Biopharmaceutical Importance of Particle Size in Drug Absorption
17 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What does the contact angle (θ) measurement in the context of wetting powders indicate?

  • The particle size of the powder
  • The nature of the surface of the powder (correct)
  • The volume of solvent required for wetting
  • The solubility of the drug in the powder

What is one method mentioned in the text to improve wettability of powders?

  • Increasing the particle size
  • Decreasing the contact angle
  • Including wetting agents (surfactants) (correct)
  • Polishing the surface of the powder particles

How does a contact angle (θ) close to 180° affect wetting tendency?

  • It indicates complete wetting
  • It increases the wetting tendency
  • It decreases the wetting tendency (correct)
  • It does not affect the wetting tendency

What does solubility refer to?

<p>The maximum quantity of drug dissolved in a given volume of a solvent solution (A)</p> Signup and view all the answers

How can solubility of a drug be increased?

<p>Applying various methods such as particle size reduction (C)</p> Signup and view all the answers

What does a contact angle less than 90° indicate about wetting?

<p>Wetting would be expected (A)</p> Signup and view all the answers

How does particle size reduction impact drug dissolution?

<p>Increases drug solubility by increasing exposure of the drug surface to the solvent (B)</p> Signup and view all the answers

What is the relationship between particle size reduction and bioavailability?

<p>Particle size reduction increases bioavailability (B)</p> Signup and view all the answers

Why can very small particles in the nanometre range be transported through enterocytes?

<p>By pinocytosis as enterocytes take in fluids (B)</p> Signup and view all the answers

What is a common problem associated with hydrophobic drugs?

<p>Difficulty in formulating due to increased hydrophobicity (D)</p> Signup and view all the answers

In the context of drug absorption, what could slow dissolution indicate?

<p>Low drug solubility (D)</p> Signup and view all the answers

How does polymorphism affect drug solubility?

<p>Unpredictably affects drug solubility (A)</p> Signup and view all the answers

Which process changes the physical state of drug particles from a crystalline state to an amorphous state?

<p>Solid dispersion (D)</p> Signup and view all the answers

What is the purpose of using a hydrophilic polymer in solid dispersion?

<p>To alter drug solubility and solution rate (D)</p> Signup and view all the answers

How does solid dispersion facilitate drug dissolution without chemical modification?

<p>By leaving the drug dispersed as fine particles which dissolve rapidly in water (A)</p> Signup and view all the answers

Which factor related to pharmaceutical solids can significantly impact bioavailability?

<p>Particle size reduction (D)</p> Signup and view all the answers

Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?

<p>To affect solubility and bioavailability (C)</p> Signup and view all the answers

More Like This

Use Quizgecko on...
Browser
Browser