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Questions and Answers
Which of the following is a condition for Hardy-Weinberg equilibrium?
Which of the following is a condition for Hardy-Weinberg equilibrium?
- Mutation
- Small population size
- Random mating (correct)
- Natural selection
Genetic variation in a population will remain constant from one generation to the next if the conditions for Hardy-Weinberg equilibrium are met.
Genetic variation in a population will remain constant from one generation to the next if the conditions for Hardy-Weinberg equilibrium are met.
True (A)
If a population is NOT in Hardy-Weinberg equilibrium, what process is likely occurring?
If a population is NOT in Hardy-Weinberg equilibrium, what process is likely occurring?
- Evolution (correct)
- Genetic redundancy
- Stasis
- Gene conservation
What is the term for the movement of genes from one population to another?
What is the term for the movement of genes from one population to another?
Inbreeding is an example of random mating, which supports Hardy-Weinberg equilibrium.
Inbreeding is an example of random mating, which supports Hardy-Weinberg equilibrium.
The MN blood group system has two alleles, M and N, which code for a ______ on the surface of red blood cells.
The MN blood group system has two alleles, M and N, which code for a ______ on the surface of red blood cells.
In the context of population genetics, what do alleles M and N represent in the MN blood group system?
In the context of population genetics, what do alleles M and N represent in the MN blood group system?
What data was collected from individuals in the Philippines to study the MN locus?
What data was collected from individuals in the Philippines to study the MN locus?
Which of the following is NOT typically included in a questionnaire when studying population genetics?
Which of the following is NOT typically included in a questionnaire when studying population genetics?
The observed genotype frequencies for the MN locus are always the same across different populations.
The observed genotype frequencies for the MN locus are always the same across different populations.
How is the frequency of the M allele (denoted as $p$) calculated using genotype frequencies?
How is the frequency of the M allele (denoted as $p$) calculated using genotype frequencies?
If the frequency of the M allele ($p$) is 0.6, what is the frequency of the N allele ($q$)?
If the frequency of the M allele ($p$) is 0.6, what is the frequency of the N allele ($q$)?
In the Hardy-Weinberg equation, $p^2 + 2pq + q^2 = 1$, what does the term $2pq$ represent?
In the Hardy-Weinberg equation, $p^2 + 2pq + q^2 = 1$, what does the term $2pq$ represent?
If observed genotype frequencies deviate significantly from expected Hardy-Weinberg frequencies, the population is considered to be in equilibrium.
If observed genotype frequencies deviate significantly from expected Hardy-Weinberg frequencies, the population is considered to be in equilibrium.
Which of the following factors can cause a population to deviate from Hardy-Weinberg equilibrium?
Which of the following factors can cause a population to deviate from Hardy-Weinberg equilibrium?
According to the Hardy-Weinberg principle, the sum of allele frequencies for all alleles at a locus in a population must equal ______.
According to the Hardy-Weinberg principle, the sum of allele frequencies for all alleles at a locus in a population must equal ______.
How can comparing observed genotype frequencies with expected Hardy-Weinberg frequencies help in understanding a population?
How can comparing observed genotype frequencies with expected Hardy-Weinberg frequencies help in understanding a population?
If a population is in Hardy-Weinberg equilibrium, it means that the allele frequencies are changing rapidly from one generation to the next.
If a population is in Hardy-Weinberg equilibrium, it means that the allele frequencies are changing rapidly from one generation to the next.
What is the primary consequence of isolation and inbreeding in small populations?
What is the primary consequence of isolation and inbreeding in small populations?
Within a population, the combination of all the genes (including all the different alleles) comprises the ______.
Within a population, the combination of all the genes (including all the different alleles) comprises the ______.
Which scenario would likely result in a population NOT being in Hardy-Weinberg equilibrium?
Which scenario would likely result in a population NOT being in Hardy-Weinberg equilibrium?
Migration prevents changes in allele frequencies of a population.
Migration prevents changes in allele frequencies of a population.
Which of the following equations correctly represents the Hardy-Weinberg principle for allele frequencies?
Which of the following equations correctly represents the Hardy-Weinberg principle for allele frequencies?
What does it mean for a population to be in 'equilibrium' regarding its genetic makeup?
What does it mean for a population to be in 'equilibrium' regarding its genetic makeup?
What information is needed to apply the Hardy-Weinberg equation to a population?
What information is needed to apply the Hardy-Weinberg equation to a population?
Under Hardy-Weinberg equilibrium, the allele frequencies in a population change predictably over time.
Under Hardy-Weinberg equilibrium, the allele frequencies in a population change predictably over time.
In the context of the MN blood group in the Philippines, what might cause the observed frequencies to differ from Hardy-Weinberg expectations?
In the context of the MN blood group in the Philippines, what might cause the observed frequencies to differ from Hardy-Weinberg expectations?
If observed genotype frequencies are higher than expected under Hardy-Weinberg equilibrium, it suggests that ______ selection may be occurring.
If observed genotype frequencies are higher than expected under Hardy-Weinberg equilibrium, it suggests that ______ selection may be occurring.
According to Hardy-Weinberg, what is the relationship between allele and genotype frequencies in a population?
According to Hardy-Weinberg, what is the relationship between allele and genotype frequencies in a population?
The Hardy-Weinberg principle is most accurate for small, rapidly evolving populations.
The Hardy-Weinberg principle is most accurate for small, rapidly evolving populations.
Match these terms with their descriptions:
Match these terms with their descriptions:
Which condition, if violated, is most likely to cause significant and rapid deviations from Hardy-Weinberg equilibrium in a small population?
Which condition, if violated, is most likely to cause significant and rapid deviations from Hardy-Weinberg equilibrium in a small population?
How can understanding the Hardy-Weinberg equilibrium relate to studying genetic diseases in populations?
How can understanding the Hardy-Weinberg equilibrium relate to studying genetic diseases in populations?
What is indicated when the observed frequency of a recessive homozygous genotype is significantly higher than projected by the Hardy-Weinberg equilibrium?
What is indicated when the observed frequency of a recessive homozygous genotype is significantly higher than projected by the Hardy-Weinberg equilibrium?
If the two areas of same colors appear closer to the same height, that population should judged to be in Hardy-Weinberg equilibrium.
If the two areas of same colors appear closer to the same height, that population should judged to be in Hardy-Weinberg equilibrium.
Which condition is vital in allowing populations to stay in Hardy-Weinberg equilibrium?
Which condition is vital in allowing populations to stay in Hardy-Weinberg equilibrium?
What is the purpose of comparing HW with non-HW graph values?
What is the purpose of comparing HW with non-HW graph values?
Under HW, what would a bar that barely has a horizontal top mean?
Under HW, what would a bar that barely has a horizontal top mean?
A population in HW in never impacted by events.
A population in HW in never impacted by events.
Why is it that the ethnic regions are often an important role in maintaining Hardy-Weinberg?
Why is it that the ethnic regions are often an important role in maintaining Hardy-Weinberg?
What does a chromosome represent?
What does a chromosome represent?
If most areas are the same color, what does that imply for ethnic diversity?
If most areas are the same color, what does that imply for ethnic diversity?
Flashcards
Hardy-Weinberg Equilibrium
Hardy-Weinberg Equilibrium
States that genetic variation will remain constant from one generation to the next if certain conditions are met.
Condition 1 for H-W Equilibrium
Condition 1 for H-W Equilibrium
Very large population size to minimize genetic drift.
Condition 2 for H-W Equilibrium
Condition 2 for H-W Equilibrium
No natural selection biasing allele frequencies.
Condition 3 for H-W Equilibrium
Condition 3 for H-W Equilibrium
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Condition 4 for H-W Equilibrium
Condition 4 for H-W Equilibrium
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Condition 5 for H-W Equilibrium
Condition 5 for H-W Equilibrium
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Evolution occurs when...
Evolution occurs when...
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Alleles
Alleles
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"p" in H-W Equations
"p" in H-W Equations
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"q" in H-W Equations
"q" in H-W Equations
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Allele Frequency Equation
Allele Frequency Equation
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p² in H-W Equations
p² in H-W Equations
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2pq in H-W Equations
2pq in H-W Equations
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q² in H-W Equations
q² in H-W Equations
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Genotype Frequency Equation
Genotype Frequency Equation
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Population not in equilibrium.
Population not in equilibrium.
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Population is in equilibrium.
Population is in equilibrium.
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Population Size and Equilibrium
Population Size and Equilibrium
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Karyotype
Karyotype
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Study Notes
- Integrating Concepts in Biology is about Variation and Population Genetics
- Section 16.2 is about using population genetic information to predict evolution
- Biology Learning Objectives are to explain the Hardy-Weinberg equilibrium, evaluate its application, and determine if a population is evolving using the equation
Hardy – Weinberg Equilibrium
- States that genetic variation in a population will remain constant from one generation to the next if the following conditions are met:
- Population is very large
- No natural selection
- No mutation
- No migration (gene flow)
- Random mating (no inbreeding)
- If these conditions are not met, the Allele frequencies will change resulting in evolution
Karyotype
- There are two copies of every chromosome, one from the mother and one from the father
- There are 2 alleles in the population for the blood group MN
- The gene codes for a glycoprotein on the surface of red blood cells
- Glycoprotein is coded by allele M
- Glycoprotein coded by allele N
- Alleles are variations of the same gene
- Many genes code for proteins
MN Locus in Several Populations
- 500 individuals were selected from populations in the Philippines along a north-south gradient
- Blood samples were collected
- A questionnaire was administered asking about place of birth, ethnic identity, and migration of individuals
Observed genotype frequencies of the MN genetic locus in Philippine populations
- In Isabela, the frequency of MM = 0.73, MN = 0.12, and NN = 0.15
- Frequency of M allele (denoted p) is fMM + fMN/2 which is 0.73 + 0.12/2 = 0.79
- The frequency of N allele (denoted q) is fNN + MN/2 = 0.15 + 0.12/2 = 0.21
- In Manilla, the frequency of MM = 0.26, MN = 0.52, and NN = 0.22
- The frequency of M allele (denoted p) is fMM + fMN/2 = 0.26 + 0.52/2 = 0.52
- The frequency of N allele (denoted q) is fNN + fMN/2 = 0.22 + 0.52/2 = 0.48
- In Cebu, the frequency of MM = 0.36, MN = 0.59, and NN = 0.05
- The frequency of M allele (denoted p) is fMM + fMN/2 = 0.36 + 0.59/2 = 0.655
- The frequency of N allele (denoted q) is fNN + fMN/2 = 0.05 + 0.59/2 = 0.345
- There is no north to south trend
Hardy – Weinberg Equilibrium Equation
- Dominant allele frequency = p
- Recessive allele frequency = q
- Genotype frequencies:
- AA = p2
- Aa = 2pq
- aa = q2
- Important Equations
- p + q = 1 (Allele frequencies)
- p² + 2pq + q² = 1 (Genotype frequencies)
- MN Blood group
- M + N = 1
- M² + 2MN + N2
Example
- If the frequency of the M allele in populations is 0.79, then the frequency of the N allele is ___ according to Hardy-Weinberg
- The frequency of the MM genotype is ___
- The frequency of the MN genotype is ___
- The frequency of the NN genotype is ___
Observed and HW genotype frequencies of the MN genetic locus in Philippine populations
- If bars of a similar color are different heights, the population is judged to NOT be in Hardy-Weinberg equilibrium
- If bars of a similar color are the same or similar height, then the population is judged to be in Hardy-Weinberg equilibrium
- The population Isabela is judged to NOT be in Hardy-Weinberg equilibrium with a localized migration from nearby towns
- Isolation and inbreeding in small populations can lead to populations not in HW equilibrium
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