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Questions and Answers
Which germ layer is responsible for forming organs in the respiratory system?
Which germ layer is responsible for forming organs in the respiratory system?
What is one of the primary roles of the amnion during embryonic development?
What is one of the primary roles of the amnion during embryonic development?
Which embryonic membrane contributes to the formation of the placenta?
Which embryonic membrane contributes to the formation of the placenta?
What function is primarily associated with the yolk sac during early embryonic development?
What function is primarily associated with the yolk sac during early embryonic development?
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Which system is formed by the mesoderm?
Which system is formed by the mesoderm?
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What triggers the secondary oocyte to complete meiosis II?
What triggers the secondary oocyte to complete meiosis II?
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What is the role of the flagellum in sperm?
What is the role of the flagellum in sperm?
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What role does the allantois primarily serve?
What role does the allantois primarily serve?
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What does the zygote develop into after fertilization?
What does the zygote develop into after fertilization?
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Which of the following structures are derived from the ectoderm?
Which of the following structures are derived from the ectoderm?
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Which of the following is NOT a function of the chorion?
Which of the following is NOT a function of the chorion?
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How does the zygote transition from one cell to a blastocyst?
How does the zygote transition from one cell to a blastocyst?
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Why is implantation crucial for pregnancy?
Why is implantation crucial for pregnancy?
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What hormone sustains progesterone production after implantation?
What hormone sustains progesterone production after implantation?
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What is the inner cell mass of the blastocyst composed of?
What is the inner cell mass of the blastocyst composed of?
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What function does the placenta serve after implantation?
What function does the placenta serve after implantation?
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What is the role of hCG in the early stages of pregnancy?
What is the role of hCG in the early stages of pregnancy?
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What type of cells does the inner cell mass of the blastocyst develop into?
What type of cells does the inner cell mass of the blastocyst develop into?
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Which hormone is primarily produced by the corpus luteum to support pregnancy?
Which hormone is primarily produced by the corpus luteum to support pregnancy?
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What is the fate of the zygote after fertilization until it becomes a blastocyst?
What is the fate of the zygote after fertilization until it becomes a blastocyst?
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Which layer of the blastocyst gives rise to skin and nervous tissue?
Which layer of the blastocyst gives rise to skin and nervous tissue?
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During which week does the inner cell mass undergo changes to form the primary germ layers?
During which week does the inner cell mass undergo changes to form the primary germ layers?
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The blastocyst depends on progesterone to perform which of the following actions?
The blastocyst depends on progesterone to perform which of the following actions?
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What does the zygote become as it moves down the fallopian tube and undergoes cell division?
What does the zygote become as it moves down the fallopian tube and undergoes cell division?
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What initiates the process of labor?
What initiates the process of labor?
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How long does it typically take from full dilation to birth?
How long does it typically take from full dilation to birth?
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What happens to the baby's head during delivery?
What happens to the baby's head during delivery?
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What major circulatory change occurs in a newborn immediately after birth?
What major circulatory change occurs in a newborn immediately after birth?
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What is the role of the placenta during pregnancy?
What is the role of the placenta during pregnancy?
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What physiological change during pregnancy particularly contributes to slower digestion?
What physiological change during pregnancy particularly contributes to slower digestion?
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What occurs immediately after the baby's head emerges during delivery?
What occurs immediately after the baby's head emerges during delivery?
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Why does heartburn and acid reflux often worsen after large meals in pregnant women?
Why does heartburn and acid reflux often worsen after large meals in pregnant women?
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What is the first stage of labor primarily characterized by?
What is the first stage of labor primarily characterized by?
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How is blood loss managed during the expulsion of the afterbirth?
How is blood loss managed during the expulsion of the afterbirth?
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What is one effect of the growing baby's pressure on the intestines?
What is one effect of the growing baby's pressure on the intestines?
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What happens to the umbilical cord immediately after birth?
What happens to the umbilical cord immediately after birth?
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Which of the following correctly describes the process of contractions during the first stage of labor?
Which of the following correctly describes the process of contractions during the first stage of labor?
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What happens to the cervix during the preparation for labor?
What happens to the cervix during the preparation for labor?
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What contributes to discomfort during digestion for heavily pregnant women?
What contributes to discomfort during digestion for heavily pregnant women?
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Which statement about the second stage of labor is accurate?
Which statement about the second stage of labor is accurate?
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How does increased pressure from the growing baby affect digestion during pregnancy?
How does increased pressure from the growing baby affect digestion during pregnancy?
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What hormonal change is primarily responsible for the relaxation of smooth muscles in the digestive tract during pregnancy?
What hormonal change is primarily responsible for the relaxation of smooth muscles in the digestive tract during pregnancy?
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At what measurement is the cervix considered fully dilated during the first stage of labor?
At what measurement is the cervix considered fully dilated during the first stage of labor?
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What role do uterine contractions play during the first stage of labor?
What role do uterine contractions play during the first stage of labor?
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What characterizes the second stage of labor?
What characterizes the second stage of labor?
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What changes in the abdominal organs occur as pregnancy progresses?
What changes in the abdominal organs occur as pregnancy progresses?
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Why is frequent, smaller meal consumption often recommended for pregnant women experiencing heartburn?
Why is frequent, smaller meal consumption often recommended for pregnant women experiencing heartburn?
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What physical changes occur in the cervix in preparation for labor?
What physical changes occur in the cervix in preparation for labor?
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What role do muscular contractions play in the transport of sperm through the female reproductive system?
What role do muscular contractions play in the transport of sperm through the female reproductive system?
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How does the zygote transition from a single cell to a blastocyst?
How does the zygote transition from a single cell to a blastocyst?
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Describe the structural components of the blastocyst.
Describe the structural components of the blastocyst.
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What triggers the completion of meiosis II in the secondary oocyte?
What triggers the completion of meiosis II in the secondary oocyte?
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Explain the significance of implantation in early pregnancy.
Explain the significance of implantation in early pregnancy.
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What is the primary function of the inner cell mass in the blastocyst?
What is the primary function of the inner cell mass in the blastocyst?
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What hormones are primarily responsible for the successful implantation and development of the blastocyst?
What hormones are primarily responsible for the successful implantation and development of the blastocyst?
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How does the zygote transition from being totipotent to pluripotent?
How does the zygote transition from being totipotent to pluripotent?
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Describe the role of hormones such as progesterone and estrogen during implantation.
Describe the role of hormones such as progesterone and estrogen during implantation.
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How does the zygote's totipotency change as it develops into a blastocyst?
How does the zygote's totipotency change as it develops into a blastocyst?
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What are the three primary germ layers formed during embryonic development?
What are the three primary germ layers formed during embryonic development?
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What structures are derived from the ectoderm layer of the primary germ layers?
What structures are derived from the ectoderm layer of the primary germ layers?
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What role does the corpus luteum play during early pregnancy?
What role does the corpus luteum play during early pregnancy?
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What cell type does the inner cell mass of the blastocyst develop into?
What cell type does the inner cell mass of the blastocyst develop into?
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What is the function of hCG during the early stages of pregnancy?
What is the function of hCG during the early stages of pregnancy?
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During which week of development do the primary germ layers begin to form?
During which week of development do the primary germ layers begin to form?
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What marks the beginning of the labor process?
What marks the beginning of the labor process?
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What physiological change occurs in the baby's head during delivery?
What physiological change occurs in the baby's head during delivery?
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What happens to the umbilical cord once the baby is born?
What happens to the umbilical cord once the baby is born?
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What is the significance of the foramen ovale closing after birth?
What is the significance of the foramen ovale closing after birth?
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Describe the changes that occur in the circulatory system of a newborn immediately after birth.
Describe the changes that occur in the circulatory system of a newborn immediately after birth.
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What role do abdominal muscles play in the delivery process?
What role do abdominal muscles play in the delivery process?
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What is the third stage of labor, and what happens during it?
What is the third stage of labor, and what happens during it?
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How does the baby's skull adapt during delivery?
How does the baby's skull adapt during delivery?
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What is the primary purpose of tracking cervical mucus in the mucus method of ovulation detection?
What is the primary purpose of tracking cervical mucus in the mucus method of ovulation detection?
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How does the Temperature method enhance the prediction of ovulation?
How does the Temperature method enhance the prediction of ovulation?
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What are the functions of mechanical barrier methods in contraception?
What are the functions of mechanical barrier methods in contraception?
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In what way do spermicides work to prevent pregnancy?
In what way do spermicides work to prevent pregnancy?
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What role do estrogen and progesterone play in the effectiveness of combined oral contraceptive pills?
What role do estrogen and progesterone play in the effectiveness of combined oral contraceptive pills?
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What distinguishes a copper IUD from a hormonal IUD in terms of contraceptive mechanism?
What distinguishes a copper IUD from a hormonal IUD in terms of contraceptive mechanism?
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How do hormonal implants function as a long-term contraceptive method?
How do hormonal implants function as a long-term contraceptive method?
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What are some challenges associated with developing hormonal contraception for men?
What are some challenges associated with developing hormonal contraception for men?
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Study Notes
Fertilization
- Sperm tail is absorbed as head enters the secondary oocyte, becoming the male pronucleus.
- Sperm entry triggers the completion of meiosis II in the secondary oocyte.
- The oocyte nucleus develops into the female pronucleus.
- Fertilization is complete when male and female pronuclei fuse, forming a zygote.
- Sperm travels quickly due to uterine contractions and beating cilia, along with flagellum-driven motility.
Zygote Development to Blastocyst
- The zygote undergoes mitotic division, increasing cell number.
- Initially, the zygote is totipotent, capable of forming all cell types.
- After 6 days, the zygote becomes a blastocyst, a hollow ball of cells.
- The inner cell mass within the blastocyst contains pluripotent cells, which have the potential to develop into various tissues and organs.
Implantation
- The blastocyst embeds into the endometrium, the uterine lining.
- This provides nourishment for the blastocyst from the uterine lining's glands and blood vessels.
- Implantation is crucial for pregnancy because it:
- Connects the blastocyst to the mother's blood supply, ensuring oxygen and nutrient delivery.
- Triggers hCG production, which maintains the uterine lining and prevents menstruation.
- Initiates the formation of the placenta, facilitating nutrient and waste exchange between mother and fetus.
- Provides a safe and stable environment for embryo development.
Hormonal Dependence of the Blastocyst
- The blastocyst relies on hCG, progesterone, and estrogen for implantation and development.
- These hormones sustain the uterine lining, prevent menstruation, and support embryo and placenta growth.
- The corpus luteum produces estrogen and progesterone until the placenta is formed and can produce hCG.
Cell Differentiation Process
- The zygote transitions from totipotent to pluripotent cells during early development.
- This involves multiple rounds of cell division and specialized gene expression.
Primary Germ Layers
- During the third week of development, the inner cell mass differentiates into three primary germ layers: ectoderm, mesoderm, and endoderm.
- Each germ layer gives rise to specific tissues and organs:
- Ectoderm: Nervous system, skin, sensory organs
- Mesoderm: Skeletal and muscular systems, circulatory, reproductive, urinary systems, connective tissues
- Endoderm: Gastrointestinal tract, respiratory system, liver, pancreas, urinary bladder lining, thyroid and parathyroid glands
Embryonic Membranes
- Amnion: Surrounds the embryo, filled with amniotic fluid, cushioning and protecting the embryo.
- Chorion: Outermost membrane, contributes to placenta formation, facilitates nutrient and gas exchange with the mother, produces hCG.
- Allantois: Sac-like structure, stores waste, participates in blood vessel development for umbilical cord and placenta, involved in gas exchange.
- Yolk Sac: Surrounds the yolk, provides nutrients to the early embryo, produces the first blood cells.
Digestive System Changes During Pregnancy
- The growing baby and uterus pressure the abdominal organs.
- This can lead to slower digestion, bloating, indigestion, and constipation.
- The pressure on the stomach can cause heartburn and acid reflux.
Stages of Labor and Delivery
- Stage 1 (Dilation): The cervix opens up, aided by uterine contractions and shortening of muscle fibers.
- Stage 2 (Expulsion): The foetus is delivered through the birth canal with strong contractions and voluntary abdominal muscle contractions by the mother.
- Stage 3 (Afterbirth): The placenta and tissues are expelled from the uterus following the baby's birth.
Newborn Changes
- Foramen Ovale Closure: The hole between the heart chambers closes after birth as blood flow shifts to the lungs for oxygen.
- Ductus Arteriosus Closure: The blood vessel connecting the pulmonary artery and the aorta closes after birth as the baby begins to breathe independently.
Fertilization and Early Embryonic Development
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Sperm Entry and Fertilization:
- Sperm tail is absorbed upon entry into the oocyte.
- Sperm head travels through the cytoplasm forming the male pronucleus.
- Sperm entry stimulates the secondary oocyte to complete meiosis II.
- The oocyte nucleus develops into the female pronucleus.
- Fertilization is complete when the male and female pronuclei fuse, forming a zygote.
- Sperm travel is aided by uterine and fallopian tube contractions, cilia, and the sperm flagellum.
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Zygote Development and Blastocyst Formation:
- Fertilized oocyte, now a zygote, travels down the fallopian tube.
- Zygote undergoes mitotic cell division (1 to 2 to 4 to 8 cells, etc.)
- Zygote is totipotent, meaning each cell can develop into a complete organism.
- After 6 days, the zygote reaches the uterus and becomes a blastocyst.
- Blastocyst is a hollow ball of cells surrounding a fluid-filled cavity.
- Inner cell mass (about 30 cells) located on one side of the blastocyst consists of pluripotent stem cells that can develop into various body tissues.
Implantation and its Significance
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Implantation:
- Blastocyst attaches to the uterine wall after floating freely for 3 days.
- Implantation connects the blastocyst to the mother's blood supply.
- Uterine lining, thickened by progesterone and estrogen, provides nutrients to the blastocyst.
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Why Implantation is Crucial:
- Enables nutrient and oxygen delivery to the embryo.
- Provides a protective and stable environment for the embryo.
- Triggers hCG secretion, maintaining the uterine lining and preventing menstruation.
- Leads to placenta formation for nutrient and waste exchange between mother and fetus.
- Without implantation, pregnancy cannot proceed.
Blastocyst Dependence on Hormones
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Hormonal Reliance:
- Blastocyst depends on hCG, progesterone, and estrogen for survival and development.
- Hormones maintain the uterine lining, suppress contractions, and support embryo/placenta growth.
- Corpus luteum produces estrogen and progesterone until the placenta takes over hCG production after 8 weeks.
Cell Differentiation and Primary Germ Layers
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Totipotent to Pluripotent Transition:
- Zygote starts as totipotent (capable of forming any cell type), but becomes pluripotent during blastocyst formation.
- Pluripotent cells can still form many cell types, but not a complete organism.
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Primary Germ Layers:
- Formed during the third week of development from the inner cell mass.
- Three layers: Ectoderm, Mesoderm, and Endoderm.
- Each layer differentiates into specific tissues and organs:
- Ectoderm: Nervous system (brain, spinal cord, nerves), skin, sensory organs, mammary glands, tooth enamel.
- Mesoderm: Musculoskeletal system (muscles, bones, cartilage), circulatory system (heart, blood vessels), excretory system (kidneys, bladder), reproductive system.
- Endoderm: Digestive system (stomach, intestines), respiratory system (lungs, trachea), liver, pancreas, thyroid gland.
Pregnancy and Digestive Changes
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Pressure on the Digestive System: The growing uterus and fetus put pressure on the digestive system, leading to:
- Slower digestion: This can cause bloating, indigestion, and constipation.
- Heartburn and acid reflux: Pressure on the stomach can force acid back into the esophagus.
- Dietary Recommendations: It is often recommended to eat smaller, more frequent meals during pregnancy to alleviate these discomforts.
Stages of Labor and Delivery
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Preparation for Labor: Several hormonal changes prepare the body for labor:
- Pelvic ligaments soften, uterus strengthens.
- Cervix softens, shortens, and begins to open.
- Fetal Position: The fetus settles head-down in the pelvis, with head facing the mother's hip bone.
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Three Stages of Labor:
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Stage 1 (Dilation): Cervix gradually opens (dilates) to 10 cm:
- Weak contractions become stronger, pulling the cervix open.
- Fetus moves deeper into the pelvis.
- Contractions push the fetal head against the cervix.
- Birth canal forms.
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Stage 2 (Expulsion): Delivery of the fetus:
- Amniotic sac ruptures (water breaking).
- Fetus passes through the birth canal.
- Mother's abdominal muscles contract, pushing the baby out.
- Head emerges first, followed by the shoulders.
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Stage 3 (Afterbirth): Expulsion of the placenta and other tissues:
- Umbilical cord is clamped and cut.
- Uterus continues contracting, expelling the placenta, membranes, and cord.
- Blood clots stop leakage from the placental vessels.
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Stage 1 (Dilation): Cervix gradually opens (dilates) to 10 cm:
Changes in the Newborn's Circulatory System at Birth
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Foramen Ovale Closure:
- Before birth, the foramen ovale allows blood to bypass the lungs.
- After birth, the first breath sends blood to the lungs, causing the foramen ovale to close.
- This ensures proper blood flow through the heart and lungs.
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Other Changes:
- Umbilical cord circulation shuts down, requiring the newborn's own circulatory system to function.
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Description
This quiz covers the key processes of fertilization, zygote development, and implantation. It explains the formation of the male and female pronuclei, the transition from zygote to blastocyst, and the embedding of the blastocyst in the uterine lining. Test your understanding of these essential concepts in human development.