Bone Anatomy and Functions
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Questions and Answers

What is the primary function of the rib cage in the human body?

To shield the heart and lungs

What is the significance of calcium reserves in the skeletal system?

To supply calcium to the muscular and nervous systems when blood calcium levels are low

How do bones contribute to movement in the human body?

By serving as attachment sites for skeletal muscles and altering the direction and magnitude of forces generated by these muscles

What is the primary function of the vertebrae in the human body?

<p>To enclose and protect the spinal cord</p> Signup and view all the answers

What is the role of bones in providing structural support to the body?

<p>To serve as a framework for the entire body</p> Signup and view all the answers

What is the significance of the pelvic bone in the human body?

<p>To cradle urinary and reproductive organs, as well as the terminal end of the gastrointestinal tract</p> Signup and view all the answers

How do bones support the nervous system?

<p>By protecting delicate tissues and organs, including the brain and spinal cord</p> Signup and view all the answers

What is the role of bones in hematopoiesis?

<p>To provide a site for blood cell production</p> Signup and view all the answers

What is the main function of the diaphysis in a long bone?

<p>The diaphysis provides for the leverage and major weight support of a long bone.</p> Signup and view all the answers

What type of bone marrow is present in the medullary cavity of children?

<p>Red bone marrow</p> Signup and view all the answers

What is the function of the articular cartilage in a movable joint?

<p>It helps reduce friction and absorb shock.</p> Signup and view all the answers

What is the epiphyseal plate responsible for in a growing bone?

<p>It provides for the continued lengthwise growth of the bone.</p> Signup and view all the answers

What is the purpose of the periosteum?

<p>It protects the bone from surrounding structures, anchors blood vessels and nerves, and serves as an attachment site for ligaments and tendons.</p> Signup and view all the answers

What is the function of the endosteum?

<p>It is active during bone growth, repair, and remodeling.</p> Signup and view all the answers

What is the main difference between the gross anatomic structure of long bones and short, flat, and irregular bones?

<p>Long bones have a medullary cavity, while short, flat, and irregular bones do not.</p> Signup and view all the answers

What is the diploë in a flat bone of the skull?

<p>It is a region of spongy bone sandwiched between two layers of compact bone.</p> Signup and view all the answers

What is the metaphysis responsible for in a long bone?

<p>It transfers forces between the diaphysis and the epiphysis.</p> Signup and view all the answers

What is the remnant of the epiphyseal plate in adults?

<p>A thin, defined area of compact bone called the epiphyseal line.</p> Signup and view all the answers

What is the main difference in the location of red bone marrow between children and adults?

<p>In children, red bone marrow is more widely distributed, whereas in adults, it is primarily found in selected portions of the axial skeleton and proximal epiphyses of long bones.</p> Signup and view all the answers

What is the primary function of red bone marrow?

<p>Forming blood cells of the body</p> Signup and view all the answers

What is the name of the fatty-appearing substance that replaces red bone marrow in adults?

<p>Yellow bone marrow</p> Signup and view all the answers

What is the term for the opening or hole in the bone through which blood vessels enter and exit?

<p>Nutrient foramen</p> Signup and view all the answers

What type of nerves accompany blood vessels through the nutrient foramen?

<p>Sensory nerves</p> Signup and view all the answers

What is the name of the soft connective tissue of bone that includes both red and yellow bone marrow?

<p>Bone marrow</p> Signup and view all the answers

What is the term for the process of forming bone matrix?

<p>Bone matrix formation</p> Signup and view all the answers

What is the name of the layer of bone that covers the diaphysis of a long bone?

<p>Periosteum</p> Signup and view all the answers

What is the term for the process of breaking down bone matrix?

<p>Bone matrix resorption</p> Signup and view all the answers

What is the name of the type of connective tissue that comprises bone?

<p>Osseous connective tissue</p> Signup and view all the answers

What is the purpose of bone marrow transplantation in individuals with leukemia?

<p>To replace abnormal functioning red bone marrow with healthy donor marrow</p> Signup and view all the answers

Why is it essential to 'match' donor and recipient bone marrow, just like blood types?

<p>To prevent the immune system from attacking the transplanted tissue as foreign</p> Signup and view all the answers

What is the role of osteoprogenitor cells in the skeletal system?

<p>They develop into osteoblasts, which mature to become osteocytes</p> Signup and view all the answers

What is the function of osteoblasts in bone connective tissue?

<p>To synthesize and secrete osteoid, the initial semisolid organic form of bone matrix</p> Signup and view all the answers

How do osteocytes maintain the bone matrix?

<p>By detecting mechanical stress on a bone and signaling osteoblasts to deposit new bone matrix</p> Signup and view all the answers

What is the function of osteoclasts in bone connective tissue?

<p>To break down and resorb bone matrix</p> Signup and view all the answers

From which cells are osteoclasts derived?

<p>Fused bone marrow cells similar to those that produce monocytes</p> Signup and view all the answers

What is the term for the depression or pit on the bone surface where osteoclasts are often located?

<p>Resorption lacuna (Howship's lacuna)</p> Signup and view all the answers

Where are osteoprogenitor cells typically located in the bone?

<p>In both the periosteum and endosteum</p> Signup and view all the answers

What is the term for the initial semisolid organic form of bone matrix produced by osteoblasts?

<p>Osteoid</p> Signup and view all the answers

What is the function of hydrochloric acid (HCl) in bone resorption?

<p>Hydrochloric acid (HCl) dissolves the mineral parts (calcium and phosphate crystals) of the bone matrix.</p> Signup and view all the answers

What is the main component of an osteon that surrounds the central canal and forms the bulk of the osteon?

<p>Concentric lamellae</p> Signup and view all the answers

What is the function of canaliculi in bone tissue?

<p>Canaliculi are tiny, interconnecting channels that extend from each lacuna, through the lamellae, and connect to other lacunae and the central canal, allowing for the exchange of nutrients, minerals, gases, and wastes between osteocytes and blood vessels.</p> Signup and view all the answers

What is the function of osteocytes in bone tissue?

<p>Osteocytes maintain the bone matrix.</p> Signup and view all the answers

What is the function of perforating (Volkmann) canals in compact bone?

<p>Perforating canals help connect multiple central canals within different osteons, forming a channel for vascular and innervation connections among multiple osteons.</p> Signup and view all the answers

What is the orientation of collagen fibers in adjacent lamellae in an osteon?

<p>The collagen fibers in adjacent lamellae are oriented at an angle that is 90 degrees different from both the previous and the next lamellae.</p> Signup and view all the answers

What is the function of circumferential lamellae in compact bone?

<p>Circumferential lamellae are rings of bone immediately internal to the periosteum of the bone (external circumferential lamellae) or immediately external to the endosteum (internal circumferential lamellae).</p> Signup and view all the answers

What is the central canal of an osteon composed of?

<p>The central canal is a cylindrical channel that lies in the center of the osteon and runs parallel to it, containing blood vessels and nerves that supply the bone.</p> Signup and view all the answers

How do osteons contribute to the overall strength and resilience of bone?

<p>The alternating pattern of collagen fiber direction in adjacent lamellae within an osteon gives bone part of its strength and resilience.</p> Signup and view all the answers

What is the relationship between the direction of collagen fibers in adjacent lamellae and the strength of bone?

<p>The alternating pattern of collagen fiber direction in adjacent lamellae within an osteon gives bone part of its strength.</p> Signup and view all the answers

What is the primary source of oxygen and nutrients for cartilage, and how do they reach the cartilage cells?

<p>The primary source of oxygen and nutrients for cartilage is the blood vessels in the perichondrium, which supply them to the cartilage cells through diffusion.</p> Signup and view all the answers

What are the main differences between the connective tissue of bone and hyaline cartilage?

<p>The main differences are that bone connective tissue is formed by osteoblasts, has osteocytes as the mature cell type, has calcium present in the matrix, and has an extensive blood supply, whereas hyaline cartilage connective tissue is formed by chondroblasts, has chondrocytes as the mature cell type, does not have calcium present in the matrix, and is avascular.</p> Signup and view all the answers

How do the cells that form the matrix of bone and hyaline cartilage differ?

<p>The cells that form the matrix of bone are osteoblasts, whereas the cells that form the matrix of hyaline cartilage are chondroblasts.</p> Signup and view all the answers

What is the main difference in the blood supply of mature bone tissue and hyaline cartilage tissue?

<p>Mature bone tissue has an extensive blood supply, whereas hyaline cartilage tissue is avascular.</p> Signup and view all the answers

How do the mature cell types of bone and hyaline cartilage differ?

<p>The mature cell type of bone is the osteocyte, whereas the mature cell type of hyaline cartilage is the chondrocyte.</p> Signup and view all the answers

What is the main difference between compact bone and spongy bone in terms of osteon structure?

<p>Compact bone contains osteons with a central canal, whereas spongy bone lacks osteons and has a lattice-like structure of trabeculae.</p> Signup and view all the answers

How do nutrients reach osteocytes in spongy bone?

<p>Nutrients reach osteocytes in spongy bone through diffusion via cytoplasmic processes that extend within canaliculi, which open onto the surfaces of trabeculae.</p> Signup and view all the answers

What is the function of the perichondrium in hyaline cartilage?

<p>The perichondrium helps maintain the shape of hyaline cartilage.</p> Signup and view all the answers

What is the significance of the high water content in hyaline cartilage?

<p>The high water content makes hyaline cartilage highly compressible, allowing it to function as a good shock absorber.</p> Signup and view all the answers

What is the difference between chondroblasts and chondrocytes in hyaline cartilage?

<p>Chondroblasts produce the cartilage matrix, whereas chondrocytes are mature cartilage cells that maintain the matrix.</p> Signup and view all the answers

What is the characteristic of the ground substance in hyaline cartilage?

<p>The ground substance in hyaline cartilage is similar to that of bone, but lacks calcium, and contains proteoglycans such as chondroitin sulfate.</p> Signup and view all the answers

What is the structure of an osteon in compact bone?

<p>An osteon is composed of concentric lamellae surrounding a central canal, with osteocytes in lacunae between the lamellae.</p> Signup and view all the answers

What are interstitial lamellae, and what is their characteristic?

<p>Interstitial lamellae are components of compact bone between osteons or leftover parts of osteons that have been partially resorbed, and they often lack a central canal.</p> Signup and view all the answers

What is the structure of spongy bone, and what is its function?

<p>Spongy bone is composed of an open lattice of trabeculae, and it provides great resistance to stresses applied in many directions by distributing the stress throughout the entire framework.</p> Signup and view all the answers

What is the significance of canaliculi in compact bone?

<p>Canaliculi are small channels that allow for the diffusion of nutrients and waste products between osteocytes in lacunae and the bloodstream.</p> Signup and view all the answers

What is the process of forming blood cells and platelets from stem cells called?

<p>Hematopoiesis</p> Signup and view all the answers

What two minerals are stored in bone and released into the blood when needed?

<p>Calcium and phosphate</p> Signup and view all the answers

What are the four classes of bones classified by shape?

<p>Long bones, short bones, flat bones, and irregular bones</p> Signup and view all the answers

What type of bone has an elongated, cylindrical shaft and is found in the upper and lower limbs?

<p>Long bones</p> Signup and view all the answers

What is the largest sesamoid bone in the body?

<p>Patella (kneecap)</p> Signup and view all the answers

What is the function of flat bones in the body?

<p>Provide extensive surface areas for muscle attachment and protect underlying soft tissues</p> Signup and view all the answers

What are some examples of irregular bones in the body?

<p>Vertebrae, ossa coxae (hip bones), ethmoid, sphenoid, and maxilla</p> Signup and view all the answers

What is the function of blood vessels and nerves that serve a bone?

<p>To provide oxygen and nutrients to the bone cells and remove waste products</p> Signup and view all the answers

What is the innermost layer of tissue that lines the medullary cavity of a long bone?

<p>Endosteum</p> Signup and view all the answers

What is the outermost layer of tissue that lines the external surface of a long bone?

<p>Periosteum</p> Signup and view all the answers

What is the term for the process by which osteoclasts break down bone, and what is its significance in the body?

<p>The term is bone resorption, and it is significant in maintaining bone health by removing old or damaged bone tissue and allowing for new bone growth.</p> Signup and view all the answers

What is osteitis deformans, and what are its characteristic features?

<p>Osteitis deformans is a bone disorder characterized by excessive bone resorption followed by excessive bone deposition, resulting in poorly formed and unstable bone. It is also known as Paget disease of bone.</p> Signup and view all the answers

What is the composition of osteoid, and what is its role in bone structure?

<p>Osteoid is composed of collagen and a semisolid ground substance of proteoglycans and glycoproteins. It provides tensile strength to bone by resisting stretching and twisting.</p> Signup and view all the answers

What is hydroxyapatite, and how does it contribute to bone structure?

<p>Hydroxyapatite is a type of calcium phosphate crystal that deposits around collagen fibers in the extracellular matrix, hardening the matrix and providing compressional strength to bone.</p> Signup and view all the answers

What is the process of calcification, and what are the essential substances required for it?

<p>Calcification is the process of hydroxyapatite crystal deposition in the bone matrix. It requires calcium ions, phosphate ions, vitamin D, and vitamin C.</p> Signup and view all the answers

How do osteoclasts and osteoblasts work together to maintain bone health?

<p>Osteoclasts break down old or damaged bone tissue, while osteoblasts deposit new bone tissue. This balance of bone resorption and formation maintains bone health and allows for repair and remodeling.</p> Signup and view all the answers

What is the consequence of abnormal protein or mineral composition in the bone matrix?

<p>Abnormal protein composition can result in brittle bones, while insufficient calcium can lead to soft bones.</p> Signup and view all the answers

What is the role of osteoblasts in bone formation, and what substances do they secrete?

<p>Osteoblasts secrete osteoid, which is composed of collagen and ground substance, and initiate calcification by depositing hydroxyapatite crystals.</p> Signup and view all the answers

How does vitamin D contribute to bone health, and what other vitamin is essential for collagen formation?

<p>Vitamin D enhances calcium absorption from the gastrointestinal tract, while vitamin C is required for collagen formation.</p> Signup and view all the answers

What is the significance of the correct proportion of organic and inorganic substances in the bone matrix?

<p>The correct proportion of organic and inorganic substances allows bone to function optimally, providing both tensile strength and compressional strength.</p> Signup and view all the answers

Study Notes

Functions of Bone

  • Support and protection: bones provide structural support and serve as a framework for the entire body, protecting many delicate tissues and organs from injury and trauma
  • Levers for movement: bones serve as attachment sites for skeletal muscles, other soft tissues, and some organs, and alter the direction and magnitude of the forces generated by the skeletal muscles
  • Hematopoiesis: red bone marrow connective tissue contains stem cells that form blood cells and platelets
  • Storage of mineral and energy reserves: bones store minerals such as calcium and phosphate, and lipids for energy release

Classification of Bones

  • Long bones: greater in length than width, with an elongated, cylindrical shaft (diaphysis), found in upper and lower limbs
  • Short bones: nearly equal in length and width, found in wrist (carpals) and foot (tarsals), and include sesamoid bones
  • Flat bones: thin, flat surfaces, found in the skull, scapulae, sternum, and ribs
  • Irregular bones: complex shapes, found in vertebrae, ossa coxae (hip bones), and some bones in the skull

Gross Anatomy of Bones

  • Long bones:
    • Diaphysis (shaft): composed of compact bone, with a hollow, cylindrical space called the medullary cavity
    • Epiphysis (knobby region): composed of compact bone and spongy bone, found at each end of the bone
    • Metaphysis (region of bone widening): connects the diaphysis and epiphysis
    • Periosteum (tough sheath): covers the outer surface, with a fibrous layer and a cellular layer that includes osteoprogenitor cells, osteoblasts, and osteoclasts
    • Endosteum (thin layer): lines the medullary cavity, with osteoprogenitor cells, osteoblasts, and osteoclasts
  • Short, flat, and irregular bones:
    • Compact bone on the surface
    • Spongy bone on the inside
    • No medullary cavity

Blood Supply and Innervation of Bone

  • Blood vessels enter bones from the periosteum, with one nutrient artery and one nutrient vein
  • Nerves innervate the bone, periosteum, endosteum, and marrow cavity, transmitting nerve impulses when the skeleton is injured

Bone Marrow

  • Red bone marrow (myeloid tissue): contains reticular connective tissue, developing blood cells, and adipocytes, found in flat bones of the skull, vertebrae, ribs, sternum, and ossa coaxe in adults
  • Yellow bone marrow: found in medullary cavities of long bones and inner core of most epiphyses in adults, with a decrease in developing blood cells and an increase in adipocytes

Bone Cells

  • Osteoprogenitor cells: stem cells derived from mesenchyme, found in periosteum and endosteum
  • Osteoblasts: formed from osteoprogenitor cells, synthesize and secrete osteoid, and differentiate into osteocytes
  • Osteocytes: mature bone cells, maintain the bone matrix, and detect mechanical stress on a bone
  • Osteoclasts: large, multinuclear, phagocytic cells, break down bone in the process of bone resorption, derived from fused bone marrow cells

Bone Matrix

  • Organic component: osteoid, produced by osteoblasts, composed of collagen and a semisolid ground substance of proteoglycans and glycoproteins
  • Inorganic component: salt crystals, primarily calcium phosphate, that form hydroxyapatite crystals, which give bone hardness and rigidity### Bone Matrix: Its Formation and Resorption
  • Bone formation begins with osteoblasts secreting osteoid, which is then calcified with hydroxyapatite crystals to form bone matrix.
  • Calcification requires calcium and phosphate ions, as well as vitamins D and C.
  • Bone resorption, the destruction of bone matrix, occurs when osteoclasts release substances that break down collagen fibers and dissolve calcium and phosphate crystals.

Compact Bone Microscopic Anatomy

  • Compact bone is composed of osteons, which are the basic functional and structural units of mature compact bone.
  • Each osteon has a central (Haversian) canal, concentric lamellae, lacunae, canaliculi, and osteocytes.
  • The central canal contains blood vessels and nerves that supply the bone.
  • Concentric lamellae are rings of bone connective tissue that surround the central canal and form the bulk of the osteon.
  • Lacunae are small spaces that house osteocytes, which maintain the bone matrix.
  • Canaliculi are tiny, interconnecting channels within the bone connective tissue that permit intercellular contact and communication.

Spongy Bone Microscopic Anatomy

  • Spongy bone contains no osteons, but instead has an open lattice structure composed of trabeculae (narrow rods and plates of bone).
  • Trabeculae provide great resistance to stresses applied in many directions by distributing the stress throughout the entire framework.
  • Bone marrow fills in between the trabeculae.
  • Osteocytes rest in lacunae between adjacent lamellae, with canaliculi radiating from the lacunae.

Bone Matrix Composition

  • Bone matrix is composed of both organic and inorganic substances.
  • Organic substances include collagen fibers and proteoglycans, such as chondroitin sulfate.
  • Inorganic substances include calcium and phosphate crystals.

Hyaline Cartilage Connective Tissue

  • Hyaline cartilage contains a population of cells scattered throughout a matrix of protein fibers (primarily collagen) embedded within a gel-like ground substance.
  • The ground substance includes proteoglycans, such as chondroitin sulfate, but does not include calcium.
  • Hyaline cartilage is both resilient and flexible, and its high water content (60% to 70% by weight) makes it compressible and a good shock absorber.
  • Chondroblasts produce the cartilage matrix, and once encased within the matrix, they become chondrocytes that maintain the matrix.
  • Hyaline cartilage is avascular and contains no nerves, and nutrients and oxygen are supplied by diffusion from blood vessels in the perichondrium.

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Learn about the general functions, classification, gross anatomy, and histology of bones, including their structure and composition.

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