Biomolecules: Chemistry Foundation
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Questions and Answers

What is a characteristic of proteins?

  • High molecular masses expressed in kDa (correct)
  • Low molecular masses expressed in kDa
  • Low molecular masses expressed in grams
  • High molecular masses expressed in grams

What is the general term for carbohydrates that are covalently bonded to other biomolecules?

  • Bioconjugates (correct)
  • Polysaccharides
  • Glycoproteins
  • Glycolipids

What is the general term for lipids that show a dual nature with hydrophilic and lipophilic parts?

  • Monoglycerides
  • Amphiphilic lipids (correct)
  • Hydrophilic lipids
  • Lipophilic lipids

What is the building block of nucleic acids?

<p>Nucleotides (D)</p> Signup and view all the answers

What is the term for lipids that are derived from phosphoric acids and esterified with fatty acids?

<p>Phospholipids (B)</p> Signup and view all the answers

What is the term used to describe the building blocks of larger molecules called polymers?

<p>Monomers (D)</p> Signup and view all the answers

Which of the following is an example of a polymer?

<p>Polysaccharide (D)</p> Signup and view all the answers

What is the term used to describe the study of the qualitative and quantitative analysis of biological activity and detection of biological molecules?

<p>BioAnalytical Chemistry (A)</p> Signup and view all the answers

Which of the following biomolecules includes lipids and derivatives?

<p>Small molecules (C)</p> Signup and view all the answers

What is the term used to describe the nitrogen-containing ring structure found in nucleotides?

<p>Nitrogenous base (B)</p> Signup and view all the answers

What is the primary function of insoluble carbohydrate polymers in cell walls?

<p>To serve as structural and protective elements (B)</p> Signup and view all the answers

What is the main difference between RNA and DNA in terms of stability?

<p>DNA is more stable than RNA (A)</p> Signup and view all the answers

What type of molecules are formed when carbohydrate polymers are covalently attached to proteins or lipids?

<p>Glycoproteins (A)</p> Signup and view all the answers

What comprises the lipophilic fraction of a biological sample?

<p>Triglycerides, fatty acids, alcohols, sterols, and fat-soluble vitamins (D)</p> Signup and view all the answers

What is the purpose of carbohydrate polymers in lubricating skeletal joints?

<p>To reduce friction between moving joints (D)</p> Signup and view all the answers

What is the process by which polysaccharides, nucleic acids, and proteins are formed?

<p>Polymerization (D)</p> Signup and view all the answers

What is the molecular weight of the monomers that make up macromolecules?

<p>500 or less Da (C)</p> Signup and view all the answers

What type of bond links amino acids together in proteins?

<p>Peptide bond (C)</p> Signup and view all the answers

What is the term for the complex formed by the assembly of macromolecules?

<p>Supramolecular complex (A)</p> Signup and view all the answers

What is the term for the end of a polypeptide chain?

<p>C-terminal (A)</p> Signup and view all the answers

What is the primary purpose of quenching metabolism in metabolomics?

<p>To stop or slow down the metabolic process (A)</p> Signup and view all the answers

Approximately what percentage of total dry mass in cells are proteins?

<p>50% (A)</p> Signup and view all the answers

What is the estimated number of different proteins in the human body?

<p>100,000 (D)</p> Signup and view all the answers

What is the process that converts CO2 and H2O into cellulose and other plant products?

<p>Photosynthesis (B)</p> Signup and view all the answers

What is the term that describes the study of small molecules or metabolites within a biological sample?

<p>Metabolomics (C)</p> Signup and view all the answers

What is the primary source of carbohydrates in nature?

<p>Plant products (D)</p> Signup and view all the answers

What is the ratio of proteins to other macromolecules in cells?

<p>5:1 (B)</p> Signup and view all the answers

What is the term that describes the extraction of metabolites from a biological sample?

<p>Extraction (C)</p> Signup and view all the answers

What is the importance of stopping or slowing down metabolism in highly metabolically active systems?

<p>To prevent sample degradation (C)</p> Signup and view all the answers

What percentage of the hemoglobin molecule's mass is made up of iron ions?

<p>0.3% (A)</p> Signup and view all the answers

What are the building blocks of DNA?

<p>Nucleotides (B)</p> Signup and view all the answers

What is the typical molecular weight range of small biomolecules in cells?

<p>100 to 500 Da (D)</p> Signup and view all the answers

Which of the following biomolecules are often polyfunctional, containing two or more different kinds of functional groups?

<p>Many biomolecules (A)</p> Signup and view all the answers

What is the term for large biomolecules composed of simpler subunits?

<p>Macromolecules (B)</p> Signup and view all the answers

What is the name of the biomolecule that is a carrier of acetyl groups in some enzymatic reactions?

<p>Acetyl-CoA (A)</p> Signup and view all the answers

What are the four major classes of biomolecules that are important for all living things?

<p>Carbohydrates, lipids, proteins, and nucleic acids (B)</p> Signup and view all the answers

What is the concentration range of small biomolecules in cells?

<p>μmol to mmol (A)</p> Signup and view all the answers

What is the characteristic of biomolecules in the aqueous phase of cells?

<p>Polar or charged and water-soluble (B)</p> Signup and view all the answers

What is the result of replacing hydrogen atoms with functional groups in hydrocarbons?

<p>An increase in the variety of organic compounds (B)</p> Signup and view all the answers

What is the main cause of denaturation of proteins?

<p>pH changes, mercaptoethanol, detergents, urea/guanidine and heat (D)</p> Signup and view all the answers

What is the term for the structure that conserves a native-like secondary structure content but without the tightly packed protein interior?

<p>Molten globule (C)</p> Signup and view all the answers

What is the reason why proline creates a bend in an α-helix?

<p>All of the above (D)</p> Signup and view all the answers

What is the type of protein structure that describes the completely folded and compacted polypeptide chain?

<p>Tertiary (3°) structure (C)</p> Signup and view all the answers

What is the function of molecular chaperones?

<p>To restore proteins that have become misfolded (D)</p> Signup and view all the answers

What is the type of protein that contains polypeptide chains organized approximately parallel along a single axis?

<p>Fibrous protein (B)</p> Signup and view all the answers

What is the result of heat-induced denaturation of proteins?

<p>Exposure of non-polar segments to aqueous solvent (C)</p> Signup and view all the answers

What is the term for the association of polypeptide chains?

<p>Quaternary (4°) structure (C)</p> Signup and view all the answers

What is the driving force behind the hydrophobic effect?

<p>Decrease in entropy in water (A)</p> Signup and view all the answers

What is the location of hydrophobic residues in globular proteins?

<p>Inside the protein (A)</p> Signup and view all the answers

What is the role of 2,3-BPG in hemoglobin?

<p>Decreases the affinity of hemoglobin for oxygen (A)</p> Signup and view all the answers

What is the role of chaperones in protein folding?

<p>To guide misfolded regions back into place (D)</p> Signup and view all the answers

What is the difference between myoglobin and hemoglobin?

<p>Myoglobin binds 1 O2 molecule, while hemoglobin binds 4 O2 molecules (A)</p> Signup and view all the answers

What is the consequence of protein misfolding?

<p>Loss of biological activity (C)</p> Signup and view all the answers

What is the purpose of hydrogen bonding in the β-pleated sheet?

<p>To form a sheet-like structure (A)</p> Signup and view all the answers

What is the term for the change in direction of a polypeptide chain?

<p>β-Reverse turn (D)</p> Signup and view all the answers

What is the effect of pH changes on proteins?

<p>Denaturation of proteins (A)</p> Signup and view all the answers

What is the characteristic of globular proteins?

<p>They are soluble in water and have a spherical shape (A)</p> Signup and view all the answers

What is the function of cryo-electron microscopy?

<p>To study the structure of proteins using complex computational processing algorithms (C)</p> Signup and view all the answers

What is the term for the non-covalent interactions that stabilize the tertiary structure of a protein?

<p>Hydrogen bonds, electrostatic interactions, and hydrophobic interactions (A)</p> Signup and view all the answers

What is the 1° structure of a protein?

<p>The sequence of amino acids in a polypeptide chain (D)</p> Signup and view all the answers

What type of bond is responsible for the formation of α-helices in proteins?

<p>Hydrogen bond (C)</p> Signup and view all the answers

What is the characteristic of the R groups of amino acids in an α-helix?

<p>They stick outward from the α-helix (C)</p> Signup and view all the answers

What is the distance between each turn of the α-helix?

<p>5.4 Ã… (B)</p> Signup and view all the answers

What is the number of amino acids per turn in an α-helix?

<p>3.6 (B)</p> Signup and view all the answers

What type of structure is formed by a regular pattern of hydrogen bonds between the amide N-H and C=O groups of amino acids?

<p>α-helix (A)</p> Signup and view all the answers

Which bonds have free rotation in a protein?

<p>Both of the above (C)</p> Signup and view all the answers

What is the direction of the hydrogen bonds in an α-helix?

<p>Parallel to the axis (A)</p> Signup and view all the answers

What is the role of hydrogen bonds in the formation of an α-helix?

<p>They pull the polypeptide chain into a helical structure (C)</p> Signup and view all the answers

What is the sequence of amino acids in a polypeptide chain read from?

<p>N-terminal end to C-terminal end (B)</p> Signup and view all the answers
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