BRCA Mutations and Ovarian Cancer Risk
77 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the typical age range in which testicular cancer occurs?

  • 5-15
  • 15-35 (correct)
  • 45-55
  • 35-45

Which of the following is NOT a risk factor for testicular cancer?

  • Family history of testicular cancer
  • Inguinal hernia
  • Undescended testicle
  • Diabetes (correct)

What is a typical presentation of testicular cancer?

  • Painless, hard, heavy, firm testicular mass (correct)
  • Fluctuant mass
  • Painful, soft, movable testicular mass
  • Transilluminating tumor

Which symptom may indicate metastasis to the lung in testicular cancer?

<p>Cough or dyspnea (C)</p> Signup and view all the answers

Which imaging technique can distinguish between extra-testicular masses and intra-testicular masses in evaluating a testicular mass?

<p>Scrotal ultrasound (C)</p> Signup and view all the answers

What is the significance of gynecomastia in relation to testicular cancer?

<p>It is not common but may occur (D)</p> Signup and view all the answers

What might be indicated by a firm, hard, or fixed area during a testicular exam?

<p>Suspicion of malignancy (A)</p> Signup and view all the answers

What is the average age difference in developing ovarian cancer between individuals with BRCA1 mutation compared to those with BRCA2 mutation?

<p>10 years (D)</p> Signup and view all the answers

What is the absolute risk of developing ovarian cancer over a lifetime for individuals with BRCA1 mutation?

<p>35-45% (A)</p> Signup and view all the answers

Which factor is not thought to contribute to the development of ovarian cancer?

<p>Pregnancy and use of contraceptives (A)</p> Signup and view all the answers

What manifestation is rare in cases where ovarian cancer is localized to the ovary?

<p>Painful intercourse (B)</p> Signup and view all the answers

Which symptom is not typically associated with advanced ovarian cancer?

<p>Hematuria (B)</p> Signup and view all the answers

What acute presentations can patients with ovarian cancer have?

<p>Bowel obstructions and pleural effusions (B)</p> Signup and view all the answers

Which of the following conditions reduces the risk of developing ovarian cancer?

<p><strong>Tubal ligation</strong> (A)</p> Signup and view all the answers

What diagnostic imaging modality is recommended as the first line for evaluating endometrial cancer?

<p>Pelvic sonogram (C)</p> Signup and view all the answers

In postmenopausal women with a thin endometrial lining, when is an endometrial biopsy not required?

<p>In the presence of ongoing bleeding (D)</p> Signup and view all the answers

What is the treatment of choice for early stages of endometrial cancer?

<p>Hysterectomy (A)</p> Signup and view all the answers

What is a characteristic feature of multiple myeloma?

<p>Malignant transformation and proliferation of plasma cells in the bone marrow (A)</p> Signup and view all the answers

Which demographic group has a higher risk of developing multiple myeloma?

<p>African Americans (C)</p> Signup and view all the answers

At what age does multiple myeloma typically occur?

<p>Between 65-74 years old (A)</p> Signup and view all the answers

What is the primary risk factor for multiple myeloma?

<p>Gender (being male) (C)</p> Signup and view all the answers

What may be required in advanced stages of multiple myeloma treatment?

<p>Chemotherapy and radiation therapy (A)</p> Signup and view all the answers

What is the main treatment for TLS?

<p>IV Hydration (B)</p> Signup and view all the answers

When should hypocalcemia be treated in TLS?

<p>After treating hyperphosphatemia (B)</p> Signup and view all the answers

What is the diagnostic imaging modality preferred for diagnosing Superior Vena Cava Syndrome in life-threatening cases?

<p>Catheter-based venography (A)</p> Signup and view all the answers

Which patients should receive rasburicase for TLS prevention?

<p>Patients at high risk of TLS (B)</p> Signup and view all the answers

What symptoms are characteristic of Superior Vena Cava Syndrome?

<p>Headache, dyspnea, hoarseness (D)</p> Signup and view all the answers

How much IV hydration per day is recommended for patients at risk of TLS?

<p>$3000$ ml/m2/day (A)</p> Signup and view all the answers

What happens in Superior Vena Cava Syndrome?

<p>Obstruction of the superior vena cava (C)</p> Signup and view all the answers

Which treatment option is NOT advisable for hyperkalemia in TLS?

<p>Standard hyperkalemia treatments (B)</p> Signup and view all the answers

Which chemotherapy drug is associated with dose-related cardiotoxicity?

<p>Danuorubicin (Cerubidine) (C)</p> Signup and view all the answers

Which chemotherapy drug may cause red/orange urine as a side effect?

<p>Doxorubicin (Adriamycin) (A)</p> Signup and view all the answers

Which chemotherapy drug is linked to peripheral neuropathy as a side effect?

<p>Paclitaxel (Taxol) (A)</p> Signup and view all the answers

Which cancer type is most commonly associated with Spinal Cord Compression from metastasis?

<p>Breast cancer (B)</p> Signup and view all the answers

Which chemotherapy drug side effect includes photosensitivity?

<p>Fluorouracil (5-FU) (C)</p> Signup and view all the answers

Which chemotherapy drug may lead to malaise and toxic effects on the colon?

<p>Vinblastine (Velban) (C)</p> Signup and view all the answers

What is a common side effect of Gemcitabine (Gemzar)?

<p><strong>Fever</strong> (D)</p> Signup and view all the answers

Which chemotherapy drug is known for causing edema and mucositis as potential side effects?

<p><strong>Paclitaxel (Taxol)</strong> (A)</p> Signup and view all the answers

How can tumor markers help in cancer management?

<p>Resurgence of tumor markers suggests cancer recurrence (B)</p> Signup and view all the answers

Which organ is NOT commonly affected by metastasis in breast cancer?

<p>Pancreas (D)</p> Signup and view all the answers

Which organ is NOT listed as a site of metastasis for lung cancer?

<p>Kidney (D)</p> Signup and view all the answers

What is a common site of metastasis for melanoma?

<p>Peritoneum (B)</p> Signup and view all the answers

Which cancer type is NOT known to metastasize to the liver?

<p>Testicular cancer (A)</p> Signup and view all the answers

Which organ is NOT mentioned as a site of metastasis for uterine cancer?

<p>Liver (D)</p> Signup and view all the answers

What is the significance of detecting tumor markers in cancer patients?

<p>Rising tumor marker levels may suggest progression or recurrence of the disease (C)</p> Signup and view all the answers

Which of these cancers does NOT commonly metastasize to the brain?

<p>Kidney cancer (B)</p> Signup and view all the answers

What is the primary goal of surgery in treating ovarian cancer?

<p>To remove all tumor nodules larger than 1cm (C)</p> Signup and view all the answers

Why is surgical exploration necessary for a definitive diagnosis of ovarian cancer?

<p>To confirm elevated CA125 marker levels (B)</p> Signup and view all the answers

Why are there no recommended screening tests for ovarian cancer?

<p>As per recommendations from the USPSTF and Society of Gynecologic Oncology (A)</p> Signup and view all the answers

What is the most common gynecologic malignancy in developed countries?

<p>Endometrial Cancer (C)</p> Signup and view all the answers

When should women who are BRCA1 and BRCA2 positive consider prophylactic bilateral salpingo-oophorectomy?

<p>Before childbearing (C)</p> Signup and view all the answers

What reduces the risk of developing ovarian cancer by 90% in high-risk individuals?

<p>Prophylactic bilateral salpingo-oophorectomy (A)</p> Signup and view all the answers

What does the Society of Gynecologic Oncology recommend regarding ovarian cancer screening for low-risk females?

<p>Against screening low-risk females (D)</p> Signup and view all the answers

What is the major reason for the lack of reliable screening tests for ovarian cancer?

<p>Recommendations against screening by medical societies (B)</p> Signup and view all the answers

What is the main treatment for Superior Vena Cava Syndrome?

<p>IV Hydration (D)</p> Signup and view all the answers

When should hypocalcemia be treated in a patient with Superior Vena Cava Syndrome?

<p>After treating hyperphosphatemia (A)</p> Signup and view all the answers

Which imaging modality is recommended for diagnosing Superior Vena Cava Syndrome in life-threatening cases?

<p>CT Scan (D)</p> Signup and view all the answers

What is the primary risk factor for developing Superior Vena Cava Syndrome?

<p>Tumor expansion obstructing the vena cava (D)</p> Signup and view all the answers

What is the cornerstone in preventing Tumor Lysis Syndrome (TLS) in patients at risk?

<p>Aggressive hydration (A)</p> Signup and view all the answers

In patients with high risk of TLS, what medication should be used for prevention?

<p>Bicarb for metabolic acidosis (C)</p> Signup and view all the answers

What diagnostic method provides the most expedient way to diagnose and treat Superior Vena Cava Syndrome in life-threatening cases?

<p>Catheter-based venography (D)</p> Signup and view all the answers

What may be required if standard hyperkalemia treatments fail in a patient with Superior Vena Cava Syndrome?

<p>Dialysis (C)</p> Signup and view all the answers

What side effect is not associated with Vinblastine (Velban)?

<p>Malaise (C)</p> Signup and view all the answers

Which chemotherapy drug is linked to red/orange urine as a side effect?

<p>Doxorubicin (Adriamycin) (D)</p> Signup and view all the answers

Which cancer type commonly metastasizes to cause Spinal Cord Compression?

<p>Breast cancer (C)</p> Signup and view all the answers

Which chemotherapy drug side effect includes peripheral neuropathy?

<p>Vincristine (Oncovin) (D)</p> Signup and view all the answers

Which symptom is not typically associated with Fluorouracil (5-FU)?

<p>Edema (D)</p> Signup and view all the answers

Which chemotherapy drug may lead to fever and hypotension as side effects?

<p>Etoposide (Vepesid) (D)</p> Signup and view all the answers

Which chemotherapy drug is associated with edema as a potential side effect?

<p>Gemcitabine (Gemzar) (C)</p> Signup and view all the answers

What is the primary management strategy for patients with Hyperleukocytosis?

<p>Start emergent chemotherapy (D)</p> Signup and view all the answers

Which leukemia types are most commonly associated with Hyperleukocytosis?

<p>Acute myelogenous leukemia and chronic myeloid leukemia (C)</p> Signup and view all the answers

What is a potential consequence of untreated Hyperleukocytosis?

<p>Symptomatic leukostasis leading to impaired microcirculation (D)</p> Signup and view all the answers

In Hyperleukocytosis, what symptoms may indicate intracranial hemorrhage?

<p>Headache, blurry vision, confusion (B)</p> Signup and view all the answers

What is the most appropriate initial treatment for Hyperleukocytosis if emergent chemotherapy is not immediately possible?

<p>Administer Hydroxyurea as a first-line treatment (B)</p> Signup and view all the answers

For patients with Hyperleukocytosis unable to receive emergent chemotherapy, what treatment alternative may be considered?

<p>Leukapheresis as a temporary measure (B)</p> Signup and view all the answers

What should be avoided in patients with Hyperleukocytosis to prevent symptomatic leukostasis?

<p>Administering red blood cell transfusions (A)</p> Signup and view all the answers

Why is it essential to provide treatment to prevent tumor lysis syndrome in patients with Hyperleukocytosis?

<p>To mitigate metabolic derangements due to cellular breakdown products (B)</p> Signup and view all the answers

More Like This

BRCA1 and BRCA2 Mutations Quiz
20 questions

BRCA1 and BRCA2 Mutations Quiz

MiraculousBildungsroman4805 avatar
MiraculousBildungsroman4805
Breast Cancer Assessment and Genetics Quiz
8 questions
Patologia Generale - Domande e Risposte
15 questions
Use Quizgecko on...
Browser
Browser