13 Questions
What is the role of the HLA-DR4 molecule in the context of citrullination and autoimmune diseases?
It is associated with anti-citrulline antibody production.
In the context of molecular mimicry, what happens when a microbial antigen resembles a self-antigen?
T-cell activation occurs instead of anergy.
How do environmental factors like smoking contribute to the pathogenesis of rheumatoid arthritis?
They may enhance the citrullination of self-proteins.
What is the main pathologic change in Rheumatoid Arthritis (RA)?
Inflammatory cytokines
Which genetic factor is associated with more severe disease in RA?
HLA DR1
How does smoking contribute to the risk of developing RA?
By inducing autoantibody production
What percentage of RA's etiology is attributed to genetic factors?
50-60%
Which type of arthritis has a characteristic of being a relapsing-remitting illness?
Rheumatoid Arthritis (RA)
What are the main pathologic changes in RA mediated by?
Inflammatory cytokines
Which inflammatory mediator secreted from CD4+ T-cells activates macrophages and resident synovial cells?
INF-𝛾
What cytokine from _____cells recruits neutrophils and monocytes in RA pathophysiology?
IL-17
Which type of auto-antibodies in RA bind to the IgG Fc region and are collectively referred to as rheumatoid factor?
IgM
What is the significant antigen recognized by auto-antibodies like anti-CCP in patients with RA?
Citrullinated proteins
This quiz covers the pathophysiology, epidemiology, clinical features, diagnosis, and prognosis of Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Osteoarthritis, and Infectious Arthropathies. Topics include Lyme disease, TB arthritis, viral arthritis, and suppurative arthritis.
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