BMS 150 Week 4: Pathophysiology of RA, OA, and Infectious Arthropathies
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Questions and Answers

What is the role of the HLA-DR4 molecule in the context of citrullination and autoimmune diseases?

  • It sensitizes CD4+ cells to recognize self-antigens.
  • It is associated with anti-citrulline antibody production. (correct)
  • It triggers anergy in T-cells during infection.
  • It promotes the conversion of arginine amino acids to citrulline.

    • In the context of molecular mimicry, what happens when a microbial antigen resembles a self-antigen?

  • T-cell activation occurs instead of anergy. (correct)
  • The microbial antigen suppresses the immune response.
  • Anergy is induced in CD4+ cells.
  • The self-antigen becomes inactive.

    • How do environmental factors like smoking contribute to the pathogenesis of rheumatoid arthritis?

  • They may enhance the citrullination of self-proteins. (correct)
  • They inhibit the citrullination of self-proteins.
  • They prevent molecular mimicry from occurring.
  • They promote the conversion of citrulline back to arginine.

    • What is the main pathologic change in Rheumatoid Arthritis (RA)?

    <p>Inflammatory cytokines</p> Signup and view all the answers

    Which genetic factor is associated with more severe disease in RA?

    <p>HLA DR1</p> Signup and view all the answers

    How does smoking contribute to the risk of developing RA?

    <p>By inducing autoantibody production</p> Signup and view all the answers

    What percentage of RA's etiology is attributed to genetic factors?

    <p>50-60%</p> Signup and view all the answers

    Which type of arthritis has a characteristic of being a relapsing-remitting illness?

    <p><strong>Rheumatoid Arthritis (RA)</strong></p> Signup and view all the answers

    What are the main pathologic changes in RA mediated by?

    <p><strong>Inflammatory cytokines</strong></p> Signup and view all the answers

    Which inflammatory mediator secreted from CD4+ T-cells activates macrophages and resident synovial cells?

    <p>INF-𝛾</p> Signup and view all the answers

    What cytokine from _____cells recruits neutrophils and monocytes in RA pathophysiology?

    <p>IL-17</p> Signup and view all the answers

    Which type of auto-antibodies in RA bind to the IgG Fc region and are collectively referred to as rheumatoid factor?

    <p>IgM</p> Signup and view all the answers

    What is the significant antigen recognized by auto-antibodies like anti-CCP in patients with RA?

    <p>Citrullinated proteins</p> Signup and view all the answers

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