Body Movement Year 2 Unit 1

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Questions and Answers

What is the primary role of skeletal muscles in body movement?

  • Generating heat for the body
  • Providing structural support to the bones
  • Contracting and relaxing to mechanically move the body (correct)
  • Converting chemical energy into electrical energy

What structure forms the postsynaptic part of the neuromuscular junction?

  • Myelin sheath
  • Synaptic cleft
  • Axon terminal
  • Motor end plate (correct)

Which neurotransmitter is involved in the activation of skeletal muscle fibers at the neuromuscular junction?

  • Acetylcholine (correct)
  • Serotonin
  • Norepinephrine
  • Dopamine

What condition results from antibodies against cholinergic receptors in the postsynaptic membrane?

<p>Myasthenia Gravis (C)</p> Signup and view all the answers

What is the purpose of junctional folds in the motor end plate?

<p>To increase surface area for ACh receptors (C)</p> Signup and view all the answers

What initiates the functional activation of skeletal muscle fibers to contract?

<p>Excitation signals from neurons (C)</p> Signup and view all the answers

Which disorder is characterized by antibodies to calcium channels in the presynaptic axon terminal?

<p>Eaton-Lambert syndrome (C)</p> Signup and view all the answers

What role do voltage-gated sodium channels (VGSCs) play in neuromuscular transmission?

<p>Generating action potentials in muscle fibers (C)</p> Signup and view all the answers

What is the primary role of myosin in skeletal muscle contraction?

<p>It serves as a polymer that generates force through ATP binding. (A)</p> Signup and view all the answers

What must occur for a skeletal muscle contraction to take place?

<p>ATP must be available along with a neural stimulus and calcium ions. (D)</p> Signup and view all the answers

What process leads to the reuptake of calcium ions into the sarcoplasmic reticulum during muscle relaxation?

<p>Function of SERCA. (D)</p> Signup and view all the answers

What is the main consequence of the body entering rigor mortis after death?

<p>Depletion of glycogen and inability to release cross-bridges. (C)</p> Signup and view all the answers

What happens to calcium ions when neural stimulation of muscle fibers stops?

<p>Calcium ions are pumped back into the sarcoplasmic reticulum. (D)</p> Signup and view all the answers

What triggers the muscle fiber repolarization during relaxation?

<p>Shutdown of the motor neuron signaling. (B)</p> Signup and view all the answers

What is the function of ATP in the myosin-actin contraction cycle?

<p>To energize cross-bridges for force generation. (A)</p> Signup and view all the answers

What initiates the contraction cycle in skeletal muscle fibers?

<p>Presence of high calcium levels and a neural stimulus. (B)</p> Signup and view all the answers

What effect does botulinum toxin have on neuromuscular function?

<p>It inhibits the release of ACh from presynaptic membranes. (D)</p> Signup and view all the answers

What is the role of Dihydropyridine (DHP) receptors in skeletal muscle contraction?

<p>They sense action potentials and trigger the opening of calcium channels. (D)</p> Signup and view all the answers

Which statement accurately describes the organization of a sarcomere?

<p>The M-line is located in the center of the A-band and does not contain actin. (B)</p> Signup and view all the answers

Which of the following best describes the sliding filament theory?

<p>Thin filaments slide past thick filaments, allowing sarcomeres to shorten. (C)</p> Signup and view all the answers

What is the primary source of calcium influx in skeletal muscles?

<p>Release from the sarcoplasmic reticulum. (B)</p> Signup and view all the answers

How many actin filaments can one myosin filament interact with in a sarcomere?

<p>Six actin filaments. (A)</p> Signup and view all the answers

What characterizes the I-band in a sarcomere?

<p>It consists of thin actin filaments only. (B)</p> Signup and view all the answers

During repolarization of the T-tubule, what happens to the calcium release channels in the SR?

<p>They close shortly after repolarization begins. (B)</p> Signup and view all the answers

Flashcards

Skeletal Muscle Contraction

Skeletal muscles move the body by contracting and relaxing. This movement is coordinated with bones.

Neuromuscular Junction (NMJ)

The connection point between a motor neuron and a muscle fiber where signals are passed to make the muscle contract.

Synaptic Cleft

The small gap between the nerve ending and muscle fiber in the NMJ.

Motor End Plate

The part of the muscle fiber where the motor neuron connects, containing receptors for signals.

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Acetylcholine (ACh)

A chemical messenger that transmits signals across the synaptic cleft to stimulate muscle contraction.

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Eaton-Lambert Syndrome

An autoimmune disorder that affects neuromuscular function due to calcium channel antibodies.

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Myasthenia Gravis

An autoimmune disorder targeting the receptors in the NMJ, making muscle movement difficult.

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Motor Neuron

A nerve cell that sends signals to skeletal muscles to make them contract.

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Botulism

A neuromuscular junction disorder caused by a toxin produced by the bacteria Clostridium botulinum, which inhibits the release of acetylcholine (ACh).

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Neuromuscular Junction

The interface between a motor neuron and a muscle fiber, where nerve impulses are transmitted to cause muscle contraction.

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Sarcomere

The basic contractile unit of a muscle fiber, composed of overlapping thin (actin) and thick (myosin) filaments.

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Sliding Filament Theory

The mechanism of muscle contraction, where myosin filaments pull actin filaments closer together, shortening the sarcomeres.

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Excitation-Contraction Coupling

The process by which an action potential in a muscle fiber leads to muscle cell contraction.

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Ca++2

Calcium ions, crucial for muscle contraction, released from the sarcoplasmic reticulum (SR).

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Myofibrils

Thread-like structures within muscle fibers, composed of repeating sarcomeres.

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Sarcoplasmic Reticulum (SR)

A specialized type of endoplasmic reticulum in muscle cells that stores and releases calcium ions, which trigger muscle contraction.

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Myosin

A protein that forms the thick filaments in muscle fibers, It has cross-bridges that bind to actin and use ATP for energy.

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Sarcomere contraction

The process by which muscle fibers shorten during contraction, involving the sliding of actin and myosin filaments.

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ATP's role in muscle relaxation

ATP is needed to detach myosin cross-bridges from actin, allowing muscles to relax.

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Rigor Mortis

The stiffening of muscles after death due to the inability to break actin-myosin cross-bridges because of a lack of ATP.

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Role of Calcium in Muscle Contraction

Calcium ions (Ca2+) initiate muscle contraction by allowing myosin to bind to actin.

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SERCA

Sarcoendoplasmic Reticulum Calcium ATPase, a pump that returns calcium to the sarcoplasmic reticulum after contraction, ending the contraction.

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Muscle relaxation triggers

A lack of neural stimulation and the re-sequestration of calcium ions in the Sarcoplasmic Reticulum result in muscle relaxation.

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Contraction cycle

The repeating steps in which myosin heads attach, pull on actin, release, and reattach to produce muscle shortening.

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Study Notes

Body Movement - Year 2, Unit 1

  • Course: Body Movement
  • Year: 2
  • Unit: 1
  • Academic Year: 2024-2025
  • Instructor: Dr. Tariq Alshaibani

Learning Objectives

  • Describe the neuromuscular junction (NMJ) and how action potentials in the motor neuron lead to skeletal muscle excitation and contraction.
  • Detail the molecular and electrical makeup of muscle cell excitation-contraction coupling.
  • Define the elements of the sarcomere that underlie striated muscle contraction.

Skeletal Muscle Contraction & Body Movement

  • Skeletal muscles contract and relax to move the body (e.g., walking, running, manipulating objects).
  • Skeletal muscle works with bones to create body movements.
  • Muscle fibers contract, generating tension transmitted through tendons to bones, enabling movement.

Neuromuscular Control

  • Stimulation of skeletal muscle fibers (motor neurons in the spinal cord/brainstem) is the only way to make them contract.

The Neuromuscular Junction (NMJ)

  • The NMJ is where the axon terminal of a motor neuron meets a muscle fiber.
  • The synaptic cleft is a 20-30nm gap containing acetylcholinesterase (AChE).
  • The motor end plate is the postsynaptic part of the NMJ; it features junctional folds increasing the surface area of the postsynaptic membrane.
  • The motor end plate contains ACh receptors and voltage-gated sodium channels.

Acetylcholine Release

  • Calcium channels are localized around dense bars on the presynaptic membrane where vesicles containing ACh fuse.
  • Acetylcholine (ACh) receptors are located at the top of the subneural cleft, and voltage-gated sodium channels are found in the bottom half of the subneural cleft.
  • Voltage-gated sodium channels facilitate action potential generation.

Main Schema for Neuromuscular Transmission

  • Action potentials travel down motor neuron axons, triggering calcium release.
  • Calcium release triggers the release of acetylcholine (ACh).
  • ACh binds to receptors on the muscle fiber, initiating an action potential.
  • This action potential triggers calcium release from the sarcoplasmic reticulum, leading to muscle contraction.

Disorders

  • Eaton-Lambert syndrome: Autoimmune disorder affecting calcium channels in the presynaptic axon terminal.
  • Botulism: Toxin produced by Clostridium botulinum bacteria, inhibiting the release of acetylcholine (ACh).
  • Myasthenia gravis: Autoimmune disorder affecting cholinergic receptors in the postsynaptic membrane.

Excitation-Contraction Coupling

  • Describes how the action potential entering the muscle cell causes a contraction within the muscle.

Ca+2 for Excitation-Contraction Coupling

  • Action potentials travel through T-tubules.
  • Calcium released from the sarcoplasmic reticulum (SR).
  • Calcium binds to troponin, causing tropomyosin to shift, exposing binding sites on actin.
  • Myosin heads bind to actin, producing a power stroke, pulling actin filaments.

Release of Ca+2 from Sarcoplasmic Reticulum

  • Dihydropyridine (DHP) receptors sense the muscle action potential in the membrane.
  • DHP receptors are linked to calcium release channels (ryanodine receptors).
  • Triggering calcium release from the sarcoplasmic reticulum by activating DHP receptors in the T-tubules.

Organization of Skeletal Muscle

  • Describes how skeletal muscle fibers, fascicles, and bundles are organized.

Skeletal Muscle Structure- Gross to Cellular

  • Muscle, tendon, and bone relationships are described, from whole muscle to individual muscle fibers.
  • Myofibril structure is described.

The Myofilaments

  • Arrangement of thin (actin) and thick (myosin) filaments creates the sarcomere structure that is responsible for skeletal muscle contraction.

The Sarcomere

  • The sarcomere is the fundamental unit of skeletal muscle contraction.
  • A band contains thick filaments; an I-band contains thin filaments.
  • The structure of Z-lines, A-bands, I-bands, and M-lines is detailed for understanding skeletal muscle contraction.

The Sliding Filament Theory of Contraction

  • Myosin filaments pull actin filaments closer together, shortening sarcomeres within a muscle fiber.
  • Sliding of actin past myosin generates muscle tension.

Ultrastructure of Skeletal Muscle – Molecular Basis of Contraction

  • Description of the structural components related to skeletal muscle contraction.

Contractile Proteins of Skeletal Muscle

  • Myosin and actin filament structure are described to explain how they enable skeletal muscle contraction.

The Molecular Basis of Skeletal Muscle Contraction

  • How Ca+2 levels and ATP hydrolysis lead to skeletal muscle contraction and enable myosin to detach from actin are explained.

The Contraction Cycle - Role of Ca+2 and ATP

  • The process, starting with ATP hydrolysis, of how myosin heads bind to actin followed by the power stroke (myosin heads pull actin) and detachment, and repeating to enable skeletal muscle contraction is explained.

Rigor Mortis

  • After death, the process of rigor mortis, where muscles stiffen, occurs because there is no more ATP to detach myosin from actin.

In order for a skeletal muscle contraction to occur: (Summary)

  • There must be a neural stimulus.
  • There must be Ca+2 in the cytosol of the muscle cells.
  • ATP must be available for energy.
  • Relaxation occurs when Ca+2 levels decrease and ATP is available.

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