Bisphosphonates: Action, Uses, and Side Effects

What is the action of bisphosphonates in the body?

Which of the following is a potential side effect of bisphosphonates?

What is a rare but serious complication associated with bisphosphonates?

When should bisphosphonates be taken to minimize esophageal irritation?

What patient teaching should be provided regarding dental procedures for those taking bisphosphonates?

Which other drugs may be used to suppress hormone-dependent tumors according to the text?

Bisphosphonates in Advanced Breast Cancer

Used to delay bone metastases and reduce skeletal problems in patients with advanced breast cancer
Example: pamidronate sodium (Aredia)

Action and Uses

Calcium-modifying drugs to prevent and manage osteoporosis
Act by binding to calcium in the bone, preventing osteoclasts from destroying bone cells and resorbing calcium

Expected Side and Adverse Effects

Common: headache, esophageal reflux, and nausea
Rare: jawbone necrosis (osteonecrosis) with tooth extraction or invasive dental procedures

Nursing Implications and Patient Teaching

Take bisphosphonates early in the morning, right after breakfast, with a full glass of water
Remain in the upright position for at least 30 minutes after taking these drugs to prevent esophageal irritation and reflux
Inform dentist or oral surgeon before tooth extraction or invasive dental procedure involving the jawbone
Report signs of infection in the gums, such as swelling, pain, redness, that may indicate osteonecrosis

Additional Hormone-Dependent Tumor Suppression

Examples of additional drugs: megestrol, diethylstilbestrol, and fluoxymesterone

Learn about how bisphosphonates, such as pamidronate sodium (Aredia), help delay bone metastases and prevent skeletal problems in patients with advanced breast cancer. Discover how these calcium-modifying drugs work to prevent and manage osteoporosis, as well as the potential side effects like headache, esophageal reflux, and nausea.