Podcast
Questions and Answers
Which of the following is NOT a potential adverse effect associated with albumin administration?
Which of the following is NOT a potential adverse effect associated with albumin administration?
- Anaphylaxis
- Fluid overload
- Renal dysfunction (correct)
- Infection
A patient is about to receive a unit of Packed Red Blood Cells (PRBCs). Which of the following considerations is NOT critical for administration?
A patient is about to receive a unit of Packed Red Blood Cells (PRBCs). Which of the following considerations is NOT critical for administration?
- Ensuring use of special filters and tubing
- Verifying appropriate vascular access
- Administering through the same IV line as medications (correct)
- Confirming ABO and Rh compatibility
Why is informed consent required before administering blood products?
Why is informed consent required before administering blood products?
- Blood products are analogous to human tissue transplants, necessitating consent. (correct)
- Blood products are considered medications, requiring consent for use.
- To comply with the regulatory requirements of blood banks.
- Consent is only required for specific blood products, such as FFP.
Following the infusion of one unit of PRBC, how much would the expected hemoglobin increase?
Following the infusion of one unit of PRBC, how much would the expected hemoglobin increase?
Which of the following statements accurately describes Fresh Frozen Plasma (FFP)?
Which of the following statements accurately describes Fresh Frozen Plasma (FFP)?
Which of the following best describes the primary role of water in the body's thermoregulation?
Which of the following best describes the primary role of water in the body's thermoregulation?
What is the primary difference between hydrostatic pressure and oncotic pressure in the context of fluid movement?
What is the primary difference between hydrostatic pressure and oncotic pressure in the context of fluid movement?
If a cell is placed in a hypertonic solution, what is the expected net movement of water and the effect on the cell?
If a cell is placed in a hypertonic solution, what is the expected net movement of water and the effect on the cell?
Which of the following properties of water make it ideal as a transport medium in the body?
Which of the following properties of water make it ideal as a transport medium in the body?
Which of the following is NOT a direct function of water in the body?
Which of the following is NOT a direct function of water in the body?
According to the content provided, what role does water play in the building of cell protoplasm?
According to the content provided, what role does water play in the building of cell protoplasm?
Which statement best differentiates diffusion from osmosis?
Which statement best differentiates diffusion from osmosis?
Which crystalloid solution is considered physiologically hypotonic due to the rapid uptake of dextrose?
Which crystalloid solution is considered physiologically hypotonic due to the rapid uptake of dextrose?
Which intravenous fluid is characterized by a high sodium load and may cause hyperchloremic acidosis?
Which intravenous fluid is characterized by a high sodium load and may cause hyperchloremic acidosis?
A patient with a clotting impairment needs intravenous fluids. Which of the following is the most important consideration?
A patient with a clotting impairment needs intravenous fluids. Which of the following is the most important consideration?
Which crystalloid solution has a pH closest to that of plasma?
Which crystalloid solution has a pH closest to that of plasma?
Which of the following is NOT a primary function of crystalloid fluids?
Which of the following is NOT a primary function of crystalloid fluids?
Which intravenous fluid is NOT suitable as a resuscitation fluid?
Which intravenous fluid is NOT suitable as a resuscitation fluid?
A continuous infusion of which solution should be used carefully due to potential drug incompatibilities?
A continuous infusion of which solution should be used carefully due to potential drug incompatibilities?
What is the approximate osmolarity of 0.9% Sodium Chloride?
What is the approximate osmolarity of 0.9% Sodium Chloride?
A patient requires an intravenous solution. Which of these factors is NOT considered during the determination of the appropriate IV fluid?
A patient requires an intravenous solution. Which of these factors is NOT considered during the determination of the appropriate IV fluid?
Which property BEST differentiates crystalloid infusions from plasma-volume expanders?
Which property BEST differentiates crystalloid infusions from plasma-volume expanders?
What is the primary rationale for using crystalloid infusions for maintenance fluids?
What is the primary rationale for using crystalloid infusions for maintenance fluids?
In which of the following situations is a crystalloid bolus MOST likely contraindicated?
In which of the following situations is a crystalloid bolus MOST likely contraindicated?
Why might Lactated Ringer’s solution be preferred over other crystalloid solutions in cases where large volumes of fluids may be administered?
Why might Lactated Ringer’s solution be preferred over other crystalloid solutions in cases where large volumes of fluids may be administered?
A patient is receiving a crystalloid infusion. Which of the following is a potential adverse effect related to its dilution of plasma proteins?
A patient is receiving a crystalloid infusion. Which of the following is a potential adverse effect related to its dilution of plasma proteins?
How does the administration of crystalloid fluids impact a patient's hematocrit (Hct)?
How does the administration of crystalloid fluids impact a patient's hematocrit (Hct)?
When is the use of crystalloid infusions in hemorrhagic shock considered a last resort?
When is the use of crystalloid infusions in hemorrhagic shock considered a last resort?
A patient is being administered crystalloid fluids at a rate of 75 mL/h. What type of fluid maintenance is being provided?
A patient is being administered crystalloid fluids at a rate of 75 mL/h. What type of fluid maintenance is being provided?
What is the typical order of distribution of crystalloids administered, between extravascular and intravascular spaces?
What is the typical order of distribution of crystalloids administered, between extravascular and intravascular spaces?
What potential effect could crystalloid infusions have in a patient experiencing hypothermia?
What potential effect could crystalloid infusions have in a patient experiencing hypothermia?
What characteristic of hypertonic saline solutions makes them effective in increasing vascular volume?
What characteristic of hypertonic saline solutions makes them effective in increasing vascular volume?
A hypertonic saline solution is typically defined as having a concentration greater than what percentage?
A hypertonic saline solution is typically defined as having a concentration greater than what percentage?
What is the primary difference between a 5% Albumin solution and a 25% Albumin solution regarding volume expansion?
What is the primary difference between a 5% Albumin solution and a 25% Albumin solution regarding volume expansion?
Why is a transfusion consent required prior to administering albumin?
Why is a transfusion consent required prior to administering albumin?
Which of the following is NOT a characteristic of colloid solutions?
Which of the following is NOT a characteristic of colloid solutions?
What is the primary mechanism through which colloids such as albumin increase intravascular volume?
What is the primary mechanism through which colloids such as albumin increase intravascular volume?
Which of the following is a contraindication for the use of colloids such as albumin?
Which of the following is a contraindication for the use of colloids such as albumin?
What is a significant precaution to keep in mind when administering albumin?
What is a significant precaution to keep in mind when administering albumin?
While colloids are used in various shock states, what does new evidence suggest about their benefit in initial resuscitation compared to crystalloids?
While colloids are used in various shock states, what does new evidence suggest about their benefit in initial resuscitation compared to crystalloids?
The effect of a 25% albumin solution used for volume expansion persists for how long?
The effect of a 25% albumin solution used for volume expansion persists for how long?
Flashcards
Diffusion
Diffusion
The movement of molecules from an area of higher concentration to an area of lower concentration.
Osmosis
Osmosis
The movement of water molecules across a semi-permeable membrane from an area of higher water concentration to an area of lower water concentration.
Osmotic Pressure
Osmotic Pressure
The force exerted by water molecules against a semi-permeable membrane, caused by the concentration of dissolved solutes.
Oncotic Pressure
Oncotic Pressure
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Hydrostatic Pressure
Hydrostatic Pressure
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Hypotonic Solution
Hypotonic Solution
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Hypertonic Solution
Hypertonic Solution
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Crystalloid Infusions
Crystalloid Infusions
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Crystalloid Bolus
Crystalloid Bolus
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Maintenance Fluid
Maintenance Fluid
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4-2-1 Rule
4-2-1 Rule
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Plasma-Volume Expander
Plasma-Volume Expander
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Sodium Concentration
Sodium Concentration
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Crystalloids
Crystalloids
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Normal Saline (0.9% NaCl)
Normal Saline (0.9% NaCl)
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Half Normal Saline (0.45% NaCl)
Half Normal Saline (0.45% NaCl)
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Hypertonic Saline (3% NaCl)
Hypertonic Saline (3% NaCl)
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Lactated Ringer's
Lactated Ringer's
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Dextrose Solutions (D5W, D10W)
Dextrose Solutions (D5W, D10W)
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Dextrose with Sodium Chloride (D5NS, D5+0.45NS)
Dextrose with Sodium Chloride (D5NS, D5+0.45NS)
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Intravascular Volume
Intravascular Volume
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Total Body Fluid Volume
Total Body Fluid Volume
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Hypertonic Saline
Hypertonic Saline
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Hypertonic Saline Solution
Hypertonic Saline Solution
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What do you look for when assessing a patient with low blood pressure due to a gastrointestinal illness?
What do you look for when assessing a patient with low blood pressure due to a gastrointestinal illness?
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Colloids: Albumin
Colloids: Albumin
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Albumin Properties
Albumin Properties
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Albumin: Blood Product
Albumin: Blood Product
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Albumin Solutions
Albumin Solutions
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Albumin: Benefits
Albumin: Benefits
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Albumin: Precautions
Albumin: Precautions
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Albumin: Limitations
Albumin: Limitations
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What are PRBCs?
What are PRBCs?
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What is the role of FFP?
What is the role of FFP?
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Why are platelets important?
Why are platelets important?
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What is cryoprecipitate used for?
What is cryoprecipitate used for?
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For what is PCC used?
For what is PCC used?
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Study Notes
Fluid Therapy Overview
- Fluid therapy is used to increase blood volume and organ/tissue perfusion.
- Common indications include shock, burns, and severe dehydration.
- Important factors to consider include the IV site, gauge, fluid type, flow rate, total body fluid volume (TBF), intravascular volume, oxygen, and clotting impairment.
- Crystallloids and colloids are both used; crystallloids include 0.9% saline, 0.45%, 3%, 7.5% NaCl.
- Ringer's solution is similar to plasma pH, contains a lactate buffer, and contains calcium.
- Dextrose is a physiological hypotonic solution and is not a resuscitation fluid.
- Hypertonic saline has a higher sodium concentration than 0.9% saline, often 3%, 5%, or 7%.
Fluid Composition
- Intracellular fluid (ICF) is 2/3 of the total body fluid and extracellular fluid (ECF) is 1/3.
- ECF is further divided into interstitial fluid (80%) and plasma (20%).
- Intracellular fluid contains proteins, ATP, potassium, magnesium, and chloride.
- Extracellular fluid contains proteins and sodium.
Water Movement
- Diffusion is the random movement of molecules from high to low concentration.
- Osmosis is the spontaneous movement of water across a semipermeable membrane from low to high solute concentration.
- Water moves from hypotonic to hypertonic solutions.
- Osmotic pressure is the pressure applied to stop water movement across a semipermeable membrane.
- Hydrostatic pressure is the pressure exerted by a solution at equilibrium.
- Oncotic pressure is the pressure that proteins exert on one side of the membrane; these large proteins can't cross the membrane causing water to cross.
- The relationship between hydrostatic and oncotic pressure results in fluid moving in and out of blood vessels through filtration and reabsorption.
Fluid Therapy Objectives
- Discuss the functions of water in the body.
- Describe the different ways that water moves within the body.
- Explain diffusion, osmosis, osmotic pressure, oncotic pressure, and hydrostatic pressure.
- Provide details about body fluid compartments and fluid composition.
- Identify the tonicity of various solutions.
- Differentiate between crystallloid and colloid fluids, including indications, contraindications, precautions, does and adverse effects.
- List and differentiate between the different blood and blood products. Provide indications for their use.
- Discuss transfusion-related reactions.
Crystalloids
- Crystalloids are fluids with dissolved electrolytes, are isotonic, and used to supply water and electrolytes. Indications for use include hypovolemia, maintaining fluids, and replacing fluids lost during insensible losses.
- Precautions include their use with caution in patients with heart or kidney failure or electrolyte abnormalities. Potential adverse effects include fluid overload, edema, dilution of plasma proteins, and worsen or cause acidosis.
- Crytsalloids are supplied in bags of 50, 100, 250, 500, and 1000 ml.
- Examples include 0.9% saline, Ringer's solution, and dextrose.
Colloids
- Colloids are fluids that remain intravascular and may draw fluid from the extracellular space.
- Examples include albumin and starches; these are generally more expensive than crystallloids.
- Colloids are used in fluid resuscitation; indications include drawing excess extravascular fluid into the intravascular space and replacing low albumin.
- Potential adverse effects include allergy, CHF (congestive heart failure), and volume overload.
Blood and Blood Products
- Blood products are considered human tissue transplants.
- Consent is required before transfusion.
- Blood products include packed red blood cells (PRBC), fresh frozen plasma (FFP), platelets, cryoprecipitate, and prothrombin complex concentrates (PCC).
- Things to consider include vascular access, special filters and tubing, and incompatibility with medications; cross-matching should be done.
- Important to note that each blood product has a different storage time and method of delivery.
- Cryoprecipitate is made from FFP and contains fibrinogen, Factor VIII and XIII, and Von Willebrand Factor.
- PCC contains factors II, VII, IX, X, and proteins.
Transfusion Reactions
- Hemolysis occurs due to blood group incompatibility, causing hemolysis of red blood cells, fever, chills, back pain, dyspnea, hypotension, and hemoglobinuria.
- Erythroblastosis fetalis occurs due to Rh incompatibility between mother and fetus, causing massive hemolysis in the fetus..
- Transfusion-related lung injury (TRALI) is related to antibody or neutrophil-related immune response, with symptoms including fever, chills, urticaria, or full-blown anaphylaxis.
- Transfusion-related circulatory overload (TACO) occurs due to poor heart function or rapid fluid administration, symptoms are dyspnea, hypertension and cyanosis, tachycardia, increased venous pressure and pulmonary edema.
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