Bowman's Space and Nephron Function

Questions and Answers

What passes through the fenestrations into Bowman's space?

Red and white blood cells

Only ions and glucose

Ions, amino acids, glucose, and water (correct)

Amino acids, glucose, and giant proteins

What prevents giant proteins in red and white blood cells from leaking through?

Podocytes

Basement membrane (correct)

Tubule cells

Endothelial cells

What type of cells are the tubule cells that help line the nephron?

Connective tissue cells

Epithelial cells (correct)

Muscle cells

Endothelial cells

What happens to the rate of filtration if the diameter of the afferent arteriole is increased?

The rate of filtration increases Signup and view all the answers

What happens to the filtration rate if the diameter of the efferent arteriole is increased?

It decreases Signup and view all the answers

What can be compared to a marathon in terms of blood flow in the glomerulus?

The diameter of the afferent and efferent arterioles Signup and view all the answers

What is the effect of decreasing the diameter of the afferent arteriole on the filtration rate?

It decreases the filtration rate Signup and view all the answers

What is the function of podocytes in the nephron?

To hold on to endothelial cells Signup and view all the answers

What happens to the filtration rate if the diameter of the efferent arteriole is decreased?

It increases Signup and view all the answers

What is Bowman's space?

The space between the glomerulus and the tubules Signup and view all the answers

Why is it unusual to have an arteriole giving off another arteriole?

Because arterioles usually go into capillaries and then give off a venule Signup and view all the answers

What is the term for a very narrow or stenosed vessel?

Stenosis Signup and view all the answers

What is the result of renal artery stenosis on the filtration rate?

It decreases the filtration rate Signup and view all the answers

What happens to the ions, amino acids, and glucose in the blood if the diameter of the efferent arteriole is decreased?

They back up and are filtered through the fenestrations Signup and view all the answers

What is the purpose of learning about what can go wrong with the filtration process?

To think about what can go wrong with the process Signup and view all the answers

What is the term for the space where filtered substances are collected?

Bowman's space Signup and view all the answers

Study Notes

Bowman's Space and Filtration

Smaller ions, amino acids, glucose, and water can leak through fenestrations into Bowman's space.
Podocytes hug the arterioles by holding onto endothelial cells.
The basement membrane prevents giant proteins in red and white blood cells from leaking through.
Tubule cells, which are epithelial cells, line the other side of Bowman's space.

Afferent and Efferent Arterioles

An increase in the diameter of the afferent arteriole increases the rate of filtration, as more blood flows into the glomerulus.
A decrease in the diameter of the afferent arteriole decreases the rate of filtration, as less blood flows into the glomerulus.
An increase in the diameter of the efferent arteriole decreases the rate of filtration, as blood flows away from the glomerulus more quickly.
A decrease in the diameter of the efferent arteriole increases the rate of filtration, as blood backs up and spends more time near the fenestrations.

Effects on Filtration Rate

Renal artery stenosis (narrowing of the renal artery) decreases the filtration rate, as less blood flows into the afferent arteriole.
Decreasing the diameter of the efferent arteriole can increase the filtration rate, as blood backs up and spends more time near the fenestrations.