Biopharmaceutical Importance of Particle Size in Drug Absorption
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Questions and Answers

What does the contact angle (θ) measurement in the context of wetting powders indicate?

  • The particle size of the powder
  • The nature of the surface of the powder (correct)
  • The volume of solvent required for wetting
  • The solubility of the drug in the powder

    • What is one method mentioned in the text to improve wettability of powders?

  • Increasing the particle size
  • Decreasing the contact angle
  • Including wetting agents (surfactants) (correct)
  • Polishing the surface of the powder particles

    • How does a contact angle (θ) close to 180° affect wetting tendency?

  • It indicates complete wetting
  • It increases the wetting tendency
  • It decreases the wetting tendency (correct)
  • It does not affect the wetting tendency

    • What does solubility refer to?

    <p>The maximum quantity of drug dissolved in a given volume of a solvent solution</p> Signup and view all the answers

    How can solubility of a drug be increased?

    <p>Applying various methods such as particle size reduction</p> Signup and view all the answers

    What does a contact angle less than 90° indicate about wetting?

    <p>Wetting would be expected</p> Signup and view all the answers

    How does particle size reduction impact drug dissolution?

    <p>Increases drug solubility by increasing exposure of the drug surface to the solvent</p> Signup and view all the answers

    What is the relationship between particle size reduction and bioavailability?

    <p>Particle size reduction increases bioavailability</p> Signup and view all the answers

    Why can very small particles in the nanometre range be transported through enterocytes?

    <p>By pinocytosis as enterocytes take in fluids</p> Signup and view all the answers

    What is a common problem associated with hydrophobic drugs?

    <p>Difficulty in formulating due to increased hydrophobicity</p> Signup and view all the answers

    In the context of drug absorption, what could slow dissolution indicate?

    <p>Low drug solubility</p> Signup and view all the answers

    How does polymorphism affect drug solubility?

    <p>Unpredictably affects drug solubility</p> Signup and view all the answers

    Which process changes the physical state of drug particles from a crystalline state to an amorphous state?

    <p>Solid dispersion</p> Signup and view all the answers

    What is the purpose of using a hydrophilic polymer in solid dispersion?

    <p>To alter drug solubility and solution rate</p> Signup and view all the answers

    How does solid dispersion facilitate drug dissolution without chemical modification?

    <p>By leaving the drug dispersed as fine particles which dissolve rapidly in water</p> Signup and view all the answers

    Which factor related to pharmaceutical solids can significantly impact bioavailability?

    <p>Particle size reduction</p> Signup and view all the answers

    Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?

    <p>To affect solubility and bioavailability</p> Signup and view all the answers

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