Biology Chapter on Antibodies and Blood
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Questions and Answers

Their blood should be screened for antibodies against the common congenital ______.

infections

IgG antibodies in newborns are of ______ origin.

maternal

Newborns normally synthesize both IgM and ______ after birth.

IgG

Children have higher serum alkaline phosphatase (ALP) levels due to increased bone ______.

<p>growth</p> Signup and view all the answers

For normal mineralization of bone to occur, phosphorus is required to drive ______ into bone.

<p>calcium</p> Signup and view all the answers

When compared to an adult, children have a lower Hb concentration of ______ g/dL.

<p>11.5</p> Signup and view all the answers

The circulating pool is located in the central axial stream of blood flowing through ______ blood vessels.

<p>small</p> Signup and view all the answers

In AI, RBCs aggregate into ______ in the venules.

<p>rouleaux</p> Signup and view all the answers

The predictive value of a positive test result (PV+) reflects the likelihood that a positive test result is a true ______ rather than a false positive.

<p>positive</p> Signup and view all the answers

The formula for calculating PV+ is TP ÷ (TP + ______).

<p>FP</p> Signup and view all the answers

Tests with 100% specificity have a PV+ of ______%.

<p>100</p> Signup and view all the answers

Arachidonic acid is released from membrane phospholipids by ______.

<p>phospholipase A2</p> Signup and view all the answers

Prevalence refers to the total number of people with ______ in the population under study.

<p>disease</p> Signup and view all the answers

Cyclooxygenase (COX) is inhibited by ______ and NSAIDs.

<p>aspirin</p> Signup and view all the answers

To calculate prevalence, people with disease are in the numerator (TP + FN) and the total population in the denominator is (TP + FN + TN + ______).

<p>FP</p> Signup and view all the answers

5-Lipoxygenase is inhibited by ______.

<p>zileuton</p> Signup and view all the answers

Thromboxane A2 (TXA2) is associated with ______.

<p>vasoconstriction</p> Signup and view all the answers

In a low prevalence population, PV− increases because more TNs are present than ______.

<p>FNs</p> Signup and view all the answers

An ideal test has 100% ______ and 100% specificity.

<p>sensitivity</p> Signup and view all the answers

Examples of mediators that produce pain include PGE2 and ______.

<p>bradykinin</p> Signup and view all the answers

Most normal ranges do not distinguish between the normal and the ______ population.

<p>disease</p> Signup and view all the answers

LTB4 is involved in ______.

<p>chemotaxis</p> Signup and view all the answers

The receptors for LTC4, LTD4, and LTE4 are inhibited by ______.

<p>montelukast</p> Signup and view all the answers

Prostaglandins (PGs) are converted from PGH2 in ______.

<p>platelets</p> Signup and view all the answers

Effective therapy that is safe and inexpensive must be available for ______.

<p>screening</p> Signup and view all the answers

The disease must have a high enough ______ to justify the expense.

<p>prevalence</p> Signup and view all the answers

The test must not have many false ______ to ensure accuracy.

<p>positives</p> Signup and view all the answers

Mammography is considered the best screening test for ______.

<p>breast cancer</p> Signup and view all the answers

Cervical Papanicolaou (Pap) smear is used for screening ______ cancer.

<p>cervical</p> Signup and view all the answers

Colonoscopy is used to detect and remove precancerous ______.

<p>polyps</p> Signup and view all the answers

Fasting lipid profiles are evaluated to assess ______ artery risk.

<p>coronary</p> Signup and view all the answers

Chest x-ray can be used to confirm ______.

<p>pneumonia</p> Signup and view all the answers

The NBT dye test has been replaced by a more sensitive test involving oxidation of dihydrorhodamine to fluorescent ______.

<p>rhodamine</p> Signup and view all the answers

Treatment of CGD involves prophylaxis and treatment of infections and ______ transplantation.

<p>bone marrow</p> Signup and view all the answers

In myeloperoxidase (MPO) deficiency, both O2 and ______ are produced with a normal respiratory burst.

<p>H2O2</p> Signup and view all the answers

G6PD deficiency interferes with the normal function of the NADPH oxidase complex due to the lack of ______.

<p>NADPH</p> Signup and view all the answers

Patients with G6PD deficiency are very susceptible to bacterial and certain fungal infections due to a dysfunctional ______ system.

<p>O2-dependent MPO</p> Signup and view all the answers

Oxygen-independent systems for killing bacteria involve the release of lethal substances from ______ granules.

<p>leukocyte</p> Signup and view all the answers

Lactoferrin, present in neutrophil granules, binds ______ that is necessary for normal bacterial growth.

<p>iron</p> Signup and view all the answers

Arachidonic acid mediators are released from membrane ______ in macrophages, endothelial cells, and platelets.

<p>phospholipids</p> Signup and view all the answers

Acute inflammation is characterized by the presence of ______ as primary cells involved.

<p>neutrophils</p> Signup and view all the answers

Chronic inflammation involves ______ and T lymphocytes among other cells.

<p>B</p> Signup and view all the answers

The key mediator of acute inflammation is ______.

<p>histamine</p> Signup and view all the answers

Scar tissue formation is a prominent feature of ______ inflammation.

<p>chronic</p> Signup and view all the answers

Acute inflammation typically has an ______ onset.

<p>immediate</p> Signup and view all the answers

Chronic inflammation can last for ______, months, or even years.

<p>weeks</p> Signup and view all the answers

The main immunoglobulin present in acute inflammation is ______.

<p>IgM</p> Signup and view all the answers

Neutrophilic leukocytosis is a response seen in ______ inflammation.

<p>acute</p> Signup and view all the answers

Cytokines like ______ play a key role in chronic inflammation.

<p>IL-1</p> Signup and view all the answers

In chronic inflammation, the degree of ______ is often greater compared to acute inflammation.

<p>hypoalbuminemia</p> Signup and view all the answers

Study Notes

Book Title and Edition

  • Rapid Review PATHOLOGY, Fourth Edition

Author

  • Edward F. Goljan, MD

Series Editor

  • Edward F. Goljan, MD

Book Information

  • Published by ELSEVIER, SAUNDERS
  • Searchable full text online at studentconsult.com
  • Includes activation code for online access
  • Book also available in other editions and formats
  • ISBNs for different books and editions provided

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Description

This quiz explores concepts related to antibodies, particularly IgG, and their roles in newborns, as well as various blood parameters in children. It also addresses key terms like alkaline phosphatase and predictive values in tests. Test your understanding of these important biological principles.

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