BMS 151: Tissue Accumulations & Deposits

Which alteration in purine metabolism leads to the deposition of sodium urate crystals in tissues, characteristic of gout?

A patient with a history of chronic alcohol abuse presents with an enlarged liver and elevated liver enzymes. A liver biopsy reveals intracellular accumulation of a clear, PAS-positive substance. Which of the following is the most likely diagnosis?

A researcher is studying a biopsy sample from a patient with suspected hyalinosis. Which of the following microscopic characteristics would be most consistent with this condition?

A patient with a history of chronic inflammatory disease develops kidney failure. A renal biopsy shows extracellular deposition of an amorphous, eosinophilic substance. Which of the following stains would be most appropriate to confirm a diagnosis of amyloidosis?

Which of the following mechanisms is most directly implicated in the pathogenesis of dystrophic calcification?

A coal miner who has worked for 30 years presents with shortness of breath and a chronic cough. A lung biopsy reveals black pigment accumulation in the lung parenchyma. Which of the following best describes the type of pigmentation observed?

An elderly patient presents with brown atrophy of the heart. Microscopic examination reveals a yellowish-brown, fat-soluble pigment within cardiomyocytes. Which of the following pigments is most likely responsible for this finding?

A patient with hemochromatosis undergoes a liver biopsy. Histological examination reveals an accumulation of iron within hepatocytes. Which special stain would best highlight the presence of this pigment?

A patient presents with painful swelling of the metatarsophalangeal joint of the big toe. Analysis of synovial fluid reveals needle-shaped crystals that are negatively birefringent under polarized light. Which of the following substances is most likely deposited in the joint?

A 5-year-old child is diagnosed with a glycogen storage disease. Which of the following microscopic findings in a liver biopsy would be most suggestive of this diagnosis?

A pathologist examines a breast biopsy and identifies signet-ring cells. Further analysis reveals that these cells contain an accumulation of mucin. In which of the following conditions would the accumulation of mucin be most likely the predominant abnormality in the histological analysis?

A patient with a history of chronic renal failure develops secondary hyperparathyroidism. Which of the following sites is most likely to exhibit metastatic calcification in this patient?

A patient undergoes a tissue biopsy, and the pathologist reports the presence of psammoma bodies. Which type of tissue accumulation is most likely represented by psammoma bodies?

A patient presents with jaundice and is found to have increased levels of bilirubin in the liver. What would this be classified as?

A woman who had repeated blood transfusions due to Thalassemia over many years develops liver damage. Which type of pigment accumulation is most likely present in her liver?

A patient with renal tubular acidosis has increased tubular calcium concentrations. What type of calcification is she at risk of developing?

Chronic heart failure (brown atrophy) causes what type of tissue accumulation?

In necrotizing pancreatitis, foci of fat necrosis may develop in the peripancreatic adipose fat. What type of tissue accumuluation can occur in this scenerio?

A patient undergoes a skin biopsy, and the pathologist reports the presence of melanin. Which type of classification of tissue accumulation would melanin be?

A patient undergoes a biopsy, and the pathologist stains the tissue with Periodic Acid-Schiff (PAS). Which of the following might the pathologist be testing for?

What color does Congo Red stain and what can it be used to detect?

Which of the following best describes the pathogenesis of primary gout?

In the context of cellular pathology, what is the clinical significance of identifying Russell bodies?

Which factor most directly contributes to the development of metastatic calcification?

A patient who has chronic lead poisoning (plumbism) has increased levels of lead. What is this an example of?

Which statement accurately links a pathological condition with its diagnostic histological finding?

A patient with hyperparathyroidism develops nephrocalcinosis and calcium deposits in the gastric mucosa. What type of tissue accumulation is this?

What key feature distinguishes localized from systemic amyloidosis concerning their extent of impact on the body?

What is the role of vascular compression and pressure atrophy in the pathogenesis of amyloidosis-related organ dysfunction?

What is the underlying process that increases lipofuscin accumulation in tissues and the heart?

What mechanism underlies the development of urate crystals in gout, especially affecting joints?

A patient with a history of tuberculosis (TB) undergoes a tissue biopsy, and pathologist reports the presence of 2ry amyloidosis. What best describes type of infection?

A patient undergoes a tattoo. Which type of classification of tissue accumulation is tattooing?

What is the main characteristic one might observe histologically in an individual that has gout?

A 60-year-old man has localized amyloidosis. What type of amyloidosis can he have?

What is the common site that Na urates deposit at?

An individual who has had significant sun exposure can develop hyperpigmentaiton of the skin due to localized deposits of melanin. Which of the following is NOT a skin condition that can be caused by melanin deposits?