6 Questions
What is the action of bisphosphonates in the body?
Binding to calcium in the bone and preventing osteoclasts from destroying bone cells
Which of the following is a potential side effect of bisphosphonates?
Nausea
What is a rare but serious complication associated with bisphosphonates?
Jawbone necrosis
When should bisphosphonates be taken to minimize esophageal irritation?
Right after breakfast with a full glass of water
What patient teaching should be provided regarding dental procedures for those taking bisphosphonates?
Inform the dentist before any tooth extraction
Which other drugs may be used to suppress hormone-dependent tumors according to the text?
Megestrol, diethylstilbestrol, and fluoxymesterone
Study Notes
Bisphosphonates in Advanced Breast Cancer
- Used to delay bone metastases and reduce skeletal problems in patients with advanced breast cancer
- Example: pamidronate sodium (Aredia)
Action and Uses
- Calcium-modifying drugs to prevent and manage osteoporosis
- Act by binding to calcium in the bone, preventing osteoclasts from destroying bone cells and resorbing calcium
Expected Side and Adverse Effects
- Common: headache, esophageal reflux, and nausea
- Rare: jawbone necrosis (osteonecrosis) with tooth extraction or invasive dental procedures
Nursing Implications and Patient Teaching
- Take bisphosphonates early in the morning, right after breakfast, with a full glass of water
- Remain in the upright position for at least 30 minutes after taking these drugs to prevent esophageal irritation and reflux
- Inform dentist or oral surgeon before tooth extraction or invasive dental procedure involving the jawbone
- Report signs of infection in the gums, such as swelling, pain, redness, that may indicate osteonecrosis
Additional Hormone-Dependent Tumor Suppression
- Examples of additional drugs: megestrol, diethylstilbestrol, and fluoxymesterone
Learn about how bisphosphonates, such as pamidronate sodium (Aredia), help delay bone metastases and prevent skeletal problems in patients with advanced breast cancer. Discover how these calcium-modifying drugs work to prevent and manage osteoporosis, as well as the potential side effects like headache, esophageal reflux, and nausea.
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