Biology Chapter on Fertilization and Implantation
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Questions and Answers

What is the term for the fusion of the sperm and egg nuclei?

  • Zygote formation
  • Conception (correct)
  • Acrosome reaction
  • Mitosis
  • What is the normal diploid number of chromosomes found in a zygote?

  • 64
  • 23
  • 32
  • 46 (correct)
  • What is the primary role of progesterone in the early stages of pregnancy?

  • Inhibiting cell division in the blastocyst
  • Prepping the uterine lining for implantation (correct)
  • Stimulating sperm motility
  • Initiating meiotic division in the egg
  • What occurs during implantation that may be mistaken for menstruation?

    <p>Implantation bleeding (A)</p> Signup and view all the answers

    What occurs if the morula arrives in the uterus prematurely?

    <p>It dies. (C)</p> Signup and view all the answers

    What is the solid ball of 16 cells formed by the rapidly dividing zygote called?

    <p>Morula (D)</p> Signup and view all the answers

    What is the primary role of the trophoblast after implantation?

    <p>To form the fetal portion of the placenta (A)</p> Signup and view all the answers

    Which part of the blastocyst is responsible for inserting into the endometrium during implantation?

    <p>Trophoblasts (B)</p> Signup and view all the answers

    What does the inner cell mass of the blastocyst become?

    <p>The embryo (D)</p> Signup and view all the answers

    What happens to the zona pellucida during the implantation process?

    <p>It dissolves. (C)</p> Signup and view all the answers

    What phase follows the formation of the morula during early stages of pregnancy?

    <p>Division into blastocyst (C)</p> Signup and view all the answers

    A triploid cell results from what event during fertilization?

    <p>Polyspermy (C)</p> Signup and view all the answers

    Approximately how many cells does a blastocyst consist of when ready for implantation?

    <p>50 cells (C)</p> Signup and view all the answers

    What is the normal duration of pregnancy counted from?

    <p>The first day of the last menstrual period (B)</p> Signup and view all the answers

    What is the role of the zona pellucida during the early stages of pregnancy?

    <p>To assist in sperm entry (C)</p> Signup and view all the answers

    What major change occurs in the endometrial tissue at the contact site during implantation?

    <p>It undergoes dramatic changes to support the embryo (A)</p> Signup and view all the answers

    During which trimester is the highest rate of miscarriage observed?

    <p>First trimester (week 1–13) (C)</p> Signup and view all the answers

    What is the definition of preterm birth?

    <p>Live birth before the completion of 37 weeks (D)</p> Signup and view all the answers

    What event marks Day 6 in the early stages of pregnancy?

    <p>Implantation of the blastocyst (C)</p> Signup and view all the answers

    What processes begin with spermatozoa penetrating into the egg's corona radiata?

    <p>Fertilization (C)</p> Signup and view all the answers

    Which hormone is not produced by the gonads?

    <p>Oxytocin (D)</p> Signup and view all the answers

    What is the correct sequence of events in fertilization?

    <p>Entry of sperm, ovum uptake, intermingling of chromosomes (D)</p> Signup and view all the answers

    What term is used for a live birth after 42 weeks of pregnancy?

    <p>Post-term birth (C)</p> Signup and view all the answers

    Which of the following is a function of the gonads?

    <p>Secretion of sex hormones (B)</p> Signup and view all the answers

    What characterizes the placenta's hormone secretion?

    <p>It depends mainly on the stage of pregnancy. (B)</p> Signup and view all the answers

    Which hormone is produced first by the developing chorion?

    <p>hCG (C)</p> Signup and view all the answers

    What is a primary function of hCG during early pregnancy?

    <p>It maintains the corpus luteum to prevent menstrual flow. (C)</p> Signup and view all the answers

    Which hormone secreted by the placenta is crucial for masculinizing the fetal reproductive tract?

    <p>Testosterone (C)</p> Signup and view all the answers

    What role does hPL (human placental lactogen) play during pregnancy?

    <p>Supports maternal metabolic adaptation. (C)</p> Signup and view all the answers

    Which of the following hormones is NOT primarily secreted by the placenta?

    <p>Thyroid hormones (D)</p> Signup and view all the answers

    Which statement about the placenta is true?

    <p>It is formed by tissues from both the mother and the fetus. (A)</p> Signup and view all the answers

    What is the effect of oxytocin during pregnancy?

    <p>Stimulates contraction of the uterine muscles during labor. (B)</p> Signup and view all the answers

    What is the primary function of progesterone in the uterus?

    <p>Inhibits uterine contractions, preventing premature delivery (D)</p> Signup and view all the answers

    Which hormone significantly increases uterine responsiveness to oxytocin during pregnancy?

    <p>Estrogen (D)</p> Signup and view all the answers

    What is the primary source of estrogen during pregnancy?

    <p>Placenta (B)</p> Signup and view all the answers

    Which of the following factors contributes to cervical ripening and increased uterine responsiveness to oxytocin?

    <p>Production of prostaglandins (A)</p> Signup and view all the answers

    How does oxytocin contribute to labor initiation?

    <p>By increasing the sensitivity of the uterus to its own effects (C)</p> Signup and view all the answers

    Which of the following is NOT a function of oxytocin?

    <p>Stimulation of fetal growth and development (C)</p> Signup and view all the answers

    What is the typical duration of the placental delivery stage after childbirth?

    <p>15-30 minutes (B)</p> Signup and view all the answers

    What is the approximate weight of a mature placenta at term?

    <p>500g (D)</p> Signup and view all the answers

    What happens to the blastocyst after it burrows into the decidua?

    <p>It becomes completely covered by endometrial cells. (D)</p> Signup and view all the answers

    Which of the following structures primarily contributes to the formation of the placenta?

    <p>Chorionic tissue (D)</p> Signup and view all the answers

    What is the function of the trophoblastic layer during the early stages of pregnancy?

    <p>It digests surrounding decidual cells for energy. (D)</p> Signup and view all the answers

    How is uteroplacental circulation established?

    <p>Involving endovascular trophoblast invasion and vascular remodeling. (A)</p> Signup and view all the answers

    What is the role of chorionic villi in the placenta?

    <p>They facilitate nutrient exchange with maternal blood. (C)</p> Signup and view all the answers

    Which process occurs on day 12 of embryonic development in relation to the decidua?

    <p>The embryo becomes embedded in the decidua. (C)</p> Signup and view all the answers

    What is the significance of the thin barrier between maternal and fetal blood in the placenta?

    <p>It allows for efficient nutrient and gas exchange. (B)</p> Signup and view all the answers

    What are cotyledons in the context of the placenta?

    <p>Groups of chorionic villi that aggregate. (D)</p> Signup and view all the answers

    Which of the following events directly precedes the formation of the morula?

    <p>The zygote completes the second meiotic division. (C)</p> Signup and view all the answers

    The blastocyst's primary function is to:

    <p>Implant into the uterine wall. (B)</p> Signup and view all the answers

    What is the primary role of the trophoblast during implantation?

    <p>Penetrate the endometrium, allowing the blastocyst to embed itself. (C)</p> Signup and view all the answers

    The endometrial secretory phase is characterized by:

    <p>Preparation for implantation by storing glycogen and becoming richly vascularized. (C)</p> Signup and view all the answers

    Which statement accurately describes the relationship between the morula and the blastocyst?

    <p>The morula develops into the blastocyst through a process of cellular differentiation. (C)</p> Signup and view all the answers

    Why is it crucial for sufficient progesterone to be present for the morula to enter the uterus?

    <p>Progesterone prepares the uterus for implantation, providing the necessary environment for the morula to survive. (D)</p> Signup and view all the answers

    What would be the most likely consequence of a premature arrival of the morula in the uterine cavity?

    <p>The morula would be unable to implant and would be expelled during the next menstrual cycle. (D)</p> Signup and view all the answers

    What is the main reason for the triploid cell being lethal?

    <p>The extra chromosome disrupts normal cell division. (C)</p> Signup and view all the answers

    Which hormone is most closely associated with signaling that ovulation has occurred?

    <p>Luteinizing hormone (B)</p> Signup and view all the answers

    What primary role does fetal cortisol play during the parturition process?

    <p>Maturation of the fetal lungs (A)</p> Signup and view all the answers

    During labor, which hormone's increase is crucial for uterine changes that lead to parturition?

    <p>Estrogen (B)</p> Signup and view all the answers

    Which of these hormones is indicative of preparing the uterine environment for pregnancy?

    <p>Progesterone (B)</p> Signup and view all the answers

    What is the primary function of GATA-4 in embryogenesis?

    <p>Regulating genes involved in embryogenesis (B)</p> Signup and view all the answers

    What is the primary estrogen synthesized by the placenta from fetal DHEA?

    <p>Estriol (B)</p> Signup and view all the answers

    What is the primary function of the placental barrier?

    <p>Limit contact between maternal blood and fetal blood (C)</p> Signup and view all the answers

    During which stage of labor does cervical dilation primarily occur?

    <p>Stage 1 (D)</p> Signup and view all the answers

    What significant change in progesterone levels is observed during the last 7 months of gestation?

    <p>Notable increase (A)</p> Signup and view all the answers

    Which blood vessels are contained within the umbilical cord?

    <p>One umbilical vein and two umbilical arteries (A)</p> Signup and view all the answers

    What is the duration range of Stage 2 of labor during a typical first delivery?

    <p>30 to 90 minutes (D)</p> Signup and view all the answers

    How does the amniotic sac contribute to fetal development?

    <p>It provides mechanical protection and cushioning (D)</p> Signup and view all the answers

    What does the placenta extract from fetal blood for conversion into estrogen?

    <p>DHEA (B)</p> Signup and view all the answers

    What is the length of a typical umbilical cord at full term?

    <p>50–70 cm (C)</p> Signup and view all the answers

    What is the frequency of uterine contractions shortly before the transition from Stage 1 to Stage 2 of labor?

    <p>Every 2-3 minutes (C)</p> Signup and view all the answers

    What happens to the umbilical cord immediately after childbirth?

    <p>It is delivered alongside the placenta (A)</p> Signup and view all the answers

    What process is critically related to the timing of implantation?

    <p>Formation of uterine receptors (D)</p> Signup and view all the answers

    What is the role of uterine contractions during the second stage of labor?

    <p>To expel the fetus (B)</p> Signup and view all the answers

    What is the composition of the umbilical vein in the umbilical cord?

    <p>Oxygenated, nutrient-rich blood (D)</p> Signup and view all the answers

    Which structure primarily forms the fetal part of the placenta?

    <p>Chorionic villi (C)</p> Signup and view all the answers

    What structure is primarily responsible for the invasive behavior during the establishment of uteroplacental circulation?

    <p>Syncytiotrophoblast (C)</p> Signup and view all the answers

    What role does the chorion play after the embedding of the embryo into the decidua?

    <p>It releases enzymes and forms cavities within the decidua. (A)</p> Signup and view all the answers

    What physical change occurs to the trophoblastic layer by day 12 of embryonic development?

    <p>It transforms into the chorion with two cell layers. (A)</p> Signup and view all the answers

    What is the significance of the interlocking maternal and fetal structures in the placenta?

    <p>They ensure that maternal and fetal blood do not come into direct contact. (C)</p> Signup and view all the answers

    What happens to maternal blood as it interacts with the developing structures of the placenta?

    <p>It leaks into pools created by the chorionic tissue. (C)</p> Signup and view all the answers

    Which characteristic makes the placenta unique among endocrine tissues?

    <p>It is a transient tissue composed of tissues from both the embryo and mother. (C)</p> Signup and view all the answers

    What is the main form of nutrient supply to the embryo during the initial stages before the placenta fully develops?

    <p>Histotrophic nutrition via uterine secretions (C)</p> Signup and view all the answers

    What is the main structural feature that defines cotyledons in the placenta?

    <p>Groups of chorionic villi aggregating into structures (C)</p> Signup and view all the answers

    What stimulates the corpus luteum to remain functional during early pregnancy?

    <p>Human chorionic gonadotropin (hCG) (D)</p> Signup and view all the answers

    Which statement accurately describes the barrier between maternal and fetal blood in the placenta?

    <p>It is extremely thin, allowing exchanges to occur efficiently. (B)</p> Signup and view all the answers

    Which hormone is responsible for masculinizing the developing reproductive tract in male fetuses?

    <p>hCG (C)</p> Signup and view all the answers

    What is the primary factor influencing the rate of hormone secretion by the placenta?

    <p>Stage of pregnancy (B)</p> Signup and view all the answers

    What dual role does the placenta fulfill during pregnancy?

    <p>Hormone secretion and immune response suppression. (D)</p> Signup and view all the answers

    Which of the following hormones increases progesterone production during pregnancy?

    <p>hCG (B)</p> Signup and view all the answers

    What is one of the first endocrine events in pregnancy?

    <p>Secretion of hCG by the developing chorion (D)</p> Signup and view all the answers

    What prevents the corpus luteum from degenerating during early pregnancy?

    <p>Production of hCG (C)</p> Signup and view all the answers

    Flashcards

    Fertilization

    The process where sperm penetrates the egg, leading to conception.

    Implantation

    When a fertilized egg attaches to the uterine wall.

    Duration of Pregnancy

    Normal pregnancy lasts 40 weeks from the last menstrual period.

    Trimesters of Pregnancy

    Pregnancy is divided into three trimesters: 1st, 2nd, and 3rd.

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    Miscarriage

    Spontaneous expulsion of a fetus before survivability.

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    Gonads

    The primary reproductive organs: testes in males, ovaries in females.

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    Endocrine Function of Placenta

    The placenta produces hormones that support pregnancy.

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    Parturition

    The process of giving birth triggered by endocrine factors.

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    Blastocyst embedding

    Process where the blastocyst burrows into the decidua, becoming covered by endometrial cells.

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    Trophoblastic digestion

    The process where the trophoblastic layer digests surrounding decidual cells to provide energy for the embryo.

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    Endocrine Function of the Placenta

    The placenta functions as an endocrine organ, secreting hormones that support pregnancy.

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    Uteroplacental circulation

    Circulation established between maternal and fetal blood, crucial for nutrient exchange through the placenta.

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    Transient Tissue

    The placenta is temporary, present only during pregnancy.

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    Chorion

    The trophoblastic layer that becomes two cell layers thick, involved in placenta formation.

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    Hormone Secretion Control

    Placental hormone secretion is not controlled by external factors, but by the pregnancy stage.

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    Chorionic villi

    Finger-like projections of chorionic tissue extending into maternal blood pools, forming placental villi.

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    Key Placental Hormones

    Important hormones from the placenta include hCG, hPL, estrogen, progesterone, and CRH.

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    Cotyledons

    Groups of aggregated chorionic villi within the placenta, important for nutrient absorption.

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    Human Chorionic Gonadotropin (hCG)

    hCG is secreted by the chorion and later by the placenta, crucial for pregnancy maintenance.

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    Placental barrier

    Extremely thin barrier separating maternal and fetal blood, allowing for nutrient exchange.

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    Function of hCG

    hCG maintains the corpus luteum and increases progesterone, preventing menstruation.

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    Placenta composition

    The placenta is made up of trophoblastic and decidual tissue, facilitating maternal-fetal interaction.

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    Leydig Cells Stimulation

    In male fetuses, hCG stimulates Leydig cells to produce testosterone, aiding male development.

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    Other Important Pregnancy Hormones

    Thyroid hormones, oxytocin, and prolactin also play vital roles during pregnancy.

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    Acrosome Reaction

    The process where the sperm penetrates the ovum's membrane.

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    Zygote

    The fertilized ovum, which results from the fusion of sperm and egg nuclei.

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    Morula

    A solid ball of 16 cells formed after several mitotic divisions of the zygote.

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    Blastocyst

    The stage following the morula with two layers: trophoblasts and embryoblasts.

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    Polyspermy

    When more than one sperm enters the egg, causing a triploid cell.

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    Progesterone

    A hormone that helps prepare the uterine lining for implantation.

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    Zona Pellucida

    A protective glycoprotein layer surrounding the oocyte and zygote.

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    Trophoblast

    The outer layer of cells in the blastocyst that helps with implantation.

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    Implantation Bleeding

    Bloody vaginal discharge that occurs during implantation, often mistaken for menstruation.

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    Capacitation

    The process that sperm undergo to gain the ability to fertilize an egg, occurring in the female reproductive tract.

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    Endometrium

    The inner lining of the uterus, becomes suitable for implantation about a week after ovulation.

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    Decidua

    The modified endometrial tissue that supports the implanting embryo due to changes stimulated by the trophoblast.

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    Stage 3 Delivery

    The phase when the placenta is expelled after birth, lasting 15-30 mins.

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    Uterine Contractions

    Muscle contractions of the uterus that assist in childbirth.

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    Effacement

    The process where the cervix stretches and thins out.

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    Estrogen

    A hormone that increases uterine responsiveness and prepares for labor.

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    Oxytocin

    A hormone from the hypothalamus that triggers contractions during labor.

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    Cervical Ripening

    Softening and thinning of the cervix to facilitate labor.

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    Onset of Parturition

    The start of labor triggered by hormonal and mechanical changes.

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    Zygote Formation

    The fusion of sperm and egg nuclei creates a zygote.

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    Meiotic Division

    The zygote undergoes the 2nd meiotic division after fertilization.

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    Morula Development

    The zygote divides into a solid ball of 16 cells known as morula.

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    Blastocyst Structure

    The morula develops into a blastocyst with trophoblasts and embryoblasts.

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    Progesterone Role

    Progesterone prepares the uterine lining for implantation.

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    Polyspermy Consequence

    When multiple sperm enter the egg, causing lethal triploidy.

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    Blastocyst Implantation

    The process where the blastocyst attaches to the endometrium.

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    CRH level in labor

    Corticotropin-releasing hormone that prepares the infant for birth by raising cortisol and estrogen levels.

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    Luteinizing hormone

    A hormone that surges indicating ovulation has occurred, crucial for conception.

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    GATA-4

    A transcription factor regulating genes involved in embryogenesis, indicated in mouse embryos.

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    Role of cortisol in labor

    Cortisol is crucial for fetal lung maturation, preparing the infant for breathing after birth.

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    Estrogen in pregnancy

    A hormone that increases uterine changes necessary for labor initiation.

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    Thyroid Hormones Role in Pregnancy

    Thyroid hormones support fetal development and maternal metabolism during pregnancy.

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    Syncytiotrophoblasts

    Cells that invade and erode endometrial tissues, aiding implantation and nutrient absorption.

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    Endovascular trophoblast invasion

    Process where trophoblast cells invade maternal blood vessels, helping establish uteroplacental circulation.

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    Histotrophic nutrition

    Nutrient supply to the embryo from maternal blood through the placenta before placental vessels are formed.

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    Myometrium Growth

    Increase in uterine muscle size during pregnancy for labor.

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    Uterine Blood Flow

    Increased blood supply to the uterus during pregnancy.

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    Uterine Receptors

    Formation of receptors for progesterone and oxytocin in the uterus.

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    Estrogen Increase

    Estradiol increases by 50-fold and estriol by 1000-fold by term.

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    Stages of Labor

    Three phases of childbirth: dilation, delivery, and placenta expulsion.

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    Cervical Dilation

    First stage of labor where the cervix opens up for delivery.

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    Delivery Time

    Second stage of labor, baby is delivered typically in 30-90 minutes.

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    Formation of Estriol

    Estriol is synthesized from fetal DHEA by the placenta.

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    Placenta

    A fetomaternal organ that enables nutrient and gas transfer between mother and fetus.

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    Umbilical Cord

    A cord around 50–70 cm long connecting the placenta to the fetus, with one vein and two arteries.

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    Amniotic Sac

    A fluid-filled sac that surrounds and protects the fetus.

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    Umbilical Vein

    The vessel in the umbilical cord that carries oxygenated, nutrient-rich blood from the placenta to the fetus.

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    Umbilical Arteries

    The two vessels in the umbilical cord that carry deoxygenated blood from the fetus back to the placenta.

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    Amniotic Fluid

    Liquid within the amniotic sac that provides mechanical protection to the fetus.

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    Fetal Membranes

    Structures surrounding the fetus, including the amnion and chorion, that support its development.

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    Study Notes

    Pregnancy Course Information

    Learning Outcomes

    • Outline the processes of fertilization & implantation
    • Describe the endocrine function of the placenta and the hormones involved
    • Explain the endocrine factors that trigger parturition and maintain labor

    Recap from Previous Lectures - The Gonads

    • The primary reproductive organs (gonads) consist of the testes in males and the ovaries in females
    • Mature gonads produce gametes (sperm and ova) and secrete sex hormones (testosterone, progesterone, and estrogen)
    • Gonads and reproductive system do not contribute to homeostasis but are essential for the perpetuation of the species

    Recap from Previous Lectures - Correlation between hormonal levels & cyclic ovarian & uterine changes

    • FSH and LH stimulate oocyte development and follicle growth
    • LH burst triggers ovulation
    • LH stimulates development and maintenance of corpus luteum
    • Plasma concentrations of estrogen and progesterone fluctuate throughout cycle phases

    Pregnancy

    • Pregnancy begins with fertilization of the ovum and subsequent implantation into the uterine wall
    • Pregnancy duration is measured in weeks of gestation from the first day of the last menstrual period, typically 40 weeks (280 days)
    • Preterm birth: live birth before 37 weeks
    • Post-term birth: live birth after 42 weeks
    • Trimesters of pregnancy: First (weeks 1-13), Highest rate of miscarriage; Second (weeks 14-26); Third (weeks 27-40)

    Fertilization/Conception

    • Fertilization is a series of processes starting when sperm penetrate the corona radiata surrounding the egg, culminating in the intermingling of maternal and paternal chromosomes
    • Oviduct (specifically, the ampulla) is the usual site of fertilization, ideally within 24 hours post-ovulation
    • Sperm can survive for up to 5 days in the female reproductive tract
    • Sperm cells undergo functional maturation (capacitation) in the female genital tract, allowing them to penetrate the ovulated oocyte (impregnation)

    Fertilization/Conception - Additional details

    • When released, the oocyte is surrounded by the corona radiata (follicular cells) and zona pellucida (glycoprotein matrix)
    • Human fertilization begins when sperm penetrates the corona radiata and binds to a sugar group in the zona pellucida

    Capacitation

    • Spermatozoa recovered at the time of ejaculation are unable to fertilize for several hours
    • After intercourse, sperm recovered from the uterus or Fallopian tube are capable of immediate fertilization due to capacitation
    • Capacitation results in the removal of a glycoprotein coat from the sperm cell membrane surface by enzymes present in the uterus
    • Changes in the sperm's acrosomal cap allow acrosome reaction
    • Removal of cholesterol, glycoproteins, and proteins from plasma membrane around the sperm head
    • Hyperactivity of the sperm tail

    Acrosome Reaction

    • The fertilizing sperm penetrates the corona radiata and binds to ZP3 receptors in the zona pellucida, triggering the acrosome reaction
    • Hydrolytic enzymes in the acrosome are released onto the zona pellucida, creating a pathway for sperm to reach the ovum's plasma membrane
    • Fusion of sperm and ovum plasma membranes
    • The sperm nucleus enters the ovum cytoplasm, activating the ovum and initiating fertilization

    Early Stages of Pregnancy

    • Within 1 hour, sperm and egg nuclei fuse to form a zygote.
    • Zygote completes its 2nd meiotic division to develop into normal diploid number of chromosomes (46 in humans)
    • Within 3-4 days, zygote develops into a morula (a solid ball of 16 cells)
    • Rising progesterone levels from the developing corpus luteum stimulate glycogen release from the endometrium for embryonic energy
    • The morula matures into a blastocyst, accumulating nutrients in the uterine lumen
    • The blastocyst implants in the uterine wall, if prematurely arrives, it dies.

    Early Stages of Pregnancy - Implantation

    • The blastocyst implants into the uterine lining
    • Trophoblast cells penetrate endometrium, forming the placenta later on
    • Implantation occurs after the zona pellucida dissolves
    • The inner cell mass differentiates into the embryo
    • Implantation bleeding may occur, potentially mistaken for menstruation

    Summary of Early Stages of Pregnancy

    • Day 0: Capacitation, fertilization, impregnation, single-celled zygote
    • Day 1-5: Zygote travels down fallopian tube, divisions into morula, and then into blastocyst
    • Day 6: Zona pellucida dissolves; implantation

    Implantation

    • Endometrium is suited to implantation approximately one week after ovulation
    • Inner cell mass becomes the embryo
    • The trophoblast performs dual functions in supporting the embryo and developing the fetal portion of the placenta

    Implantation (Further Detail)

    • Trophoblastic cells release enzymes, guiding them through the endometrial lining
    • Plasma membranes of advancing trophoblastic cells degenerate, forming the fetal portion of the placenta
    • Endometrial tissue near contact site dramatically changes to support the embryo
    • Blastocyst burrows into the decidua, with its surface completely covered by endometrial cells.
    • Trophoblast layer digests surrounding cells to supply energy to the embryo until placenta develops

    Placenta

    • Uteroplacental circulation is established with multiple steps—endometrium and vascular remodeling
    • Embryo implants in the decidua by day 12 of the pregnancy, and is surrounded by chorionic villi
    • Chorionic villi form from trophoblast cells and reach into the pools of maternal blood, forming cotyledons.
    • Maternal blood leaks into these cavities

    Placenta (Further Detail)

    • Maternal and fetal blood do not mix but exchange nutrients across a thin barrier
    • Entire system of maternal (decidual) and fetal (chorionic) structures compose the placenta
    • Placenta develops from trophoblastic and decidual tissue

    Endocrine Function of the Placenta

    • The placenta acts as a unique endocrine tissue, connecting embryo and mother
    • Hormones secreted are not subject to external control, but levels depend on pregnancy stage
    • The placenta secretes steroid and peptide hormones, adapting the maternal body to pregnancy

    hCG (Human Chorionic Gonadotropin)

    • Early event in pregnancy: secreted by the developing chorion (later placenta)
    • Stimulates and maintains corpus luteum to prevent menstruation, providing progesterone until placenta takes over
    • Increases progesterone production by the trophoblast
    • In male fetuses, it stimulates Leydig cells for testosterone production, masculinizng reproductive tract.

    hPL (Human Placental Lactogen)

    • Initially produced by trophoblast, then placenta
    • Lactogenic & growth hormone-like actions — stimulates mammary glands.
    • Less potent than prolactin and GH for milk production and growth processes
    • Ensures adequate fuel for fetus (carbohydrates, proteins, and fats), aiding in adaptation to pregnancy
    • Antagonistic action to insulin to support pregnancy-related glucose homeostasis

    Progesterone

    • Initially secreted by corpus luteum, then placenta
    • Essential for maintaining the uterus and early embryo, facilitating implantation
    • Inhibits contractions to prevent miscarriage
    • Important for fetal development and supporting maternal immunological system
    • Serves as a precursor to steroid production in adrenal glands, stimulating mammary development.

    Estrogens

    • Primarily secreted by the placenta
    • Increase uterine size, blood flow, and uterine receptor production for progesterone and oxytocin.
    • Essential for uterine development and fetal organ maturation
    • Contributes substantially to mammary duct growth

    Secretion of Estrogens and Progesterone by the Placenta

    • Placenta converts fetal DHEA into estrogen and extracts DHEA from fetal blood
    • Placenta produces estrogen only after the fetal adrenal cortex is secreting DHEA (the direct source of fetal DHEA)
    • The main estrogen product of the placenta is estriol
    • Measurement of estriol in maternal urine can assess fetal viability

    Stages of Labour

    • Stage 1 (Cervical dilation & effacement): Cervical dilation and softening, rhythmic contractions
    • Stage 2 (Delivery of baby): Begins with complete cervical dilation; intense coordinated contractions expel the fetus
    • Stage 3 (Delivery of placenta): Uterine contractions separate the placenta from the uterine wall

    Factors That Trigger Onset of Parturition

    • Hormones are progesterone, estrogen, prostaglandins, oxytocin, and CRH
    • Mechanical factors are distention of uterine muscles and softening of the cervix

    Factors That Trigger Onset of Parturition (Oxytocin)

    • Oxytocin is produced by the maternal hypothalamus and increases throughout pregnancy
    • Uterine responsiveness to oxytocin is much higher during labor than in non-pregnant women
    • Wide acceptance that labor begins when myometrial responsiveness to oxytocin is critical to induce strong and coordinated contractions
    • Clinically useful for inducing labor
    • Plays a key role in bonding between mother and child

    Factors That Trigger Onset of Parturition (Ferguson Reflex)

    • Uterine contractions drive the fetus towards the cervix
    • Head pushing against the cervix opens the cervical canal, stimulating oxytocin release
    • Oxytocin further stimulates uterine contractions as a positive feedback loop
    • Oxytocin causes prostaglandin production and further intensifies uterine contractions.

    Factors That Raise Levels of Placental Estrogen Secretion

    • Corticotrophin-releasing hormone (CRH), secreted by the fetal placenta, regulates fetal cortisol and DHEA output by adrenal cortex
    • Increased CRH leads to increased fetal cortisol levels (needed for lung maturation)
    • Rising levels of placental estrogen (influenced by CRH in a positive feedback loop), drive uterine changes necessary at birth
    • Pregnancy duration and timing determined by placental clock (CRH levels)

    Corticotrophin-relasing hormone (CRH) and Parturition

    • When a critical level of placental CRH is reached, parturition is triggered.
    • This critical level ensures the infant is ready for life outside the womb by increasing fetal cortisol needed for lung maturation, along with estrogen changes for uterine changes to support labor

    Initiation and Progression of Parturition

    • Placental hormones (CRH, DHEA) contribute to fetal lung maturation and uterine changes
    • This triggers the onset of parturition
    • Active feedback mechanisms regulate uterine contractions and fetal expulsion.

    Question

    • What hormone increase is the best indicator of ovulation in a healthy 31-year-old woman trying to conceive?
    • Luteinizing hormone (LH)
    • Medical Sciences, by Jeannette Naish
    • Endocrine and Reproductive Physiology, by Bruce White, John Harrison, Lisa Mehlman
    • Master Medicine: Physiology, by J McGeown

    Six Key Pregnancy Hormones

    • Human Chorionic Gonadotropin (hCG): Produced by placenta to support corpus luteum initially; for pregnancy detection
    • Progesterone: Produced by initial corpus luteum and later by placenta; maintains pregnancy by preventing uterine contractions and supporting other essential functions
    • Estrogen: Produced primarily by placenta; stimulates development of uterine lining and mammary ducts
    • Prolactin: Produced by pituitary gland; crucial for breast milk production
    • Relaxin: Produced by placenta; relaxes connective tissues (especially in pelvis and cervix) to facilitate pregnancy and birth
    • Oxytocin: Produced by pituitary gland; stimulates uterine contractions during labor and milk ejection

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    Description

    Test your knowledge about the processes of fertilization and implantation in early embryonic development. This quiz covers key concepts such as zygote formation, chromosome numbers, and hormonal roles during pregnancy. Assess your understanding of these foundational biological processes through a series of thought-provoking questions.

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