Biomaterials Formulation and Patterning Quiz

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Questions and Answers

What are the advantages of micro/nanosized systems in biomaterials formulation?

Small size compared to surgical implants (correct)

Higher mechanical strength than surgical implants

Can replace surgical implants entirely

Easier to synthesize than macrosized systems

Which is a naturally derived polymer used for microparticle preparation?

Polyethylene

Polystyrene

Polyvinyl chloride

Chitosan (correct)

What is a method for the preparation of microparticles mentioned in the text?

Direct crystallization

Single and double emulsion solvent evaporation (correct)

Gas phase deposition

Mechanical compression

What is the topic of Lecture 2 in the context of biomaterials formulation and patterning?

Formulation and patterning of biomaterials Signup and view all the answers

What method is used for the preparation of microparticles in Flow-focusing microfluidics?

Flow-focusing microfluidics Signup and view all the answers

Which shape of microparticles is mentioned in the text?

Janus microparticles Signup and view all the answers

What is the definition of liposomes?

Vesicles consisting of one or more phospholipid bilayers enclosing an aqueous volume Signup and view all the answers

What role does cholesterol play in the cell membrane?

Decreases membrane fluidity at high temperature Signup and view all the answers

In which journal was the article 'Variety of polymeric microparticles' published?

Eur. Polymer J. Signup and view all the answers

What is the topic of the article by Talelli et al, Nano Today 2015?

Definition & Size comparison of nanoparticles Signup and view all the answers

What is the primary method for the preparation of microparticles mentioned in the text?

Flow-focusing microfluidics Signup and view all the answers

What is the shape of the microparticles mentioned in the text that resembles a crescent moon?

Crescent moon-shaped microparticles Signup and view all the answers

Which of the following is NOT a property of a 'thrombogenic' or 'not blood-compatible' material?

Enhancement of platelet function and coagulation process Signup and view all the answers

What is the primary method for assessing blood change in vitro in the context of blood-material interaction?

Measuring blood clotting time Signup and view all the answers

Which factor affects the initial platelet attachment to a material surface?

Blood viscosity Signup and view all the answers

What does 'blood-compatibility' of a material or device refer to?

The property of a material or device that allows it to function in contact with blood without inducing adverse reactions Signup and view all the answers

Which is a commonly applied in vitro test for blood-material interaction in the regulatory process?

Measuring blood clotting time Signup and view all the answers

What are the challenges in the assessment of blood-compatibility of materials?

All of the above Signup and view all the answers

What does 'thrombogenicity' of a device refer to?

The extent to which a device induces adverse response in its intended use configuration Signup and view all the answers

Which of the following is NOT a bulk property used for optimal structural compatibility of hip joint implants?

Electrical conductivity Signup and view all the answers

What is the main reason for the unique reactivity of the surface of materials?

Smaller mass compared to bulk Signup and view all the answers

Which technique is used for assessing hydrophobicity/hydrophilicity of material surfaces?

Contact angle measurement Signup and view all the answers

What is the potential drawback of surface characterization techniques for polymeric biomaterials?

Potential alteration of surface properties Signup and view all the answers

What is the primary focus of biological characterization of tissue-material interaction?

Host response to material implant Signup and view all the answers

What is the main purpose of in vitro assessment of cell/tissue-material compatibility?

To study biological compatibility Signup and view all the answers

Which type of grafts are mentioned in the text as being fabricated from polyesters or ePTFE?

Vascular grafts Signup and view all the answers

What is the primary focus of the study on biomaterials and tissue-material interaction?

The effects of materials on host tissues, particularly focusing on protein adsorption Signup and view all the answers

What is the main distinction made in the study regarding 'cell and tissue compatibility' and 'biocompatibility'?

Cell and tissue compatibility provides insight into safety/toxicology aspects but not functional performance Signup and view all the answers

What technique is used for the in vivo assessment of tissue-material compatibility in the study?

Implanting biomaterials in mice and evaluating the host response through histology processing Signup and view all the answers

What does the study provide a timeline of in the context of cellular recruitment in the host response?

Cellular recruitment in the host response, detailing the stages of host response to implanted biomaterials Signup and view all the answers

What is the main limitation of the in vitro assessment of cell and tissue compatibility mentioned in the study?

It has limitations such as reduced complexity and lack of immune/inflammatory response Signup and view all the answers

What specific cellular responses to biomaterials are observed in the study, providing insights into tissue-material compatibility?

Neutrophils, macrophages, and foreign body giant cells Signup and view all the answers

What is the focus of the interaction of biomaterials with tissue in the study, specifically looking at the interaction of fibrinogen on self-assembled monolayers?

The interaction of fibrinogen on self-assembled monolayers Signup and view all the answers

What is the primary focus of the article by Liu WF, Ma M, Bratlie KM, Dang TT et al, Biomaterials 2011?

Non-invasive imaging to evaluate host response to biomaterials Signup and view all the answers

What is the main function of reactive oxygen species (ROS) mentioned in the text?

Serving as an important regulator in cellular processes Signup and view all the answers

What is the significance of the Prosense fluorescent efficiency values provided in the text?

Indicating the degradation rate of PLGA particles Signup and view all the answers

What is the role of neutrophils and macrophages in relation to reactive oxygen species (ROS) as mentioned in the text?

They contribute to the oxidative degradation of biomaterials Signup and view all the answers

What is the method of imaging mentioned in the text for evaluating host response to biomaterials?

Imaging with IVIS system Signup and view all the answers

What is the significance of the difference in Prosense fluorescent efficiency between PLGA particles without drug and PLGA particles with dexamethasone?

It shows the impact of dexamethasone on ROS production Signup and view all the answers

What is the main focus of the article by Dang TT, Anh VT, Cohen J et al, Biomaterials 2013?

Effects of implanted biomaterials on host biological systems Signup and view all the answers

What is the purpose of the i.V injection of imaging probe and s.q injection of particles mentioned in the text?

To evaluate the compatibility of biomaterials with host tissues Signup and view all the answers

What is the significance of the value 0.40 in the table provided in the text?

It represents the fluorescent efficiency of PLGA particles without drug Signup and view all the answers

What is the role of PLGA particles with dexamethasone in the context of the text?

To reduce the production of ROS Signup and view all the answers

Study Notes

Characterization of Biomaterials and Tissue-Material Interaction

The study involves the characterization of biomaterials and their interaction with host tissues.
It explores the effects of materials on host tissues, particularly focusing on protein adsorption.
The interaction of biomaterials with tissue is computationally simulated, specifically looking at the interaction of fibrinogen on self-assembled monolayers.
The study also delves into the monolayer model of protein adsorption on solid surfaces, using Langmuir adsorption isotherm.
The research examines the cell binding to surfaces, involving integrin receptors and proteins in extracellular liquid.
It provides a timeline of cellular recruitment in the host response, detailing the stages of host response to implanted biomaterials.
The assessment of cell and tissue compatibility involves the examination of potential xenobiotics that might be released from a medical device or implanted material.
The study distinguishes "cell and tissue compatibility" from "biocompatibility," emphasizing that the former provides insight into safety/toxicology aspects but not functional performance.
In vitro assessment of cell and tissue compatibility involves scanning electron microscopy images of cells adhering to surfaces, but has limitations such as reduced complexity and lack of immune/inflammatory response.
The in vivo assessment of tissue-material compatibility involves implanting biomaterials in mice and evaluating the host response through histology processing.
Specific cellular responses to biomaterials are observed, such as neutrophils, macrophages, and foreign body giant cells, providing insights into tissue-material compatibility.
Non-invasive imaging, such as IVIS Spectrum imaging, is used to evaluate the host response to biomaterials, providing information on the dynamics of cellular enzymatic activity and allowing parallel analysis of multiple materials.

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Description

Test your knowledge on the formulation and patterning of biomaterials with this quiz. Covering topics such as microparticles, nanoparticles, and their applications, this quiz will help you assess your understanding of biomaterials in the field of advanced biomaterials.