Blood Cell Morphology and Parasites Quiz

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Questions and Answers

What is the grading system for polychromatophilia based on the number of red blood cells per field?

  • 1+= 3 to 10; 2+= 11 to 20; 3+= greater than 20
  • 1+= 1 to 5; 2+= greater than 10; 3+= 6 to 10
  • 1+= 6 to 10; 2+= 1 to 5; 3+= greater than 10
  • 1+= 1 to 5; 2+= 6 to 10; 3+= greater than 10 (correct)

Which feature is characteristic of red blood cells with Hb H bodies?

  • Pitted golf ball appearance (correct)
  • Elliptocyte configuration
  • Stomatocyte appearance
  • Burr cell shape

What staining method reveals pink dots scattered in the cytoplasm of red blood cells?

  • Hematoxylin and eosin stain
  • Wright stain
  • Gram stain
  • Giemsa stain (correct)

Which condition is associated with increased serum protein, potentially leading to rouleaux formation?

<p>Multiple myeloma (C)</p> Signup and view all the answers

What is the grading for schistocytes in the red cell morphology chart?

<p>1+, 2+, or 3+ (A)</p> Signup and view all the answers

What type of red blood cells is indicated by the presence of Schuffner's dots?

<p>Malaria-infected RBCs (B)</p> Signup and view all the answers

Which of the following conditions can falsely indicate the presence of rouleaux formation?

<p>Overlapping red blood cells in the examination area (B)</p> Signup and view all the answers

What is the significance of a 3+ grading for poikilocytosis?

<p>Indicates more than 20 abnormal cells per field (B)</p> Signup and view all the answers

What could cause the formation of target cells in blood samples?

<p>Decreased hemoglobin production (B)</p> Signup and view all the answers

Bentz Jones Protein is associated with rouleaux formation related to which condition?

<p>Multiple myeloma (D)</p> Signup and view all the answers

Flashcards

RBC Morphology Grading

A system for classifying and quantifying different shapes and appearances of red blood cells (RBCs) in a blood sample.

Polychromatophilia

Presence of immature red blood cells in blood, marked by increased basophilia.

Helmet Cells

Red blood cell fragments with a characteristic 'helmet' or 'spur' shape.

Dacryocytes

Teardrop-shaped red blood cells seen in certain conditions.

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Acanthocytes

Red blood cells with irregular, thorny projections.

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Schistocytes

Fragmented red blood cells, often seen in situations of mechanical trauma.

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Spherocytes

Small, spherical red blood cells lacking central pallor.

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Poikilocytosis

Presence of abnormally shaped red blood cells.

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Ovalocytes

Oval-shaped red blood cells.

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Elliptocytes

Elliptical-shaped red blood cells.

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Burr Cells

Red blood cells with small, evenly spaced projections.

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Bizarre-shaped RBCs

Red blood cells with unusual shapes.

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Target Cells

Red blood cells that have a central and peripheral area of hemoglobin concentration with a region of reduced concentration between them.

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Mexican Hat Cells/Greek Helmet Cells/Platycytes

Red blood cells with a central indentation and thickened, flat rim.

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Stomatocytes

Red blood cells with a central slit-like opening.

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Rouleaux

Stacking of red blood cells like coins, a result of abnormal plasma proteins.

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Hb H Bodies

Characteristic appearance of red blood cells containing abnormal hemoglobin.

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Study Notes

Parasites

  • Protozoa/Protozoans are examples
  • Malaria is an example
  • Schuffner's dots (eosinophilic stippling)
  • Babesia spp.

Red Blood Cell Morphology Grading Chart

  • Grading of Red Blood Cell Morphology

    • 1+ = 1 to 5 per field
    • 2+ = 6 to 10 per field
    • 3+ = greater than 10 per field

  • Polychromatophilia:

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Helmet cells (helmet-shaped schistocytes)

    • 1+ = 1 to 5 per field
    • 2+ = 6 to 10 per field
    • 3+ = more than 10 per field

  • Dacryocytes (teardrop cells)

    • 1+ = 1 to 5 per field
    • 2+ = 6 to 10 per field
    • 3+ = more than 10 per field

  • Acanthocytes (thorn or spur cells)

    • 1+ = 1 to 5 per field
    • 2+ = 6 to 10 per field
    • 3+ = more than 10 per field

  • Schistocytes (fragmented RBCs)

    • 1+ = 1 to 5 per field
    • 2+ = 6 to 10 per field
    • 3+ = more than 10 per field

  • Spherocytes

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = more than 20 per field

  • Ovalocytes

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Elliptocytes

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Burr cells

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Bizarre-shaped RBC

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Target cells (codocytes/leptocytes/bull's eye cells)

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = greater than 20 per field

  • Mexican hat cells/Greek helmet cells/platycytes

    • 1+ = 3 to 10 per field
    • 2+ = 11 to 20 per field
    • 3+ = more than 20 per field

  • Stomatocytes (mouth cells)

  • Rouleaux (aka: Pseudo agglutination)

    • 1+ = aggregates of 3 to 4 RBCs
    • 2+ = aggregates of 5 to 10 RBCs
    • 3+ = many aggregates with only a few free RBCs

Additional Notes

  • Rouleaux formation is associated with increased serum globulin or fibrinogen
  • Rouleaux formation may be observed in Multiple Myeloma (now called Plasma cell myeloma/Kahler's disease) myelomatosis
  • Rouleaux is sometimes misreported because of overlapping cells in the thick portion of the blood smear

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