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Questions and Answers
What is the primary metabolic pathway for primary aliphatic amines involving the formation of carbonyl metabolites and ammonia?
What is the primary metabolic pathway for primary aliphatic amines involving the formation of carbonyl metabolites and ammonia?
- N-dealkylation
- N-oxidation
- Oxidative deamination (correct)
- N-hydroxylation
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation according to the text?
Which type of amines can undergo oxidative N-dealkylation and N-oxide formation according to the text?
- Tertiary aromatic amines (correct)
- Primary aliphatic amines
- Tertiary aliphatic amines
- Primary aromatic amines
What kind of products can result from the further oxidation of N-hydroxylamine according to the text?
What kind of products can result from the further oxidation of N-hydroxylamine according to the text?
- Nitrone products (correct)
- Nitroso and nitro products
- Primary hydroxylamines
- Carbonyl metabolites
What is the result of the process involving an initial α-carbon hydroxylation reaction followed by carbon-nitrogen cleavage?
What is the result of the process involving an initial α-carbon hydroxylation reaction followed by carbon-nitrogen cleavage?
Which type of amines can metabolize to their corresponding lactam derivatives?
Which type of amines can metabolize to their corresponding lactam derivatives?
What are N-hydroxylamine metabolites susceptible to after being generated from secondary amines?
What are N-hydroxylamine metabolites susceptible to after being generated from secondary amines?
Which process involves a direct oxidative deamination reaction?
Which process involves a direct oxidative deamination reaction?
What is the main purpose of oxidative N-dealkylation in nitrogen functionality metabolism?
What is the main purpose of oxidative N-dealkylation in nitrogen functionality metabolism?
Why is N-dealkylation of the t-butyl group not possible via the carbinolamine pathway?
Why is N-dealkylation of the t-butyl group not possible via the carbinolamine pathway?
What is the fate of the unstable carbinolamine intermediate formed during oxidative N-dealkylation?
What is the fate of the unstable carbinolamine intermediate formed during oxidative N-dealkylation?
Which nitrogen-containing compounds are primarily involved in oxidative N-dealkylation?
Which nitrogen-containing compounds are primarily involved in oxidative N-dealkylation?
What is the main outcome of the metabolic oxidation involving carbon–nitrogen, carbon–oxygen, and carbon–sulfur systems?
What is the main outcome of the metabolic oxidation involving carbon–nitrogen, carbon–oxygen, and carbon–sulfur systems?
Which group is commonly found in many medicinal agents and is susceptible to mixed-function oxidation or alicyclic hydroxylation?
Which group is commonly found in many medicinal agents and is susceptible to mixed-function oxidation or alicyclic hydroxylation?
What can enzymatic introduction of a hydroxyl group into a monosubstituted cyclohexane ring lead to?
What can enzymatic introduction of a hydroxyl group into a monosubstituted cyclohexane ring lead to?
In oxidative N-, O-, and S-dealkylation reactions, what happens to the resulting intermediate?
In oxidative N-, O-, and S-dealkylation reactions, what happens to the resulting intermediate?
What is a common metabolic pathway for alicyclic tertiary amines resulting in the formation of lactam metabolites?
What is a common metabolic pathway for alicyclic tertiary amines resulting in the formation of lactam metabolites?
Which type of amine is susceptible to oxidative N-dealkylation, oxidative deamination, and N-oxidation reactions according to the text?
Which type of amine is susceptible to oxidative N-dealkylation, oxidative deamination, and N-oxidation reactions according to the text?
What fate do some tertiary alicyclic amines face after undergoing oxidative N-dealkylation?
What fate do some tertiary alicyclic amines face after undergoing oxidative N-dealkylation?
Which type of reaction leads to the formation of Noxide metabolites from tertiary amines according to the text?
Which type of reaction leads to the formation of Noxide metabolites from tertiary amines according to the text?
What is the metabolic fate of primary alcohol metabolites that are oxidized to aldehydes and carboxylic acids according to the text?
What is the metabolic fate of primary alcohol metabolites that are oxidized to aldehydes and carboxylic acids according to the text?
In the metabolism of benzyl carbon atoms, what can secondary alcohols be converted into by alcohol and aldehyde dehydrogenases?
In the metabolism of benzyl carbon atoms, what can secondary alcohols be converted into by alcohol and aldehyde dehydrogenases?
What is the expected outcome from the covalent binding of reactive intermediates formed from olefin-containing compounds on the heme portion of CYP?
What is the expected outcome from the covalent binding of reactive intermediates formed from olefin-containing compounds on the heme portion of CYP?
What is the role of the corresponding epoxide metabolites of olefinic compounds in cellular toxicity according to the text?
What is the role of the corresponding epoxide metabolites of olefinic compounds in cellular toxicity according to the text?
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