Blood Products Quiz

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Questions and Answers

What is the shelf life of whole blood when stored between 1°C and 6°C?

24 hours

42 days

21 days (correct)

35 days

What is the shelf life of whole blood stored in CPD anticoagulant?

1 year

42 days

24 days

35 days (correct)

What is the main therapeutic use of whole blood?

To increase RBC mass in patients with symptomatic anemia

In cases of rapid blood loss when increased volume and RBC mass is needed (correct)

To reduce febrile transfusion reactions and CMV transmission

To minimize febrile or allergic reactions

What is the primary use of packed RBCs?

To increase RBC mass in patients with symptomatic anemia Signup and view all the answers

What is the shelf life of packed RBCs in closed systems with an additive bag?

42 days Signup and view all the answers

What is the shelf life of deglycerolized frozen RBCs after deglycerolization?

2 hours Signup and view all the answers

What is the purpose of washing RBCs?

To reduce the risk of febrile or allergic reactions Signup and view all the answers

What is the main therapeutic use of deglycerolized frozen RBCs?

To minimize febrile or allergic reactions Signup and view all the answers

What is the shelf life of washed RBCs after opening?

24 hours Signup and view all the answers

What is the primary use of leukocyte-poor RBCs?

To reduce febrile transfusion reactions and CMV transmission Signup and view all the answers

What percentage of original WBCs are removed in leukocyte-poor RBC preparations?

70% Signup and view all the answers

What is the shelf life of platelets?

3 to 5 days Signup and view all the answers

What is the primary use of fresh frozen plasma (FFP)?

To treat liver failure, vitamin K deficiency, DIC, and massive transfusions Signup and view all the answers

What is the main therapeutic use of fresh frozen plasma (FFP)?

To treat liver failure, vitamin K deficiency, DIC, and massive transfusions Signup and view all the answers

What is the shelf life of platelets?

3 to 5 days Signup and view all the answers

What is the shelf life of cryoprecipitate?

24 hours Signup and view all the answers

What is the shelf life of plasma derivatives when stored between 1°C and 6°C?

5 years Signup and view all the answers

What is the shelf life of cryoprecipitate?

24 hours Signup and view all the answers

What is the main therapeutic use of cryoprecipitate?

To treat bleeding disorders Signup and view all the answers

What is the preparation process for packed RBCs?

Removing 200-250 mL of plasma from a unit of whole blood Signup and view all the answers

Study Notes

A Guide to Blood Products: Preparation, Shelf Life, and Therapeutic Uses

Whole Blood

Preparation involves collecting 450 mL of blood with 63 mL of anticoagulant, usually CPD or CPDA-1.
The shelf life of whole blood is 21 days when stored between 1°C and 6°C, which is extended to 35 days in CPDA-1 anticoagulant.
Whole blood is used in cases of rapid blood loss when increased volume and RBC mass is needed, and in exchange transfusions.

Packed RBCs

Preparation involves removing 200-250 mL of plasma from a unit of whole blood, and the cells are prepared in an open or closed system.
The shelf life is 24 hours for open systems and extended to 42 days for closed systems with an additive bag.
Packed RBCs are used to increase RBC mass in patients with symptomatic anemia.

Deglycerolized Frozen RBCs

RBCs to be frozen are collected in CPD, CPDA-1, or other additive systems and frozen at -65°C.
The cells must be deglycerolized before transfusion, which involves thawing, washing in a gradient concentration of saline, and ending with an isotonic saline solution containing glucose.
Deglycerolized RBCs have a shelf life of 2 hours after deglycerolization and are used to minimize febrile or allergic reactions.

Washed RBCs

Plasma is removed from whole blood after centrifugation, and the remaining RBCs are washed three times with 0.9% saline.
Washed RBCs have a shelf life of 24 hours after opening and are used to reduce the risk of febrile or allergic reactions in susceptible patients.

Leukocyte-Poor RBCs

Leukocyte-poor RBC preparations have at least 70% of the original WBCs removed.
Shelf life is the same as the original unit of blood when a closed system is used, and 24 hours for open systems.
Leukocyte-poor RBCs are used to reduce febrile transfusion reactions and CMV transmission.

Fresh Frozen Plasma (FFP)

FFP is separated from whole blood and frozen within 6 hours of collection.
FFP has a shelf life of 1 year after collection and must be stored at or below -18°C.
FFP contains all coagulation factors and is used to treat liver failure, vitamin K deficiency, DIC, and massive transfusions.

Platelets

Platelet-rich plasma is separated at room temperature by centrifugation from RBCs within 6 hours of collection of whole blood.
Platelets are stored at room temperature with continuous gentle agitation and have a shelf life of 3 to 5 days.
Platelet concentrate is used to treat thrombocytopenia, dysfunctional platelets, DIC, and ITP.

Plasma Derivatives

Plasma derivatives have a shelf life of 5 years when stored between 1°C and 6°C and are used primarily as volume expanders.

Cryoprecipitate

Cryoprecipitate is prepared from FFP that has been partially thawed, centrifuged, and had the supernatant removed.
Cryoprecipitate has a shelf life of up to

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Description

Test your knowledge on blood products with this informative quiz! Learn about the preparation, shelf life, and therapeutic uses of whole blood, packed RBCs, deglycerolized frozen RBCs, washed RBCs, leukocyte-poor RBCs, fresh frozen plasma, platelets, plasma derivatives, and cryoprecipitate. This quiz is perfect for healthcare professionals or anyone interested in learning more about blood products and their uses in transfusion medicine.