Biosynthesis of Eicosanoids and Leukotrienes Quiz

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What is the immediate precursor of the predominant type of human prostaglandins (series 2)?

Thromboxanes

Linoleic acid

Arachidonic acid (correct)

Lipoxygenase pathway

Where is arachidonic acid typically incorporated in membrane phospholipids before being released by phospholipase A2?

C-2 (correct)

C-6

C-10

C-8

Which enzyme catalyzes the oxidative cyclization of free arachidonic acid to yield PGH2?

Phospholipase A2

Peroxidase

Cyclooxygenase (correct)

Lipoxygenase

What is a key difference between eicosanoids and endocrine hormones?

Eicosanoids act locally and are produced in small amounts in almost all tissues. Signup and view all the answers

What happens to eicosanoids after they are produced?

They are rapidly metabolized to inactive products. Signup and view all the answers

Which statement accurately describes the role of eicosanoids?

Eicosanoids maintain platelet homeostasis and regulate blood vessel diameter. Signup and view all the answers

Which enzyme converts arachidonic acid to 5-hydroperoxy-6,8,11,14 eicosatetraenoic acid?

5-LOX Signup and view all the answers

Which eicosanoid has a major effect of vasodilatation and inhibits platelet aggregation?

Prostacyclin (PGI2) Signup and view all the answers

Which type of cells lack nuclei and therefore cannot overcome COX-1 inhibition?

Platelets Signup and view all the answers

What is the main prostaglandin produced by platelets that promotes thrombus formation?

Thromboxane (TXA2) Signup and view all the answers

Biosynthesis of Eicosanoids and Leukotrienes Quiz

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Questions and Answers

What is the immediate precursor of the predominant type of human prostaglandins (series 2)?

Where is arachidonic acid typically incorporated in membrane phospholipids before being released by phospholipase A2?

Which enzyme catalyzes the oxidative cyclization of free arachidonic acid to yield PGH2?

What is a key difference between eicosanoids and endocrine hormones?

What happens to eicosanoids after they are produced?

Which statement accurately describes the role of eicosanoids?

Which enzyme converts arachidonic acid to 5-hydroperoxy-6,8,11,14 eicosatetraenoic acid?

Which eicosanoid has a major effect of vasodilatation and inhibits platelet aggregation?

Which type of cells lack nuclei and therefore cannot overcome COX-1 inhibition?

What is the main prostaglandin produced by platelets that promotes thrombus formation?

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