Biology Lecture 20: Heme Biosynthesis and Catabolism
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Questions and Answers

What is the primary function of oxidoreductases in biochemical reactions?

  • Catalyze hydrolysis reactions
  • Catalyze oxidation-reduction (redox) reactions (correct)
  • Catalyze the transfer of functional groups from one molecule to another
  • Catalyze the joining of two molecules using ATP for energy
  • What is the term for the condition characterized by an increase in serum total bilirubin level >1.2 mg/dL?

  • Jaundice
  • Hyperbilirubinemia (correct)
  • Hemolytic anemia
  • Liver disease
  • What is the region of an enzyme where substrate molecules bind and undergo a chemical reaction?

  • Catalytic site
  • Binding site
  • Reaction site
  • Active site (correct)
  • What is the end-product of heme catabolism?

    <p>Bilirubin</p> Signup and view all the answers

    Which of the following enzymes is involved in the degradation of heme?

    <p>Hemoxygenase</p> Signup and view all the answers

    What is the term for the different forms of the same enzyme that catalyze the same biochemical reaction?

    <p>Isozymes</p> Signup and view all the answers

    What is the level of bilirubin that indicates jaundice?

    <p>Above 2.5 mg/dL</p> Signup and view all the answers

    What are the precursors for the biosynthesis of heme?

    <p>Glycine and succinylcholine</p> Signup and view all the answers

    What is the effect of a competitive inhibitor on $V_{max}$ and $K_m$?

    <p>$V_{max}$ stays the same, $K_m$ increases</p> Signup and view all the answers

    Which mechanism of enzyme action explains that the enzyme changes its shape when the substrate binds?

    <p>Koshland’s induced fit theory</p> Signup and view all the answers

    What is the clinical significance of CK-MB and CK-MM?

    <p>CK-MB is highly specific for cardiac muscle, CK-MM is found in skeletal muscle</p> Signup and view all the answers

    What occurs to an enzyme after the optimum pH has been exceeded, leading to a decrease in the rate of enzymatic reaction?

    <p>The active site of the enzyme denatures</p> Signup and view all the answers

    What defines the $K_m$ in enzymatic reactions?

    <p>Substrate concentration at half-maximum velocity</p> Signup and view all the answers

    Which of the following is an example of non-competitive inhibition?

    <p>Binding at an allosteric site</p> Signup and view all the answers

    Which are the 5 isoenzymes of Lactate Dehydrogenase?

    <p>LDH1, LDH2, LDH3, LDH4, LDH5</p> Signup and view all the answers

    What is hypervitaminosis?

    <p>Excess storage levels of vitamins leading to toxic symptoms</p> Signup and view all the answers

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