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Questions and Answers
What is the action of bisphosphonates in the body?
What is the action of bisphosphonates in the body?
- Promoting the development of jawbone necrosis
- Increasing calcium resorption by osteoclasts
- Binding to calcium in the bone and preventing osteoclasts from destroying bone cells (correct)
- Stimulating osteoclast activity for bone regeneration
Which of the following is a potential side effect of bisphosphonates?
Which of the following is a potential side effect of bisphosphonates?
- Improved dental health
- Weight loss
- Nausea (correct)
- Decreased heart rate
What is a rare but serious complication associated with bisphosphonates?
What is a rare but serious complication associated with bisphosphonates?
- Vision improvement
- Jawbone necrosis (correct)
- Skin rash
- Hair growth stimulation
When should bisphosphonates be taken to minimize esophageal irritation?
When should bisphosphonates be taken to minimize esophageal irritation?
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What patient teaching should be provided regarding dental procedures for those taking bisphosphonates?
What patient teaching should be provided regarding dental procedures for those taking bisphosphonates?
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Which other drugs may be used to suppress hormone-dependent tumors according to the text?
Which other drugs may be used to suppress hormone-dependent tumors according to the text?
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Study Notes
Bisphosphonates in Advanced Breast Cancer
- Used to delay bone metastases and reduce skeletal problems in patients with advanced breast cancer
- Example: pamidronate sodium (Aredia)
Action and Uses
- Calcium-modifying drugs to prevent and manage osteoporosis
- Act by binding to calcium in the bone, preventing osteoclasts from destroying bone cells and resorbing calcium
Expected Side and Adverse Effects
- Common: headache, esophageal reflux, and nausea
- Rare: jawbone necrosis (osteonecrosis) with tooth extraction or invasive dental procedures
Nursing Implications and Patient Teaching
- Take bisphosphonates early in the morning, right after breakfast, with a full glass of water
- Remain in the upright position for at least 30 minutes after taking these drugs to prevent esophageal irritation and reflux
- Inform dentist or oral surgeon before tooth extraction or invasive dental procedure involving the jawbone
- Report signs of infection in the gums, such as swelling, pain, redness, that may indicate osteonecrosis
Additional Hormone-Dependent Tumor Suppression
- Examples of additional drugs: megestrol, diethylstilbestrol, and fluoxymesterone
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