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Questions and Answers
What does the contact angle (θ) measurement in the context of wetting powders indicate?
What does the contact angle (θ) measurement in the context of wetting powders indicate?
- The particle size of the powder
- The nature of the surface of the powder (correct)
- The volume of solvent required for wetting
- The solubility of the drug in the powder
What is one method mentioned in the text to improve wettability of powders?
What is one method mentioned in the text to improve wettability of powders?
- Increasing the particle size
- Decreasing the contact angle
- Including wetting agents (surfactants) (correct)
- Polishing the surface of the powder particles
How does a contact angle (θ) close to 180° affect wetting tendency?
How does a contact angle (θ) close to 180° affect wetting tendency?
- It indicates complete wetting
- It increases the wetting tendency
- It decreases the wetting tendency (correct)
- It does not affect the wetting tendency
What does solubility refer to?
What does solubility refer to?
How can solubility of a drug be increased?
How can solubility of a drug be increased?
What does a contact angle less than 90° indicate about wetting?
What does a contact angle less than 90° indicate about wetting?
How does particle size reduction impact drug dissolution?
How does particle size reduction impact drug dissolution?
What is the relationship between particle size reduction and bioavailability?
What is the relationship between particle size reduction and bioavailability?
Why can very small particles in the nanometre range be transported through enterocytes?
Why can very small particles in the nanometre range be transported through enterocytes?
What is a common problem associated with hydrophobic drugs?
What is a common problem associated with hydrophobic drugs?
In the context of drug absorption, what could slow dissolution indicate?
In the context of drug absorption, what could slow dissolution indicate?
How does polymorphism affect drug solubility?
How does polymorphism affect drug solubility?
Which process changes the physical state of drug particles from a crystalline state to an amorphous state?
Which process changes the physical state of drug particles from a crystalline state to an amorphous state?
What is the purpose of using a hydrophilic polymer in solid dispersion?
What is the purpose of using a hydrophilic polymer in solid dispersion?
How does solid dispersion facilitate drug dissolution without chemical modification?
How does solid dispersion facilitate drug dissolution without chemical modification?
Which factor related to pharmaceutical solids can significantly impact bioavailability?
Which factor related to pharmaceutical solids can significantly impact bioavailability?
Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?
Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?
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