Bone Structure and Development Quiz
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Questions and Answers

What is the primary function of osteoblasts in bone remodeling?

  • Forming new bone tissue (correct)
  • Producing osteoid
  • Breaking down bone tissue
  • Regulating bone marrow function

    • What is the percentage of the body's calcium found in bone?

  • 99% (correct)
  • 90%
  • 95%
  • 80%

    • Which of the following statements about bone remodeling is true?

  • Bone remodeling is a constant process that occurs throughout life (correct)
  • Bone remodeling only involves osteoblasts
  • Bone remodeling is a process that only occurs in response to injury
  • Bone remodeling is a slow process that occurs only in childhood

    • What is the role of osteoprotegerin (OPG) in bone remodeling?

    <p>Inhibiting osteoclast formation and activity</p> Signup and view all the answers

    What is RANKL, and what is its role in bone remodeling?

    <p>A ligand that stimulates osteoclast formation and activity</p> Signup and view all the answers

    What is the primary function of osteoclasts in bone remodeling?

    <p>Breaking down bone tissue</p> Signup and view all the answers

    What can delay the biological process of fracture healing?

    <p>Displaced and comminuted fractures</p> Signup and view all the answers

    What is the result of localized problems in the migration of mesenchymal cells and the formation of condensations?

    <p>Dysostoses</p> Signup and view all the answers

    What is the effect of a mutation in the Homeobox gene?

    <p>Extra digits</p> Signup and view all the answers

    What is the most common form of dwarfism?

    <p>Achondroplasia</p> Signup and view all the answers

    What is a result of defects in hormones and signal transduction?

    <p>Achondroplasia</p> Signup and view all the answers

    What is a characteristic of Dysplasias?

    <p>Affecting cartilage and bone tissues globally</p> Signup and view all the answers

    What is the effect of FGFR3 inhibition on growth plate chondrocytes?

    <p>Inhibited proliferation and function</p> Signup and view all the answers

    What is the characteristic of Thanatophoric dwarfism?

    <p>Enlarged head and shortened proximal extremities</p> Signup and view all the answers

    What is the fundamental abnormality in Osteogenesis Imperfecta?

    <p>Too little bone</p> Signup and view all the answers

    What is the effect of mucopolysaccharides accumulation in chondrocytes?

    <p>Induction of apoptosis</p> Signup and view all the answers

    What is the characteristic of Mucopolysaccharidoses?

    <p>Defect in macromolecule degradation</p> Signup and view all the answers

    What is the effect of Achondroplasia?

    <p>Shortened limbs and small chest cavity</p> Signup and view all the answers

    What is the primary cause of reduced bone resorption in osteopetrosis?

    <p>Dysfunction of osteoclasts</p> Signup and view all the answers

    What is the consequence of defective acidification in osteoclasts in osteopetrosis?

    <p>Inability to dissolve calcium hydroxyapatite</p> Signup and view all the answers

    What is the effect of reduced osteoclast activity on bone structure in osteopetrosis?

    <p>No medullary canal and small neural foramina</p> Signup and view all the answers

    What is the primary consequence of severe osteopenia?

    <p>Significantly increased risk of fracture</p> Signup and view all the answers

    What is the average rate of cortical bone loss per year in the first postmenopausal decade?

    <p>2% per year</p> Signup and view all the answers

    What is a potential complication of narrowed bone marrow in osteopetrosis?

    <p>Anemia</p> Signup and view all the answers

    What is the distinct feature of osteoporosis in contrast to osteopetrosis?

    <p>Decreased bone mass</p> Signup and view all the answers

    What is the characteristic of trabecular bone in the low turnover variant of osteoporosis?

    <p>Thinned plates with lost interconnections</p> Signup and view all the answers

    What is the effect of decreased estrogen levels on bone metabolism during menopause?

    <p>Increased osteoclast activity and bone loss</p> Signup and view all the answers

    What is the genetic mutation associated with Paget Disease (Osteitis Deformans)?

    <p>SQSTM1 gene mutation</p> Signup and view all the answers

    What is the result of inactivating mutations in OPG in Paget Disease?

    <p>Increased osteoclast activity</p> Signup and view all the answers

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