Podcast
Questions and Answers
Which phase of the cell cycle are most antimetabolites targeted at?
Which phase of the cell cycle are most antimetabolites targeted at?
- G2 phase
- G1 phase
- S phase (correct)
- M phase
How do antimetabolites mainly interfere with DNA and RNA synthesis?
How do antimetabolites mainly interfere with DNA and RNA synthesis?
- Acting as false metabolites (correct)
- Promoting replication
- Enhancing transcription
- Inhibiting translation
Which enzyme do antimetabolites like Methotrexate inhibit?
Which enzyme do antimetabolites like Methotrexate inhibit?
- Helicase
- Thymidylate synthetase (correct)
- RNA polymerase
- DNA ligase
What is the main mechanism of action for antimetabolites acting as Folic Acid analogues?
What is the main mechanism of action for antimetabolites acting as Folic Acid analogues?
Which of the following is NOT an antimetabolite?
Which of the following is NOT an antimetabolite?
What is the primary target of antimetabolites like 5-Fluorouracil?
What is the primary target of antimetabolites like 5-Fluorouracil?
How do antimetabolites prevent cancer cells from dividing and spreading?
How do antimetabolites prevent cancer cells from dividing and spreading?
What is the specific target of antimetabolites in cancer cells?
What is the specific target of antimetabolites in cancer cells?
Which of the following mechanisms do antimetabolites primarily disrupt in cancer cells?
Which of the following mechanisms do antimetabolites primarily disrupt in cancer cells?
What is the role of antimetabolites in preventing DNA replication in cancer cells?
What is the role of antimetabolites in preventing DNA replication in cancer cells?
How do antimetabolites affect the ability of cancer cells to divide?
How do antimetabolites affect the ability of cancer cells to divide?
Which cellular process is primarily disrupted by antimetabolites to inhibit cancer cell proliferation?
Which cellular process is primarily disrupted by antimetabolites to inhibit cancer cell proliferation?
Which adverse effect is associated with Methotrexate?
Which adverse effect is associated with Methotrexate?
What is the mechanism of resistance to Methotrexate?
What is the mechanism of resistance to Methotrexate?
Which drug is an analog of THF used as a rescue therapy for high-dose intrathecally administered MTX?
Which drug is an analog of THF used as a rescue therapy for high-dose intrathecally administered MTX?
What is the main adverse effect associated with Doxorubicin?
What is the main adverse effect associated with Doxorubicin?
How does Doxorubicin cause cell death?
How does Doxorubicin cause cell death?
What resistance mechanism is associated with Doxorubicin?
What resistance mechanism is associated with Doxorubicin?
