions like status asthmaticus and acute mucosal edema?

<p>Racemic epinephrine (D)</p> Signup and view all the answers

Which adverse effect is associated with adrenergic bronchodilators?

<p>Tremors (C)</p> Signup and view all the answers

Which category of bronchodilators are used for acute relief of airflow obstruction and maintenance bronchodilation in patients with obstructive lung disease?

<p>Adrenergic (B)</p> Signup and view all the answers

Which medication is a long-acting bronchodilator that provides bronchodilation for extended periods?

<p>Formoterol (B)</p> Signup and view all the answers

Flashcards

Inhaled aerosols

Medications delivered directly to the lungs using fine particles.

Lung receptors

Sympathetic and parasympathetic receptors that regulate airway tone.

Adrenergic bronchodilators

Medications that relax bronchial smooth muscle via adrenergic receptors.

Alpha-receptors

Receptors in blood vessels that cause vasoconstriction when stimulated.

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Beta-1 receptors

Receptors that increase heart rate and contractility when activated.

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Beta-2 receptors

Receptors that cause relaxation of bronchial smooth muscle.

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Sympathomimetics

Medications that mimic sympathetic nervous system responses.

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Corticosteroids

Anti-inflammatory drugs used to reduce airway inflammation.

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SABA

Short-acting beta-agonists used for quick relief of bronchospasm.

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LABA

Long-acting beta-agonists for maintenance bronchodilation.

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Nonselective sympathomimetics

Activate multiple adrenergic receptors for broader effects.

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Albuterol

A SABA with rapid onset for acute bronchospasm.

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Levalbuterol

A SABA with a longer duration of action, safer for the heart.

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Long-acting bronchodilators

Medications providing prolonged airway dilation.

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Anticholinergic bronchodilators

Medications that block acetylcholine to relax airway smooth muscle.

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Long-acting antimuscarinic agents

Anticholinergics providing extended bronchodilation.

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Tachycardia

Rapid heart rate, a potential side effect of adrenergic bronchodilators.

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Evaluate bronchodilator therapy

Assessing vital signs and breath sounds pre- and post-treatment.

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Racemic epinephrine

A nonselective sympathomimetic used for severe airway obstruction.

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Adverse effects of bronchodilators

Side effects including tremors, headaches, and insomnia.

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Mucosal edema

Swelling of the airway lining often treated with bronchodilators.

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Status asthmaticus

A severe asthma attack requiring immediate treatment.

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Competitive antagonists

Compounds that block neurotransmitter action at receptors.

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Bronchodilation duration

The length of time that a bronchodilator is effective.

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Study Notes

Bronchodilator Medications in Respiratory Therapy

  • Inhaled aerosols have advantages such as rapid drug action and targeted delivery, but they also have disadvantages due to variable delivered doses and lack of knowledge of device performance.
  • The lung contains sympathetic (adrenergic) and parasympathetic (cholinergic) receptors, with norepinephrine and acetylcholine as the respective neurotransmitters.
  • Adrenergic bronchodilators, including short-acting and long-acting agents, are used for acute relief of airflow obstruction and maintenance bronchodilation in patients with obstructive lung disease.
  • Adrenergic bronchodilators work by stimulating alpha-receptors, beta-1 receptors, and beta-2 receptors to achieve vasoconstriction, increased heart rate, and relaxation of bronchial smooth muscle.
  • Sympathomimetics and corticosteroids help relieve mucosal edema, while sympathomimetics and anticholinergics are used to relieve bronchospasm.
  • Adrenergic bronchodilators are classified as short-acting (SABA), long-acting (LABA), and ultra long-acting, with examples including albuterol, levalbuterol, and racemic epinephrine.
  • Albuterol, a short-acting bronchodilator, has rapid onset (within 10 mins) and is used for acute bronchospasm, while levalbuterol has a longer duration of action and is usually indicated for patients with cardiac concerns.
  • Long-acting bronchodilators, such as arformoterol, formoterol, indacaterol, olodaterol, salmeterol, and vilanterol, provide bronchodilation for extended periods.
  • Nonselective sympathomimetics like epinephrine and racemic epinephrine are used for conditions like status asthmaticus and acute mucosal edema.
  • Adverse effects of adrenergic bronchodilators include tremors, headache, insomnia, and tachycardia, and assessment of bronchodilator therapy involves evaluating vital signs and breath sounds before and after treatment.
  • Anticholinergic bronchodilators, also known as parasympatholytics, are used for maintenance treatment in COPD and during acute asthma attacks, and they act as competitive antagonists for acetylcholine on airway smooth muscle.
  • Long-acting antimuscarinic agents, such as aclidinium, glycopyrrolate, tiotropium, and umeclidinium, provide bronchodilation for extended periods and have varying durations of action.

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Description

Test your knowledge of bronchodilator medications in respiratory therapy with this quiz. Explore the mechanisms of action, classification, and examples of adrenergic and anticholinergic bronchodilators, along with their indications and adverse effects. Brush up on essential concepts for managing obstructive lung diseases and acute airflow obstruction.

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