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Questions and Answers
What determines the number of pivoting cross bridges in a muscle fiber during contraction?
What determines the number of pivoting cross bridges in a muscle fiber during contraction?
What is the purpose of muscle tone?
What is the purpose of muscle tone?
Which of the following correctly differentiates between isometric and isotonic contractions?
Which of the following correctly differentiates between isometric and isotonic contractions?
What primarily causes muscle fatigue?
What primarily causes muscle fatigue?
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How is the relative size of a motor unit related to muscle control?
How is the relative size of a motor unit related to muscle control?
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What is the primary factor that determines the tension produced during a twitch in muscle fibers?
What is the primary factor that determines the tension produced during a twitch in muscle fibers?
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Which phase of a twitch involves the propagation of the action potential and the release of calcium ions from the sarcoplasmic reticulum?
Which phase of a twitch involves the propagation of the action potential and the release of calcium ions from the sarcoplasmic reticulum?
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How can muscle tension be increased beyond a single twitch?
How can muscle tension be increased beyond a single twitch?
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Which statement correctly describes a motor unit?
Which statement correctly describes a motor unit?
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What primarily affects the length-tension relationships in muscle fibers?
What primarily affects the length-tension relationships in muscle fibers?
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What maintains high calcium concentration during sustained muscle contraction?
What maintains high calcium concentration during sustained muscle contraction?
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What is NOT a factor that influences muscle tension production?
What is NOT a factor that influences muscle tension production?
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What is the result of sustained muscle contraction without adequate relaxation?
What is the result of sustained muscle contraction without adequate relaxation?
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What is the primary function of muscle spindles found within regular contractile muscle fibers?
What is the primary function of muscle spindles found within regular contractile muscle fibers?
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What type of muscle fiber changes does training typically induce?
What type of muscle fiber changes does training typically induce?
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Which type of cells are primarily responsible for repairing injured skeletal muscle?
Which type of cells are primarily responsible for repairing injured skeletal muscle?
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What is a characteristic of the majority of mature skeletal muscle fiber nuclei?
What is a characteristic of the majority of mature skeletal muscle fiber nuclei?
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What factors influence the precise changes in muscle fibers due to training?
What factors influence the precise changes in muscle fibers due to training?
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What type of contraction occurs when muscle tension exceeds the load while the muscle shortens?
What type of contraction occurs when muscle tension exceeds the load while the muscle shortens?
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What role do antagonists play in muscle movement?
What role do antagonists play in muscle movement?
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How does recruitment of motor units occur during muscle contractions?
How does recruitment of motor units occur during muscle contractions?
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What is true about isometric contractions?
What is true about isometric contractions?
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During sustained contractions, what role do motor units play?
During sustained contractions, what role do motor units play?
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What type of contraction is identified when muscle length decreases while maintaining constant tension?
What type of contraction is identified when muscle length decreases while maintaining constant tension?
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Which muscle group assists the agonists by minimizing unwanted movement during contraction?
Which muscle group assists the agonists by minimizing unwanted movement during contraction?
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How does heightened muscle tone affect voluntary contractions?
How does heightened muscle tone affect voluntary contractions?
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What defines eccentric contractions?
What defines eccentric contractions?
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Which statement about muscle fibers in motor units is correct?
Which statement about muscle fibers in motor units is correct?
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What primary role does ATP play in muscle contraction?
What primary role does ATP play in muscle contraction?
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Which process contributes to the immediate energy supply for muscles during contraction?
Which process contributes to the immediate energy supply for muscles during contraction?
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What is the net gain of ATP from glycolytic catabolism?
What is the net gain of ATP from glycolytic catabolism?
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What happens to pyruvic acid when there is insufficient oxygen during intense exercise?
What happens to pyruvic acid when there is insufficient oxygen during intense exercise?
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How does lactic acid accumulation affect muscle fibers?
How does lactic acid accumulation affect muscle fibers?
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What is the primary source of oxygen for muscle tissues during aerobic respiration?
What is the primary source of oxygen for muscle tissues during aerobic respiration?
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Which of the following contributes to muscle fatigue?
Which of the following contributes to muscle fatigue?
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What does Excess Postexercise Oxygen Consumption (EPOC) refer to?
What does Excess Postexercise Oxygen Consumption (EPOC) refer to?
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What factors can affect the time it takes for the body to recover after exercise?
What factors can affect the time it takes for the body to recover after exercise?
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Which mechanism does not occur simultaneously to generate ATP in muscle cells?
Which mechanism does not occur simultaneously to generate ATP in muscle cells?
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Study Notes
Tension Generation in Muscle Fibers
- The amount of tension produced by a single muscle fiber can vary.
- The number pivoting cross-bridges is determined by:
- Degree of overlap between thick and thin filaments when contraction begins
- Frequency of stimulation by the motor neuron
- Greatest tension is produced within a narrow range of sarcomere lengths.
- A twitch is a single stimulus-contraction-relaxation sequence in a muscle fiber.
- A twitch has three phases:
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Latent Period: Time for action potential to:
- Propagate across sarcolemma
- Release Ca++ from SR
- Contraction Period: Repeated cross-bridge cycles generate tension.
- Relaxation Period: Calcium ion levels reduced in cytosol by SR pumps; tension diminishes.
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Latent Period: Time for action potential to:
- Tension produced during a twitch varies due to:
- Timing and frequency of stimulation.
- Length of fiber at rest.
- Type of muscle fiber.
- Wave summation increases tension with more frequent stimulation.
- Calcium levels remain high, allowing contraction to continue.
- Action potentials are so frequent that the SR cannot pump the Ca++ back.
- Increased tension can be achieved through repeated stimulation.
Tension Production in Skeletal Muscles
- Tension is determined by:
- Total number of muscle fibers stimulated.
- Total tension produced by the individual muscle fibers.
- Motor neurons innervate a subset of muscle fibers.
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Motor unit: A motor neuron controls all the muscle fibers within it.
- Size varies significantly
- Single motor neuron controlling a few muscle fibers provides precise control.
- Single motor neuron controlling thousands of muscle fibers provides less precise control.
- Size varies significantly
- All muscle fibers within a motor unit are the same type.
- Motor units are intermingled throughout the muscle.
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Muscle tone is the resting tension caused by some motor units always being active.
- Higher tone accelerates recruitment during voluntary contractions.
- Makes skeletal muscles more defined.
- Increases resting metabolic rate.
- Recruitment increases the number of active motor units starting with the smallest to the largest.
- During sustained contractions, motor units are activated on a rotating basis to allow for rest and recovery.
Types of Muscle Contractions
-
Isotonic Contractions: tension is constant, but muscle length changes:
- Concentric Contractions: muscle shortens, force generated is greater than external force.
- Eccentric Contractions: muscle lengthens, external force is greater than force generated by the muscle.
- Isometric Contractions: Muscle length remains unchanged because tension does not exceed the load.
Functional Groups of Muscles
- Agonists (Prime Movers): Primary force for movement.
- Antagonists: In contrast to agonist; provide control.
- Synergists: Provide supplemental force, minimize unwanted movement, stabilize joints.
- Fixators: Stabilizing force that anchors bone; provides movement efficiency and prevents injury.
Muscle Metabolism
- Skeletal muscle requires ATP for:
- Na+/K+ pumps to maintain ion gradients.
- Release myosin heads from actin active sites.
- Pump calcium back into the sarcoplasmic reticulum.
- Muscles cannot get ATP from the blood or other tissues.
- ATP present in muscle cells is only sufficient for a few seconds of contraction.
- ATP for contraction comes from three mechanisms that can occur simultaneously:
-
Creatine Phosphate (CP): Provides energy for about 15 seconds.
- Resting muscle fibers produce more ATP than needed.
- Excess ATP is used to synthesize CP.
- CP can transfer P to ADP to generate new ATP.
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Glycolytic Catabolism: Anaerobic process that occurs in the cytosol.
- Glucose from the bloodstream and glycogen are broken down into pyruvic acid.
- Pyruvic acid is converted to lactic acid if not enough oxygen is present.
- Rapid production of lactic acid can lead to muscle fatigue.
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Oxidative Catabolism: Aerobic process that occurs in the mitochondria.
- Pyruvic acid from glycolysis undergoes reactions to produce ATP, CO2, water, and heat.
- Slower process than glycolysis, but yields 30+ ATP.
- Oxygen comes from the blood and myoglobin.
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Creatine Phosphate (CP): Provides energy for about 15 seconds.
Muscle Fatigue
- Inability to maintain a given level of intensity during activity.
- Factors that contribute to fatigue:
- Central Fatigue: Feeling of tiredness; wanting to stop activity.
- Depletion of Metabolites: Glucose, glycogen and creatine phosphate.
- Decreased Oxygen Availability.
- Buildup of Lactic Acid, ADP and Other Chemicals.
- Environmental Conditions: Excessive heat leading to electrolyte imbalances.
Muscle Recovery Period
- Time taken for the body and muscles to return to the pre-exercise state.
- Can take minutes to days depending on intensity.
- Requires:
- Heat dissipation
- Restoration of intra- and extracellular ion concentrations.
- Correction of blood pH.
- EPOC (Excess Postexercise Oxygen Consumption): Increased oxygen intake compared to resting levels.
Types of Muscle Fibers
- Classified based on:
- Speed of contraction
- Primary method of ATP generation (oxidative vs.glycolytic)
- Type I (Slow Oxidative Fibers): Slow contraction speeds, high oxidative capacity.
- Type IIa (Fast Oxidative-Glycolytic Fibers): Fast contraction speeds, intermediate oxidative capacity.
- Type IIb (Fast Glycolytic Fibers): Fast contraction speeds, high glycolytic capacity.
Changes Due to Physical Training
- Muscle fibers can change in response to training, but not in number.
- Endurance Training: Focuses on increasing oxidative capacity and mitochondrial density in fibers.
- Resistance Training: Focuses on increasing size and strength of muscle fibers.
Muscle Spindles and Golgi Tendon Organs
- Muscle Spindles: Sensory structures that monitor the degree of stretching in a muscle.
- Golgi Tendon organs: Sensory structures located in tendons that monitor the degree of tension generated by the muscle.
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Description
Test your knowledge on tension generation in muscle fibers, including the phases of a twitch and factors influencing tension production. Understand the relationship between sarcomere length, frequency of stimulation, and the types of muscle fibers involved. This quiz will cover essential concepts related to muscle contraction and physiology.