10 Questions
What is the main difference between protein-bound drugs and unbound drugs?
Protein-bound drugs are inactive, while unbound drugs are active.
Which proteins do acidic drugs primarily bind to in the plasma?
Albumin
In the context of plasma protein binding, what does it mean when two drugs bind at the same site of the protein and are administered together?
It can lead to potential problems or drug interactions.
What factor should be considered when treating an elderly person with a basic drug?
The increase in globin levels with age.
What happens to the protein-bound drug once the free drug enters the target tissue?
It is released to maintain equilibrium.
What effect does a diseased state have on the effectiveness of a drug that undergoes plasma protein binding?
It can cause problems on the effectiveness of the drug.
Which type of drugs primarily bind to α1 – acid glycoprotein in plasma?
Basic drugs
How is the bound drug different from the unbound drug in terms of pharmacological activity?
The bound drug is inactive, while the unbound drug is active.
Why is it important to consider protein binding when administering drugs?
To predict potential drug-drug interactions.
What role does equilibrium play between protein-bound and free drug in target tissues?
Protein-bound drug is released to maintain equilibrium with free drug.
Learn about the structure and function of the blood-brain barrier (BBB) in the central nervous system. Explore how the BBB selectively allows only certain molecules to cross into the brain, providing protection to the brain. Understand the implications of the BBB in drug delivery and neurology.
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