Podcast
Questions and Answers
What is the role of the HLA-DR4 molecule in the context of citrullination and autoimmune diseases?
What is the role of the HLA-DR4 molecule in the context of citrullination and autoimmune diseases?
- It sensitizes CD4+ cells to recognize self-antigens.
- It is associated with anti-citrulline antibody production. (correct)
- It triggers anergy in T-cells during infection.
- It promotes the conversion of arginine amino acids to citrulline.
In the context of molecular mimicry, what happens when a microbial antigen resembles a self-antigen?
In the context of molecular mimicry, what happens when a microbial antigen resembles a self-antigen?
- T-cell activation occurs instead of anergy. (correct)
- The microbial antigen suppresses the immune response.
- Anergy is induced in CD4+ cells.
- The self-antigen becomes inactive.
How do environmental factors like smoking contribute to the pathogenesis of rheumatoid arthritis?
How do environmental factors like smoking contribute to the pathogenesis of rheumatoid arthritis?
- They may enhance the citrullination of self-proteins. (correct)
- They inhibit the citrullination of self-proteins.
- They prevent molecular mimicry from occurring.
- They promote the conversion of citrulline back to arginine.
What is the main pathologic change in Rheumatoid Arthritis (RA)?
What is the main pathologic change in Rheumatoid Arthritis (RA)?
Which genetic factor is associated with more severe disease in RA?
Which genetic factor is associated with more severe disease in RA?
How does smoking contribute to the risk of developing RA?
How does smoking contribute to the risk of developing RA?
What percentage of RA's etiology is attributed to genetic factors?
What percentage of RA's etiology is attributed to genetic factors?
Which type of arthritis has a characteristic of being a relapsing-remitting illness?
Which type of arthritis has a characteristic of being a relapsing-remitting illness?
What are the main pathologic changes in RA mediated by?
What are the main pathologic changes in RA mediated by?
Which inflammatory mediator secreted from CD4+ T-cells activates macrophages and resident synovial cells?
Which inflammatory mediator secreted from CD4+ T-cells activates macrophages and resident synovial cells?
What cytokine from _____cells recruits neutrophils and monocytes in RA pathophysiology?
What cytokine from _____cells recruits neutrophils and monocytes in RA pathophysiology?
Which type of auto-antibodies in RA bind to the IgG Fc region and are collectively referred to as rheumatoid factor?
Which type of auto-antibodies in RA bind to the IgG Fc region and are collectively referred to as rheumatoid factor?
What is the significant antigen recognized by auto-antibodies like anti-CCP in patients with RA?
What is the significant antigen recognized by auto-antibodies like anti-CCP in patients with RA?
