Brain Sex Differences and Testosterone

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Questions and Answers

What is the primary androgen secreted by the testes before puberty?

  • Testosterone (T) (correct)
  • Anti-Müllerian Hormone (AMH)
  • Estrogen (E)
  • Dihydrotestosterone (DHT)

What is the function of 5α-reductase in gonadal steroid synthesis?

  • Converting testosterone to dihydrotestosterone (correct)
  • Converting anti-müllerian hormone to testosterone
  • Converting cholesterol to estrogen
  • Converting estrogen to testosterone

What is the role of Sertoli cells in the male fetus?

  • Producing anti-müllerian hormone (correct)
  • Producing testosterone
  • Producing estrogen
  • Producing sperm

What is the process by which testosterone is converted within target cells?

<p>5α-reduction (D)</p> Signup and view all the answers

What is the origin of medullary cords in the male fetus?

<p>Coelomic epithelium (A)</p> Signup and view all the answers

What is the outcome of cortical cords in the male fetus?

<p>They degenerate (D)</p> Signup and view all the answers

What is the primary mechanism by which perinatal androgens or their metabolites affect reproductive behavior?

<p>They permanently alter brain structures that regulate reproductive behavior. (A)</p> Signup and view all the answers

What is the role of steroid hormones in the activation of reproductive behavior in adulthood?

<p>They activate brain structures to elicit reproductive behavior. (A)</p> Signup and view all the answers

What is the result of giving androgens perinatally to female rats?

<p>They develop a male-like pattern of behavior. (D)</p> Signup and view all the answers

What is the aromatization hypothesis proposed by Christensen et al. in 1978?

<p>Estradiol activates estrogen receptors. (D)</p> Signup and view all the answers

Why don't circulating estrogens from the mother masculinize female rats perinatally?

<p>Because estrogens are present in low concentrations. (C)</p> Signup and view all the answers

What is the role of ERα and ERβ in male sex behavior?

<p>They are necessary for male sex behavior. (A)</p> Signup and view all the answers

What is the name of the protein that protects female fetuses from the effects of testosterone?

<p>α-fetoprotein (C)</p> Signup and view all the answers

Which brain region is larger in males and is dependent on testosterone?

<p>Sexually dimorphic nucleus of the preoptic area (A)</p> Signup and view all the answers

What is the name of the hypothesis that explains how testosterone influences sexual differentiation of the brain?

<p>Aromatization Hypothesis (C)</p> Signup and view all the answers

What is the effect of the absence of perinatal androgen on the anteroventral periventricular nucleus?

<p>It becomes larger and more dense (A)</p> Signup and view all the answers

Which of the following is NOT a possible mechanism of steroid hormone-induced sex differences in the brain?

<p>Differential gene expression in the kidneys (D)</p> Signup and view all the answers

What is the enzyme responsible for converting testosterone to estrogen in the brain?

<p>Aromatase (A)</p> Signup and view all the answers

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