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Questions and Answers
An ideal surface treatment should be thick to ensure significant effects on bulk properties.
An ideal surface treatment should be thick to ensure significant effects on bulk properties.
False
A high water contact angle indicates high wettability or a hydrophilic surface.
A high water contact angle indicates high wettability or a hydrophilic surface.
False
PDMS stands for Polydimethylsiloxane and is a hydrophobic polymer.
PDMS stands for Polydimethylsiloxane and is a hydrophobic polymer.
True
Young’s equation describes the relationship of surface tension at the intersection of liquid, vapor, and solid boundaries.
Young’s equation describes the relationship of surface tension at the intersection of liquid, vapor, and solid boundaries.
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APTES is used to enhance the electrical conductivity of materials.
APTES is used to enhance the electrical conductivity of materials.
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The contact angle measurement is used to evaluate the wettability of biomaterials.
The contact angle measurement is used to evaluate the wettability of biomaterials.
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The drop shape analyzer is an example of contact angle measuring equipment.
The drop shape analyzer is an example of contact angle measuring equipment.
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A low water contact angle indicates a hydrophobic surface.
A low water contact angle indicates a hydrophobic surface.
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A biomaterial is defined as any substance that can be used in the body to treat, support, or replace tissues.
A biomaterial is defined as any substance that can be used in the body to treat, support, or replace tissues.
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The surface characteristics of a biomaterial do not influence its biocompatibility.
The surface characteristics of a biomaterial do not influence its biocompatibility.
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Cells adhere better to hydrophobic surfaces than to moderately wettable surfaces.
Cells adhere better to hydrophobic surfaces than to moderately wettable surfaces.
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Completing mandatory online safety training is a requirement for the biomaterials lab.
Completing mandatory online safety training is a requirement for the biomaterials lab.
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The lab report contributes 20% to the total grade in the biomaterials lab.
The lab report contributes 20% to the total grade in the biomaterials lab.
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Water spreads out on hydrophilic surfaces, indicating good wettability.
Water spreads out on hydrophilic surfaces, indicating good wettability.
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Personal protective equipment (PPE) includes laboratory coats, protective gloves, and safety goggles.
Personal protective equipment (PPE) includes laboratory coats, protective gloves, and safety goggles.
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The flammable hazard symbol indicates a chemical that is toxic to the environment.
The flammable hazard symbol indicates a chemical that is toxic to the environment.
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Study Notes
Course Information
- Course Title: Biomaterials
- Course Number: ENGR-UH 4810
- Professor: Jeremy Teo
- Instructor: Shafiya Sabah
- Semester: Fall 2024
Lab Information
- Biomaterials lab: 30% of total grade
- Lab Report: 10%
- Lab Quiz 1: 10%
- Lab Quiz 2: 10%
Requirements
- Complete mandatory online safety training
Lab Safety
-
Personal Protective Equipment (PPE):
- Laboratory coats
- Protective gloves
- Safety goggles
- Long pants
- Closed toe shoes
Hazard Symbols
- Corrosive chemical
- Skin and Eye irritant
- Flammable
- Biohazard sign
- Toxic
- Harmful to environment
- Health hazard (Carcinogen - Organ Toxicity)
- Explosive
Lab 1: Surface Wettability Characterization
Biomaterial surface wettability
- Biomaterial: Any substance (natural or synthetic) used in the body for treatment, support, or replacement of tissues/organs/body functions. Biocompatibility measures how well it integrates with a biological system.
- Wettability: Ease with which a fluid spreads across a solid surface
- Hydrophilic surfaces: Water spreads out on these surfaces.
- Hydrophobic surfaces: Water forms droplets/beads on these surfaces.
- Surface characteristics (wettability, topography, and surface energy), influence biocompatibility.
- Wettability of biomaterials affects protein adsorption and cellular response. Cells adhere better to moderate wettable surfaces.
Surface modification techniques
- Surface treatments alter surface composition using physical/chemical reactions.
- An ideal treatment is thin (minimizes effects on bulk properties), resistant to delamination, and simple/robust (promotes commercialization).
Water Contact Angle
- Contact angle measurements evaluate biomaterial wettability in vitro
- A liquid drop on a solid surface forms an angle at the intersection of liquid, vapor, and solid boundaries.
-
Young's Equation: Ysv - Ysl - Ylv cosθ = 0
- YLV: Surface tension of the liquid
- YSL: Solid-liquid interfacial tension
- YSV: Surface energy of the solid
- θ: Contact angle
- High contact angle = low wettability (hydrophobic)
- Low contact angle = high wettability (hydrophilic)
Contact Angle Measuring Equipment
- Drop shape analyzer (Krüss DSA25S) includes:
- Illumination
- Dosing unit
- Lens
- Camera
- Sample stage
PDMS (Polydimethylsiloxane)
- Clear, non-toxic silicone (hydrophobic) polymer
- Excellent biocompatibility, thermal stability, and flexibility.
- Widely used in microfluidic chips, biosensors, and drug delivery carriers.
APTES (3-Aminopropyl)triethoxysilane
- Silane reagent chemically modifies material surfaces.
- Creates a durable, functional layer introducing chemical groups (e.g., amines) increasing hydrophilicity.
Plasma Treatment
- Physical surface modification technique improving wettability.
- Gas/mixture of gases in a sealed, low-pressure vacuum chamber.
- RF (radio frequency) power energizes the gases.
- A purplish glow indicates plasma generation.
- Activated ions vibrate cleaning contaminants from the surface.
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Description
Test your understanding of surface wettability characterization in biomaterials. This quiz focuses on the properties and safety precautions necessary for handling various biomaterials in a laboratory setting. Ensure you are familiar with the types of PPE and hazard symbols relevant to lab safety.
