Podcast
Questions and Answers
True or false: Fibroadenoma is a malignant tumor composed of both epithelial and stromal components.
True or false: Fibroadenoma is a malignant tumor composed of both epithelial and stromal components.
False
True or false: Fibroadenoma occurs most commonly in women in their 40s and 50s.
True or false: Fibroadenoma occurs most commonly in women in their 40s and 50s.
False
True or false: Intralobular stroma in the breast is the source of fibroadenoma and phyllodes tumor.
True or false: Intralobular stroma in the breast is the source of fibroadenoma and phyllodes tumor.
True
Phyllodes tumors are more common than fibroadenomas, accounting for 97.5% of all fibroepithelial tumors of the breast.
Phyllodes tumors are more common than fibroadenomas, accounting for 97.5% of all fibroepithelial tumors of the breast.
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Benign phyllodes tumors are characterized by increased stromal cellularity compared to fibroadenoma.
Benign phyllodes tumors are characterized by increased stromal cellularity compared to fibroadenoma.
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Phyllodes tumors are capable of a diverse range of biologic behavior, with 95% of them behaving similarly to benign fibroadenomas.
Phyllodes tumors are capable of a diverse range of biologic behavior, with 95% of them behaving similarly to benign fibroadenomas.
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Somatic mutations of the MED12 gene have been identified in about 70% of phyllodes tumors, similar to fibroadenomas.
Somatic mutations of the MED12 gene have been identified in about 70% of phyllodes tumors, similar to fibroadenomas.
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True or false: Fibroadenomas are generally considered true neoplasms rather than hyperplastic lesions?
True or false: Fibroadenomas are generally considered true neoplasms rather than hyperplastic lesions?
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True or false: Fibroadenomas are correlated with a decreased risk of breast cancer compared to the general population?
True or false: Fibroadenomas are correlated with a decreased risk of breast cancer compared to the general population?
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True or false: Fibroadenomas are commonly found in the male breast and are clinically diagnosed as gynecomastia?
True or false: Fibroadenomas are commonly found in the male breast and are clinically diagnosed as gynecomastia?
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True or false: Fibroadenomas are generally considered true neoplasms rather than hyperplastic lesions?
True or false: Fibroadenomas are generally considered true neoplasms rather than hyperplastic lesions?
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True or false: Fibroadenomas are correlated with a decreased risk of breast cancer compared to the general population?
True or false: Fibroadenomas are correlated with a decreased risk of breast cancer compared to the general population?
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True or false: Fibroadenomas are commonly found in the male breast and are clinically diagnosed as gynecomastia?
True or false: Fibroadenomas are commonly found in the male breast and are clinically diagnosed as gynecomastia?
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Study Notes
Understanding Fibroadenomas: Key Points
- Fibroadenomas are associated with higher levels of plasma estradiol, suggesting estrogen dependency for their growth, and tamoxifen treatment reduces their proliferation activity.
- Cellular analyses show that both stromal and epithelial cells in fibroadenomas are polyclonal, indicating they are hyperplastic lesions rather than true neoplasms.
- Mutations of the MED12 gene have been identified in up to 65% of fibroadenoma cases, indicating monoclonality and suggesting some fibroadenomas may be neoplastic rather than hyperplastic lesions.
- Fibroadenomas usually present as solitary, painless nodules, but in 15% of cases, they can be multiple and may grow rapidly under certain conditions such as pregnancy, hormone replacement therapy, or immunosuppression.
- Grossly, fibroadenomas appear as spherical nodules with a whorled-like pattern, and microscopically, they show combined proliferation of mesenchymal and epithelial elements.
- Fibroadenomas are markers for increased risk of breast cancer, with a 1.3 to 2.1 increased risk compared to the general population, and there are simple and complex subtypes with varying risks.
- Malignant transformations within fibroadenomas are rare, with the incidence of carcinoma in situ or invasive breast carcinoma evolving within a fibroadenoma being reported as 0.002% to 0.0125%.
- On mammograms, fibroadenomas appear as smooth-margined oval or round masses, and on ultrasound, they appear solid, well-circumscribed, and hypoechoic.
- Most fibroadenomas grow to a size of 2 to 3 cm over a 12-month period, after which they remain unchanged for several years, and regression or complete resolution is noted in 50% of cases.
- Fibroadenomas are very uncommon in the male breast and are usually diagnosed clinically as gynecomastia, presenting with an enlarged breast and a painful nodule.
- Fibroadenomas have a spherical, sharply demarcated appearance with a firm, grayish-white consistency, and a whorled-like pattern upon cut section.
- The stromal component of fibroadenomas is made up of loose connective tissue, while the epithelial component arises from the terminal duct lobular unit, leading to two main histological features: intracanalicular and pericanalicular.
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Description
Test your knowledge of breast stroma neoplasms by taking this quiz. Learn about the distinct types of neoplasms that arise from intralobular stroma and interlobular stroma and understand their impact on breast health.
