17 Questions
What does the contact angle (θ) measurement in the context of wetting powders indicate?
The nature of the surface of the powder
What is one method mentioned in the text to improve wettability of powders?
Including wetting agents (surfactants)
How does a contact angle (θ) close to 180° affect wetting tendency?
It decreases the wetting tendency
What does solubility refer to?
The maximum quantity of drug dissolved in a given volume of a solvent solution
How can solubility of a drug be increased?
Applying various methods such as particle size reduction
What does a contact angle less than 90° indicate about wetting?
Wetting would be expected
How does particle size reduction impact drug dissolution?
Increases drug solubility by increasing exposure of the drug surface to the solvent
What is the relationship between particle size reduction and bioavailability?
Particle size reduction increases bioavailability
Why can very small particles in the nanometre range be transported through enterocytes?
By pinocytosis as enterocytes take in fluids
What is a common problem associated with hydrophobic drugs?
Difficulty in formulating due to increased hydrophobicity
In the context of drug absorption, what could slow dissolution indicate?
Low drug solubility
How does polymorphism affect drug solubility?
Unpredictably affects drug solubility
Which process changes the physical state of drug particles from a crystalline state to an amorphous state?
Solid dispersion
What is the purpose of using a hydrophilic polymer in solid dispersion?
To alter drug solubility and solution rate
How does solid dispersion facilitate drug dissolution without chemical modification?
By leaving the drug dispersed as fine particles which dissolve rapidly in water
Which factor related to pharmaceutical solids can significantly impact bioavailability?
Particle size reduction
Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?
To affect solubility and bioavailability
Learn about how particle size reduction can affect the solubility and bioavailability of drugs in biopharmaceutical contexts. Understand the impact of drug dissolution rate on absorption and bioavailability.
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