Podcast
Questions and Answers
What is the primary focus of Mendel's discoveries?
What is the primary focus of Mendel's discoveries?
- The synthesis of proteins
- The patterns of inheritance (correct)
- The organization of eukaryotic genomes
- The role of DNA replication
Which of the following best describes the relationship between genes and proteins?
Which of the following best describes the relationship between genes and proteins?
- Genes are synthesized directly into proteins without any intermediates.
- Proteins can replicate and repair DNA independently of genes.
- Genes encode the information needed to synthesize proteins. (correct)
- Proteins are the only functional product of genetic material.
What method is primarily used to clone DNA?
What method is primarily used to clone DNA?
- DNA transcription
- Polymerase chain reaction (PCR) (correct)
- DNA ligation
- Gel electrophoresis
What is the role of sex chromosomes in inheritance?
What is the role of sex chromosomes in inheritance?
Which stage of reproduction primarily introduces genetic variation?
Which stage of reproduction primarily introduces genetic variation?
What is a key characteristic of eukaryotic genomes compared to prokaryotic genomes?
What is a key characteristic of eukaryotic genomes compared to prokaryotic genomes?
Which process is responsible for the synthesis of RNA from a DNA template?
Which process is responsible for the synthesis of RNA from a DNA template?
What concept refers to the idea that inherited traits blend together from the parents?
What concept refers to the idea that inherited traits blend together from the parents?
What is the term used to describe the physical appearance of an individual?
What is the term used to describe the physical appearance of an individual?
What does it mean when a trait is described as dominant?
What does it mean when a trait is described as dominant?
Which combination of alleles represents a recessive trait?
Which combination of alleles represents a recessive trait?
What must be true about traits if they are determined by factors according to the assumptions presented?
What must be true about traits if they are determined by factors according to the assumptions presented?
What is the relationship between genotype and phenotype?
What is the relationship between genotype and phenotype?
According to the first law of probability, how does one event affect another?
According to the first law of probability, how does one event affect another?
What characteristics differentiate dominant traits from recessive traits?
What characteristics differentiate dominant traits from recessive traits?
What is a factor in the context of traits?
What is a factor in the context of traits?
Which of the following parental genotypes is a product of a monohybrid cross?
Which of the following parental genotypes is a product of a monohybrid cross?
What is the product of the probabilities of two independent events occurring together?
What is the product of the probabilities of two independent events occurring together?
Which set of gametes exhibits evidence of independent assortment?
Which set of gametes exhibits evidence of independent assortment?
In a genetic cross between two heterozygous plants (T/t), what is the expected genotypic ratio of the offspring?
In a genetic cross between two heterozygous plants (T/t), what is the expected genotypic ratio of the offspring?
What represents the traits in the context of segregation?
What represents the traits in the context of segregation?
What gametes can be formed by the genotype AaBb?
What gametes can be formed by the genotype AaBb?
What is the phenotypic ratio observed in the F2 generation after segregation?
What is the phenotypic ratio observed in the F2 generation after segregation?
From the cross AaBb x AaBb, what are the expected phenotypic ratios?
From the cross AaBb x AaBb, what are the expected phenotypic ratios?
Which of the following correctly identifies the gametes from AABb?
Which of the following correctly identifies the gametes from AABb?
What conclusion can be drawn about the parents of a child born with b-thalassemia?
What conclusion can be drawn about the parents of a child born with b-thalassemia?
In terms of seed texture, which trait is dominant between R (smooth) and r (rough)?
In terms of seed texture, which trait is dominant between R (smooth) and r (rough)?
What does the term 'segregation' refer to in the context of genetics?
What does the term 'segregation' refer to in the context of genetics?
What does a baby diagnosed with b-thalassemia reveal about its genotype?
What does a baby diagnosed with b-thalassemia reveal about its genotype?
What term describes an organism that has two identical alleles for a particular gene?
What term describes an organism that has two identical alleles for a particular gene?
Which term refers to the outward expression of a genetic trait?
Which term refers to the outward expression of a genetic trait?
If a child is born to two parents who are both heterozygous for a trait, what is the probability that the child will be albino if the alleles are TYR (dominant) and tyr (recessive)?
If a child is born to two parents who are both heterozygous for a trait, what is the probability that the child will be albino if the alleles are TYR (dominant) and tyr (recessive)?
What is the consequence of the law of independent assortment during inheritance?
What is the consequence of the law of independent assortment during inheritance?
What is the modern term used to describe Mendelian factors that determine traits?
What is the modern term used to describe Mendelian factors that determine traits?
How many alleles for each gene are typically found in diploid organisms?
How many alleles for each gene are typically found in diploid organisms?
What was the primary focus of Gregor Mendel's research?
What was the primary focus of Gregor Mendel's research?
In the context of genetics, what do we call the reproductive cells that contain a single set of chromosomes?
In the context of genetics, what do we call the reproductive cells that contain a single set of chromosomes?
Which of the following is true about a heterozygous organism?
Which of the following is true about a heterozygous organism?
Which of the following best describes Mendel's method of cross-pollination?
Which of the following best describes Mendel's method of cross-pollination?
What is one major outcome of Mendel's experiments?
What is one major outcome of Mendel's experiments?
Which factor did Mendel manipulate in his experiments?
Which factor did Mendel manipulate in his experiments?
What did Mendel conclude about true breeding plants?
What did Mendel conclude about true breeding plants?
How did Mendel's experiments contribute to the field of genetics?
How did Mendel's experiments contribute to the field of genetics?
Mendel conducted his key experiments at which location?
Mendel conducted his key experiments at which location?
What is NOT a characteristic of Mendel's approach to studying heredity?
What is NOT a characteristic of Mendel's approach to studying heredity?
Flashcards
Inheritance
Inheritance
The process by which traits are passed from parents to offspring.
Blending Inheritance
Blending Inheritance
An outdated idea suggesting traits mix like paint, losing their original forms in offspring.
Preformation
Preformation
An early idea suggesting a complete miniature version of the offspring is present in the parent.
Asexual Reproduction
Asexual Reproduction
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Sexual Reproduction
Sexual Reproduction
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Meiosis
Meiosis
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Genetic Variation
Genetic Variation
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Mendel's Laws
Mendel's Laws
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Chromosomes
Chromosomes
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Sex Chromosomes
Sex Chromosomes
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Sex-Linked Inheritance
Sex-Linked Inheritance
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DNA Replication
DNA Replication
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DNA Repair
DNA Repair
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Gene to Protein
Gene to Protein
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RNA Synthesis
RNA Synthesis
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Hartsoecker (1695)
Hartsoecker (1695)
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Mendel's Laws
Mendel's Laws
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Gregor Mendel
Gregor Mendel
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Pea Plants
Pea Plants
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Flower (plant organ)
Flower (plant organ)
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True-breeding
True-breeding
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Blending Inheritance
Blending Inheritance
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Mendel's Experiment
Mendel's Experiment
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Heritable Features
Heritable Features
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Traits
Traits
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Factors (genes)
Factors (genes)
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Dominant Trait
Dominant Trait
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Recessive Trait
Recessive Trait
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Phenotype
Phenotype
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Genotype
Genotype
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Probability of an event
Probability of an event
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Second Law of Probability
Second Law of Probability
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Punnett Square
Punnett Square
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Interpreting Punnett Square Results
Interpreting Punnett Square Results
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Segregation
Segregation
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Homozygous
Homozygous
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Heterozygous
Heterozygous
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Genotype
Genotype
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Phenotype
Phenotype
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Recessive Disorder
Recessive Disorder
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b-thalassemia
b-thalassemia
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AABB Genotype
AABB Genotype
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AaBb Genotype
AaBb Genotype
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Monohybrid Cross
Monohybrid Cross
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Hybrid Genotype
Hybrid Genotype
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Parental Gametes
Parental Gametes
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Independent Assortment
Independent Assortment
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Punnett Square
Punnett Square
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Genotype
Genotype
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Phenotype
Phenotype
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Gamete Formation
Gamete Formation
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Dominant allele
Dominant allele
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Phenotype
Phenotype
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Allele
Allele
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Test cross
Test cross
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Law of Segregation
Law of Segregation
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Law of Independent Assortment
Law of Independent Assortment
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Homozygous
Homozygous
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Heterozygous
Heterozygous
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Diploid
Diploid
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Gamete
Gamete
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Haploid
Haploid
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Monohybrid Cross
Monohybrid Cross
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Punnett Square
Punnett Square
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Genetic Cross
Genetic Cross
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Study Notes
Lecture 1: Why Biology? (25 September 2024)
- YouTube videos on introduction to biology, genetics, and DNA were used for the class.
- Introduction to the key concepts of heredity, inheritance, and DNA were covered, according to the provided resources.
Lecture 1: Principles of Inheritance (Part II) (25 September 2024)
- Information processing in living systems.
- Introduction to heredity, including asexual and sexual reproduction.
- Meiosis and sexual life cycles along with origins of genetic variations.
- Mendel's discoveries, further exploring Mendel's laws and genetic principles.
- Chromosomal basis of inheritance; relating Mendel's principles to chromosomes, Sex chromosomes and sex-linked inheritance, errors and exceptions in chromosomal inheritance.
- DNA as the genetic material.
- DNA replication and repair.
- Gene to protein and synthesis of protein.
- Organization and control of prokaryotic and eukaryotic genomes, including chromatin structure.
- Control of gene expression and DNA technology.
- Genomics, DNA cloning, DNA analysis and practical applications of DNA technology.
- Genetic basis of development from single cells to multicellular organisms.
Course Evaluation (25 September 2024)
- Questions from the first part of the course will not be included in the final exam.
- The exam will consist of 50% of the first and 50% of the second part to achieve 100% of the final score.
- Attendance, mid-term and final exam are each worth 10 marks.
Topic 1: Laws of Inheritance (LIF101)
- Learning goals: What is transmitted from parents to progeny?
- What determines our traits?
- Do transmissions of these traits follow a certain rule?
- Investigates the fundamental laws that govern inheritance.
Background Information: Heredity/Inheritance
- Historical concepts, including preformation and blending inheritance.
- Preformation theory (1695).
- Blending inheritance (19th Century):
- Early conceptions about how characteristics are passed down from one generation to the next.
Mendel's Laws
- First scientific theory explaining heredity
- Mendel's experiments and the laws he discovered about inheritance.
- Mendel's work represent an early example of experimental biology
- Used pea plants, which are self-pollinating, for his experiments and their traits, like flower color and seed texture
- Mendel's background - a priest in an Augustinian Monastery.
- Experimentation with cross-pollination.
- Discovery of traits, dominant and recessive.
- The concept of independent assortment.
- Law of segregation
- Monohybrid cross
- Dihybrid ratio.
- Dihybrid cross
- Punnett square used to predict offspring (F2) outcomes.
Mendel's Experiment
- Describes the methodology of Mendel's experiments
- Diagram of a flower structure: stamen, carpel, petals and sepals
- Procedures for cross-pollinating peas
- Diagram of results: plants
- Data analysis and interpretation.
- Results and data of inheritance studies.
Genotypic and Phenotypic Ratios in F2 Generations
- Homozygous and heterozygous genotypes
- Phenotypes of each genotype in the F2 generation, in the form of ratio 3:1.
End of Essential Concept of Inheritance
- Application of these concepts, practical use of concepts, applications of these laws, practical applications.
Solving Problems using Mendelian Laws
- Recessive genetic disorders like beta-thalassemia.
- Concepts explained with different example problem-solving.
- Tyrosinase gene, its role in melanin production, and issues with recessive alleles.
- Determining the probability of offspring inheriting recessive traits, given the genotypes of parents.
- Problem-solving using allele pairs, gamete types, Punnett squares and probability principles.
Law of Independent Assortment
- Alleles of different genes are distributed independently of one another, this independent assortment impacting gamete formation.
- This impact on different combinations or combinations of alleles, leading to more possible outcomes.
Concepts for Revision
- Alleles, diploid cell, gamete, gene, haploid cell
- Homozygous genotype, heterozygous genotype, dominant trait, recessive trait
- Distinguishing between dominant alleles, recessive alleles, homozygous, and heterozygous conditions
- Define different terms in biology: genotype, phenotype, phenotype.
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