Bone Histology and Classification

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Questions and Answers

Which of the following best describes the relationship between the inner and outer layers in the network?

  • The outer layer contains multiple inner layers.
  • The inner most layer is contained within the outer layer. (correct)
  • The inner and outer layers are identical.
  • The inner most layer is independent of the outer layer.

What does the notation '00' signify in the network's structure?

  • It is the most outer layer.
  • It corresponds to the inner most layer.
  • It represents a combination of both inner and outer layers.
  • It is a separate, distinct layer from both inner and outer layers. (correct)

In the given network diagram, which layer appears to be the simplest representation?

  • The inner most layer.
  • None of the layers can be considered simple.
  • The outermost layer, represented by '0'. (correct)
  • The combined representation of inner and outer layers.

If the network structure were to be expanded, which layer would likely contain the most complex elements?

<p>The inner most layer. (D)</p> Signup and view all the answers

Flashcards

Network Layers

Different levels of abstraction in a network, each with specific responsibilities.

Outermost Layer

The layer farthest from the core of the network. It interacts directly with users.

Innermost Layer

The layer closest to the core; this is often the physical hardware.

Network

A system of interconnected devices that allow communication.

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Network Structure

The arrangement of the network layers and communication methods.

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Study Notes

Bone Histology

  • Bone is a highly specialized connective tissue. Its matrix is calcified, making it hard and strong.
  • It is composed of bone cells, fibers, and a hard matrix.
  • Anatomically, bone is classified as long, short, flat, and irregular, according to its shape and location in the body.
    • Examples of long bones: humerus, femur
    • Examples of short bones: carpal, tarsal
    • Examples of flat bones: skull, ribs
    • Examples of irregular bones: vertebrae
  • Bone functions include support, protection, movement, mineral storage, and blood cell formation.

Learning Objectives

  • Classify bone anatomically and histologically
  • Identify the location of compact and spongy bone in the human body
  • Understand the microstructure of bone

Histological Classification

  • Compact bone: Dense, solid lamellae, without cavities, located in the shaft surrounding the medullary canal and on the surface of flat, short, and irregular bones.
  • Cancellous (spongy) bone: Irregular, branching, anastomosing bony trabeculae enclose bone marrow cavities. Found in the center of flat bones, short bones, irregular bones, and the epiphysis of long bones

Bone Structure

  • Bone cells:

    • Osteogenic cells (osteoprogenitor cells): precursor cells for osteoblasts.
    • Osteoblasts: bone-forming cells
    • Osteocytes: mature bone cells, maintaining bone hardness. They reside within lacunae of the matrix. They function in maintaining bone health and assisting in calcium homeostasis.
    • Osteoclasts: large, multinucleated bone-resorbing cells. They resorb bone by releasing hydrogen ions and lysosomal enzymes. They reside in Howship's lacunae.
  • Fibers: Collagen fiber type I, which makes up 35% of the organic portion of bone.

  • Ground Substance: GAGs and glycoproteins

  • Hydroxyapatite Crystals: Inorganic part (65%) comprises calcium salts. They are deposited on collagen fibers and within the ground substance, hardens the matrix.

Histology of Compact Bone

  • Periosteum: Outermost layer of fibrous connective tissue.
  • External circumferential lamellae: Layers immediately beneath the periosteum
  • Haversian system (osteon): Fundamental structural unit of compact bone, concentric lamellae surrounding a central Haversian canal. The central canal contains blood vessels, nerves, and loose connective tissue
  • Interstitial lamellae: Irregularly arranged lamellae between osteons.
  • Internal circumferential lamellae: Layers parallel to the endosteum
  • Endosteum: Innermost single layer of osteoblasts lining the marrow cavity

Histology of Spongy Bone

  • Formed by irregular branching, anastomosing bony trabeculae (T) that enclose bone marrow (BM) cavities in between.
  • Each trabeculum is formed of irregularly arranged bone lamellae enclosing osteocytes but lacks osteons.

References

  • Junqueira's Basic Histology (2013) by Anthony L. Mescher (Text and atlas, 13th Edition)

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