Boyle's Law and Breathing Mechanics

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Questions and Answers

According to Boyle's Law, what change in lung pressure occurs when chest volume increases?

  • Lung pressure remains constant.
  • Lung pressure increases.
  • The relationship between chest volume and lung pressure is unrelated.
  • Lung pressure decreases. (correct)

Which of the following muscles are NOT primarily involved in inhalation?

  • Scalenes
  • Internal intercostals (correct)
  • Diaphragm
  • External intercostals

What is the primary mechanism driving quiet exhalation?

  • Active contraction of the external intercostal muscles.
  • Reliance on kinetic energy and relaxation of inspiratory muscles. (correct)
  • Active contraction of the diaphragm.
  • Forced contraction of accessory muscles.

During deep breathing, which of the following occurs in addition to the actions during quiet breathing?

<p>Forceful contraction of inspiratory and accessory muscles. (D)</p> Signup and view all the answers

What role do the thin layers of smooth muscle play in the respiratory tubes?

<p>Maintaining airway diameter. (C)</p> Signup and view all the answers

Which of the following is true regarding the relationship between pressure and volume, as described by the equation $P_1V_1 = P_2V_2$?

<p>Pressure and volume are inversely proportional. (C)</p> Signup and view all the answers

During quiet inspiration, which muscles contract to facilitate air intake?

<p>Diaphragm and external intercostals (C)</p> Signup and view all the answers

If a container with a volume of 1.0 L has a pressure of 100 mm Hg, what is the new pressure if the volume is decreased to 0.5 L, assuming constant temperature and number of gas molecules?

<p>200 mm Hg (A)</p> Signup and view all the answers

Based on your understanding, which statement is correct regarding the lungs?

<p>Lungs rely on external muscles to facilitate their inflation and deflation. (A)</p> Signup and view all the answers

In what units is pressure typically measured when discussing respiratory physiology?

<p>Millimeters of mercury (mmHg) (B)</p> Signup and view all the answers

Which of the following best describes the flow of air during respiration?

<p>Air flows down the pressure gradient, from high pressure to low pressure. (A)</p> Signup and view all the answers

Which muscles are used during forceful exhalation?

<p>Internal intercostals and abdominal muscles. (D)</p> Signup and view all the answers

How do the actions of the diaphragm and external intercostal muscles contribute to inhalation?

<p>They increase the volume of the thoracic cavity, decreasing pressure. (D)</p> Signup and view all the answers

For a gas mixture, which law applies?

<p>Physical laws apply to all gases and gas mixtures. (A)</p> Signup and view all the answers

How does deep breathing differ from quiet breathing in terms of muscle involvement?

<p>Deep breathing involves forceful contraction of inspiratory and accessory muscles, while quiet breathing primarily uses the diaphragm and external intercostals. (C)</p> Signup and view all the answers

What happens during quiet expiration?

<p>Diaphragm and external intercostals relax. (B)</p> Signup and view all the answers

What is the role of the external oblique and rectus abdominis muscles in breathing?

<p>They aid in forceful expiration. (C)</p> Signup and view all the answers

During quiet breathing, what is the sequence of events that lead to air entering the lungs?

<p>Muscle contraction increased lung volume decreased lung pressure air enters. (C)</p> Signup and view all the answers

According to Boyle's law, if the volume of a gas is doubled, what happens to the pressure, assuming the temperature and amount of gas remain constant?

<p>The pressure is halved. (C)</p> Signup and view all the answers

Which muscles are responsible for elevating the rib cage during inspiration?

<p>External intercostals (D)</p> Signup and view all the answers

Why is it essential to have a pressure gradient between intra-alveolar pressure and atmospheric pressure?

<p>To facilitate the movement of air into and out of the lungs. (B)</p> Signup and view all the answers

What would happen if the intrapleural pressure equalized with atmospheric pressure?

<p>The lungs would collapse due to their natural elastic recoil. (A)</p> Signup and view all the answers

How do the elastic fibers of the lungs contribute to the process of exhalation?

<p>They exert an inward pull, aiding in the recoil of the lungs and expulsion of air. (B)</p> Signup and view all the answers

What is the role of surfactant in the alveoli?

<p>Reducing surface tension to prevent alveolar collapse (D)</p> Signup and view all the answers

Which of the following is a direct consequence of an increase in lung volume?

<p>Decreased pressure within the lungs (A)</p> Signup and view all the answers

During inhalation, how does the diaphragm contribute to the change in alveolar pressure?

<p>It contracts and flattens, increasing the volume of the thoracic cavity and decreasing alveolar pressure. (B)</p> Signup and view all the answers

How do the parietal and visceral pleurae interact to aid in lung function?

<p>They slide past each other, separated by fluid, allowing the lungs to move smoothly within the thoracic cavity. (D)</p> Signup and view all the answers

What is the pressure in the pleural sac typically compared to atmospheric pressure, and what force causes this difference?

<p>Slightly less than atmospheric pressure, due to the elastic recoil of the lungs. (B)</p> Signup and view all the answers

What causes air to flow out of the lungs during exhalation?

<p>Relaxation of the diaphragm and intercostal muscles, which increases alveolar pressure above atmospheric pressure (C)</p> Signup and view all the answers

How do variations in atmospheric conditions affect the amount of inspired oxygen?

<p>Atmospheric variations directly change the total amount of available and inspired oxygen. (D)</p> Signup and view all the answers

What happens to alveolar pressure during inhalation?

<p>It decreases below atmospheric pressure. (D)</p> Signup and view all the answers

Which event directly follows the contraction of the diaphragm during normal quiet breathing?

<p>Intrapleural pressure increases (becomes less negative). (D)</p> Signup and view all the answers

During forced exhalation, which muscles contribute to decreasing the size of the chest cavity?

<p>The internal intercostals and abdominal muscles (B)</p> Signup and view all the answers

What is the alveolar pressure typically equal to at rest?

<p>Equal to atmospheric pressure. (D)</p> Signup and view all the answers

How does the contraction of the external intercostal muscles contribute to inhalation?

<p>They elevate the rib cage, increasing thoracic volume. (A)</p> Signup and view all the answers

What is the primary function of the pleural fluid found between the visceral and parietal pleura?

<p>To reduce friction as the lungs expand and contract (A)</p> Signup and view all the answers

How does the body achieve a greater drop in alveolar pressure during deep inhalation compared to quiet inhalation?

<p>By recruiting additional muscles like the scalene and sternocleidomastoid alongside the diaphragm and external intercostals. (D)</p> Signup and view all the answers

Which of the following best describes the relationship between lung compliance and the effort required for breathing?

<p>Higher compliance requires less effort to breathe. (D)</p> Signup and view all the answers

What directly causes the chest cavity to contract during exhalation?

<p>The lungs and chest wall recoil due to their elastic properties and muscle relaxation. (B)</p> Signup and view all the answers

How does the interaction between the chest wall and lungs contribute to maintaining a negative intrapleural pressure?

<p>The chest wall tries to expand outward while the lungs try to collapse inward. (B)</p> Signup and view all the answers

How does the gradual decrease in diameter of the airways, from trachea to bronchioles, impact airflow?

<p>It decreases airflow due to increased resistance. (D)</p> Signup and view all the answers

What effect does histamine, released during an allergic reaction, have on the bronchioles?

<p>It causes bronchoconstriction, decreasing airflow. (B)</p> Signup and view all the answers

How does adrenaline reverse the effects of histamine on the bronchioles?

<p>By causing bronchodilation. (B)</p> Signup and view all the answers

What scenarios might lead to decreased lung compliance?

<p>Presence of scar tissue or collagen in the lungs. (A)</p> Signup and view all the answers

How does the blockage of bronchi affect lung compliance and ventilation?

<p>It decreases lung compliance and impairs ventilation. (C)</p> Signup and view all the answers

What change in lung volume is necessary to facilitate air movement into the lungs?

<p>Lung volume must increase to decrease pressure. (D)</p> Signup and view all the answers

How does decreased lung elasticity typically affect ventilation?

<p>It negatively affects ventilation due to impaired recoil. (C)</p> Signup and view all the answers

How does emphysema, a disease characterized by loss of elastic recoil, impact the energy expenditure during exhalation?

<p>It increases the energy expenditure during exhalation. (B)</p> Signup and view all the answers

What is the general relationship between airflow, pressure difference, and airway resistance?

<p>Airflow is directly proportional to pressure difference and inversely proportional to airway resistance. (B)</p> Signup and view all the answers

How does reducing the cross-sectional area of the airways impact the movement of air into the lungs?

<p>It decreases the movement of air by increasing resistance. (A)</p> Signup and view all the answers

Surface area of the respiratory membrane greatly affects ventilation. What statement best describes its importance?

<p>Higher surface area is crucial for efficient ventilation. (D)</p> Signup and view all the answers

How does an increase in the number of tubes (airways) correlate with the overall diameter in the lungs?

<p>It means that more tubes need to cope with airflow, and decreases the average diameter, increasing resistance. (B)</p> Signup and view all the answers

How might inflammation or endogenous cytokine release from immune cells influence the diameter of airways and airflow?

<p>It can cause constriction of smooth muscle, decreasing airway diameter and airflow. (D)</p> Signup and view all the answers

How does the flexibility of the thoracic cage impact lung compliance?

<p>Impaired thoracic cage flexibility decreases lung compliance. (A)</p> Signup and view all the answers

When less surfactant is produced in the lungs, how is lung compliance affected?

<p>Lung compliance is decreased because of increased surface tension. (C)</p> Signup and view all the answers

How is the work of breathing altered in a patient with fibrosis, and what effect does this have on ventilation?

<p>Increased work of breathing and decreased ventilation. (C)</p> Signup and view all the answers

What happens to the intrapleural pressure if the lung volume is prevented from increasing?

<p>It becomes more positive. (A)</p> Signup and view all the answers

Why will reducing the amount of surfactant in the alveoli cause a decrease in ventilation efficiency?

<p>Because it increases the surface tension inside the alveoli, collapsing the alveoli. (A)</p> Signup and view all the answers

How does decreased lung elasticity influence the body's ability to exhale?

<p>Reduces the body's ability to exhale passively and requires active muscle contraction. (B)</p> Signup and view all the answers

What is the initial effect on ventilation effectiveness with a large decrease in the surface area around alveoli?

<p>Decreased Ventilation. (B)</p> Signup and view all the answers

How would an increase in age typically affect lung volumes, assuming other factors remain constant?

<p>Decrease in vital capacity and increase in residual volume. (B)</p> Signup and view all the answers

If a patient's lung volumes are measured using spirometry and found to be outside the normal range, what could this indicate?

<p>The patient has a respiratory or other underlying health condition. (D)</p> Signup and view all the answers

What is the significance of expressing lung volume predictions at body temperature, ambient pressure, and saturated (BTPS) conditions?

<p>It standardizes measurements to account for temperature and humidity effects in the lungs. (C)</p> Signup and view all the answers

What percentage of the general population typically falls within the reference or normal range for physiological measurements?

<p>Approximately 95% (B)</p> Signup and view all the answers

How does gender influence the prediction of lung volumes, assuming other factors are constant?

<p>Males typically have larger lung volumes due to larger average body size. (D)</p> Signup and view all the answers

Which of the following values is LEAST likely to be obtained directly from a simple spirometry test?

<p>Residual Volume (RV) (B)</p> Signup and view all the answers

How does the measurement of lung volumes with a wet spirometer correlate with inhalation?

<p>The spirometer bell falls as the subject exhales. (B)</p> Signup and view all the answers

Considering the typical composition of lung volumes, what happens to the Expiratory Reserve Volume (ERV) after maximal expiration?

<p>It decreases and becomes part of the Residual Volume. (A)</p> Signup and view all the answers

In a scenario where an individual has a reduced Inspiratory Reserve Volume (IRV), what might this indicate about their respiratory function?

<p>The individual may have a reduced ability to take deep breaths. (D)</p> Signup and view all the answers

How would emphysema, characterized by destruction of alveolar walls, impact the Total Lung Capacity (TLC) and Residual Volume (RV)?

<p>Increase in both TLC and RV. (D)</p> Signup and view all the answers

During normal breathing, what portion of the Total Lung Capacity (TLC) is typically utilized?

<p>A small fraction, primarily the Tidal Volume (D)</p> Signup and view all the answers

Why is it important to establish a reference or normal range for lung volumes?

<p>To compare individual lung volume measurements against a standard for healthy individuals. (C)</p> Signup and view all the answers

If a patient's height is greater than average, what would you expect to see in terms of lung volume predictions?

<p>Higher lung volumes because lung size correlates with body size. (C)</p> Signup and view all the answers

In the context of spirometry, how is the severity of a respiratory condition typically assessed based on lung volume measurements?

<p>By comparing measured values to predicted normal values and observing deviations. (A)</p> Signup and view all the answers

What is the functional role of the air that remains in the lungs as Residual Volume (RV)?

<p>It keeps the alveoli inflated and prevents lung collapse. (D)</p> Signup and view all the answers

How would significant scarring and stiffening of lung tissue alter lung volumes and capacities?

<p>Decrease in Total Lung Capacity, decrease in Vital Capacity. (A)</p> Signup and view all the answers

What would be the effect on lung volume measurements if a patient is unable to fully expand their chest cavity due to musculoskeletal limitations?

<p>Underestimation of Total Lung Capacity and Inspiratory Capacity. (D)</p> Signup and view all the answers

How does the percentage of the population falling within the 'normal' range relate to the biological variability of lung volumes?

<p>It acknowledges that there is inherent variability, but most people cluster within a defined range. (C)</p> Signup and view all the answers

How would readings from a spirometer be affected if it were not properly sealed, allowing air to leak during measurement?

<p>Measurements of Tidal Volume and Vital Capacity would likely be underestimated. (C)</p> Signup and view all the answers

Flashcards

Quiet Inspiration

Active process using the diaphragm (contracts downwards) and external intercostal muscles (contract).

Quiet Expiration

Passive process relying on kinetic energy; the diaphragm relaxes, and internal intercostal muscles contract.

Deep Breathing

Forceful contraction of inspiratory and accessory muscles, generating a larger change in lung volume.

Pressure

Measured in mmHg (millimeters of mercury).

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Boyle's Law

P1V1 = P2V2; describes the inverse relationship between pressure and volume of a gas.

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Pressure and Volume

An inverse relationship.

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Air Flow

Air flows down the pressure gradient; pressure changes are manipulated according to Boyle's Law.

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Airway Smooth Muscle

Thin layers of smooth muscle that help maintain airway diameter in respiratory tubes.

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Inspired Oxygen

Atmospheric variations can alter the amount of inspired oxygen available.

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Pressure Gradient

For air to move, there must be a pressure difference between intra-alveolar pressure and atmospheric pressure.

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Pleural Sac Pressure

The pressure in the pleural sac is slightly less than atmospheric pressure due to elastic recoil on the parietal pleura.

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Pleural layers

The combined parietal and visceral pleura are pulled away from each other, creating a potential space.

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Lung Elasticity

Elastic fibers in the lungs promote lung collapse due to their inherent recoil.

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Pulmonary Surfactant

Surfactant reduces surface tension within the alveoli, preventing collapse.

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Inhalation Mechanism

During inhalation, the diaphragm contracts, expanding the chest cavity, which reduces alveolar pressure and allows air to flow in.

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Exhalation Mechanism

During exhalation, the diaphragm relaxes, the chest cavity contracts, and alveolar pressure increases, forcing air out of the lungs.

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Resistance in Airways

Ease at which air moves into lungs. Increases with constriction of airways.

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Air Flow Relationship

Air flow is directly proportional to the pressure difference and inversely proportional to resistance in the airways.

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Lung compliance

The ease at which lungs can expand; affected by stretch of elastic fibers and surface tension in the alveoli.

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Cross-Sectional Area Impact

Reducing the cross-sectional area of the tubes decreases the movement of air into the lungs.

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Airway Structure

Air moves along tubes, gradually decreasing in diameter but increasing in the muscle lining of bronchioles.

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Pressure Gradient Requirement

For air to move into the lungs, this must decrease and lung volume must increase to enable air movement.

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Elastic Recoil Loss Effect

A loss of elastic recoil, as seen in emphysema, means 25% of total energy is spent exhaling.

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Spirometry

A measurement using a wet spirometer where the subject inserts a mouthpiece; volume decreases on inhalation.

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Lung Volumes

Can change by pathogenic or physiological conditions and depend on age, gender and height.

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Residual Volume (RV)

The volume of air remaining in the lungs after maximal expiration; cannot be measured by spirometry.

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Functional Residual Capacity (FRC)

The expiratory reserve volume plus the residual volume; the volume of air remaining after a normal expiration

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Inspiratory Capacity (IC)

The maximum volume of air that can be inspired after a normal expiration.

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Total Lung Capacity (TLC)

The total volume of air the lungs can hold.

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Expiratory Reserve Volume (ERV)

The amount of air you can forcefully breathe out.

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Inspiratory Reserve Volume (IRV)

The extra amount of air you can breathe in.

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Reference/Normal Range

A range of values for a physiological measurement in healthy persons.

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Study Notes

  • Spirometry measures lung volumes and can be affected by pathological or physiological conditions.
  • Lung size depends on age, gender, and height.
  • Predictions of lung volumes can be made and are expressed at body temperature, ambient pressure, and saturated.
  • A reference/normal range is a range of values for a physiological measurement in healthy persons.
  • Usually approximately 95% of the total population falls within the reference range.

Spirometer

  • The spirometer is a traditional wet spirometer.
  • The subject inserts a mouthpiece into the spirometer to breathe in and out of.
  • The volume of the bell indicates the volume of the subject's respiratory system.
  • The bell is suspended in water.
  • Volume decreases on inhalation.

Lung Volumes

  • Normal breathing involves air moving into the lungs during inspiration and out during expiration, with some residual volume remaining.
  • Lung volumes includes Tidal Volume (TV), Inspiratory Reserve Volume (IRV), Expiratory Reserve Volume (ERV), and Residual Volume (RV).
  • Shown in liters (L)

Lung Capacities

  • Lung capacities are combinations of lung volumes such as Inspiratory Capacity (IC), Functional Residual Capacity (FRC), and Total Lung Capacity (TLC).

Lung Volume Values (70kg adult)

  • Tidal Volume (TV): 0.5L
  • Inspiratory Reserve Volume (IRV): 2.5L
  • Expiratory Reserve Volume (ERV): 1.5L
  • Residual Volume (RV): 1.5L
  • Inspiratory Capacity (IC): 3.0L
  • Functional Residual Capacity (FRC): 3.0L
  • Total Lung Capacity (TLC): 6.0L
  • There is no air in the lungs at maximal expiration.

Units

  • L = litre
  • Dl or dL = decilitre or 100mL
  • fL = femto lire or 1 x 10^-15 L
  • pg = picograms
  • deci (d) = 0.1 (10^-1)
  • centi (c) = 0.01 (10^-2)
  • milli (m) = 0.001 (10^-3)
  • micro (μ) = 0.000001 (10^-6)
  • nano (n) = 0.000000001 (10^-9)
  • pico (p) = 0.000000000001 (10^-12)
  • femto (f) = 0.000000000000001 (10^-15)

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