Podcast
Questions and Answers
What is the role of the H gene in blood group determination?
What is the role of the H gene in blood group determination?
- It determines the presence of A or B antigens.
- It inhibits the production of A and B antigens.
- It encodes an enzyme that converts the precursor substance into the H antigen. (correct)
- It directly produces the H antigen.
Which gene is responsible for the production of the A antigen on red blood cells?
Which gene is responsible for the production of the A antigen on red blood cells?
- A gene (correct)
- O gene
- H gene
- B gene
What is the primary function of the transferase enzymes encoded by the A, B, and H genes?
What is the primary function of the transferase enzymes encoded by the A, B, and H genes?
- Regulating the production of red blood cells
- Determining the ABO blood group type
- Converting the precursor substance into specific blood group antigens (correct)
- Inhibiting the production of specific antigens
How does the O gene differ from the A and B genes in terms of its enzymatic product?
How does the O gene differ from the A and B genes in terms of its enzymatic product?
What is the significance of the H substance in the blood typing system?
What is the significance of the H substance in the blood typing system?
What is the blood group phenotype of an individual with the hh genotype?
What is the blood group phenotype of an individual with the hh genotype?
Which blood group phenotype would exhibit the highest concentration of H antigen?
Which blood group phenotype would exhibit the highest concentration of H antigen?
What is the difference between the H gene and the I gene in determining blood group?
What is the difference between the H gene and the I gene in determining blood group?
Flashcards
ABH Genes
ABH Genes
Genes responsible for determining blood group antigens A, B, and H.
Transferase Enzyme
Transferase Enzyme
An enzyme that transfers monosaccharides to precursors for antigen formation.
H Antigen
H Antigen
The basic antigen produced from precursor substances before A or B modification.
A and B Antigens
A and B Antigens
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Group O Blood
Group O Blood
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Oh (Bombay Group)
Oh (Bombay Group)
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Precursor Substance
Precursor Substance
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Inactive Enzyme in Group O
Inactive Enzyme in Group O
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Study Notes
Blood Group Inheritance
- Blood type antigens (A, B, and H) are not direct gene products.
- Genes code for specific transferase enzymes, transferring monosaccharides to a precursor substance.
- This conversion of precursor substance produces the specific blood group substance.
ABH Gene Products
- H gene: Encodes an enzyme converting the precursor substance into H substance (H antigen).
- A gene: Encodes an enzyme converting H substance into A antigen.
- B gene: Encodes an enzyme converting H substance into B antigen.
- O gene: Encodes an inactive enzyme, resulting in no conversion and high H antigen concentration in O blood.
- hh genotype: Individuals with this genotype cannot produce H substance, meaning no A or B antigens are formed (Bombay phenotype).
Enzyme Details (Table 1.1 Implication)
- H gene: L-fucosyltransferase
- A gene: 3-N-acetyl-D-galactosaminyl transferase
- B gene: 3-D-galactosyl transferase
- O gene: No enzyme activity
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