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Questions and Answers
What is the ploidy level of gametes produced by meiosis?
What is the ploidy level of gametes produced by meiosis?
- Tetraploid
- Haploid (correct)
- Diploid
- Triploid
How many chromosomes are present in a germ cell prior to meiosis?
How many chromosomes are present in a germ cell prior to meiosis?
- 23 chromosomes
- 40 chromosomes
- 46 chromosomes (correct)
- 92 chromosomes
Which process involves the union of homologs during meiosis?
Which process involves the union of homologs during meiosis?
- Synapsis (correct)
- Differentiation
- Replication
- Cytokinesis
What is the function of the gonads in the context of germ cells?
What is the function of the gonads in the context of germ cells?
What type of division occurs during meiosis I?
What type of division occurs during meiosis I?
During which stage are dyads formed?
During which stage are dyads formed?
Which term describes the genetic makeup represented by 'N'?
Which term describes the genetic makeup represented by 'N'?
What is the outcome of meiosis in terms of chromosome number?
What is the outcome of meiosis in terms of chromosome number?
What change occurs to chromosome structure before meiosis begins?
What change occurs to chromosome structure before meiosis begins?
How many daughter cells are produced at the end of meiosis?
How many daughter cells are produced at the end of meiosis?
Which theory suggests that DNA is inherited from all body parts?
Which theory suggests that DNA is inherited from all body parts?
Who disproved the theory of Pangenesis using the rat experiment?
Who disproved the theory of Pangenesis using the rat experiment?
What does Blending Inheritance propose about offspring traits?
What does Blending Inheritance propose about offspring traits?
In genetics, what do independent events refer to?
In genetics, what do independent events refer to?
When using the Rule of Multiplication, what does it calculate?
When using the Rule of Multiplication, what does it calculate?
What is the term for traits acquired by an organism that can be passed down to offspring?
What is the term for traits acquired by an organism that can be passed down to offspring?
What does the term 'mutually exclusive events' refer to in probability?
What does the term 'mutually exclusive events' refer to in probability?
In the context of genetics, what do gametes contribute to?
In the context of genetics, what do gametes contribute to?
Which example illustrates a binomial probability scenario?
Which example illustrates a binomial probability scenario?
Which of the following statements best summarizes the Germ-Plasm Theory?
Which of the following statements best summarizes the Germ-Plasm Theory?
What is the primary distinction between sexual and asexual reproduction?
What is the primary distinction between sexual and asexual reproduction?
Which phase of the eukaryotic cell cycle is primarily responsible for DNA replication?
Which phase of the eukaryotic cell cycle is primarily responsible for DNA replication?
In meiosis, which statement accurately describes the outcome?
In meiosis, which statement accurately describes the outcome?
What are cohesins primarily responsible for during cell replication?
What are cohesins primarily responsible for during cell replication?
During which phase do the chromosomes line up at the equatorial plane?
During which phase do the chromosomes line up at the equatorial plane?
What is the Hayflick limit associated with in cellular biology?
What is the Hayflick limit associated with in cellular biology?
Which structures are primarily involved in the separation of sister chromatids during anaphase?
Which structures are primarily involved in the separation of sister chromatids during anaphase?
What kind of chromosomes contain the same gene order but may differ in alleles?
What kind of chromosomes contain the same gene order but may differ in alleles?
What is the primary role of the centrosome during cell division?
What is the primary role of the centrosome during cell division?
Which of the following statements about prokaryotic binary fission is accurate?
Which of the following statements about prokaryotic binary fission is accurate?
During which phase are the nuclear envelope and nucleolus reformed?
During which phase are the nuclear envelope and nucleolus reformed?
What are alleles?
What are alleles?
What is a defining feature of triploid organisms?
What is a defining feature of triploid organisms?
Which protein is primarily responsible for degrading securin during anaphase?
Which protein is primarily responsible for degrading securin during anaphase?
What is the primary outcome of spermatogenesis?
What is the primary outcome of spermatogenesis?
Which process during oogenesis results in the production of polar bodies?
Which process during oogenesis results in the production of polar bodies?
After cytokinesis in oogenesis, how many viable gametes are produced?
After cytokinesis in oogenesis, how many viable gametes are produced?
What is the role of independent assortment in genetics?
What is the role of independent assortment in genetics?
What is the result of chemical stimulation during spermatogenesis?
What is the result of chemical stimulation during spermatogenesis?
Which model organism was primarily used by Mendel for genetic research?
Which model organism was primarily used by Mendel for genetic research?
What describes the gametes produced during spermatogenesis?
What describes the gametes produced during spermatogenesis?
What is the final result of sperm differentiation in spermatogenesis?
What is the final result of sperm differentiation in spermatogenesis?
Which aspect of oogenesis differs significantly from spermatogenesis?
Which aspect of oogenesis differs significantly from spermatogenesis?
What is produced during the first meiotic division in oogenesis?
What is produced during the first meiotic division in oogenesis?
What is the primary purpose of colchicine in cell biology?
What is the primary purpose of colchicine in cell biology?
Which type of mutation specifically involves a change in a single base pair?
Which type of mutation specifically involves a change in a single base pair?
What characterizes a balanced chromosomal rearrangement?
What characterizes a balanced chromosomal rearrangement?
Which of the following describes germ-line mutations?
Which of the following describes germ-line mutations?
Which of the following accurately defines aneuploidy?
Which of the following accurately defines aneuploidy?
What is a key characteristic of somatic cells?
What is a key characteristic of somatic cells?
Which term best describes a mutation that alters one part of a chromosome?
Which term best describes a mutation that alters one part of a chromosome?
What effect does an unbalanced chromosomal rearrangement typically have on a cell?
What effect does an unbalanced chromosomal rearrangement typically have on a cell?
What is the consequence of chromosomal mutations on development?
What is the consequence of chromosomal mutations on development?
How are mutations classified based on their location in the organism?
How are mutations classified based on their location in the organism?
What does a Monohybrid Cross examine?
What does a Monohybrid Cross examine?
Which of the following accurately describes Incomplete Dominance?
Which of the following accurately describes Incomplete Dominance?
In a Dihybrid Cross, what ratios are typically observed for phenotype?
In a Dihybrid Cross, what ratios are typically observed for phenotype?
What is the significance of Mendel's First Law?
What is the significance of Mendel's First Law?
What does Epistasis refer to in genetics?
What does Epistasis refer to in genetics?
Which blood type is considered the universal donor?
Which blood type is considered the universal donor?
Which of the following describes Codominance?
Which of the following describes Codominance?
What is Penetrance in genetics?
What is Penetrance in genetics?
Nondisjunction can lead to which of the following?
Nondisjunction can lead to which of the following?
What does the equation $2^n$ represent in genetics?
What does the equation $2^n$ represent in genetics?
What type of dominance results in an intermediate phenotype in offspring?
What type of dominance results in an intermediate phenotype in offspring?
If a parent has genotype $Tt$ and another parent has $tt$, what is the possible genotypic ratio of their offspring?
If a parent has genotype $Tt$ and another parent has $tt$, what is the possible genotypic ratio of their offspring?
What is an example of a violation of Mendel's Second Law?
What is an example of a violation of Mendel's Second Law?
In genetics, what does the term 'Hypostatic Loci' refer to?
In genetics, what does the term 'Hypostatic Loci' refer to?
Flashcards
Pangenesis
Pangenesis
The incorrect idea that traits acquired during an organism's lifetime are passed down to offspring. This was proposed by Darwin.
Inheritance of Acquired Characteristics
Inheritance of Acquired Characteristics
The idea that traits gained during an organism's lifetime are inherited by offspring.
Germ-Plasm Theory
Germ-Plasm Theory
The correct theory that inheritance occurs through specific particles (genes) found only in reproductive cells, not the whole body.
Gametes
Gametes
The reproductive cells (sperm and egg) that carry genetic information from parents to offspring.
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Zygote
Zygote
The single cell formed when a sperm fertilizes an egg.
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Simple Probability
Simple Probability
The probability of a single event, expressed as a fraction or decimal.
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Combined Probability
Combined Probability
The probability of multiple events happening together or one after another.
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Rule of Multiplication
Rule of Multiplication
Used to calculate the probability of multiple independent events happening together.
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Rule of Addition
Rule of Addition
Used to calculate the probability of one of multiple mutually exclusive events occurring.
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Binomial Probability
Binomial Probability
Used to calculate the probability of a specific number of successes (or failures) in a series of independent trials.
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Germ cells
Germ cells
Specialized cells that give rise to gametes (sperm or egg cells).
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Chromosome number in germ cells
Chromosome number in germ cells
Germ cells have 46 chromosomes, the same number as a normal body cell.
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Chromosome number in gametes
Chromosome number in gametes
Gametes have 23 chromosomes, half the number found in germ cells and body cells.
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Gonads
Gonads
Organs that produce germ cells (testes in males, ovaries in females).
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Meiosis
Meiosis
A type of cell division that reduces the number of chromosomes in a cell by half, producing gametes.
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Synapsis
Synapsis
The pairing of homologous chromosomes (pairs of chromosomes with similar genes) during meiosis.
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Tetrad
Tetrad
A group of four chromatids (copies of a chromosome) formed by the synapsis of homologous chromosomes.
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Meiosis I (Reduction division)
Meiosis I (Reduction division)
The first stage of meiosis where the number of chromosomes is halved, resulting in two daughter cells with half the number of chromosomes.
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Meiosis II
Meiosis II
The second stage of meiosis, similar to mitosis, where sister chromatids separate, resulting in four daughter cells with half the number of chromosomes.
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Sexual Reproduction
Sexual Reproduction
A type of reproduction involving the genetic contribution of two individuals, resulting in offspring that are genetically distinct.
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Asexual Reproduction
Asexual Reproduction
A type of reproduction involving only one parent, resulting in offspring that are genetically identical clones.
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Prokaryotic Binary Fission
Prokaryotic Binary Fission
A form of asexual reproduction in prokaryotes where a single-celled organism divides into two identical daughter cells.
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Eukaryotic Cell Cycle
Eukaryotic Cell Cycle
The series of stages that a eukaryotic cell goes through during its life, including growth, DNA replication, and division.
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G1 Phase
G1 Phase
The first phase of the eukaryotic cell cycle where the cell grows and carries out normal metabolic activities.
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S Phase
S Phase
The phase of the eukaryotic cell cycle where DNA replication occurs, doubling the amount of genetic material in the cell.
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G2 Phase
G2 Phase
The second growth phase of the eukaryotic cell cycle where the cell prepares for mitosis.
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M Phase
M Phase
The phase of the eukaryotic cell cycle where mitosis and cytokinesis occur, resulting in the division of the cell into two daughter cells.
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Prophase
Prophase
The first stage of mitosis where chromosomes condense, the nuclear envelope breaks down, and the mitotic spindle forms.
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Prometaphase
Prometaphase
The stage of mitosis where the nuclear envelope completely dissolves and the spindle fibers attach to the chromosomes at their kinetochores.
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Metaphase
Metaphase
The stage of mitosis where the chromosomes align along the equatorial plane of the cell, ensuring equal distribution of genetic material.
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Anaphase
Anaphase
The stage of mitosis where the sister chromatids of each chromosome separate and move to opposite poles of the cell.
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Telophase
Telophase
The final stage of mitosis where the chromosomes decondense, the nuclear envelope reforms around each set of chromosomes, and the cell divides.
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Cytokinesis
Cytokinesis
The process of cell division where the cytoplasm divides, resulting in two distinct daughter cells.
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Hayflick Limit
Hayflick Limit
The maximum number of times a normal human cell population can divide before entering senescence or death.
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Karyotype
Karyotype
A visual representation of an organism's complete set of chromosomes arranged in order of size and shape.
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Colchicine
Colchicine
A chemical used to stop cell division at metaphase by destroying spindles, which are structures that separate chromosomes during cell division.
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Mutations
Mutations
Permanent changes in the DNA sequence of a gene or chromosome.
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Somatic Mutations
Somatic Mutations
Mutations that occur in any cell of the body except sperm or egg cells, meaning they are not inherited by offspring.
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Germ-Line Mutations
Germ-Line Mutations
Mutations that occur in sperm or egg cells, meaning they are passed down to offspring.
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Point Mutation
Point Mutation
A mutation affecting a single nucleotide base pair in a DNA sequence.
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Chromosomal Rearrangements
Chromosomal Rearrangements
Mutations involving structural changes in chromosomes, such as deletions, duplications, inversions, and translocations.
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Balanced Chromosomal Rearrangement
Balanced Chromosomal Rearrangement
A chromosomal rearrangement in which no genetic material is lost or gained, so the individual is generally phenotypically normal.
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Unbalanced Chromosomal Rearrangement
Unbalanced Chromosomal Rearrangement
A chromosomal rearrangement in which genetic material is either lost or gained, leading to developmental problems or genetic abnormalities.
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Aneuploidy
Aneuploidy
A condition where an individual has an abnormal number of chromosomes, either more or fewer than the typical two copies of each chromosome.
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Spermatogenesis
Spermatogenesis
The process of sperm cell production in males, starting with a spermatogonium and ending with four mature sperm cells. It includes stages like meiosis and differentiation.
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Random Fertilization
Random Fertilization
The random union of a sperm and an egg during fertilization, contributing to genetic variation in offspring.
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Independent Assortment
Independent Assortment
The random separation of homologous chromosomes during meiosis, leading to different combinations of genes in gametes.
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Polar Body
Polar Body
A small cell produced during oogenesis that contains little cytoplasm and is eventually degraded. It serves to dispose of excess chromosomes.
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Model Organisms
Model Organisms
Organisms chosen for genetic research due to their ease of study and the possibility to make inferences about other organisms.
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Rsum Sativum (Common Garden Pea)
Rsum Sativum (Common Garden Pea)
Mendel's chosen model organism, which was essential in discovering the basic laws of inheritance.
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What is Transformation?
What is Transformation?
A process where a competent bacterial cell takes up DNA from its environment. This DNA was released from another bacterial cell that was lysed. The cell doesn't need to be alive.
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What is Conjugation?
What is Conjugation?
A process where two bacterial cells connect via a tube known as the sex pilus and transfer DNA. Often, this involves plasmids, but it can also involve chromosomal DNA in some bacteria.
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What is Hfr (High-Frequency Recombination) Conjugation?
What is Hfr (High-Frequency Recombination) Conjugation?
A specialized type of conjugation where a cell with an F factor integrated into its chromosome (Hfr) transfers chromosomal DNA to a recipient cell
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What is F' (F prime) Conjugation?
What is F' (F prime) Conjugation?
A type of conjugation where a cell with an F factor that has picked up a piece of the chromosome (F') transfers this DNA to a recipient cell. This is a mix of conjugation and recombination.
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What is Transduction?
What is Transduction?
A process where a virus (bacterial vector) carries DNA from one bacterium to another. It acts as a carrier of DNA.
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What is Generalized Transduction?
What is Generalized Transduction?
A type of transduction where any fragment of bacterial DNA can be transferred via a virus to a recipient cell.
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What is Specialized Transduction?
What is Specialized Transduction?
A type of transduction where a virus (bacteriophage) only picks up specific genes from a bacterial host because it has integrated its DNA into the host's DNA.
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What is a Telomere?
What is a Telomere?
The protective cap at the end of a chromosome that protects the DNA sequence and prevents degradation.
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What is a Centromere?
What is a Centromere?
The constricted region of a chromosome where spindle fibers attach during cell division.
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What is Euchromatin?
What is Euchromatin?
The less condensed form of DNA found in chromosomes that is actively transcribed.
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What is Heterochromatin?
What is Heterochromatin?
The more condensed form of DNA found in chromosomes that is not actively transcribed.
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What are the four types of chromosome structures?
What are the four types of chromosome structures?
Chromosomes are categorized into four types based on their structure. These types are metacentric, sub-metacentric, acrocentric, and telocentric. These structures are determined by the position of the centromere.
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What is a Karyotype?
What is a Karyotype?
The complete set of chromosomes in a cell, organized by size and shape. This is useful for studying chromosome number and structure, and can help detect abnormalities.
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What is a Gene?
What is a Gene?
A segment of DNA that codes for a particular protein or functional RNA.
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What is an Allele?
What is an Allele?
Alternative forms of a gene, found at the same locus on homologous chromosomes. Different alleles can lead to different traits.
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What is a Locus?
What is a Locus?
The specific location of a gene on a chromosome.
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Genetics Overview
- Karyotype: full set of chromosomes in an organism
- Vertical gene transfer: DNA exchange from parent to offspring
- Horizontal gene transfer: DNA exchange between individuals of the same generation (mostly prokaryotes)
- Germplasm refers to reproductive material that's passed down
- Particulate inheritance: traits are inherited as discrete units, not blended
- Mendel's Laws : 1st Law of Segregation, 2nd Law of Independent Assortment
Probability
- Simple probability: (number of desired outcomes)/(total possible outcomes)
- Combined probability: depends on whether events are independent or mutually exclusive
- Independent events ("and"): multiply individual probabilities
- Mutually exclusive events ("either/or"): sum individual probabilities
Prokaryotic Cell Cycle and Binary Fission
- Binary fission: asexual reproduction in prokaryotes
- Chromosome replication occurs during binary fission.
- Prokaryotes don't have a nucleus
- Prokaryotic replication is much quicker than eukaryotic
Eukaryotic Cell Cycle and Mitosis
- Eukaryotes have a nucleus that contains chromosomes.
- Mitosis results in two identical daughter cells
- The process involves 4 stages
- Interphase (growth period)
- Prophase(chromosome condense)
- Metaphase (chromosomes line up)
- Anaphase (sister chromatids separate)
- Telophase (chromosomes arrive at opposite poles)
- Cytokinesis (cell division)
Meiosis
- Meiosis is a type of cell division that produces gametes
- Meiosis involves two rounds of cell division produces four genetically different daughter cells
- Homologous chromosomes pair up during meiosis I
- Crossing over exchange genetic material occurs
- Sister chromatids separate during meiosis II
- Diploid (2n) to haploid (n) gametes
Sex Determination
- Mechanisms: XO, XX/XY, ZW
- Sex-linked genes: located on sex chromosomes, usually X
- Dosage compensation: regulation of X-chromosome gene expression to balance expression in different sexes (in mammals, one X is inactivated)
Genetic Mutations
- Somatic mutations- occur in non-reproductive cells
- Germline mutations - occur in reproductive cells
- Point mutations: change in a single base pair
- Chromosomal mutations: changes in chromosome structure (e.g., deletions, duplications, inversions, translocations)
- Aneuploidy: abnormal number of chromosomes due to nondisjunction (e.g., monosomy, trisomy)
- Polyploidy: having more than two sets of chromosomes (common in plants)
Genetic Variation
- Mutations: changes in the DNA sequence
- Recombination generating new combinations of alleles
- Errors in replication affecting the sequence
- Non-random mating: changes in allelic frequencies
- Natural Selection altering frequencies of alleles depending on their survival value
- Gene Flow allele movement between populations
Non-Mendelian Inheritance
- Mitochondrial: passed down maternally
- Maternal Effect: mother's genotype determines offspring phenotype
- Genomic Imprinting: expression of a gene depends on which parent it's inherited from
- Sex-limited/Sex-influenced traits: traits with different expression in each sex
Genetic Regulation
- Transcriptional Regulation: factors control if/how to transcribe gene
- Epigenetics: modification of gene expression without changes in DNA sequence
- Methylation, Histone modifications
- RNA interference
- Riboswitches (regulatory regions in mRNA)
Genetic Technologies
- Polymerase Chain Reaction (PCR): to copy DNA fragments for analysis
- DNA sequencing: to determine a DNA sequence
- Transformation + Recombinant DNA: Combine DNA segments from different sources/species
Human Genetics
- Pedigrees: Family trees showing the inheritance of traits over generations
- X-linked traits: gene on x-chromosome affects both males and females differently
Bacterial Genetics/Horizontal Gene Transfer
- Transformation
- Transduction
- Conjugation
- Plasmids
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