Bone Marrow and Hematopoiesis Quiz
45 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What proportion of bone marrow is typically hematopoietically active in a normal adult?

  • 25%
  • 75%
  • 100%
  • 50% (correct)

    • Which type of marrow increases activity when faced with conditions that require heightened hematopoiesis?

  • Spongy marrow
  • Red marrow (correct)
  • Yellow marrow
  • White marrow

    • What is the defining characteristic of hypercellular or hyperplastic bone marrow?

  • Less than 30% hematopoietic cells
  • More than 70% hematopoietic cells (correct)
  • 30-70% hematopoietic cells
  • Consistently 50% hematopoietic cells

    • What type of cells originate from mesenchymal cells in the bone marrow?

    <p>Stromal cells</p> Signup and view all the answers

    Which of the following describes the role of osteoblasts in bone marrow?

    <p>They are involved in bone remodeling</p> Signup and view all the answers

    What is the purpose of the autoimmune hemolysis tests mentioned in the content?

    <p>To measure the amount of hemolysis</p> Signup and view all the answers

    Which condition is associated with a marked decrease in reticulocytes?

    <p>Aplastic crisis</p> Signup and view all the answers

    What does the acidified glycerol test measure?

    <p>Amount of hemolysis</p> Signup and view all the answers

    What is a significant complication associated with viral syndromes in HS patients?

    <p>Hemolytic crisis</p> Signup and view all the answers

    What technique is used to assess variations in membrane surface area and cell water content?

    <p>Osmotic gradient ektacytometry</p> Signup and view all the answers

    What is the main inheritance pattern of hereditary elliptocytosis (HE)?

    <p>Autosomal dominant</p> Signup and view all the answers

    Which gene is associated with coding for α-spectrin in hereditary elliptocytosis?

    <p>SPTA1</p> Signup and view all the answers

    What structural component is disrupted in the RBC membrane due to mutations in HE?

    <p>Horizontal linkages in the protein cytoskeleton</p> Signup and view all the answers

    What defines cases classified under hereditary pyropoikilocytosis (HPP)?

    <p>Marked RBC fragmentation on heating</p> Signup and view all the answers

    Which of the following is NOT a gene mutation associated with hereditary elliptocytosis?

    <p>GPC</p> Signup and view all the answers

    What percentage of HE patients typically exhibit moderate to severe anemia?

    <p>10%</p> Signup and view all the answers

    What is a common laboratory finding in individuals with hereditary elliptocytosis?

    <p>Majority of patients are asymptomatic</p> Signup and view all the answers

    What is the result of the mutations affecting GPC in hereditary elliptocytosis?

    <p>Absence of Gerbich antigens</p> Signup and view all the answers

    What is the main application of holotranscobalamin in clinical settings?

    <p>Detecting vitamin B12 deficiency</p> Signup and view all the answers

    What type of anemia is characterized by unimpaired DNA synthesis?

    <p>Macrocytic nonmegaloblastic anemia</p> Signup and view all the answers

    Which diagnostic test is utilized to analyze the presence of parasitic infections related to vitamin B12 deficiency?

    <p>Stool analysis for eggs or proglottids</p> Signup and view all the answers

    What is the consequence of achlorhydria with respect to serum gastrin levels?

    <p>Increased serum gastrin levels</p> Signup and view all the answers

    Which method is NOT typically used to detect anti-intrinsic factor antibodies?

    <p>GC-MS</p> Signup and view all the answers

    What is a common trait of patients with nonmegaloblastic, macrocytic anemia?

    <p>Lack of oval macrocytes in peripheral blood</p> Signup and view all the answers

    Which vitamin deficiency requires reflexive testing for MMA and homocysteine levels?

    <p>Vitamin B12 deficiency</p> Signup and view all the answers

    What is a common physiological condition associated with macrocytosis?

    <p>Newborn status</p> Signup and view all the answers

    What specific test is most indicative of pernicious anemia?

    <p>Antibody assays for anti-IF antibodies</p> Signup and view all the answers

    What is the primary function of platelets in hemostasis?

    <p>They form a platelet plug at the site of bleeding.</p> Signup and view all the answers

    What type of blood specimen is typically used for a Complete Blood Count (CBC)?

    <p>Capillary blood and venous blood</p> Signup and view all the answers

    Which characteristic indicates that a blood film must be stained before examination?

    <p>To enhance the visibility of cell morphology</p> Signup and view all the answers

    What is an indicator of macrocytic cells in a blood film?

    <p>Larger cells than normal size</p> Signup and view all the answers

    What type of blood color would indicate hypochromic red blood cells?

    <p>Decreased concentration of hemoglobin</p> Signup and view all the answers

    What is the primary role of the phlebotomist in the laboratory setting?

    <p>To collect blood samples from patients for examination</p> Signup and view all the answers

    What is indicated by the formulation of fibrin after an injury?

    <p>The activation of coagulation factors</p> Signup and view all the answers

    How should a good blood smear be prepared?

    <p>With the correct amount of blood for optimal presentation</p> Signup and view all the answers

    What is the shape and size of normal platelets?

    <p>Very small, round, and anucleated</p> Signup and view all the answers

    What must a blood smear be examined under for proper morphology identification?

    <p>Under oil immersion objective</p> Signup and view all the answers

    What laboratory tests may be needed to rule out conditions associated with elliptocytes?

    <p>Iron studies and tests for vitamin B12 deficiency</p> Signup and view all the answers

    In cases of acquired defects related to elliptocytosis, which gene is mentioned as being affected?

    <p>Gene for protein 4.1</p> Signup and view all the answers

    What is the most likely condition associated with hemolytic anemia leading to cholelithiasis due to bilirubin gallstones?

    <p>Hereditary elliptocytosis</p> Signup and view all the answers

    What type of crises can patients with hereditary elliptocytosis experience?

    <p>Hemolytic, aplastic, and megaloblastic crises</p> Signup and view all the answers

    What is the expected MCV range in patients with the HPP phenotype?

    <p>50 to 65 fL</p> Signup and view all the answers

    What is a primary treatment for HE patients who are significantly anemic and show signs of hemolysis?

    <p>Splenectomy</p> Signup and view all the answers

    What physical examination finding is most associated with the HPP phenotype?

    <p>Extreme poikilocytosis</p> Signup and view all the answers

    How do elliptocytes correlate with disease severity in patients with elliptocytosis?

    <p>Does not correlate</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser