Biosynthesis of Eicosanoids and Leukotrienes Quiz
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Questions and Answers

What is the immediate precursor of the predominant type of human prostaglandins (series 2)?

  • Thromboxanes
  • Linoleic acid
  • Arachidonic acid (correct)
  • Lipoxygenase pathway
  • Where is arachidonic acid typically incorporated in membrane phospholipids before being released by phospholipase A2?

  • C-2 (correct)
  • C-6
  • C-10
  • C-8
  • Which enzyme catalyzes the oxidative cyclization of free arachidonic acid to yield PGH2?

  • Phospholipase A2
  • Peroxidase
  • Cyclooxygenase (correct)
  • Lipoxygenase
  • What is a key difference between eicosanoids and endocrine hormones?

    <p>Eicosanoids act locally and are produced in small amounts in almost all tissues.</p> Signup and view all the answers

    What happens to eicosanoids after they are produced?

    <p>They are rapidly metabolized to inactive products.</p> Signup and view all the answers

    Which statement accurately describes the role of eicosanoids?

    <p>Eicosanoids maintain platelet homeostasis and regulate blood vessel diameter.</p> Signup and view all the answers

    Which enzyme converts arachidonic acid to 5-hydroperoxy-6,8,11,14 eicosatetraenoic acid?

    <p>5-LOX</p> Signup and view all the answers

    Which eicosanoid has a major effect of vasodilatation and inhibits platelet aggregation?

    <p>Prostacyclin (PGI2)</p> Signup and view all the answers

    Which type of cells lack nuclei and therefore cannot overcome COX-1 inhibition?

    <p>Platelets</p> Signup and view all the answers

    What is the main prostaglandin produced by platelets that promotes thrombus formation?

    <p>Thromboxane (TXA2)</p> Signup and view all the answers

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