BM402: Engineering in Medicine Quiz

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Questions and Answers

What mathematical operations form the basis of Filtered Back Projection (FBP)?

  • Fourier transforms and convolution (correct)
  • Matrix multiplication and scalar addition
  • Normalization and standardization
  • Differentiation and integration

What is the primary goal of applying a Fourier transform in the context of FBP?

  • To decompose projection data into frequency components (correct)
  • To create a 3D representation of the image
  • To reduce the image size
  • To enhance color saturation

Normal intracranial calcifications are characterized by which of the following definitions?

  • Age-related calcifications without evidence of disease (correct)
  • Calcifications leading to neurological conditions
  • Calcifications due to genetic disorders
  • Calcifications resulting from infections

How does the frequency domain representation assist in FBP?

<p>It filters out unwanted noise and enhances edges. (A)</p> Signup and view all the answers

What type of calcifications does the definition provided in the content specifically exclude?

<p>Calcifications with a pathological cause (D)</p> Signup and view all the answers

What type of injuries are commonly detected by X-rays?

<p>Broken arm (B)</p> Signup and view all the answers

What characteristic of bones makes them appear whiter on X-rays?

<p>High content of calcium (A)</p> Signup and view all the answers

Which of the following conditions can X-rays help to identify?

<p>Certain tumors (B)</p> Signup and view all the answers

What type of medical imaging specifically utilizes X-rays to examine the breast?

<p>Mammography (A)</p> Signup and view all the answers

How do X-rays interact with air-filled cavities in the body?

<p>They pass through easily (D)</p> Signup and view all the answers

What is one limitation of X-ray imaging?

<p>It cannot show soft tissue injuries (A)</p> Signup and view all the answers

Which of the following best describes the contrast seen in X-ray images?

<p>Bony structures appear whiter than surrounding tissues (A)</p> Signup and view all the answers

What can X-rays detect in addition to bone fractures?

<p>Tumors (D)</p> Signup and view all the answers

Which physiological response is associated with the release of adrenaline during emotions such as fear or anger?

<p>Rapid breathing (A)</p> Signup and view all the answers

Which brain region is NOT primarily involved in recalling happy events according to neuroimaging studies?

<p>Amygdala (B)</p> Signup and view all the answers

What is the primary purpose of neurofeedback training?

<p>To self-regulate brain activity (B)</p> Signup and view all the answers

In real-time fMRI, what is the critical aspect of how data is presented to the user?

<p>Data is displayed continuously and in real-time (A)</p> Signup and view all the answers

Which of the following conditions can neurofeedback help manage?

<p>ADHD (D)</p> Signup and view all the answers

What distinguishes a Brain-Computer Interface (BCI) from neurofeedback?

<p>BCI operates by translating brain signals for device control (D)</p> Signup and view all the answers

Which physiological change is triggered by happiness according to the content?

<p>Release of endorphins (C)</p> Signup and view all the answers

Which area of the brain is involved in managing fear and stress responses?

<p>Hypothalamus (D)</p> Signup and view all the answers

What is the primary purpose of neurofeedback (NFB)?

<p>To train individuals to control their brain activity (A)</p> Signup and view all the answers

Which of the following best describes the relationship between neurofeedback and BCI technology?

<p>Neurofeedback is a specialized application of BCI with different intents. (A)</p> Signup and view all the answers

What neural network is primarily associated with emotional processing and decision-making?

<p>Fronto-temporo-limbic network (A)</p> Signup and view all the answers

During the 'Happy Memories' condition of fMRI neurofeedback, what were participants instructed to do?

<p>Evoking happy autobiographical memories (B)</p> Signup and view all the answers

Which brain region is NOT included in the fronto-temporo-limbic network?

<p>Motor cortex (B)</p> Signup and view all the answers

How does neurofeedback aim to improve emotional functioning?

<p>Through operant conditioning techniques (D)</p> Signup and view all the answers

What aspect of cognitive performance can neurofeedback aim to regulate?

<p>Stress levels and attention (D)</p> Signup and view all the answers

In the context of neurofeedback, the red bar represents what?

<p>A measure of brain activity (D)</p> Signup and view all the answers

What is a primary function of the brainstem that can be impaired due to injury?

<p>Regulation of heart rate (C)</p> Signup and view all the answers

What critical condition may arise from significant brainstem damage?

<p>Locked-in syndrome (A)</p> Signup and view all the answers

During which phase is immediate medical intervention crucial for a brain injury patient?

<p>Acute phase (A)</p> Signup and view all the answers

Which rehabilitation therapy is introduced in the rehabilitation phase for addressing swallowing difficulties?

<p>Speech therapy (D)</p> Signup and view all the answers

What type of image do X-rays produce when taken of the body?

<p>Radiographs (A)</p> Signup and view all the answers

What limitations do X-rays have in diagnosing injuries?

<p>They cannot show soft tissue injuries. (A)</p> Signup and view all the answers

What intervention is used during the acute phase to assist with breathing?

<p>Use of a ventilator (A)</p> Signup and view all the answers

What is a common imaging technique to observe fractures or dislocations?

<p>X-ray (D)</p> Signup and view all the answers

What appearance do tumors typically have on imaging?

<p>Brighter than surrounding tissue (A)</p> Signup and view all the answers

Which of the following is true about microcalcifications on a mammogram?

<p>They appear as bright specks (A)</p> Signup and view all the answers

Which step in CT image formation involves the rotation of the X-ray tube and detectors?

<p>X-ray Source and Detector Rotation (A)</p> Signup and view all the answers

What is the purpose of reconstruction in CT imaging?

<p>To create cross-sectional slices using collected data (C)</p> Signup and view all the answers

How do different tissues in the body affect X-ray absorption during a CT scan?

<p>Different tissues absorb X-rays at varying degrees (C)</p> Signup and view all the answers

What algorithm is mentioned for the reconstruction of CT images?

<p>Filtered back projection (D)</p> Signup and view all the answers

In CT imaging, what is adjusted before the image display?

<p>Contrast and brightness (D)</p> Signup and view all the answers

What defines normal intracranial calcifications?

<p>Age-related and neurodegenerative without disease evidence (A)</p> Signup and view all the answers

Flashcards

Neurofeedback

A type of biofeedback that teaches self-regulation of brain activity, focusing on improving cognitive functions or managing conditions like ADHD or anxiety.

Real-time fMRI (rtfMRI)

fMRI data processing and display happen quickly, enabling people to see and change their own brain activity in real time.

Biofeedback

A technique to become aware of your own bodily responses that can be used for a multitude of self-regulation exercises.

Brain-Computer Interface (BCI)

A system enabling direct brain-to-device communication.

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Emotions' effect on physiology

Emotions like fear increase heart rate and breathing whereas happiness reduces them, through hormone and neurotransmitter release.

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Happiness and brain areas

Recalling happy events activates specific brain regions like the anterior cingulate cortex and prefrontal cortex.

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fMRI and Neurofeedback

fMRI data, specifically real-time fMRI, can provide feedback about brain activity to help a person regulate it.

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Stress hormones

Hormones like adrenaline are released during stressful situations, impacting physiological responses.

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Neurofeedback (NFB)

A learning technique that uses operant conditioning to control brain activity for cognitive improvement, stress reduction, and better emotional regulation.

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Operant Conditioning

A learning method where behavior is modified by consequences (rewards or punishments).

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BCI

Brain-Computer Interface - technology that detects and interprets brain signals.

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fMRI

Functional Magnetic Resonance Imaging – a brain imaging technique that measures brain activity.

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Fronto-temporo-limbic network

A network of brain regions involved in emotions, decision-making, and social cognition.

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Happy Memories condition (fMRI)

Part of an fMRI study where participants evoke happy memories to increase a signal level.

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Neurofeedback fMRI signal

A measurement of brain activity during a neurofeedback session using fMRI.

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Neurofeedback and Happiness Relationship

Neurofeedback can be used in conjunction with techniques such as happy memory evocation to influence emotional states, and fMRI tracks associated brain activity during these processes.

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Brainstem function

The brainstem controls essential life functions like breathing, heart rate, and consciousness.

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Brainstem injury impact

Damage to the brainstem can lead to severe motor impairments, respiratory difficulties, swallowing problems, and even coma.

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Locked-in Syndrome

A condition where a person is fully aware but nearly completely paralyzed, unable to communicate except through eye movements.

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X-ray imaging

An X-ray uses radiation to create images of bones and teeth, showing structures like fractures, dislocations, and narrowed joint spaces.

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X-ray limitations

X-rays cannot detect soft tissue injuries, inflammation, or subtle bone damage.

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Rehabilitation phases

TBI rehabilitation involves two main phases: acute (stabilizing the injury) and rehabilitation (using therapy to regain lost functions).

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Engineering solutions

Engineering tools and technologies help facilitate neuroplasticity and recovery of lost functions in TBI rehabilitation.

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Rehabilitation goals

The focus of TBI rehabilitation is on addressing motor, respiratory, and swallowing difficulties using various therapeutic approaches.

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X-ray

A type of electromagnetic radiation used to create images of the inside of the body, particularly bones.

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What does an X-ray show?

X-rays are best at showing dense structures like bones, as well as foreign objects and some lung conditions. They are not good at showing soft tissues or inflammation.

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Mammogram

A type of X-ray specifically designed to image the breast tissue, used to detect breast cancer.

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Why are bones visible on X-rays?

Bones are dense due to calcium, which absorbs X-rays more than other tissues. This makes them appear white on the X-ray.

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What do lungs appear like on an X-ray?

Lungs appear gray on an X-ray because air in the lungs absorbs less X-ray radiation, allowing more to pass through.

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How is the X-ray image created?

X-rays pass through the body and hit a detector, creating a shadow image. Bones appear white because they block more X-rays.

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What do soft tissues look like on an X-ray?

Soft tissues like muscles and organs are less dense than bone, so they appear in shades of gray on an X-ray, making them harder to see.

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What types of injuries require an X-ray?

X-rays are used to diagnose bone fractures, dislocations, and other injuries where bone damage is suspected.

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Mammogram image

An image taken by a mammogram, showing the breast tissue. Tumors appear as bright, irregular masses, while microcalcifications are small, bright specks.

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CT Scan

A technique that uses X-rays and computer processing to create detailed, cross-sectional images of the body.

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CT Image Formation (Step 1)

The X-ray tube and detectors rotate around the patient.

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CT Image Formation (Step 2)

Different tissues absorb X-rays at varying degrees.

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CT Image Formation (Step 3)

Detectors capture X-rays passing through the body from multiple angles.

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CT Image Formation (Step 4)

The computer processes data to form cross-sectional images.

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CT Image Formation (Step 5)

The reconstructed images are displayed on a monitor.

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Normal intracranial calcifications

Age-related calcium deposits in the brain that are not caused by any disease or pathology.

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Filtered Back Projection (FBP)

A CT reconstruction technique that combines Fourier transforms and convolution to create an image from projections. It involves decomposing projections into frequencies, filtering out noise, and then reconstructing the image.

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Fourier Transform

A mathematical tool that converts data from the spatial domain (like an image) into the frequency domain. This allows analysis of data based on its frequency components.

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Convolution

A mathematical operation that combines two functions to create a third function, essentially a weighted average. In FBP, it's used to sharpen edges and reduce noise.

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Spatial Domain

The original representation of data, where information is organized based on its position or location, like a standard image.

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Frequency Domain

A representation of data where information is organized based on its frequency components. This is often used for analyzing and manipulating data.

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Study Notes

BM402: Engineering in Medicine

  • Course name: BM402: Engineering in Medicine
  • Date: 14th November 2024
  • Location: M 2170 - South Campus

Neurofeedback

  • Type of biofeedback
  • Teaches self-regulation of brain activity
  • Focuses on enhancing cognitive functions or managing conditions
  • Provides real-time feedback about one's mental state

Physiology, Emotions and Brain

  • Emotions significantly impact physiological responses, including heart rate and respiratory rate
  • Fear, anger, and anxiety increase heart rate and lead to rapid breathing.
  • Happiness reduces heart rate and shallows breathing (releases endorphins)

Happiness and fMRI

  • Studies found that recalling happy events activate areas like the anterior cingulate cortex, prefrontal cortex and insula.
  • These regions also involved in other core emotions such as sadness and anger.

fMRI - Neurofeedback

  • Real-time fMRI (rtfMRI) allows for real-time data processing and display.
  • The speed of processing keeps up with the rate of image acquisition, enabling real-time neurofeedback.
  • This helps a person regulate the fMRI signal of their own brain.
  • Neurofeedback provides real-time feedback about brain activity to help individuals learn to control their brain function.

EEG & Neurofeedback (NFB)

  • Neurofeedback (NFB) is an operant conditioning technique.
  • It helps individuals learn how to control their brain activity to improve cognitive performance, regulate stress levels, emotional functioning and behavior.

Neurofeedback as a Rehabilitation Tool

  • Neurofeedback is a non-invasive method for promoting neural plasticity.
  • It is beneficial for persons recovering from conditions such as but not limited to: stroke, traumatic brain injury, spinal cord injury, ADHD, anxiety, depression, epilepsy.

Memory Training

  • Specific neurofeedback protocols can be designed to improve working memory or long-term memory.
  • Theta/beta ratio training is an example of a technique proven helpful in conditions such as ADHD, which often coexists with cognitive dysfunction

Attention and Focus

  • In conditions like ADHD or after brain injuries, neurofeedback trains the brain to increase attention and focus by impacting brainwave frequencies (e.g. beta waves)

Reading - 15mins

  • Article title: An Overview of the Use of Neurofeedback Biofeedback for the Treatment of Symptoms of Traumatic Brain Injury in Military and Civilian Populations
  • Author: Sarah Gray, PsyD

Case Study: Engineering Solutions for Traumatic Brain Injury (TBI) Rehabilitation - Focus on Brainstem Damage Recovery

  • TBI is a significant cause of long-term disability, especially when brainstem damage occurs
  • Brainstem regulates essential functions like breathing, heart rate, consciousness
  • Injuries to this critical area can lead to motor impairments, respiratory issues, and difficulties swallowing

X-ray

  • X-ray (radiograph) uses radiation to image the body.
  • Areas with high calcium (bones, teeth) block radiation, appearing white in the image.
  • Soft tissues allow radiation to pass through, thus appearing gray/black.
  • X-ray does not show subtle bone, soft tissue injuries or inflammation.
  • Used for detecting fractures, dislocations, misalignments, narrowed joint spaces, bone tumors, foreign objects in the body and pneumonia.

When are medical x-rays used?

  • X-ray radiography - detects bone fractures, tumors, pneumonia, injuries, calcifications, foreign objects, or dental problems.
  • Mammography - detects and diagnoses breast cancer, showing tumors as masses that are either regular or irregular in shape, brighter than surrounding tissue. Mammograms can also identify small calcium deposits (microcalcifications).
  • Computed Tomography (CT) - combines traditional X-ray technology with computer processing; provides detailed, three-dimensional images for viewing structures from different angles.
  • CT Image formation process:
    • X-ray tube and detectors rotate around patient
    • Different tissues absorb X-rays at varying degrees
    • Detectors capture X-rays passing through the body from multiple angles
    • Computer processes data to reconstruct cross-sectional slices using algorithms

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