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Questions and Answers
Which bone disease is associated with the highest level of serum alkaline phosphatase activity?
Which bone disease is associated with the highest level of serum alkaline phosphatase activity?
- osteomalacia
- Paget's disease (correct)
- hypophosphatasia
- rickets
In which condition are ALP levels significantly decreased due to the absence of bone isoenzymes?
In which condition are ALP levels significantly decreased due to the absence of bone isoenzymes?
- osteogenic bone cancer
- hypophosphatasia (correct)
- Paget's disease
- osteomalacia
Which condition shows moderate rises in serum alkaline phosphatase activity that decrease following Vitamin D therapy?
Which condition shows moderate rises in serum alkaline phosphatase activity that decrease following Vitamin D therapy?
- healing bone fractures
- hypophosphatasia
- osteomalacia (correct)
- Paget's disease
During which phases are increased levels of ALP observed?
During which phases are increased levels of ALP observed?
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Which bone disease involves inadequate bone calcification due to subnormal ALP activity?
Which bone disease involves inadequate bone calcification due to subnormal ALP activity?
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Study Notes
Bone Diseases and Alkaline Phosphatase (ALP) Levels
- Paget's disease and osteogenic bone cancer, including metastases, have the highest level of serum alkaline phosphatase (ALP) activity.
- Moderate increases in ALP levels are seen in osteomalacia and rickets, which decrease with Vitamin D therapy.
- ALP levels are elevated during healing bone fractures and periods of physiologic bone growth.
- Hypophosphatasia, an inherited condition, is characterized by significantly decreased ALP levels due to the absence of bone isoenzymes, leading to inadequate bone calcification.
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Description
Quiz about bone diseases and their relation to alkaline phosphatase levels, including Paget's disease, osteomalacia, and rickets.
