24 Questions
What is the composition of bone?
Acellular portion and cellular portion
What is the difference between spongy bone and compact bone?
Spongy bone consists of trabeculae while compact bone is denser and contains Haversian systems
What is the function of osteoclasts?
Secrete substances that resorb bone
What is the cause of primary osteoporosis?
Genetic factors
Which sex hormone is osteoprotective and how does it protect bones?
Estrogen, by decreasing IL6 and RANKL levels
Which bones are most commonly affected by Paget's disease?
Skull and femur
What is the main characteristic of Paget's disease?
Production of physiologically unstable bone
What is the 'jigsaw pattern' bone deposition and in which phase of Paget's disease does it occur?
Unstable bone deposition in the osteosclerotic phase
What is the composition of bone?
Acellular portion and cellular portion
What is the difference between spongy bone and compact bone?
Spongy bone consists of trabeculae while compact bone is denser and contains Haversian systems
What is the function of osteoclasts?
Secrete substances that resorb bone
What is the cause of primary osteoporosis?
Genetic factors
Which sex hormone is osteoprotective and how does it protect bones?
Estrogen, by decreasing IL6 and RANKL levels
Which bones are most commonly affected by Paget's disease?
Skull and femur
What is the main characteristic of Paget's disease?
Production of physiologically unstable bone
What is the 'jigsaw pattern' bone deposition and in which phase of Paget's disease does it occur?
Unstable bone deposition in the osteosclerotic phase
What is bone composed of?
An acellular portion and a cellular portion
What is the difference between spongy bone and compact bone?
Spongy bone consists of trabeculae and bone marrow, while compact bone contains Haversian systems
What is the function of osteoclasts?
To secrete acidic substances that resorb bone
What is osteoporosis?
A decrease in bone mass
What is the difference between primary and secondary osteoporosis?
Primary osteoporosis is senile, while secondary osteoporosis results from underlying diseases that decrease bone mass
What is Paget's disease of bone characterized by?
The production of physiologically unstable bone due to osteogenic-osteolytic imbalance
What is the most common bone affected by Paget's disease?
The pelvic ileum
What is the 'jigsaw pattern' bone deposition in Paget's disease?
Osteoblasts form unstable bone due to 'jigsaw pattern' bone deposition, which is unstable and greatly prone to fracturing
Study Notes
Overview of Bone Structure and Non-Neoplastic Bone Diseases
- Bone is composed of an acellular portion (matrix) and a cellular portion (osteoblasts, osteocytes, and osteoclasts).
- Spongy bone consists of trabeculae that form a loose bony framework, and bone marrow is located between the trabeculae.
- Compact bone is denser and contains Haversian systems, which transmit blood vessels to spongy bone.
- Osteoclasts secrete acidic substances that resorb bone, and their function is regulated by RANK, RANKL, osteoprotegerin, and M-CSF.
- Osteoporosis is a decrease in bone mass that can result from genetic factors, physical activity, stresses on bone, and nutritional factors.
- Postmenopausal females have reduced levels of estrogen, which results in less inhibition of IL6 and RANKL and makes sex hormones osteoprotective.
- Primary osteoporosis is senile, while secondary osteoporosis results from underlying diseases that decrease bone mass.
- The entire skeleton is affected by osteoporosis, but weight-bearing areas are prone to fracturing.
- Paget's disease of bone is characterized by the production of physiologically unstable bone due to osteogenic-osteolytic imbalance.
- Paget's disease usually affects patients over 70 years old and can involve any bone, most commonly the pelvic ileum, lumbosacral spine, femur, tibia, and skull.
- Paget's disease has three phases: osteolytic, mixed, and osteosclerotic.
- In the mixed and osteosclerotic phases, osteoblasts form unstable bone due to "jigsaw pattern" bone deposition, which is unstable and greatly prone to fracturing.
Test your knowledge on bone structure and non-neoplastic bone diseases with this informative quiz! Learn about the composition of bone, the functions of osteoblasts, osteocytes, and osteoclasts, and the differences between spongy and compact bone. Explore the causes and symptoms of osteoporosis, as well as the effects of estrogen on bone health. Discover the features and phases of Paget's disease of bone, a condition that affects the production of unstable bone and can lead to
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