18 Questions
Which phase of the cell cycle are most antimetabolites targeted at?
S phase
How do antimetabolites mainly interfere with DNA and RNA synthesis?
Acting as false metabolites
Which enzyme do antimetabolites like Methotrexate inhibit?
Thymidylate synthetase
What is the main mechanism of action for antimetabolites acting as Folic Acid analogues?
Acting as a substitute for folate in DNA synthesis
Which of the following is NOT an antimetabolite?
Cyclophosphamide
What is the primary target of antimetabolites like 5-Fluorouracil?
$DNA replication$
How do antimetabolites prevent cancer cells from dividing and spreading?
By inhibiting DNA replication
What is the specific target of antimetabolites in cancer cells?
DNA and RNA synthesis
Which of the following mechanisms do antimetabolites primarily disrupt in cancer cells?
Nucleic acid metabolism
What is the role of antimetabolites in preventing DNA replication in cancer cells?
Acting as structural analogs in DNA synthesis
How do antimetabolites affect the ability of cancer cells to divide?
Inhibiting mitotic spindle formation
Which cellular process is primarily disrupted by antimetabolites to inhibit cancer cell proliferation?
Nucleotide synthesis
Which adverse effect is associated with Methotrexate?
Neutropenia
What is the mechanism of resistance to Methotrexate?
Production of altered forms of DHFR that decrease MTX affinity
Which drug is an analog of THF used as a rescue therapy for high-dose intrathecally administered MTX?
Leucovorin
What is the main adverse effect associated with Doxorubicin?
Myelosuppression
How does Doxorubicin cause cell death?
Induces DNA topoisomerase activity
What resistance mechanism is associated with Doxorubicin?
Chromosomal abnormalities consistent with gene amplification
Test your knowledge on bladder cancer, hemorrhagic cystitis, and key concepts related to platinum-containing agents such as Cisplatin. Explore topics like MESNA, resistance mechanisms, and the broad clinical spectrum of these conditions.
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