Biology Lecture 1: Principles of Inheritance

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Questions and Answers

What is the primary focus of Mendel's discoveries?

  • The synthesis of proteins
  • The patterns of inheritance (correct)
  • The organization of eukaryotic genomes
  • The role of DNA replication

Which of the following best describes the relationship between genes and proteins?

  • Genes are synthesized directly into proteins without any intermediates.
  • Proteins can replicate and repair DNA independently of genes.
  • Genes encode the information needed to synthesize proteins. (correct)
  • Proteins are the only functional product of genetic material.

What method is primarily used to clone DNA?

  • DNA transcription
  • Polymerase chain reaction (PCR) (correct)
  • DNA ligation
  • Gel electrophoresis

What is the role of sex chromosomes in inheritance?

<p>They determine the sex and carry sex-linked traits. (A)</p> Signup and view all the answers

Which stage of reproduction primarily introduces genetic variation?

<p>Meiosis (C)</p> Signup and view all the answers

What is a key characteristic of eukaryotic genomes compared to prokaryotic genomes?

<p>Eukaryotic genomes are organized within a nucleus. (D)</p> Signup and view all the answers

Which process is responsible for the synthesis of RNA from a DNA template?

<p>Transcription (C)</p> Signup and view all the answers

What concept refers to the idea that inherited traits blend together from the parents?

<p>Blending inheritance (C)</p> Signup and view all the answers

What is the term used to describe the physical appearance of an individual?

<p>Phenotype (A)</p> Signup and view all the answers

What does it mean when a trait is described as dominant?

<p>It is always expressed in the phenotype. (A)</p> Signup and view all the answers

Which combination of alleles represents a recessive trait?

<p>pp (B)</p> Signup and view all the answers

What must be true about traits if they are determined by factors according to the assumptions presented?

<p>They exist in pairs. (C)</p> Signup and view all the answers

What is the relationship between genotype and phenotype?

<p>Genotype determines the traits directly observed. (D)</p> Signup and view all the answers

According to the first law of probability, how does one event affect another?

<p>It has no effect on subsequent events. (C)</p> Signup and view all the answers

What characteristics differentiate dominant traits from recessive traits?

<p>Recessive traits are only visible when paired with another recessive allele. (D)</p> Signup and view all the answers

What is a factor in the context of traits?

<p>A gene variant determining a trait. (B)</p> Signup and view all the answers

Which of the following parental genotypes is a product of a monohybrid cross?

<p>Aabb (A)</p> Signup and view all the answers

What is the product of the probabilities of two independent events occurring together?

<p>The product of their individual probabilities (D)</p> Signup and view all the answers

Which set of gametes exhibits evidence of independent assortment?

<p>AB, Ab, aB, ab (C)</p> Signup and view all the answers

In a genetic cross between two heterozygous plants (T/t), what is the expected genotypic ratio of the offspring?

<p>1 T/T : 2 T/t : 1 t/t (B)</p> Signup and view all the answers

What represents the traits in the context of segregation?

<p>Factors represent both dominant and recessive traits (A)</p> Signup and view all the answers

What gametes can be formed by the genotype AaBb?

<p>AB, Ab, aB, ab (C)</p> Signup and view all the answers

What is the phenotypic ratio observed in the F2 generation after segregation?

<p>3:1 (D)</p> Signup and view all the answers

From the cross AaBb x AaBb, what are the expected phenotypic ratios?

<p>9:3:3:1 (C)</p> Signup and view all the answers

Which of the following correctly identifies the gametes from AABb?

<p>AB, Ab (A)</p> Signup and view all the answers

What conclusion can be drawn about the parents of a child born with b-thalassemia?

<p>Both parents are heterozygous carriers (C)</p> Signup and view all the answers

In terms of seed texture, which trait is dominant between R (smooth) and r (rough)?

<p>Only the R trait is dominant (D)</p> Signup and view all the answers

What does the term 'segregation' refer to in the context of genetics?

<p>The separation of alleles during gamete formation (C)</p> Signup and view all the answers

What does a baby diagnosed with b-thalassemia reveal about its genotype?

<p>The genotype is t/t (A)</p> Signup and view all the answers

What term describes an organism that has two identical alleles for a particular gene?

<p>Homozygous (B)</p> Signup and view all the answers

Which term refers to the outward expression of a genetic trait?

<p>Phenotype (A)</p> Signup and view all the answers

If a child is born to two parents who are both heterozygous for a trait, what is the probability that the child will be albino if the alleles are TYR (dominant) and tyr (recessive)?

<p>1/4 (B)</p> Signup and view all the answers

What is the consequence of the law of independent assortment during inheritance?

<p>Alleles from different genes segregate independently (C)</p> Signup and view all the answers

What is the modern term used to describe Mendelian factors that determine traits?

<p>Genes (B)</p> Signup and view all the answers

How many alleles for each gene are typically found in diploid organisms?

<p>Two (C)</p> Signup and view all the answers

What was the primary focus of Gregor Mendel's research?

<p>Heredity and the inheritance of traits in pea plants (C)</p> Signup and view all the answers

In the context of genetics, what do we call the reproductive cells that contain a single set of chromosomes?

<p>Haploid (D)</p> Signup and view all the answers

Which of the following is true about a heterozygous organism?

<p>It possesses different alleles for a gene (D)</p> Signup and view all the answers

Which of the following best describes Mendel's method of cross-pollination?

<p>Removing stamens from one plant before pollinating another (A)</p> Signup and view all the answers

What is one major outcome of Mendel's experiments?

<p>The demonstration that inheritance is predictable and follows certain laws (B)</p> Signup and view all the answers

Which factor did Mendel manipulate in his experiments?

<p>The genetic composition of the pea plants (D)</p> Signup and view all the answers

What did Mendel conclude about true breeding plants?

<p>They produce offspring that consistently exhibit specific traits (A)</p> Signup and view all the answers

How did Mendel's experiments contribute to the field of genetics?

<p>They introduced concepts of dominant and recessive traits (B)</p> Signup and view all the answers

Mendel conducted his key experiments at which location?

<p>The Augustinian Abbey of St Thomas (B)</p> Signup and view all the answers

What is NOT a characteristic of Mendel's approach to studying heredity?

<p>Focus solely on natural occurrences in the garden (D)</p> Signup and view all the answers

Flashcards

Inheritance

The process by which traits are passed from parents to offspring.

Blending Inheritance

An outdated idea suggesting traits mix like paint, losing their original forms in offspring.

Preformation

An early idea suggesting a complete miniature version of the offspring is present in the parent.

Asexual Reproduction

Reproduction without the fusion of gametes (sex cells).

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Sexual Reproduction

Reproduction involving the fusion of gametes from two parents to produce genetically diverse offspring.

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Meiosis

A specialized type of cell division that reduces the chromosome number by half, essential for sexual reproduction.

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Genetic Variation

Differences in the genetic makeup among individuals of a species.

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Mendel's Laws

Rules governing the inheritance of traits discovered by Gregor Mendel, a pioneer in genetics.

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Chromosomes

Threadlike structures in the nucleus containing genes, responsible for carrying genetic information.

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Sex Chromosomes

Chromosomes that determine an individual's sex.

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Sex-Linked Inheritance

Inheritance of traits determined by genes on sex chromosomes, often showing different patterns in males and females.

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DNA Replication

The process of creating identical copies of DNA molecules for cell division.

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DNA Repair

Processes that correct damaged DNA ensuring its integrity.

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Gene to Protein

Instructions contained within genes translate into functional proteins, vital for all life processes.

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RNA Synthesis

The process of creating RNA molecules from a DNA template.

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Hartsoecker (1695)

First scientific theory explaining heredity.

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Mendel's Laws

Foundation of genetics, studying inheritance through pea plants.

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Gregor Mendel

Austrian monk and scientist who studied inheritance patterns in pea plants.

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Pea Plants

Plant species used by Mendel to study inheritance patterns.

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Flower (plant organ)

Plant organ for sexual reproduction, producing gametes (sex cells).

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True-breeding

Plants that consistently produce offspring with the same traits when self-pollinated.

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Blending Inheritance

Obsolete theory suggesting traits blend, like mixing paint.

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Mendel's Experiment

Series of controlled experiments on pea plants to study inheritance.

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Heritable Features

Characteristics passed from parents to offspring.

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Traits

Variations of heritable features.

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Factors (genes)

Units determining traits, often in pairs.

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Dominant Trait

The trait physically seen when two contrasting factors are present.

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Recessive Trait

The less prominent trait masked by a dominant trait.

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Phenotype

The observable characteristics of an organism.

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Genotype

The genetic makeup; the combination of factors responsible for a trait.

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Probability of an event

The chance of an event occurring

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Second Law of Probability

The probability of independent events occurring together is the product of their individual probabilities.

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Punnett Square

A tool used to predict the possible genotypes of offspring in a genetic cross.

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Interpreting Punnett Square Results

Determining the expected ratios of genotypes and phenotypes based on the Punnett Square.

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Segregation

The separation of alleles during gamete formation.

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Homozygous

Having two identical alleles for a particular gene.

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Heterozygous

Having two different alleles for a particular gene.

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Genotype

The genetic makeup of an organism.

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Phenotype

The physical trait resulting from a genotype.

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Recessive Disorder

A genetic disorder needing two copies of a faulty gene (one from each parent) to appear.

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b-thalassemia

A genetic disorder causing reduced hemoglobin production

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AABB Genotype

A homozygous dominant genotype for two traits.

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AaBb Genotype

A heterozygous genotype for two traits.

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Monohybrid Cross

A genetic cross involving one trait.

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Hybrid Genotype

A genotype with one dominant and one recessive allele.

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Parental Gametes

Gametes (sex cells) that originate from the parents in a genetic cross.

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Independent Assortment

The principle that alleles for different traits separate independently during gamete formation.

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Punnett Square

A grid used to predict the possible genotypes of offspring from a genetic cross.

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Genotype

The genetic makeup of an organism.

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Phenotype

The observable characteristics of an organism.

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Gamete Formation

Process of creating sex cells (gametes) by meiosis.

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Dominant allele

An allele that expresses its trait even when paired with a different allele.

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Phenotype

The observable characteristic or trait of an organism.

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Allele

Different forms of a gene.

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Test cross

A genetic cross used to determine the genotype of an organism with a dominant phenotype.

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Law of Segregation

During gamete formation, paired factors (alleles) separate, passing only one factor to each gamete.

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Law of Independent Assortment

Alleles for different traits separate independently during gamete formation.

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Homozygous

Having identical alleles for a particular gene.

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Heterozygous

Having two different alleles for a particular gene.

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Diploid

Having two sets of chromosomes (and therefore alleles) in each cell.

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Gamete

A sex cell containing half the number of chromosomes as a body cell.

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Haploid

Having one set of chromosomes (and therefore alleles).

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Monohybrid Cross

Genetic cross focusing on inheritance of one trait.

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Punnett Square

Grid used to predict possible genotypes of offspring in a genetic cross.

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Genetic Cross

Pairing of parents for examining their traits for offspring.

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Study Notes

Lecture 1: Why Biology? (25 September 2024)

  • YouTube videos on introduction to biology, genetics, and DNA were used for the class.
  • Introduction to the key concepts of heredity, inheritance, and DNA were covered, according to the provided resources.

Lecture 1: Principles of Inheritance (Part II) (25 September 2024)

  • Information processing in living systems.
  • Introduction to heredity, including asexual and sexual reproduction.
  • Meiosis and sexual life cycles along with origins of genetic variations.
  • Mendel's discoveries, further exploring Mendel's laws and genetic principles.
  • Chromosomal basis of inheritance; relating Mendel's principles to chromosomes, Sex chromosomes and sex-linked inheritance, errors and exceptions in chromosomal inheritance.
  • DNA as the genetic material.
  • DNA replication and repair.
  • Gene to protein and synthesis of protein.
  • Organization and control of prokaryotic and eukaryotic genomes, including chromatin structure.
  • Control of gene expression and DNA technology.
  • Genomics, DNA cloning, DNA analysis and practical applications of DNA technology.
  • Genetic basis of development from single cells to multicellular organisms.

Course Evaluation (25 September 2024)

  • Questions from the first part of the course will not be included in the final exam.
  • The exam will consist of 50% of the first and 50% of the second part to achieve 100% of the final score.
  • Attendance, mid-term and final exam are each worth 10 marks.

Topic 1: Laws of Inheritance (LIF101)

  • Learning goals: What is transmitted from parents to progeny?
  • What determines our traits?
  • Do transmissions of these traits follow a certain rule?
  • Investigates the fundamental laws that govern inheritance.

Background Information: Heredity/Inheritance

  • Historical concepts, including preformation and blending inheritance.
  • Preformation theory (1695).
  • Blending inheritance (19th Century):
  • Early conceptions about how characteristics are passed down from one generation to the next.

Mendel's Laws

  • First scientific theory explaining heredity
  • Mendel's experiments and the laws he discovered about inheritance.
  • Mendel's work represent an early example of experimental biology
  • Used pea plants, which are self-pollinating, for his experiments and their traits, like flower color and seed texture
  • Mendel's background - a priest in an Augustinian Monastery.
  • Experimentation with cross-pollination.
  • Discovery of traits, dominant and recessive.
  • The concept of independent assortment.
  • Law of segregation
  • Monohybrid cross
  • Dihybrid ratio.
  • Dihybrid cross
  • Punnett square used to predict offspring (F2) outcomes.

Mendel's Experiment

  • Describes the methodology of Mendel's experiments
  • Diagram of a flower structure: stamen, carpel, petals and sepals
  • Procedures for cross-pollinating peas
  • Diagram of results: plants
  • Data analysis and interpretation.
  • Results and data of inheritance studies.

Genotypic and Phenotypic Ratios in F2 Generations

  • Homozygous and heterozygous genotypes
  • Phenotypes of each genotype in the F2 generation, in the form of ratio 3:1.

End of Essential Concept of Inheritance

  • Application of these concepts, practical use of concepts, applications of these laws, practical applications.

Solving Problems using Mendelian Laws

  • Recessive genetic disorders like beta-thalassemia.
  • Concepts explained with different example problem-solving.
  • Tyrosinase gene, its role in melanin production, and issues with recessive alleles.
  • Determining the probability of offspring inheriting recessive traits, given the genotypes of parents.
  • Problem-solving using allele pairs, gamete types, Punnett squares and probability principles.

Law of Independent Assortment

  • Alleles of different genes are distributed independently of one another, this independent assortment impacting gamete formation.
  • This impact on different combinations or combinations of alleles, leading to more possible outcomes.

Concepts for Revision

  • Alleles, diploid cell, gamete, gene, haploid cell
  • Homozygous genotype, heterozygous genotype, dominant trait, recessive trait
  • Distinguishing between dominant alleles, recessive alleles, homozygous, and heterozygous conditions
  • Define different terms in biology: genotype, phenotype, phenotype.

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