5 Questions
Which bone disease is associated with the highest level of serum alkaline phosphatase activity?
Paget's disease
In which condition are ALP levels significantly decreased due to the absence of bone isoenzymes?
hypophosphatasia
Which condition shows moderate rises in serum alkaline phosphatase activity that decrease following Vitamin D therapy?
osteomalacia
During which phases are increased levels of ALP observed?
physiologic bone growth
Which bone disease involves inadequate bone calcification due to subnormal ALP activity?
hypophosphatasia
Study Notes
Bone Diseases and Alkaline Phosphatase (ALP) Levels
- Paget's disease and osteogenic bone cancer, including metastases, have the highest level of serum alkaline phosphatase (ALP) activity.
- Moderate increases in ALP levels are seen in osteomalacia and rickets, which decrease with Vitamin D therapy.
- ALP levels are elevated during healing bone fractures and periods of physiologic bone growth.
- Hypophosphatasia, an inherited condition, is characterized by significantly decreased ALP levels due to the absence of bone isoenzymes, leading to inadequate bone calcification.
Quiz about bone diseases and their relation to alkaline phosphatase levels, including Paget's disease, osteomalacia, and rickets.
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