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Questions and Answers
Which of the following is primarily controlled by the Autonomic Nervous System (ANS)?
Which of the following is primarily controlled by the Autonomic Nervous System (ANS)?
What is the primary anatomical distinction between the sympathetic and parasympathetic nervous systems in terms of preganglionic fiber length?
What is the primary anatomical distinction between the sympathetic and parasympathetic nervous systems in terms of preganglionic fiber length?
Which description accurately reflects the anatomical origin of the sympathetic nervous system?
Which description accurately reflects the anatomical origin of the sympathetic nervous system?
The somatic nervous system is principally responsible for:
The somatic nervous system is principally responsible for:
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Where do the preganglionic fibers of the parasympathetic nervous system originate?
Where do the preganglionic fibers of the parasympathetic nervous system originate?
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Which of the following is considered a function of the autonomic nervous system (ANS)?
Which of the following is considered a function of the autonomic nervous system (ANS)?
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The ganglia of the sympathetic nervous system are typically located:
The ganglia of the sympathetic nervous system are typically located:
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What is a major difference between the somatic and autonomic nervous systems with respect to control?
What is a major difference between the somatic and autonomic nervous systems with respect to control?
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Which glial cells form the blood-brain barrier, protecting the central nervous system from blood-borne infections and some medications?
Which glial cells form the blood-brain barrier, protecting the central nervous system from blood-borne infections and some medications?
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What is the primary function of microglia in the nervous tissue?
What is the primary function of microglia in the nervous tissue?
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Which type of glial cell is responsible for lining the ventricles of the brain and forming a barrier with the cerebrospinal fluid?
Which type of glial cell is responsible for lining the ventricles of the brain and forming a barrier with the cerebrospinal fluid?
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Which of the following best describes the function of an efferent neuron?
Which of the following best describes the function of an efferent neuron?
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What is the role of interneurons in neural pathways?
What is the role of interneurons in neural pathways?
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What is meant by convergence in the context of neuronal pathways?
What is meant by convergence in the context of neuronal pathways?
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What is the primary function of the sensory (afferent) portion of the nervous system?
What is the primary function of the sensory (afferent) portion of the nervous system?
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Which of the following options best describes divergence in the context of neuronal function?
Which of the following options best describes divergence in the context of neuronal function?
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How do neurons transmit information to other neurons or organs?
How do neurons transmit information to other neurons or organs?
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What is a key characteristic of chemical neurotransmission compared to electrical neurotransmission?
What is a key characteristic of chemical neurotransmission compared to electrical neurotransmission?
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Which of the following best describes the function of neurons?
Which of the following best describes the function of neurons?
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What is the main role of glial cells in the nervous system?
What is the main role of glial cells in the nervous system?
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What is the approximate proportion of glial cells in the CNS by cell count?
What is the approximate proportion of glial cells in the CNS by cell count?
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What is the role of Schwann cells in the peripheral nervous system (PNS)?
What is the role of Schwann cells in the peripheral nervous system (PNS)?
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What are the small gaps between Schwann cells along an axon called?
What are the small gaps between Schwann cells along an axon called?
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Which type of glial cell produces myelinated fibers in the central nervous system?
Which type of glial cell produces myelinated fibers in the central nervous system?
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What neurotransmitter is primarily released by all preganglionic neurons?
What neurotransmitter is primarily released by all preganglionic neurons?
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Which system primarily uses norepinephrine at the postganglionic level?
Which system primarily uses norepinephrine at the postganglionic level?
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Where does the sympathetic nervous system primarily originate?
Where does the sympathetic nervous system primarily originate?
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What characterizes the postganglionic fibers of the parasympathetic nervous system?
What characterizes the postganglionic fibers of the parasympathetic nervous system?
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What is a unique aspect of postganglionic sympathetic neurons related to sweat glands?
What is a unique aspect of postganglionic sympathetic neurons related to sweat glands?
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Which type of receptors do postganglionic parasympathetic neurons utilize?
Which type of receptors do postganglionic parasympathetic neurons utilize?
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How many neurons are typically involved in each effector neuronal pathway of the autonomic nervous system?
How many neurons are typically involved in each effector neuronal pathway of the autonomic nervous system?
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Which of the following statements about the autonomic nervous system is correct?
Which of the following statements about the autonomic nervous system is correct?
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What is the primary role of the parasympathetic nervous system?
What is the primary role of the parasympathetic nervous system?
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Which process is increased by sympathetic nervous system activation?
Which process is increased by sympathetic nervous system activation?
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What neurotransmitter is converted from dopamine in norepinephrine neurons?
What neurotransmitter is converted from dopamine in norepinephrine neurons?
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What physiological effect is generally associated with increased alpha-adrenergic receptor activation?
What physiological effect is generally associated with increased alpha-adrenergic receptor activation?
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What is the concept of dual innervation in the autonomic nervous system?
What is the concept of dual innervation in the autonomic nervous system?
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Which enzyme is considered the rate-limiting step in catecholamine synthesis?
Which enzyme is considered the rate-limiting step in catecholamine synthesis?
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What does receptor up-regulation typically result from?
What does receptor up-regulation typically result from?
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What role do autoreceptors play in neurotransmission?
What role do autoreceptors play in neurotransmission?
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Which of the following adrenergic receptors is primarily associated with decreasing or relaxing effects?
Which of the following adrenergic receptors is primarily associated with decreasing or relaxing effects?
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Which type of receptors are activated by substances other than neurotransmitters released from the presynaptic neuron?
Which type of receptors are activated by substances other than neurotransmitters released from the presynaptic neuron?
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Which metabolic effect does the sympathetic nervous system primarily promote?
Which metabolic effect does the sympathetic nervous system primarily promote?
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What is the effect of catecholamines released from the adrenal medulla?
What is the effect of catecholamines released from the adrenal medulla?
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Which processes are characterized by antagonistic actions in the autonomic nervous system?
Which processes are characterized by antagonistic actions in the autonomic nervous system?
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Which effect characterizes the activation of β1 adrenergic receptors?
Which effect characterizes the activation of β1 adrenergic receptors?
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What effect does norepinephrine have on gastrointestinal activity?
What effect does norepinephrine have on gastrointestinal activity?
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Which receptor subtype is blocked by prazosin?
Which receptor subtype is blocked by prazosin?
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Which neurotransmitter is primarily involved in the sympathetic nervous system?
Which neurotransmitter is primarily involved in the sympathetic nervous system?
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What is the primary mechanism by which α2 receptor activation affects sympathetic tone?
What is the primary mechanism by which α2 receptor activation affects sympathetic tone?
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Which receptor subtype is responsible for smooth muscle relaxation through adenylyl cyclase stimulation?
Which receptor subtype is responsible for smooth muscle relaxation through adenylyl cyclase stimulation?
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Which of the following statements is true regarding β2 receptors?
Which of the following statements is true regarding β2 receptors?
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What is the role of tyrosine hydroxylase in catecholamine synthesis?
What is the role of tyrosine hydroxylase in catecholamine synthesis?
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What is the physiological effect of β3 receptor activation?
What is the physiological effect of β3 receptor activation?
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Which signaling pathway is primarily activated by β1 receptors in the heart?
Which signaling pathway is primarily activated by β1 receptors in the heart?
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Which of the following best describes the action of dopamine D2 receptors?
Which of the following best describes the action of dopamine D2 receptors?
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Which adrenoreceptor subtype is primarily involved in causing vasoconstriction of smooth vasculature?
Which adrenoreceptor subtype is primarily involved in causing vasoconstriction of smooth vasculature?
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What is the effect of β1 receptor agonism on cardiac function?
What is the effect of β1 receptor agonism on cardiac function?
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Which neurotransmitter is released by all preganglionic neurons in the autonomic nervous system?
Which neurotransmitter is released by all preganglionic neurons in the autonomic nervous system?
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What is the main second messenger activated by α1 receptors?
What is the main second messenger activated by α1 receptors?
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Which receptor is primarily targeted by experimental drugs aimed at treating obesity?
Which receptor is primarily targeted by experimental drugs aimed at treating obesity?
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Flashcards
Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
The part of the nervous system responsible for controlling bodily functions that are not consciously controlled (e.g., heart rate, digestion, breathing). Examples include the sympathetic and parasympathetic nervous systems.
Sympathetic Nervous System (SNS)
Sympathetic Nervous System (SNS)
The division of the ANS that is responsible for "fight or flight" responses; involved in stress responses and preparing the body for physical activity.
Parasympathetic Nervous System (PNS)
Parasympathetic Nervous System (PNS)
The division of the ANS that is responsible for "rest and digest" functions; conserves energy, slows heart rate, and promotes digestion.
Somatic Nervous System
Somatic Nervous System
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Central Nervous System (CNS)
Central Nervous System (CNS)
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Peripheral Nervous System (PNS)
Peripheral Nervous System (PNS)
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Motor (efferent) portion of the nervous system
Motor (efferent) portion of the nervous system
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Sensory (afferent) portion of the nervous system
Sensory (afferent) portion of the nervous system
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Oligodendrocytes
Oligodendrocytes
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Astrocytes
Astrocytes
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Microglia
Microglia
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Ependymal Cells
Ependymal Cells
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Neurons
Neurons
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Axon
Axon
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Dendrites
Dendrites
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Synapse
Synapse
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What is the efferent nervous system?
What is the efferent nervous system?
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Which neurotransmitters are used by the efferent nervous system?
Which neurotransmitters are used by the efferent nervous system?
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What neurotransmitter do preganglionic neurons release?
What neurotransmitter do preganglionic neurons release?
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What neurotransmitter do postganglionic parasympathetic neurons release?
What neurotransmitter do postganglionic parasympathetic neurons release?
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What neurotransmitter do most postganglionic sympathetic neurons release?
What neurotransmitter do most postganglionic sympathetic neurons release?
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How do the sympathetic and parasympathetic nervous systems differ?
How do the sympathetic and parasympathetic nervous systems differ?
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Describe the pathway of the autonomic nervous system.
Describe the pathway of the autonomic nervous system.
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Glial cells
Glial cells
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Where do the sympathetic and parasympathetic nerves originate?
Where do the sympathetic and parasympathetic nerves originate?
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Schwann cells
Schwann cells
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Nodes of Ranvier
Nodes of Ranvier
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Myelin sheath
Myelin sheath
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Chemical neurotransmission
Chemical neurotransmission
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Electrical neurotransmission
Electrical neurotransmission
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Distinguish between chemical and electrical neurotransmission
Distinguish between chemical and electrical neurotransmission
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Parasympathetic Nervous System function
Parasympathetic Nervous System function
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Sympathetic Nervous System function
Sympathetic Nervous System function
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Adrenal Cortex function
Adrenal Cortex function
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Adrenal Medulla function
Adrenal Medulla function
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Sympathetic Nervous System effect: Glycogenolysis
Sympathetic Nervous System effect: Glycogenolysis
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Sympathetic Nervous System effect: Glycogen phosphorylase
Sympathetic Nervous System effect: Glycogen phosphorylase
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Sympathetic Nervous System effect: Glycogenesis
Sympathetic Nervous System effect: Glycogenesis
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Sympathetic Nervous System effect: Glycolysis
Sympathetic Nervous System effect: Glycolysis
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Sympathetic Nervous System effect: Lipolysis
Sympathetic Nervous System effect: Lipolysis
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Sympathetic Nervous System effect: Triglyceride lipase
Sympathetic Nervous System effect: Triglyceride lipase
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Dual innervation of organs
Dual innervation of organs
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Dual innervation: Opposing actions
Dual innervation: Opposing actions
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Dual innervation: Homeostasis
Dual innervation: Homeostasis
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Dual innervation: Rapid adaptation
Dual innervation: Rapid adaptation
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Neurotransmission pathways: Sympathetic nervous system
Neurotransmission pathways: Sympathetic nervous system
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Norepinephrine's effect on GI activity
Norepinephrine's effect on GI activity
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Interfering with sympathetic neurotransmission
Interfering with sympathetic neurotransmission
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Therapeutic targets in sympathetic neurotransmission
Therapeutic targets in sympathetic neurotransmission
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Alpha adrenoreceptor selectivity
Alpha adrenoreceptor selectivity
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Beta adrenoreceptor selectivity
Beta adrenoreceptor selectivity
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Dopamine adrenoreceptor function
Dopamine adrenoreceptor function
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Receptor selectivity in drugs
Receptor selectivity in drugs
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Epinephrine's concentration-dependent selectivity
Epinephrine's concentration-dependent selectivity
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Alpha-1 receptor activation pathway
Alpha-1 receptor activation pathway
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Alpha-2 receptor activation pathway
Alpha-2 receptor activation pathway
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Beta receptor activation pathway
Beta receptor activation pathway
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Dopamine receptor activation pathways
Dopamine receptor activation pathways
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Nervous system organization
Nervous system organization
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Glial cells and neurons
Glial cells and neurons
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Catecholamine synthesis and metabolism
Catecholamine synthesis and metabolism
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Study Notes
Course Information
- Course title: Introduction to the Autonomic Nervous System
- Course code: PHID1502
- Winter quarter: 2024/2025
- Required reading: Foye's, Sixth Edition – Chapter 13, pages 392–416; Foye's, Fifth Edition Online – Chapter 10
- Recommended reading: Katzung, Eleventh Edition - Chapter 6, pages 77–94.
- Instructor: Oliver Grundmann, Ph.D.
Nervous System Overview
- Central Nervous System (CNS): Brain and spinal cord
- Peripheral Nervous System (PNS): Neuronal tissue outside the CNS
- Motor (efferent) portion:
- Autonomic Nervous System (ANS): Activities not under conscious control; automatic functions like digestion, cardiac output, blood flow to organs, temperature regulation
- Somatic Nervous System: Consciously controlled functions like movement, respiration rate, and posture
Autonomic Nervous System (ANS)
- Anatomical division:
- Sympathetic Nervous System (SNS): Thoracolumbar; short preganglionic fibers leaving the CNS through thoracic and lumbar spinal nerves; ganglia close to the spinal cord.
- Parasympathetic Nervous System (PNS): Craniosacral; long preganglionic fibers leaving the CNS through cranial nerves and sacral spinal roots; ganglia near the innervated tissues.
Nervous System Neurotransmission
- Sensory (afferent) portion provides feedback from internal and external environments, modifying motor output through reflex arcs.
- Chemical neurotransmission:
- Uses chemicals to transmit information across synaptic clefts onto specialized receptor molecules.
Chemical vs. Electrical Neurotransmission
- Chemical neurotransmission allows for a more distinguished and fine-tuned response.
- Electrical neurotransmission follows an all-or-nothing principle.
Neurotransmitters in Efferent Nervous System
- Two primary neurotransmitters for effector responses in both autonomic (involuntary) and somatic (voluntary) systems:
- Norepinephrine (adrenergic)
- Acetylcholine (cholinergic)
Cells of the Nervous System
- Neurons transmit information
- Glial cells support and protect neurons
Glial Cells
- Make up 90% of CNS cells (50% of volume).
- Mostly non-excitable.
- Provide structural support and insulation (some neurotransmitter systems).
- Neuroglia support neuron functioning.
- In the PNS, Schwann cells wrap around axons, leaving Nodes of Ranvier. Myelin is the lipoprotein material in Schwann cells.
Types of Glial Cells in the CNS
- Oligodendrocytes: Produce myelinated fibers in the CNS.
- Astrocytes: Form a barrier between nervous tissue and blood (Blood-Brain Barrier), protecting the CNS from blood-borne infections.
- Microglia: Phagocytic; digest foreign particles invading the nervous tissue.
- Ependymal cells: Line ventricles of the brain, acting as a barrier between cerebrospinal fluid and nervous tissue.
Neuronal Structure and Function
- Neurons are excitable, generating action potentials when ion concentrations change.
- Receive, process, initiate, and transmit information to other neurons or organs via chemical or electrical signals.
- Neurotransmitters are typically used for information transmission across synapses.
- Four main parts of a neuron: cell body, axon, dendrites, and terminal (synapse).
- Allows extensive information sharing through convergence and divergence.
Neuronal Signal Transmission Pathways
- Afferent: Transmit information from receptors and organs to the CNS.
- Efferent: Transmit information from the CNS to other neurons or organs.
- Interneurons: Transmit information directly between neurons.
Nervous System - Neurotransmission Summary
- Each effector pathway starts in the CNS and ends at an effector organ.
- A two-neuron pathway for each effector pathway.
- First neuron with its body in the CNS (preganglionic).
- Synapses with second neuron (postganglionic) in a ganglion.
- Postganglionic axons terminate in the effector organ.
Differences Between Sympathetic and Parasympathetic Neurotransmission
- Sympathetic (SNS):
- Originates in thoracic & lumbar spinal cord.
- Short preganglionic fibers.
- Ganglia near spinal cord (paravertebral) or slightly further away (prevertebral).
- Longer postganglionic fibers.
- Parasympathetic (PNS):
- Originates in cranial & sacral spinal cord.
- Long preganglionic fibers.
- Ganglia near effector organs.
- Shorter postganglionic fibers.
Sympathetic and Parasympathetic Pathways
- Diagrams show the pathways for both systems, indicating the neurotransmitters involved (e.g. acetylcholine, norepinephrine, epinephrine).
Sympathetic Nervous System - General Functions
- Adrenal cortex (glucocorticoids, aldosterone, androgens)
- Adrenal medulla (norepinephrine and epinephrine)
- Metabolic Effects (increased glycogenolysis, glycolysis, lipolysis)
Sympathetic Nervous System - Physiological Effects on Organs
- Diagrams and explanations of physiological changes in various organs (e.g., heart rate, blood pressure) in response to sympathetic activation.
Dual Innervation of Effector Organs
- Most visceral organs receive innervation from both sympathetic and parasympathetic nervous systems.
- Usually both systems are somewhat active, with largely opposing actions.
- Homeostatic concept: One system's activity often moderates the opposing one.
- Dual innervation enables rapid changes.
Dual Innervation - Types of Interactions (Organ Responses)
- Table showing opposing effects of sympathetic and parasympathetic discharge on various organs.
Neurotransmission Pathways for the Sympathetic Nervous System
- Diagrams showing the two-neuron pathway with neurotransmitter release, especially norepinephrine and epinephrine.
Neurotransmitter Synthesis Pathways for the Sympathetic Nervous System
- Explains the synthesis of catecholamines (norepinephrine, epinephrine).
Neurotransmitter Metabolism Pathways for the Sympathetic Nervous System
- Explains the metabolism of catecholamines.
Molecular Mechanisms of Adrenoreceptor Activation
- Explains the mechanisms behind G-protein coupled receptors (GPCR) activation. Describes the related intracellular signaling pathways.
Dopamine Receptors
- Effects of dopamine.
Receptor Selectivity
- Describes the differences in receptor selectivity and sensitivity.
Epinephrine – Concentration Dependent Selectivity
- Diagrams portraying how epinephrine's effect changes with concentration
Presynaptic Regulation and Negative Feedback Loop
- Explains how the release of neurotransmitters (particularly norepinephrine) is regulated through auto-receptors and other mechanisms.
Presynaptic Negative Feedback Regulation
- Diagrams show the mechanisms involved in presynaptic feedback control.
Postsynaptic Regulation
- Explains the modulation of receptors by prior activity history (receptor upregulation/downregulation), including mechanisms.
Receptor Regulation
- Describes autoreceptors and heteroreceptors, especially for norepinephrine, influencing parasympathetic neurotransmission.
Interference with Sympathetic Neurotransmission
- Describes various ways drugs modify norepinephrine neurotransmission.
Targets for Therapeutic Interference with Sympathetic Neurotransmission
Effects of Drugs on Nerve Transmission
- Table summarizing how various drugs affect different nervous system functions.
α Adrenoreceptors - Selectivity
- Potency series for various agonists on α receptors (e.g., epinephrine > norepinephrine > isoproterenol).
- Blockers of specific subtypes (e.g., prazosin, yohimbine).
β Adrenoreceptors - Selectivity
- Potency series for various agonists on β receptors (e.g., isoproterenol > epinephrine > norepinephrine).
- Explanations for subtype differences.
Dopamine Adrenoreceptors
- Important actions of dopamine (e.g., in splanchnic, renal vasculature, and brain)
- Limited use of dopamine drugs targeted at specific receptors.
Model Drugs and Adrenoreceptor Selectivity
- Table describing different drugs and their effects on various adrenoreceptor subtypes.
Receptor Selectivity
- Drug preference for specific receptor subtypes.
Epinephrine – Concentration-Dependent Selectivity
- Diagrams and descriptions on how epinephrine's effect changes with the concentration.
Molecular Mechanism of Adrenoreceptor Activation and Intracellular Signaling Cascade
- Detailed explanation of the process, including diagrams. Explains various subtypes' (α1, α2, β1, β2, β3, D1, D2, etc.) downstream signaling pathways impacting various organs and processes (specific effects in several organs).
Summary
- Summary of all the key concepts (autonomic, sympathetic, parasympathetic nervous system, and receptor types).
- Overall concepts, including the functional characteristics of each.
Kahoot!
- Instructions and prizes for Kahoot games are presented.
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Description
Test your knowledge on the Autonomic Nervous System and its functions. This quiz covers key concepts including the differences between the sympathetic and parasympathetic nervous systems, as well as the role of glial cells. Answer questions to reinforce your understanding of human anatomy.