Biology Lecture 20: Heme Biosynthesis and Catabolism

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What is the primary function of oxidoreductases in biochemical reactions?

Catalyze hydrolysis reactions

Catalyze oxidation-reduction (redox) reactions (correct)

Catalyze the transfer of functional groups from one molecule to another

Catalyze the joining of two molecules using ATP for energy

What is the term for the condition characterized by an increase in serum total bilirubin level >1.2 mg/dL?

Jaundice

Hyperbilirubinemia (correct)

Hemolytic anemia

Liver disease

What is the region of an enzyme where substrate molecules bind and undergo a chemical reaction?

Catalytic site

Binding site

Reaction site

Active site (correct)

What is the end-product of heme catabolism?

Bilirubin Signup and view all the answers

Which of the following enzymes is involved in the degradation of heme?

Hemoxygenase Signup and view all the answers

What is the term for the different forms of the same enzyme that catalyze the same biochemical reaction?

Isozymes Signup and view all the answers

What is the level of bilirubin that indicates jaundice?

Above 2.5 mg/dL Signup and view all the answers

What are the precursors for the biosynthesis of heme?

Glycine and succinylcholine Signup and view all the answers

What is the effect of a competitive inhibitor on $V_{max}$ and $K_m$?

$V_{max}$ stays the same, $K_m$ increases Signup and view all the answers

Which mechanism of enzyme action explains that the enzyme changes its shape when the substrate binds?

Koshland’s induced fit theory Signup and view all the answers

What is the clinical significance of CK-MB and CK-MM?

CK-MB is highly specific for cardiac muscle, CK-MM is found in skeletal muscle Signup and view all the answers

What occurs to an enzyme after the optimum pH has been exceeded, leading to a decrease in the rate of enzymatic reaction?

The active site of the enzyme denatures Signup and view all the answers

What defines the $K_m$ in enzymatic reactions?

Substrate concentration at half-maximum velocity Signup and view all the answers

Which of the following is an example of non-competitive inhibition?

Binding at an allosteric site Signup and view all the answers

Which are the 5 isoenzymes of Lactate Dehydrogenase?

LDH1, LDH2, LDH3, LDH4, LDH5 Signup and view all the answers

What is hypervitaminosis?

Excess storage levels of vitamins leading to toxic symptoms Signup and view all the answers

Biology Lecture 20: Heme Biosynthesis and Catabolism

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