Exam 2

Bioreactors have different modes such as batch, fed-batch, cyclic fed-batch, continuous (chemostat), and continuous (perfusion). It is important to know them because each mode has its own advantages and disadvantages in terms of product yield, productivity, and quality.

The target parameters for bioreactors include volumetric productivity, yields, product titer, doubling time, and residence time. They are important because they help to optimize the bioreactor conditions and ensure the best possible product quality and quantity.

The different types of bioreactors include air lift, photobioreactors, bubble column, wave, and stirred tank with radial and/or axial impellers. Each type has its own advantages and disadvantages in terms of cost, scalability, and ease of use.

<p>Mammalian cells have advantages such as glycophosphylation and easier purification, but are more expensive and have longer processing times.</p> Signup and view all the answers

<p>Cell lines can be grown in finite or infinite cultures, and must be characterized for identity, stability, and purity.</p> Signup and view all the answers

<p>Biomanufacturing trains have different stages: seed train, expansion train, and production train.</p> Signup and view all the answers

<p>Critical process parameters for biomanufacturing include biological, physiological, physiochemical, and product-related factors. They are important because they help to ensure the best possible product quality and quantity.</p> Signup and view all the answers

<p>Therapeutic antibodies can be polyclonal, monoclonal, recombinant, antibody drug conjugates, bi-specific, or antibody fragments. They are typically produced using live cells.</p> Signup and view all the answers

<p>Biopharmaceuticals are generally proteins produced using live cells, while pharmaceuticals are small molecules produced through chemical synthesis.</p> Signup and view all the answers

<p>Different types of media can be used for cell culture, including defined, non-defined, serum-free, and protein-free. Each type has its own advantages and disadvantages in terms of cost, scalability, and ease of use.</p> Signup and view all the answers