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Bleeding Disorders: Causes and Characteristics

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Which of the following is NOT a common cause of a prolonged prothrombin time (PT)?

Deficiency of von Willebrand factor

A patient presents with a platelet count of 80,000/μL, easy bruising, and epistaxis that takes a long time to stop. Which of the following is the most likely diagnosis?

Immune thrombocytopenic purpura (ITP)

Which of the following is the most common hereditary coagulation disorder?

Von Willebrand disease

A patient has a normal platelet count, slightly prolonged partial thromboplastin time (PTT), and decreased von Willebrand factor antigen levels. Which of the following is the most likely diagnosis?

<p>Von Willebrand disease</p> Signup and view all the answers

Which of the following is the most common cause of acquired coagulation disorders?

<p>Liver disease</p> Signup and view all the answers

A patient presents with excessive bleeding after a minor injury, prolonged nosebleeds, and heavy menstrual periods. Which laboratory test would be the most helpful in diagnosing the underlying condition?

<p>von Willebrand factor antigen</p> Signup and view all the answers

Which of the following is NOT a common trigger for disseminated intravascular coagulation (DIC)?

<p>Hypertension</p> Signup and view all the answers

A patient has a normal platelet count, prolonged prothrombin time (PT), and prolonged partial thromboplastin time (PTT). Which of the following is the most likely cause?

<p>Vitamin K deficiency</p> Signup and view all the answers

Which of the following is the most common symptom of immune thrombocytopenic purpura (ITP)?

<p>Petechiae</p> Signup and view all the answers

A patient with known von Willebrand disease is scheduled for a surgical procedure. Which of the following treatments would be the most appropriate to prevent excessive bleeding?

<p>Desmopressin (DDAVP)</p> Signup and view all the answers

Which of the following pathways is activated by negatively charged surfaces, such as polyphosphates?

<p>Intrinsic pathway</p> Signup and view all the answers

Which laboratory test is used to evaluate the intrinsic and common coagulation pathways?

<p>Activated partial thromboplastin time (aPTT)</p> Signup and view all the answers

Which of the following is a common symptom of severe thrombocytopenia (low platelet count)?

<p>Prolonged bleeding from minor cuts or injuries</p> Signup and view all the answers

Which coagulation factor is deficient in von Willebrand disease, a common inherited bleeding disorder?

<p>von Willebrand factor (vWF)</p> Signup and view all the answers

Which of the following events marks the start of the common coagulation pathway, leading to the formation of cross-linked fibrin clots?

<p>Activation of factor X (FX)</p> Signup and view all the answers

Which component of normal clotting is activated by TF released during vascular injury?

<p>Coagulation factors</p> Signup and view all the answers

What initiates the intrinsic pathway, also known as the 'contact activation pathway'?

<p>Polyphosphates</p> Signup and view all the answers

Which factor marks the start of the common coagulation pathway leading to cross-linked fibrin clot formation?

<p>Factor X</p> Signup and view all the answers

Which component is not depicted in the schematic but is activated upon injury?

<p>Platelets</p> Signup and view all the answers

What triggers the conversion of inactive coagulation factors to their active form in the blood coagulation cascade?

<p>Enzymatic reactions</p> Signup and view all the answers

Which of the following antimalarial medications is known to be associated with the development of immune thrombocytopenic purpura (ITP)?

<p>Quinine</p> Signup and view all the answers

A patient is taking the antiepileptic medication $carbamazepine$ and presents with easy bruising and prolonged nosebleeds. Which of the following is the most likely explanation for these symptoms?

<p>Carbamazepine-induced thrombocytopenia</p> Signup and view all the answers

A patient taking the anti-inflammatory medication $ibuprofen$ presents with a low platelet count and petechial rash. Which of the following is the most likely explanation for these findings?

<p>Ibuprofen-induced thrombocytopenia</p> Signup and view all the answers

A patient develops thrombocytopenia and easy bruising after receiving the $pneumococcal vaccine$. Which of the following is the most likely explanation for these symptoms?

<p>Vaccine-induced immune thrombocytopenic purpura</p> Signup and view all the answers

A patient taking the antiepileptic medication $phenytoin$ presents with a prolonged prothrombin time (PT) and partial thromboplastin time (PTT). Which of the following is the most likely explanation for these laboratory findings?

<p>Phenytoin-induced hepatic dysfunction</p> Signup and view all the answers

A patient taking the antimycobacterial medication $rifampicin$ develops easy bruising and prolonged nosebleeds. Which of the following is the most likely explanation for these symptoms?

<p>Rifampicin-induced thrombocytopenia</p> Signup and view all the answers

A patient taking the antiepileptic medication $sodium valproate$ presents with a low platelet count and petechial rash. Which of the following is the most likely explanation for these findings?

<p>Sodium valproate-induced thrombocytopenia</p> Signup and view all the answers

A patient develops thrombocytopenia and easy bruising after receiving the $influenza vaccine$. Which of the following is the most likely explanation for these symptoms?

<p>Vaccine-induced immune thrombocytopenic purpura</p> Signup and view all the answers

A patient taking the antimalarial medication $chloroquine$ presents with a normal platelet count but prolonged prothrombin time (PT) and partial thromboplastin time (PTT). Which of the following is the most likely explanation for these laboratory findings?

<p>Chloroquine-induced hepatic dysfunction</p> Signup and view all the answers

A patient taking the antiepileptic medication $ethambutol$ develops easy bruising and prolonged nosebleeds. Which of the following is the most likely explanation for these symptoms?

<p>Ethambutol-induced thrombocytopenia</p> Signup and view all the answers

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