14 Questions
What is the primary source of energy for the brain?
Glucose
What is the effect of chronic hypertension on the autoregulatory curve?
It shifts the curve to the right
What is the term for the process by which the brain regulates its own blood flow to match metabolic demands?
Autoregulation
What is the most potent vasodilator of the CBF?
Arterial CO₂
What is the effect of a small drop in O₂ on CBF?
VD and ↑ CBF
What is the role of astrocytes in CBF regulation?
Release vasodilators
What is the effect of increased CO₂ on CBF?
VD and ↑ CBF
What is the role of myogenic factors in CBF regulation?
Respond to changes in blood pressure
What is the effect of glutamate on astrocytes?
Stimulates vasodilation
What is the primary function of the blood-brain barrier?
To restrict the movement of large molecules and maintain the constancy of the internal environment
What is the main transport mechanism across the blood-brain barrier?
Carrier-mediated transport
What is the consequence of severely high bilirubin levels in a newborn?
Kernicterus, a type of irreversible brain damage
What is the consequence of a 5-10 minute cessation of cerebral blood flow?
Irreversible brain damage
What is the characteristic of the blood-brain barrier at birth?
It is immature and incomplete
This quiz covers the physiological aspects of brain metabolism, including its high metabolic rate, glucose utilization, and insulin independence. It also touches on the effects of overtreatment with insulin in diabetic patients.
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