Breast Cancer Assessment and Genetics Quiz
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Questions and Answers

What should be done to assess for metastasis in cases of local recurrence?

  • MRI with gadolinium contrast
  • X-ray of the chest only
  • Whole-body MRI or PET-CT scan (correct)
  • Blood tests for tumor markers

Which type of breast cancer is more aggressive and commonly presents at an earlier age?

  • Triple-Negative Breast Cancer (TNBC)
  • Familial Breast Cancer (FBC)
  • Hormone-Receptor Positive Breast Cancer
  • Hereditary Breast Cancer (HBC) (correct)

What genetic mutations are associated with high penetrance in breast cancer?

  • BRCA1 and BRCA2 only
  • Peutz-Jeghers syndrome and hereditary gastric cancer syndrome only
  • BRCA1, BRCA2, and several other syndromes (correct)
  • Li-Fraumeni syndrome and Cowden syndrome only

What risk-reducing procedure may be offered to women with a BRCA mutation?

<p>Bilateral risk-reducing mastectomy (B)</p> Signup and view all the answers

What is the lifetime risk of developing breast cancer associated with BRCA1 mutations?

<p>50-85% (A)</p> Signup and view all the answers

Which imaging technique should NOT be used in pregnant women suspected of having breast cancer?

<p>CT scan (D)</p> Signup and view all the answers

Which breast cancer variant is BRCA2 primarily associated with?

<p>Prostate cancer and other solid tumors (C)</p> Signup and view all the answers

Which treatment is NOT commonly considered after systemic chemotherapy for local recurrence?

<p>Mandatory radiation to the brain (B)</p> Signup and view all the answers

Flashcards

Hereditary Breast Cancer (HBC)

A type of breast cancer that runs in families and is linked to a specific gene mutation.

Familial Breast Cancer (FBC)

A type of breast cancer affecting multiple family members without a known gene mutation.

BRCA1

A gene associated with a high risk of both breast and ovarian cancer, often leading to triple-negative breast cancer.

BRCA2

A gene associated with a high risk of various cancers, including breast, ovarian, and prostate cancer.

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Bilateral Risk-Reducing Mastectomy

The surgical removal of both breasts as a preventive measure for women with a high risk of breast cancer.

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Bilateral Salpingo-Oophorectomy

The surgical removal of both fallopian tubes and ovaries, often recommended for women with BRCA mutations to reduce cancer risk.

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Breast Cancer in Pregnancy

A type of breast cancer often associated with pregnancy, often more aggressive and triple-negative.

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MRI without Gadolinium Contrast

Imaging technique used for pregnant women with suspected breast cancer to avoid radiation exposure to the fetus.

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