Recent

  • Show all results for ""

🎧 New: AI-Generated Podcasts Turn your study notes into engaging audio conversations. Learn more

BRCA Mutations and Ovarian Cancer Risk
77 Questions
0 Views

BRCA Mutations and Ovarian Cancer Risk

Created by
@AdaptableMaclaurin

Podcast Beta

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the typical age range in which testicular cancer occurs?

  • 5-15
  • 15-35 (correct)
  • 45-55
  • 35-45

    • Which of the following is NOT a risk factor for testicular cancer?

  • Family history of testicular cancer
  • Inguinal hernia
  • Undescended testicle
  • Diabetes (correct)

    • What is a typical presentation of testicular cancer?

  • Painless, hard, heavy, firm testicular mass (correct)
  • Fluctuant mass
  • Painful, soft, movable testicular mass
  • Transilluminating tumor

    • Which symptom may indicate metastasis to the lung in testicular cancer?

    <p>Cough or dyspnea</p> Signup and view all the answers

    Which imaging technique can distinguish between extra-testicular masses and intra-testicular masses in evaluating a testicular mass?

    <p>Scrotal ultrasound</p> Signup and view all the answers

    What is the significance of gynecomastia in relation to testicular cancer?

    <p>It is not common but may occur</p> Signup and view all the answers

    What might be indicated by a firm, hard, or fixed area during a testicular exam?

    <p>Suspicion of malignancy</p> Signup and view all the answers

    What is the average age difference in developing ovarian cancer between individuals with BRCA1 mutation compared to those with BRCA2 mutation?

    <p>10 years</p> Signup and view all the answers

    What is the absolute risk of developing ovarian cancer over a lifetime for individuals with BRCA1 mutation?

    <p>35-45%</p> Signup and view all the answers

    Which factor is not thought to contribute to the development of ovarian cancer?

    <p>Pregnancy and use of contraceptives</p> Signup and view all the answers

    What manifestation is rare in cases where ovarian cancer is localized to the ovary?

    <p>Painful intercourse</p> Signup and view all the answers

    Which symptom is not typically associated with advanced ovarian cancer?

    <p>Hematuria</p> Signup and view all the answers

    What acute presentations can patients with ovarian cancer have?

    <p>Bowel obstructions and pleural effusions</p> Signup and view all the answers

    Which of the following conditions reduces the risk of developing ovarian cancer?

    <p><strong>Tubal ligation</strong></p> Signup and view all the answers

    What diagnostic imaging modality is recommended as the first line for evaluating endometrial cancer?

    <p>Pelvic sonogram</p> Signup and view all the answers

    In postmenopausal women with a thin endometrial lining, when is an endometrial biopsy not required?

    <p>In the presence of ongoing bleeding</p> Signup and view all the answers

    What is the treatment of choice for early stages of endometrial cancer?

    <p>Hysterectomy</p> Signup and view all the answers

    What is a characteristic feature of multiple myeloma?

    <p>Malignant transformation and proliferation of plasma cells in the bone marrow</p> Signup and view all the answers

    Which demographic group has a higher risk of developing multiple myeloma?

    <p>African Americans</p> Signup and view all the answers

    At what age does multiple myeloma typically occur?

    <p>Between 65-74 years old</p> Signup and view all the answers

    What is the primary risk factor for multiple myeloma?

    <p>Gender (being male)</p> Signup and view all the answers

    What may be required in advanced stages of multiple myeloma treatment?

    <p>Chemotherapy and radiation therapy</p> Signup and view all the answers

    What is the main treatment for TLS?

    <p>IV Hydration</p> Signup and view all the answers

    When should hypocalcemia be treated in TLS?

    <p>After treating hyperphosphatemia</p> Signup and view all the answers

    What is the diagnostic imaging modality preferred for diagnosing Superior Vena Cava Syndrome in life-threatening cases?

    <p>Catheter-based venography</p> Signup and view all the answers

    Which patients should receive rasburicase for TLS prevention?

    <p>Patients at high risk of TLS</p> Signup and view all the answers

    What symptoms are characteristic of Superior Vena Cava Syndrome?

    <p>Headache, dyspnea, hoarseness</p> Signup and view all the answers

    How much IV hydration per day is recommended for patients at risk of TLS?

    <p>$3000$ ml/m2/day</p> Signup and view all the answers

    What happens in Superior Vena Cava Syndrome?

    <p>Obstruction of the superior vena cava</p> Signup and view all the answers

    Which treatment option is NOT advisable for hyperkalemia in TLS?

    <p>Standard hyperkalemia treatments</p> Signup and view all the answers

    Which chemotherapy drug is associated with dose-related cardiotoxicity?

    <p>Danuorubicin (Cerubidine)</p> Signup and view all the answers

    Which chemotherapy drug may cause red/orange urine as a side effect?

    <p>Doxorubicin (Adriamycin)</p> Signup and view all the answers

    Which chemotherapy drug is linked to peripheral neuropathy as a side effect?

    <p>Paclitaxel (Taxol)</p> Signup and view all the answers

    Which cancer type is most commonly associated with Spinal Cord Compression from metastasis?

    <p>Breast cancer</p> Signup and view all the answers

    Which chemotherapy drug side effect includes photosensitivity?

    <p>Fluorouracil (5-FU)</p> Signup and view all the answers

    Which chemotherapy drug may lead to malaise and toxic effects on the colon?

    <p>Vinblastine (Velban)</p> Signup and view all the answers

    What is a common side effect of Gemcitabine (Gemzar)?

    <p><strong>Fever</strong></p> Signup and view all the answers

    Which chemotherapy drug is known for causing edema and mucositis as potential side effects?

    <p><strong>Paclitaxel (Taxol)</strong></p> Signup and view all the answers

    How can tumor markers help in cancer management?

    <p>Resurgence of tumor markers suggests cancer recurrence</p> Signup and view all the answers

    Which organ is NOT commonly affected by metastasis in breast cancer?

    <p>Pancreas</p> Signup and view all the answers

    Which organ is NOT listed as a site of metastasis for lung cancer?

    <p>Kidney</p> Signup and view all the answers

    What is a common site of metastasis for melanoma?

    <p>Peritoneum</p> Signup and view all the answers

    Which cancer type is NOT known to metastasize to the liver?

    <p>Testicular cancer</p> Signup and view all the answers

    Which organ is NOT mentioned as a site of metastasis for uterine cancer?

    <p>Liver</p> Signup and view all the answers

    What is the significance of detecting tumor markers in cancer patients?

    <p>Rising tumor marker levels may suggest progression or recurrence of the disease</p> Signup and view all the answers

    Which of these cancers does NOT commonly metastasize to the brain?

    <p>Kidney cancer</p> Signup and view all the answers

    What is the primary goal of surgery in treating ovarian cancer?

    <p>To remove all tumor nodules larger than 1cm</p> Signup and view all the answers

    Why is surgical exploration necessary for a definitive diagnosis of ovarian cancer?

    <p>To confirm elevated CA125 marker levels</p> Signup and view all the answers

    Why are there no recommended screening tests for ovarian cancer?

    <p>As per recommendations from the USPSTF and Society of Gynecologic Oncology</p> Signup and view all the answers

    What is the most common gynecologic malignancy in developed countries?

    <p>Endometrial Cancer</p> Signup and view all the answers

    When should women who are BRCA1 and BRCA2 positive consider prophylactic bilateral salpingo-oophorectomy?

    <p>Before childbearing</p> Signup and view all the answers

    What reduces the risk of developing ovarian cancer by 90% in high-risk individuals?

    <p>Prophylactic bilateral salpingo-oophorectomy</p> Signup and view all the answers

    What does the Society of Gynecologic Oncology recommend regarding ovarian cancer screening for low-risk females?

    <p>Against screening low-risk females</p> Signup and view all the answers

    What is the major reason for the lack of reliable screening tests for ovarian cancer?

    <p>Recommendations against screening by medical societies</p> Signup and view all the answers

    What is the main treatment for Superior Vena Cava Syndrome?

    <p>IV Hydration</p> Signup and view all the answers

    When should hypocalcemia be treated in a patient with Superior Vena Cava Syndrome?

    <p>After treating hyperphosphatemia</p> Signup and view all the answers

    Which imaging modality is recommended for diagnosing Superior Vena Cava Syndrome in life-threatening cases?

    <p>CT Scan</p> Signup and view all the answers

    What is the primary risk factor for developing Superior Vena Cava Syndrome?

    <p>Tumor expansion obstructing the vena cava</p> Signup and view all the answers

    What is the cornerstone in preventing Tumor Lysis Syndrome (TLS) in patients at risk?

    <p>Aggressive hydration</p> Signup and view all the answers

    In patients with high risk of TLS, what medication should be used for prevention?

    <p>Bicarb for metabolic acidosis</p> Signup and view all the answers

    What diagnostic method provides the most expedient way to diagnose and treat Superior Vena Cava Syndrome in life-threatening cases?

    <p>Catheter-based venography</p> Signup and view all the answers

    What may be required if standard hyperkalemia treatments fail in a patient with Superior Vena Cava Syndrome?

    <p>Dialysis</p> Signup and view all the answers

    What side effect is not associated with Vinblastine (Velban)?

    <p>Malaise</p> Signup and view all the answers

    Which chemotherapy drug is linked to red/orange urine as a side effect?

    <p>Doxorubicin (Adriamycin)</p> Signup and view all the answers

    Which cancer type commonly metastasizes to cause Spinal Cord Compression?

    <p>Breast cancer</p> Signup and view all the answers

    Which chemotherapy drug side effect includes peripheral neuropathy?

    <p>Vincristine (Oncovin)</p> Signup and view all the answers

    Which symptom is not typically associated with Fluorouracil (5-FU)?

    <p>Edema</p> Signup and view all the answers

    Which chemotherapy drug may lead to fever and hypotension as side effects?

    <p>Etoposide (Vepesid)</p> Signup and view all the answers

    Which chemotherapy drug is associated with edema as a potential side effect?

    <p>Gemcitabine (Gemzar)</p> Signup and view all the answers

    What is the primary management strategy for patients with Hyperleukocytosis?

    <p>Start emergent chemotherapy</p> Signup and view all the answers

    Which leukemia types are most commonly associated with Hyperleukocytosis?

    <p>Acute myelogenous leukemia and chronic myeloid leukemia</p> Signup and view all the answers

    What is a potential consequence of untreated Hyperleukocytosis?

    <p>Symptomatic leukostasis leading to impaired microcirculation</p> Signup and view all the answers

    In Hyperleukocytosis, what symptoms may indicate intracranial hemorrhage?

    <p>Headache, blurry vision, confusion</p> Signup and view all the answers

    What is the most appropriate initial treatment for Hyperleukocytosis if emergent chemotherapy is not immediately possible?

    <p>Administer Hydroxyurea as a first-line treatment</p> Signup and view all the answers

    For patients with Hyperleukocytosis unable to receive emergent chemotherapy, what treatment alternative may be considered?

    <p>Leukapheresis as a temporary measure</p> Signup and view all the answers

    What should be avoided in patients with Hyperleukocytosis to prevent symptomatic leukostasis?

    <p>Administering red blood cell transfusions</p> Signup and view all the answers

    Why is it essential to provide treatment to prevent tumor lysis syndrome in patients with Hyperleukocytosis?

    <p>To mitigate metabolic derangements due to cellular breakdown products</p> Signup and view all the answers

    More Quizzes Like This

    Genetic Screening for Hereditary Cancer Predisposition
    32 questions

    Genetic Screening for Hereditary Cancer Predisposition

    CredibleJuxtaposition avatar
    CredibleJuxtaposition
    Mechanism of HR in Human Cancers
    29 questions

    Mechanism of HR in Human Cancers

    AdequateColosseum avatar
    AdequateColosseum
    Homologous Recombination Repair in Human Cancers
    30 questions

    Homologous Recombination Repair in Human Cancers

    AdequateColosseum avatar
    AdequateColosseum
    Breast Cancer Genetics
    24 questions

    Breast Cancer Genetics

    LawAbidingGreatWallOfChina avatar
    LawAbidingGreatWallOfChina
    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser