Biology Pioneers: Anton van Leeuwenhoek and Edward Jenner
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Questions and Answers

Who is considered the 'Father' of microbiology and immunology?

  • Edward Jenner
  • Anton van Leeuwenhoek
  • Louis Pasteur (correct)
  • Joseph Lister

What was the main contribution of Edward Jenner to the field of medicine?

  • Development of the smallpox vaccine (correct)
  • Invention of the microscope
  • Discovery of the germ theory of disease
  • Discovery of microorganisms

What was the significance of Louis Pasteur's experiment in 1864?

  • Invention of the microscope
  • Demonstration of spontaneous generation
  • Discovery of microorganisms
  • Demonstration that fermentation is caused by microorganisms (correct)

What was the significance of Louis Pasteur's discovery in 1877?

<p>Obtaining pure cultures of microorganisms in liquid medium (C)</p> Signup and view all the answers

What was the main contribution of Joseph Lister to the field of medicine?

<p>Introduction of antiseptic surgery (C)</p> Signup and view all the answers

What are the criteria for establishing that an organism is the cause of a disease, according to Robert Koch?

<p>Found in all cases of the disease and absent in healthy organisms (A)</p> Signup and view all the answers

What was the significance of Louis Pasteur's discovery in 1885?

<p>Discovery of the aetiological factor of rabies - 'virus' (D)</p> Signup and view all the answers

What was the significance of Anton van Leeuwenhoek's observations?

<p>Discovery of microorganisms (A)</p> Signup and view all the answers

What generation of fluoroquinolones has broad anaerobic coverage?

<p>*trovafloxacin generation (A)</p> Signup and view all the answers

What is the mechanism of DNA Gyrase inhibition by quinolones?

<p>Formation of quinolone-DNA-Gyrase complex (C)</p> Signup and view all the answers

Which of the following is a unique quality of ciprofloxacin?

<p>It binds divalent cations, decreasing absorption (A)</p> Signup and view all the answers

What is the consequence of quinolone interaction with antacids?

<p>Decreased absorption of quinolones (D)</p> Signup and view all the answers

Which of the following is NOT a side effect of quinolones?

<p>Rash and pruritus (D)</p> Signup and view all the answers

What is the spectrum of activity of levofloxacin?

<p>Gram- rods, Strept. pneumoniae, and atypicals (D)</p> Signup and view all the answers

What is the pharmacokinetic/pharmacodynamic (PK/PD) characteristic of quinolones?

<p>Combination of time-dependent and concentration-dependent killing (D)</p> Signup and view all the answers

What is the indication for ciprofloxacin in anthrax exposure?

<p>Both treatment and prophylaxis (A)</p> Signup and view all the answers

What is the primary purpose of direct specimen staining in microbiology?

<p>To evaluate microbial morphology (C)</p> Signup and view all the answers

What is the term for 'cells agglomeration' or 'a clone' of the same species originating from one mother cell on a solid media?

<p>Colony (C)</p> Signup and view all the answers

What is the duration of action of Procaine PenG?

<p>12 hours (B)</p> Signup and view all the answers

What type of microorganisms require a specific range of oxygen concentration (2-8%) for growth?

<p>Microaerophiles (B)</p> Signup and view all the answers

What is the term for the ability of a microorganism to express virulence factors?

<p>Virulence (B)</p> Signup and view all the answers

Which of the following is a drug of choice for Listeria monocytogenes and Enterococcus?

<p>Ampicillin (A)</p> Signup and view all the answers

What is the minimum pH required for the growth of Thiobacillus thiooxidans?

<p>0.5 (B)</p> Signup and view all the answers

What is the indication for using Benzathine Pen?

<p>Syphilis (A)</p> Signup and view all the answers

What is the optimal temperature range for the growth of Listeria monocytogenes?

<p>30-37°C (D)</p> Signup and view all the answers

What is the common adverse reaction of Ampicillin and Amoxicillin when associated with a viral illness?

<p>Non-allergic rash (C)</p> Signup and view all the answers

What is the advantage of Amoxicillin over Ampicillin?

<p>Better tolerance (B)</p> Signup and view all the answers

What is the term for the measure of microbial pathogenicity, including contagiousness, invasiveness, and toxicity?

<p>Pathogenicity (B)</p> Signup and view all the answers

What is the spectrum of Piperacillin?

<p>Most Enterobacteriaceae (A)</p> Signup and view all the answers

What is the maximum temperature tolerated by Staphylococcus aureus?

<p>45°C (A)</p> Signup and view all the answers

What is the mechanism of action of β-lactamase inhibitors?

<p>Steric inhibition (B)</p> Signup and view all the answers

What is the combination of Clavulanic Acid with?

<p>Amoxicillin (D)</p> Signup and view all the answers

What is the primary goal of guided treatment?

<p>To use an antimicrobial with a narrow spectrum (C)</p> Signup and view all the answers

What is the main difference between bacterial and eukaryotic cell walls that makes antimicrobials targeting cell wall synthesis safe for humans?

<p>The presence of peptidoglycan in bacterial cell walls (A)</p> Signup and view all the answers

What is the mechanism of action of β-lactam drugs?

<p>They inhibit the function of penicillin-binding proteins (D)</p> Signup and view all the answers

What is the result of the inhibition of peptide bridge formation between glycan molecules in bacterial cell walls?

<p>The cell wall develops weak points at the growth sites and becomes fragile (B)</p> Signup and view all the answers

What is the primary concern when combining antimicrobial drugs?

<p>The antagonistic effect of the drugs (A)</p> Signup and view all the answers

What is the advantage of using antimicrobials that inhibit cell wall synthesis?

<p>They have a high therapeutic index (A)</p> Signup and view all the answers

What is a critical step in the clinical thinking process when deciding whether to use antimicrobial treatment?

<p>Determining whether antimicrobial treatment is absolutely required (D)</p> Signup and view all the answers

What is the consequence of the weakness in the bacterial cell wall caused by antimicrobials that inhibit cell wall synthesis?

<p>The cell lyses (A)</p> Signup and view all the answers

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