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Bladder Cancer and Hemorrhagic Cystitis Quiz

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Bladder Cancer and Hemorrhagic Cystitis Quiz

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Questions and Answers

Which phase of the cell cycle are most antimetabolites targeted at?

G2 phase

G1 phase

S phase (correct)

M phase

How do antimetabolites mainly interfere with DNA and RNA synthesis?

Acting as false metabolites (correct)

Promoting replication

Enhancing transcription

Inhibiting translation

Which enzyme do antimetabolites like Methotrexate inhibit?

Helicase

Thymidylate synthetase (correct)

RNA polymerase

DNA ligase

What is the main mechanism of action for antimetabolites acting as Folic Acid analogues?

Acting as a substitute for folate in DNA synthesis Signup and view all the answers

Which of the following is NOT an antimetabolite?

Cyclophosphamide Signup and view all the answers

What is the primary target of antimetabolites like 5-Fluorouracil?

$DNA replication$ Signup and view all the answers

How do antimetabolites prevent cancer cells from dividing and spreading?

By inhibiting DNA replication Signup and view all the answers

What is the specific target of antimetabolites in cancer cells?

DNA and RNA synthesis Signup and view all the answers

Which of the following mechanisms do antimetabolites primarily disrupt in cancer cells?

Nucleic acid metabolism Signup and view all the answers

What is the role of antimetabolites in preventing DNA replication in cancer cells?

Acting as structural analogs in DNA synthesis Signup and view all the answers

How do antimetabolites affect the ability of cancer cells to divide?

Inhibiting mitotic spindle formation Signup and view all the answers

Which cellular process is primarily disrupted by antimetabolites to inhibit cancer cell proliferation?

Nucleotide synthesis Signup and view all the answers

Which adverse effect is associated with Methotrexate?

Neutropenia Signup and view all the answers

What is the mechanism of resistance to Methotrexate?

Production of altered forms of DHFR that decrease MTX affinity Signup and view all the answers

Which drug is an analog of THF used as a rescue therapy for high-dose intrathecally administered MTX?

Leucovorin Signup and view all the answers

What is the main adverse effect associated with Doxorubicin?

Myelosuppression Signup and view all the answers

How does Doxorubicin cause cell death?

Induces DNA topoisomerase activity Signup and view all the answers

What resistance mechanism is associated with Doxorubicin?

Chromosomal abnormalities consistent with gene amplification Signup and view all the answers